GREMLIN Database
Q97YS4 - First ORF in partial transposon ISC1491
UniProt: Q97YS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (179)
Sequences: 1469 (1121)
Seq/√Len: 83.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_E162_K5.8791.00
10_L60_F3.5431.00
110_I117_G3.4771.00
135_R142_L3.4731.00
40_L56_L3.4271.00
82_T175_I3.1931.00
92_I165_E3.1861.00
142_L145_S3.0831.00
174_M177_S2.7761.00
10_L56_L2.6661.00
9_I30_Y2.6501.00
134_E142_L2.5991.00
96_K113_F2.4111.00
135_R139_K2.3051.00
92_I161_L2.2851.00
85_R172_E2.2571.00
78_L175_I2.2191.00
163_S167_M2.1781.00
156_Q167_M2.1641.00
99_I154_L2.1621.00
159_D166_A2.0451.00
134_E137_E1.9981.00
135_R145_S1.9431.00
159_D167_M1.9301.00
152_L174_M1.9291.00
138_L142_L1.9161.00
85_R89_M1.7481.00
99_I113_F1.7471.00
99_I161_L1.6811.00
89_M168_V1.6751.00
42_E45_G1.6701.00
88_L168_V1.6671.00
160_L163_S1.6481.00
92_I168_V1.6311.00
142_L146_L1.6081.00
141_K145_S1.5561.00
152_L156_Q1.5431.00
91_K98_E1.5251.00
94_Q97_N1.4840.99
158_V162_K1.4740.99
11_M32_V1.4530.99
18_F22_H1.4450.99
9_I25_L1.4450.99
164_L168_V1.4350.99
100_R104_E1.4280.99
91_K94_Q1.4010.99
38_L42_E1.3920.99
104_E109_K1.3540.99
16_P104_E1.3400.99
155_K159_D1.3240.99
101_K105_M1.3060.98
139_K142_L1.2780.98
160_L164_L1.2550.98
126_R129_G1.2450.98
159_D163_S1.2280.98
89_M92_I1.2270.98
172_E175_I1.2230.98
11_M18_F1.2060.97
134_E145_S1.1780.97
51_L56_L1.1620.97
93_T97_N1.1570.97
12_E17_Y1.1210.96
146_L149_A1.1150.96
118_M165_E1.1130.96
134_E139_K1.1130.96
74_E181_Q1.0860.95
139_K143_G1.0800.95
163_S166_A1.0730.95
155_K170_E1.0730.95
88_L164_L1.0590.95
98_E101_K1.0520.94
22_H34_V1.0390.94
13_S68_S1.0290.94
177_S180_P1.0280.94
134_E141_K1.0250.94
35_I65_V1.0210.93
95_V157_L1.0210.93
137_E140_E1.0020.93
84_Y160_L0.9930.92
147_N150_E0.9830.92
11_M22_H0.9730.92
141_K144_R0.9730.92
135_R141_K0.9670.91
10_L85_R0.9610.91
103_L121_L0.9550.91
133_E142_L0.9500.91
127_G131_S0.9500.91
166_A170_E0.9450.90
119_A122_E0.9430.90
148_D174_M0.9340.90
167_M170_E0.9310.90
120_L124_L0.9310.90
159_D170_E0.9260.90
43_V46_K0.9260.90
125_S129_G0.9220.89
24_E28_K0.9210.89
18_F85_R0.9110.89
137_E142_L0.9040.88
146_L151_K0.9010.88
132_K144_R0.9000.88
84_Y156_Q0.8960.88
173_D177_S0.8750.87
84_Y88_L0.8710.86
8_E60_F0.8680.86
81_L174_M0.8650.86
133_E139_K0.8630.86
132_K145_S0.8630.86
132_K142_L0.8520.85
35_I40_L0.8510.85
50_K58_K0.8480.85
148_D151_K0.8450.85
136_D142_L0.8410.84
53_A73_G0.8370.84
92_I96_K0.8360.84
115_K119_A0.8350.84
169_K172_E0.8270.83
21_L40_L0.8260.83
169_K173_D0.8180.83
174_M178_K0.8170.83
53_A118_M0.8120.82
120_L123_K0.8110.82
146_L150_E0.8090.82
138_L141_K0.8080.82
58_K62_L0.8060.82
97_N101_K0.8040.82
22_H32_V0.8000.81
37_P125_S0.7970.81
100_R112_P0.7960.81
19_F105_M0.7940.81
29_G166_A0.7920.81
21_L25_L0.7740.79
160_L167_M0.7720.79
133_E136_D0.7700.79
129_G151_K0.7680.79
95_V98_E0.7680.79
156_Q170_E0.7650.78
43_V59_A0.7600.78
139_K145_S0.7560.78
134_E146_L0.7550.77
91_K160_L0.7540.77
136_D145_S0.7540.77
95_V160_L0.7510.77
162_K165_E0.7480.77
34_V39_H0.7480.77
96_K165_E0.7440.76
137_E141_K0.7390.76
24_E107_G0.7300.75
121_L158_V0.7260.75
114_D117_G0.7260.75
84_Y157_L0.7250.75
165_E169_K0.7210.74
37_P121_L0.7200.74
98_E157_L0.7130.73
88_L171_V0.7110.73
120_L125_S0.7020.72
13_S16_P0.7020.72
87_S90_R0.7000.72
87_S98_E0.6990.72
176_I180_P0.6990.72
7_P56_L0.6870.71
122_E158_V0.6840.70
166_A174_M0.6730.69
132_K135_R0.6720.69
161_L165_E0.6690.69
111_E117_G0.6640.68
7_P10_L0.6620.68
107_G127_G0.6600.68
133_E138_L0.6590.67
10_L20_Y0.6560.67
152_L155_K0.6550.67
166_A169_K0.6540.67
107_G142_L0.6530.67
179_I182_P0.6530.67
164_L180_P0.6510.66
105_M150_E0.6500.66
94_Q168_V0.6490.66
39_H59_A0.6450.66
12_E36_N0.6440.66
38_L53_A0.6430.65
60_F65_V0.6400.65
140_E144_R0.6370.65
94_Q101_K0.6360.65
124_L130_L0.6340.64
135_R148_D0.6330.64
30_Y138_L0.6310.64
88_L167_M0.6260.63
13_S34_V0.6220.63
136_D140_E0.6220.63
112_P117_G0.6190.63
57_A61_I0.6190.63
96_K166_A0.6160.62
155_K173_D0.6120.62
175_I179_I0.6110.62
23_E48_T0.6080.61
126_R175_I0.6060.61
134_E144_R0.6040.61
36_N68_S0.6020.60
147_N151_K0.6000.60
51_L54_Q0.5970.60
162_K169_K0.5960.60
43_V55_R0.5960.60
34_V70_I0.5900.59
136_D139_K0.5870.59
170_E174_M0.5820.58
107_G124_L0.5780.57
134_E138_L0.5780.57
133_E143_G0.5770.57
103_L139_K0.5750.57
138_L145_S0.5740.57
121_L126_R0.5740.57
159_D173_D0.5740.57
165_E168_V0.5730.57
17_Y83_R0.5720.57
46_K58_K0.5690.56
95_V99_I0.5680.56
112_P154_L0.5650.56
154_L161_L0.5650.56
93_T133_E0.5600.55
72_T75_I0.5580.55
71_P112_P0.5580.55
10_L18_F0.5570.55
133_E137_E0.5550.54
59_A120_L0.5540.54
85_R168_V0.5540.54
27_E136_D0.5530.54
10_L40_L0.5520.54
143_G173_D0.5500.54
116_R120_L0.5500.54
133_E144_R0.5460.53
137_E145_S0.5450.53
44_F108_Y0.5450.53
84_Y95_V0.5440.53
71_P76_R0.5440.53
72_T167_M0.5430.53
15_G108_Y0.5390.52
99_I157_L0.5390.52
110_I172_E0.5390.52
31_K67_G0.5380.52
118_M161_L0.5320.51
87_S93_T0.5310.51
96_K103_L0.5290.51
118_M162_K0.5290.51
140_E181_Q0.5280.51
172_E176_I0.5280.51
119_A123_K0.5280.51
110_I121_L0.5270.51
136_D173_D0.5270.51
11_M17_Y0.5250.50
118_M158_V0.5250.50
45_G64_A0.5240.50
25_L53_A0.5240.50
24_E44_F0.5230.50
132_K143_G0.5230.50
38_L44_F0.5230.50
80_E149_A0.5210.50
82_T113_F0.5200.50
135_R169_K0.5200.50
74_E177_S0.5150.49
135_R149_A0.5140.49
6_F29_G0.5130.49
175_I182_P0.5120.49
13_S17_Y0.5100.48
109_K125_S0.5100.48
14_T17_Y0.5050.48
9_I12_E0.5050.48
64_A69_Y0.5040.48
174_M182_P0.5040.48
151_K155_K0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3613 63.2 0.922 Contact Map
3icxA 2 0.623 58.2 0.924 Contact Map
1keaA 2 0.534 56.2 0.925 Contact Map
3plaA 2 0.9634 55.4 0.925 Contact Map
2nnwA 2 0.9791 53 0.927 Contact Map
4ep4A 2 0.4921 50.7 0.927 Contact Map
3id6A 2 0.9162 49.9 0.928 Contact Map
5ajtA 2 0.3717 21.1 0.941 Contact Map
3c6aA 1 0.5497 20.8 0.941 Contact Map
2h21A 3 0.9372 20 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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