Q97YS4 - SULSO - GREMLIN Contacts

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Q97YS4 - First ORF in partial transposon ISC1491

UniProt:	Q97YS4	Sequences: MKSKNFPEILMESTGPYFFYLHEELTEKGYKVTVINPLHLKEVFGKKTDKLDAQRLAKAFILGAVKGSYIPTGEIRELRELTRYRESLMRKITQVKNEIRKFLEMAGYKIEPFDKRGMALLEKLSRGEGLSKEERDELKEKLGRSLNDAEKLALKQLVDLLKSLEAMVKEVEDMIISKIPQPVVELSRELV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	191 (179)
Sequences:	1469 (1121)
Seq/√Len:	83.8

SULSO - Q97YS4 Q97XZ9 Q97XG9 Q97UF7 Q97X29 Q97X07

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
122_E	162_K	5.879	1.00
10_L	60_F	3.543	1.00
110_I	117_G	3.477	1.00
135_R	142_L	3.473	1.00
40_L	56_L	3.427	1.00
82_T	175_I	3.193	1.00
92_I	165_E	3.186	1.00
142_L	145_S	3.083	1.00
174_M	177_S	2.776	1.00
10_L	56_L	2.666	1.00
9_I	30_Y	2.650	1.00
134_E	142_L	2.599	1.00
96_K	113_F	2.411	1.00
135_R	139_K	2.305	1.00
92_I	161_L	2.285	1.00
85_R	172_E	2.257	1.00
78_L	175_I	2.219	1.00
163_S	167_M	2.178	1.00
156_Q	167_M	2.164	1.00
99_I	154_L	2.162	1.00
159_D	166_A	2.045	1.00
134_E	137_E	1.998	1.00
135_R	145_S	1.943	1.00
159_D	167_M	1.930	1.00
152_L	174_M	1.929	1.00
138_L	142_L	1.916	1.00
85_R	89_M	1.748	1.00
99_I	113_F	1.747	1.00
99_I	161_L	1.681	1.00
89_M	168_V	1.675	1.00
42_E	45_G	1.670	1.00
88_L	168_V	1.667	1.00
160_L	163_S	1.648	1.00
92_I	168_V	1.631	1.00
142_L	146_L	1.608	1.00
141_K	145_S	1.556	1.00
152_L	156_Q	1.543	1.00
91_K	98_E	1.525	1.00
94_Q	97_N	1.484	0.99
158_V	162_K	1.474	0.99
11_M	32_V	1.453	0.99
18_F	22_H	1.445	0.99
9_I	25_L	1.445	0.99
164_L	168_V	1.435	0.99
100_R	104_E	1.428	0.99
91_K	94_Q	1.401	0.99
38_L	42_E	1.392	0.99
104_E	109_K	1.354	0.99
16_P	104_E	1.340	0.99
155_K	159_D	1.324	0.99
101_K	105_M	1.306	0.98
139_K	142_L	1.278	0.98
160_L	164_L	1.255	0.98
126_R	129_G	1.245	0.98
159_D	163_S	1.228	0.98
89_M	92_I	1.227	0.98
172_E	175_I	1.223	0.98
11_M	18_F	1.206	0.97
134_E	145_S	1.178	0.97
51_L	56_L	1.162	0.97
93_T	97_N	1.157	0.97
12_E	17_Y	1.121	0.96
146_L	149_A	1.115	0.96
118_M	165_E	1.113	0.96
134_E	139_K	1.113	0.96
74_E	181_Q	1.086	0.95
139_K	143_G	1.080	0.95
163_S	166_A	1.073	0.95
155_K	170_E	1.073	0.95
88_L	164_L	1.059	0.95
98_E	101_K	1.052	0.94
22_H	34_V	1.039	0.94
13_S	68_S	1.029	0.94
177_S	180_P	1.028	0.94
134_E	141_K	1.025	0.94
35_I	65_V	1.021	0.93
95_V	157_L	1.021	0.93
137_E	140_E	1.002	0.93
84_Y	160_L	0.993	0.92
147_N	150_E	0.983	0.92
11_M	22_H	0.973	0.92
141_K	144_R	0.973	0.92
135_R	141_K	0.967	0.91
10_L	85_R	0.961	0.91
103_L	121_L	0.955	0.91
133_E	142_L	0.950	0.91
127_G	131_S	0.950	0.91
166_A	170_E	0.945	0.90
119_A	122_E	0.943	0.90
148_D	174_M	0.934	0.90
167_M	170_E	0.931	0.90
120_L	124_L	0.931	0.90
159_D	170_E	0.926	0.90
43_V	46_K	0.926	0.90
125_S	129_G	0.922	0.89
24_E	28_K	0.921	0.89
18_F	85_R	0.911	0.89
137_E	142_L	0.904	0.88
146_L	151_K	0.901	0.88
132_K	144_R	0.900	0.88
84_Y	156_Q	0.896	0.88
173_D	177_S	0.875	0.87
84_Y	88_L	0.871	0.86
8_E	60_F	0.868	0.86
81_L	174_M	0.865	0.86
133_E	139_K	0.863	0.86
132_K	145_S	0.863	0.86
132_K	142_L	0.852	0.85
35_I	40_L	0.851	0.85
50_K	58_K	0.848	0.85
148_D	151_K	0.845	0.85
136_D	142_L	0.841	0.84
53_A	73_G	0.837	0.84
92_I	96_K	0.836	0.84
115_K	119_A	0.835	0.84
169_K	172_E	0.827	0.83
21_L	40_L	0.826	0.83
169_K	173_D	0.818	0.83
174_M	178_K	0.817	0.83
53_A	118_M	0.812	0.82
120_L	123_K	0.811	0.82
146_L	150_E	0.809	0.82
138_L	141_K	0.808	0.82
58_K	62_L	0.806	0.82
97_N	101_K	0.804	0.82
22_H	32_V	0.800	0.81
37_P	125_S	0.797	0.81
100_R	112_P	0.796	0.81
19_F	105_M	0.794	0.81
29_G	166_A	0.792	0.81
21_L	25_L	0.774	0.79
160_L	167_M	0.772	0.79
133_E	136_D	0.770	0.79
129_G	151_K	0.768	0.79
95_V	98_E	0.768	0.79
156_Q	170_E	0.765	0.78
43_V	59_A	0.760	0.78
139_K	145_S	0.756	0.78
134_E	146_L	0.755	0.77
91_K	160_L	0.754	0.77
136_D	145_S	0.754	0.77
95_V	160_L	0.751	0.77
162_K	165_E	0.748	0.77
34_V	39_H	0.748	0.77
96_K	165_E	0.744	0.76
137_E	141_K	0.739	0.76
24_E	107_G	0.730	0.75
121_L	158_V	0.726	0.75
114_D	117_G	0.726	0.75
84_Y	157_L	0.725	0.75
165_E	169_K	0.721	0.74
37_P	121_L	0.720	0.74
98_E	157_L	0.713	0.73
88_L	171_V	0.711	0.73
120_L	125_S	0.702	0.72
13_S	16_P	0.702	0.72
87_S	90_R	0.700	0.72
87_S	98_E	0.699	0.72
176_I	180_P	0.699	0.72
7_P	56_L	0.687	0.71
122_E	158_V	0.684	0.70
166_A	174_M	0.673	0.69
132_K	135_R	0.672	0.69
161_L	165_E	0.669	0.69
111_E	117_G	0.664	0.68
7_P	10_L	0.662	0.68
107_G	127_G	0.660	0.68
133_E	138_L	0.659	0.67
10_L	20_Y	0.656	0.67
152_L	155_K	0.655	0.67
166_A	169_K	0.654	0.67
107_G	142_L	0.653	0.67
179_I	182_P	0.653	0.67
164_L	180_P	0.651	0.66
105_M	150_E	0.650	0.66
94_Q	168_V	0.649	0.66
39_H	59_A	0.645	0.66
12_E	36_N	0.644	0.66
38_L	53_A	0.643	0.65
60_F	65_V	0.640	0.65
140_E	144_R	0.637	0.65
94_Q	101_K	0.636	0.65
124_L	130_L	0.634	0.64
135_R	148_D	0.633	0.64
30_Y	138_L	0.631	0.64
88_L	167_M	0.626	0.63
13_S	34_V	0.622	0.63
136_D	140_E	0.622	0.63
112_P	117_G	0.619	0.63
57_A	61_I	0.619	0.63
96_K	166_A	0.616	0.62
155_K	173_D	0.612	0.62
175_I	179_I	0.611	0.62
23_E	48_T	0.608	0.61
126_R	175_I	0.606	0.61
134_E	144_R	0.604	0.61
36_N	68_S	0.602	0.60
147_N	151_K	0.600	0.60
51_L	54_Q	0.597	0.60
162_K	169_K	0.596	0.60
43_V	55_R	0.596	0.60
34_V	70_I	0.590	0.59
136_D	139_K	0.587	0.59
170_E	174_M	0.582	0.58
107_G	124_L	0.578	0.57
134_E	138_L	0.578	0.57
133_E	143_G	0.577	0.57
103_L	139_K	0.575	0.57
138_L	145_S	0.574	0.57
121_L	126_R	0.574	0.57
159_D	173_D	0.574	0.57
165_E	168_V	0.573	0.57
17_Y	83_R	0.572	0.57
46_K	58_K	0.569	0.56
95_V	99_I	0.568	0.56
112_P	154_L	0.565	0.56
154_L	161_L	0.565	0.56
93_T	133_E	0.560	0.55
72_T	75_I	0.558	0.55
71_P	112_P	0.558	0.55
10_L	18_F	0.557	0.55
133_E	137_E	0.555	0.54
59_A	120_L	0.554	0.54
85_R	168_V	0.554	0.54
27_E	136_D	0.553	0.54
10_L	40_L	0.552	0.54
143_G	173_D	0.550	0.54
116_R	120_L	0.550	0.54
133_E	144_R	0.546	0.53
137_E	145_S	0.545	0.53
44_F	108_Y	0.545	0.53
84_Y	95_V	0.544	0.53
71_P	76_R	0.544	0.53
72_T	167_M	0.543	0.53
15_G	108_Y	0.539	0.52
99_I	157_L	0.539	0.52
110_I	172_E	0.539	0.52
31_K	67_G	0.538	0.52
118_M	161_L	0.532	0.51
87_S	93_T	0.531	0.51
96_K	103_L	0.529	0.51
118_M	162_K	0.529	0.51
140_E	181_Q	0.528	0.51
172_E	176_I	0.528	0.51
119_A	123_K	0.528	0.51
110_I	121_L	0.527	0.51
136_D	173_D	0.527	0.51
11_M	17_Y	0.525	0.50
118_M	158_V	0.525	0.50
45_G	64_A	0.524	0.50
25_L	53_A	0.524	0.50
24_E	44_F	0.523	0.50
132_K	143_G	0.523	0.50
38_L	44_F	0.523	0.50
80_E	149_A	0.521	0.50
82_T	113_F	0.520	0.50
135_R	169_K	0.520	0.50
74_E	177_S	0.515	0.49
135_R	149_A	0.514	0.49
6_F	29_G	0.513	0.49
175_I	182_P	0.512	0.49
13_S	17_Y	0.510	0.48
109_K	125_S	0.510	0.48
14_T	17_Y	0.505	0.48
9_I	12_E	0.505	0.48
64_A	69_Y	0.504	0.48
174_M	182_P	0.504	0.48
151_K	155_K	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3613	63.2	0.922	Contact Map
3icxA	2	0.623	58.2	0.924	Contact Map
1keaA	2	0.534	56.2	0.925	Contact Map
3plaA	2	0.9634	55.4	0.925	Contact Map
2nnwA	2	0.9791	53	0.927	Contact Map
4ep4A	2	0.4921	50.7	0.927	Contact Map
3id6A	2	0.9162	49.9	0.928	Contact Map
5ajtA	2	0.3717	21.1	0.941	Contact Map
3c6aA	1	0.5497	20.8	0.941	Contact Map
2h21A	3	0.9372	20	0.941	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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