GREMLIN Database
Y1253 - Putative esterase SSO1253
UniProt: Q97YR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (123)
Sequences: 6280 (4297)
Seq/√Len: 387.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_K100_P3.3871.00
33_E43_K3.0241.00
86_A114_L2.5831.00
41_R104_E2.5681.00
34_K41_R2.3411.00
104_E122_Y2.3391.00
34_K39_Y2.2201.00
31_E43_K2.1751.00
42_L69_A2.1661.00
63_F88_L1.9871.00
36_E39_Y1.9371.00
120_S128_L1.9161.00
70_G119_I1.8661.00
69_A103_V1.8471.00
39_Y104_E1.8171.00
39_Y106_R1.7971.00
44_F61_V1.7881.00
41_R102_T1.7551.00
74_V115_V1.7441.00
94_K127_N1.7191.00
43_K102_T1.7021.00
123_D127_N1.6981.00
66_V132_A1.6661.00
118_D131_K1.6531.00
107_V110_E1.5921.00
108_I118_D1.5601.00
45_N100_P1.5461.00
106_R120_S1.5431.00
106_R118_D1.5341.00
81_K140_R1.4751.00
70_G134_G1.4671.00
87_E91_N1.4461.00
63_F90_I1.4451.00
66_V119_I1.4401.00
33_E41_R1.4371.00
99_G124_G1.3781.00
24_I61_V1.3521.00
27_F49_K1.3271.00
96_M129_C1.3261.00
108_I131_K1.3031.00
77_L110_E1.2841.00
120_S131_K1.2841.00
38_G76_T1.2801.00
62_V130_A1.2631.00
74_V136_W1.2391.00
46_F57_L1.2301.00
24_I64_S1.2091.00
47_N50_L1.1881.00
99_G123_D1.1651.00
122_Y126_S1.1571.00
63_F92_F1.1551.00
48_E51_T1.1321.00
109_S114_L1.1241.00
90_I130_A1.1211.00
66_V121_A1.0991.00
65_A103_V1.0991.00
115_V138_V1.0981.00
96_M101_F1.0921.00
118_D133_L1.0791.00
122_Y128_L1.0761.00
57_L101_F1.0631.00
62_V121_A1.0621.00
93_L131_K1.0551.00
103_V119_I1.0381.00
31_E100_P1.0081.00
100_P124_G1.0081.00
62_V129_C1.0041.00
30_I42_L0.9851.00
56_I84_V0.9821.00
44_F65_A0.9741.00
67_D85_T0.9641.00
77_L107_V0.9491.00
74_V117_V0.9441.00
114_L137_V0.9421.00
89_K133_L0.9381.00
102_T124_G0.9311.00
60_G64_S0.9271.00
109_S116_V0.9061.00
91_N135_T0.9011.00
113_R137_V0.8941.00
31_E45_N0.8861.00
84_V139_Y0.8741.00
25_F68_Y0.8591.00
78_D81_K0.8571.00
73_A117_V0.8441.00
73_A107_V0.8401.00
87_E133_L0.8311.00
73_A105_P0.8271.00
102_T122_Y0.8211.00
104_E120_S0.8151.00
57_L96_M0.8021.00
101_F129_C0.7791.00
93_L128_L0.7761.00
33_E100_P0.7751.00
28_I64_S0.7731.00
35_L76_T0.7691.00
107_V117_V0.7691.00
93_L109_S0.7671.00
94_K109_S0.7611.00
116_V135_T0.7571.00
70_G136_W0.7551.00
103_V121_A0.7521.00
50_L61_V0.7491.00
32_F42_L0.7431.00
62_V92_F0.7411.00
91_N116_V0.7381.00
87_E135_T0.7361.00
37_K77_L0.7291.00
45_N50_L0.7291.00
88_L92_F0.7271.00
56_I95_P0.7261.00
101_F121_A0.7241.00
75_R83_G0.7131.00
83_G138_V0.7091.00
75_R82_D0.7021.00
23_E26_N0.6981.00
46_F51_T0.6971.00
59_G92_F0.6971.00
66_V90_I0.6850.99
46_F50_L0.6790.99
70_G117_V0.6760.99
38_G107_V0.6750.99
38_G77_L0.6700.99
119_I134_G0.6700.99
102_T126_S0.6690.99
104_E126_S0.6680.99
58_H68_Y0.6650.99
63_F132_A0.6580.99
21_Q26_N0.6570.99
53_I71_S0.6540.99
67_D71_S0.6470.99
88_L132_A0.6420.99
68_Y72_Y0.6350.99
85_T88_L0.6270.99
29_G49_K0.6270.99
128_L131_K0.6230.99
85_T136_W0.6220.99
93_L116_V0.6220.99
30_I44_F0.6190.99
25_F72_Y0.6190.99
20_K26_N0.6190.99
51_T98_E0.6190.99
62_V96_M0.6160.99
105_P119_I0.6160.99
57_L62_V0.6110.99
69_A105_P0.6040.99
71_S136_W0.6010.99
70_G132_A0.6010.99
85_T134_G0.6000.99
29_G47_N0.5950.98
110_E115_V0.5920.98
43_K124_G0.5910.98
56_I97_K0.5910.98
86_A137_V0.5890.98
96_M123_D0.5850.98
62_V67_D0.5770.98
32_F72_Y0.5720.98
38_G73_A0.5700.98
91_N133_L0.5690.98
119_I132_A0.5690.98
33_E42_L0.5680.98
26_N49_K0.5670.98
40_S73_A0.5670.98
102_T123_D0.5540.98
90_I132_A0.5480.97
115_V136_W0.5450.97
50_L57_L0.5450.97
82_D139_Y0.5440.97
83_G136_W0.5420.97
27_F61_V0.5400.97
84_V137_V0.5390.97
40_S76_T0.5390.97
23_E27_F0.5380.97
123_D129_C0.5360.97
54_G84_V0.5330.97
116_V131_K0.5310.97
24_I28_I0.5270.97
88_L134_G0.5240.97
116_V133_L0.5160.96
81_K138_V0.5130.96
112_K140_R0.5130.96
24_I27_F0.5130.96
25_F30_I0.5030.96
94_K137_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hduA 4 0.9 99.9 0.329 Contact Map
3e8pA 3 0.9067 99.9 0.331 Contact Map
3f1tA 2 0.88 99.9 0.333 Contact Map
4rmmA 2 0.8933 99.9 0.333 Contact Map
1t82A 2 0.9 99.9 0.347 Contact Map
3lmbA 2 0.9267 99.9 0.352 Contact Map
3gekA 3 0.8067 99.9 0.357 Contact Map
3e29A 3 0.8867 99.9 0.361 Contact Map
3e1eA 3 0.9133 99.9 0.362 Contact Map
1yocA 4 0.9 99.9 0.362 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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