GREMLIN Database
Q97YS0 - Transposase ISC1359
UniProt: Q97YS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (302)
Sequences: 167 (123)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_A276_F5.2580.99
168_L194_V4.1290.97
327_S331_D3.9300.96
173_A275_A3.6820.94
93_V154_M3.6080.93
250_V288_T3.2370.88
60_L293_K3.0720.85
161_L171_V2.9010.82
296_V300_L2.8280.80
250_V270_W2.8080.79
63_L117_T2.6040.74
126_I161_L2.5930.73
135_F276_F2.5310.71
174_D269_R2.4920.70
125_A299_L2.4320.68
54_K102_H2.3080.64
327_S330_L2.2800.63
234_Y237_I2.2600.62
94_D273_E2.2510.62
96_H280_E2.2290.61
324_V334_V2.2270.61
274_N277_R2.2210.61
175_R196_S2.2100.60
312_R316_K2.1710.59
24_I41_L2.1520.58
250_V305_L2.0130.53
206_K209_L1.9970.52
324_V328_N1.9680.51
329_L334_V1.9450.50
178_A274_N1.9430.50
186_L191_L1.9190.49
294_E308_W1.8310.46
251_R300_L1.8180.45
324_V327_S1.7880.44
57_R195_I1.7850.44
178_A197_A1.7780.44
121_L276_F1.7610.43
24_I27_I1.7570.43
95_F168_L1.7560.43
94_D174_D1.7520.43
174_D273_E1.7520.43
135_F302_Y1.7440.43
120_G270_W1.7310.42
26_S35_E1.7210.42
266_Y272_I1.6830.40
126_I137_D1.6740.40
94_D269_R1.6700.40
269_R273_E1.6700.40
238_L276_F1.6390.39
282_F305_L1.5880.37
124_A157_I1.5560.36
92_A248_F1.5520.36
326_L329_L1.5360.35
276_F286_T1.5350.35
48_Y93_V1.5250.35
33_F37_L1.5230.35
97_A122_V1.5190.34
203_K304_L1.5180.34
63_L240_K1.5180.34
59_A178_A1.5150.34
111_I114_T1.5010.34
107_F110_R1.4950.34
27_I31_I1.4920.34
177_F277_R1.4740.33
63_L113_P1.4130.31
237_I292_R1.4100.31
92_A182_V1.4040.31
75_L306_N1.4020.30
95_F141_V1.3910.30
92_A254_I1.3870.30
168_L232_G1.3850.30
168_L279_L1.3690.29
27_I41_L1.3650.29
168_L276_F1.3570.29
87_R296_V1.3480.29
86_V310_L1.3480.29
100_Q306_N1.3470.29
63_L137_D1.3400.29
113_P240_K1.3330.28
309_F312_R1.3310.28
52_L106_S1.3180.28
168_L217_G1.3100.28
288_T298_V1.3060.27
102_H123_Q1.2960.27
93_V182_V1.2940.27
142_T307_V1.2920.27
324_V330_L1.2810.27
166_L171_V1.2560.26
94_D266_Y1.2560.26
266_Y273_E1.2560.26
91_V116_G1.2540.26
319_L329_L1.2460.26
94_D272_I1.2440.26
251_R282_F1.2420.26
31_I37_L1.2400.25
319_L323_S1.2390.25
319_L327_S1.2380.25
270_W288_T1.2310.25
80_R207_G1.2300.25
171_V250_V1.2240.25
284_I297_L1.2200.25
296_V304_L1.2150.25
323_S332_R1.2150.25
304_L308_W1.2120.25
157_I276_F1.1990.24
79_G282_F1.1960.24
106_S304_L1.1910.24
203_K303_L1.1720.24
288_T305_L1.1710.24
177_F306_N1.1640.23
326_L330_L1.1590.23
298_V305_L1.1570.23
23_I27_I1.1460.23
267_R306_N1.1460.23
168_L204_K1.1450.23
96_H288_T1.1420.23
323_S334_V1.1350.23
27_I33_F1.1350.23
100_Q289_C1.1310.22
194_V267_R1.1300.22
141_V172_F1.1270.22
167_R253_E1.1230.22
274_N278_S1.1080.22
321_E324_V1.1010.22
104_N128_L1.0930.21
72_R158_V1.0870.21
175_R257_H1.0870.21
63_L175_R1.0860.21
83_L166_L1.0770.21
279_L298_V1.0720.21
209_L290_D1.0710.21
35_E40_A1.0690.21
155_E288_T1.0630.21
154_M161_L1.0620.21
283_R295_L1.0610.21
168_L188_E1.0530.20
34_L37_L1.0520.20
223_G299_L1.0490.20
28_L32_L1.0440.20
32_L41_L1.0410.20
72_R134_S1.0390.20
130_G176_E1.0380.20
86_V236_I1.0360.20
100_Q266_Y1.0350.20
56_G282_F1.0320.20
24_I60_L1.0320.20
250_V300_L1.0280.20
154_M251_R1.0280.20
328_N331_D1.0280.20
69_E82_T1.0270.20
204_K207_G1.0250.20
56_G59_A1.0220.20
285_R330_L1.0220.20
96_H133_R1.0150.19
24_I30_K1.0120.19
288_T294_E1.0070.19
274_N307_V1.0060.19
168_L235_L1.0030.19
126_I306_N0.9950.19
321_E334_V0.9890.19
67_Q218_G0.9880.19
226_C235_L0.9880.19
177_F273_E0.9850.19
94_D177_F0.9850.19
133_R169_V0.9810.19
326_L331_D0.9800.19
24_I38_L0.9790.19
129_L248_F0.9790.19
27_I34_L0.9770.19
276_F287_R0.9700.18
24_I32_L0.9670.18
181_E225_L0.9640.18
307_V334_V0.9610.18
250_V280_E0.9560.18
323_S333_E0.9500.18
230_G303_L0.9500.18
176_E212_V0.9490.18
140_P248_F0.9480.18
68_V81_M0.9440.18
136_L209_L0.9440.18
176_E198_K0.9430.18
94_D294_E0.9410.18
273_E294_E0.9410.18
166_L237_I0.9400.18
24_I179_V0.9350.18
81_M134_S0.9320.18
28_L33_F0.9260.17
116_G295_L0.9220.17
68_V293_K0.9200.17
93_V276_F0.9200.17
328_N334_V0.9160.17
133_R277_R0.9140.17
177_F272_I0.9090.17
56_G290_D0.9090.17
323_S328_N0.9070.17
77_K182_V0.9040.17
157_I251_R0.9040.17
251_R288_T0.9020.17
132_T304_L0.9000.17
267_R271_G0.8990.17
61_R290_D0.8990.17
130_G299_L0.8960.17
157_I279_L0.8880.17
305_L312_R0.8880.17
280_E288_T0.8670.16
35_E299_L0.8610.16
73_D106_S0.8610.16
60_L236_I0.8600.16
117_T299_L0.8600.16
99_P304_L0.8580.16
157_I305_L0.8540.16
60_L275_A0.8450.16
251_R298_V0.8410.16
171_V280_E0.8410.16
154_M157_I0.8310.15
154_M193_F0.8280.15
66_V246_I0.8280.15
173_A178_A0.8220.15
76_R257_H0.8220.15
169_V270_W0.8210.15
72_R296_V0.8190.15
97_A120_G0.8140.15
61_R107_F0.8130.15
167_R226_C0.8080.15
119_W194_V0.8060.15
69_E167_R0.8040.15
167_R223_G0.8040.15
236_I240_K0.8030.15
302_Y305_L0.8020.15
267_R318_K0.7920.15
91_V161_L0.7890.15
280_E305_L0.7880.15
195_I207_G0.7880.15
320_W326_L0.7870.15
293_K307_V0.7870.15
320_W323_S0.7800.14
27_I30_K0.7790.14
320_W324_V0.7780.14
137_D158_V0.7760.14
31_I41_L0.7750.14
124_A193_F0.7740.14
271_G301_S0.7730.14
139_I277_R0.7720.14
108_L154_M0.7670.14
135_F163_E0.7670.14
125_A298_V0.7650.14
83_L186_L0.7650.14
214_V224_F0.7630.14
93_V286_T0.7630.14
321_E328_N0.7610.14
274_N292_R0.7590.14
150_F226_C0.7590.14
184_R189_L0.7570.14
158_V183_I0.7470.14
248_F288_T0.7470.14
183_I274_N0.7450.14
110_R250_V0.7450.14
101_Y176_E0.7440.14
183_I193_F0.7440.14
30_K33_F0.7430.14
81_M241_E0.7430.14
158_V174_D0.7420.14
111_I259_A0.7340.14
198_K214_V0.7340.14
194_V266_Y0.7330.14
274_N310_L0.7280.13
186_L333_E0.7280.13
134_S198_K0.7270.13
214_V220_R0.7270.13
69_E91_V0.7210.13
68_V220_R0.7200.13
183_I187_L0.7150.13
24_I172_F0.7150.13
35_E42_L0.7140.13
60_L153_V0.7130.13
92_A129_L0.7110.13
165_K296_V0.7100.13
141_V182_V0.7100.13
54_K276_F0.7100.13
74_A116_G0.7090.13
193_F290_D0.7080.13
149_G195_I0.7070.13
73_D83_L0.7060.13
59_A314_W0.7050.13
287_R311_I0.7040.13
102_H289_C0.7010.13
124_A314_W0.7010.13
250_V274_N0.7010.13
251_R270_W0.7000.13
182_V276_F0.7000.13
54_K125_A0.6980.13
32_L37_L0.6970.13
293_K297_L0.6970.13
76_R91_V0.6960.13
29_T173_A0.6940.13
149_G152_A0.6930.13
102_H294_E0.6860.13
81_M204_K0.6860.13
159_K171_V0.6830.13
62_K73_D0.6820.13
176_E307_V0.6780.13
174_D272_I0.6770.13
270_W282_F0.6770.13
93_V191_L0.6750.13
59_A72_R0.6730.12
80_R108_L0.6730.12
58_R264_E0.6720.12
26_S40_A0.6710.12
124_A182_V0.6700.12
324_V333_E0.6670.12
298_V302_Y0.6660.12
31_I38_L0.6660.12
151_K186_L0.6660.12
133_R197_A0.6630.12
75_L79_G0.6610.12
50_S280_E0.6600.12
79_G277_R0.6580.12
73_D190_G0.6570.12
331_D334_V0.6540.12
311_I314_W0.6540.12
89_K302_Y0.6540.12
182_V219_V0.6530.12
41_L122_V0.6520.12
121_L203_K0.6490.12
189_L232_G0.6470.12
128_L208_M0.6450.12
73_D264_E0.6450.12
126_I230_G0.6450.12
28_L277_R0.6440.12
272_I276_F0.6430.12
194_V209_L0.6420.12
24_I31_I0.6390.12
64_N236_I0.6380.12
320_W331_D0.6360.12
263_A274_N0.6350.12
112_K285_R0.6350.12
193_F267_R0.6340.12
325_S328_N0.6320.12
96_H263_A0.6300.12
91_V259_A0.6300.12
97_A256_L0.6290.12
105_K255_D0.6280.12
141_V154_M0.6250.12
64_N110_R0.6240.12
253_E275_A0.6210.12
174_D266_Y0.6200.12
268_E292_R0.6200.12
109_S113_P0.6180.12
76_R137_D0.6180.12
257_H309_F0.6170.12
284_I298_V0.6160.12
141_V215_S0.6150.12
261_V313_S0.6150.12
54_K266_Y0.6150.12
161_L193_F0.6140.12
126_I150_F0.6140.12
125_A245_I0.6130.11
128_L296_V0.6130.11
218_G290_D0.6120.11
28_L35_E0.6110.11
51_R325_S0.6100.11
155_E189_L0.6090.11
60_L243_G0.6060.11
116_G268_E0.6060.11
65_A306_N0.6050.11
146_V195_I0.6030.11
75_L183_I0.6030.11
197_A262_L0.6020.11
318_K321_E0.6010.11
139_I271_G0.5990.11
321_E326_L0.5980.11
61_R267_R0.5970.11
50_S153_V0.5960.11
223_G260_I0.5960.11
244_K276_F0.5950.11
61_R292_R0.5940.11
325_S330_L0.5920.11
27_I272_I0.5910.11
202_Y209_L0.5890.11
323_S327_S0.5870.11
193_F312_R0.5870.11
170_M182_V0.5870.11
310_L314_W0.5860.11
329_L332_R0.5840.11
96_H140_P0.5830.11
170_M281_E0.5810.11
139_I156_V0.5800.11
35_E190_G0.5790.11
85_G207_G0.5770.11
58_R130_G0.5760.11
92_A331_D0.5760.11
117_T306_N0.5760.11
39_S60_L0.5740.11
269_R272_I0.5740.11
139_I267_R0.5700.11
172_F284_I0.5690.11
323_S326_L0.5690.11
183_I249_L0.5680.11
29_T37_L0.5640.11
54_K93_V0.5640.11
117_T285_R0.5640.11
148_E252_R0.5630.11
113_P116_G0.5610.11
237_I309_F0.5550.11
175_R286_T0.5550.11
64_N92_A0.5530.11
287_R299_L0.5530.11
100_Q196_S0.5520.11
123_Q259_A0.5520.11
251_R280_E0.5500.11
317_V321_E0.5490.11
87_R105_K0.5480.11
79_G204_K0.5460.10
214_V219_V0.5430.10
93_V297_L0.5360.10
137_D286_T0.5340.10
65_A205_Y0.5340.10
182_V272_I0.5310.10
40_A60_L0.5310.10
128_L308_W0.5300.10
125_A238_L0.5280.10
329_L333_E0.5280.10
235_L247_A0.5280.10
234_Y239_R0.5270.10
324_V329_L0.5260.10
33_F36_E0.5220.10
152_A190_G0.5210.10
32_L59_A0.5210.10
127_F276_F0.5210.10
266_Y269_R0.5190.10
55_D197_A0.5180.10
78_M185_Y0.5180.10
78_M130_G0.5150.10
99_P196_S0.5140.10
91_V129_L0.5130.10
123_Q178_A0.5120.10
246_I267_R0.5110.10
124_A298_V0.5110.10
285_R306_N0.5100.10
243_G321_E0.5090.10
127_F158_V0.5070.10
233_A237_I0.5070.10
80_R164_D0.5060.10
269_R286_T0.5050.10
56_G266_Y0.5050.10
193_F251_R0.5040.10
82_T282_F0.5030.10
147_A229_H0.5020.10
48_Y53_G0.5020.10
196_S276_F0.5020.10
40_A259_A0.5010.10
84_R132_T0.5010.10
72_R173_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9171 99.4 0.857 Contact Map
4mq3A 1 0.36 27.7 0.969 Contact Map
1b78A 2 0.4343 23.2 0.97 Contact Map
4wpeA 2 0.3171 20.5 0.971 Contact Map
3kksA 2 0.4171 18.3 0.972 Contact Map
2i4rA 6 0.2057 8 0.976 Contact Map
4cvnE 1 0.3029 7.1 0.977 Contact Map
3wx4A 2 0.2514 6.9 0.977 Contact Map
3k6qA 2 0.3886 6.9 0.977 Contact Map
2ia0A 2 0.4286 6.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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