GREMLIN Database
Q97YR5 - Citryl-CoA lyase beta subunit homolog (CitE)
UniProt: Q97YR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (257)
Sequences: 3763 (2511)
Seq/√Len: 156.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_V214_S4.2191.00
230_K249_D4.1821.00
189_R216_E4.0471.00
179_Y187_G3.9831.00
63_C89_C3.7181.00
11_A48_L3.6331.00
227_W231_V3.0501.00
40_D43_R3.0301.00
189_R193_E2.8591.00
122_K125_D2.8581.00
5_S215_N2.7091.00
127_V135_V2.6831.00
117_A145_S2.6401.00
158_Y162_L2.6071.00
183_K209_S2.4771.00
45_R77_D2.4651.00
66_V74_S2.2781.00
191_E203_K2.1781.00
232_I265_I2.1621.00
255_Y259_K2.1031.00
121_V162_L2.0931.00
230_K248_L2.0921.00
63_C91_V2.0741.00
137_Y142_L2.0731.00
188_F214_S2.0491.00
112_P132_V2.0201.00
221_S224_E1.9761.00
182_L247_R1.9631.00
259_K262_K1.9351.00
212_D216_E1.9231.00
30_F48_L1.8851.00
12_T40_D1.8641.00
92_L102_L1.8591.00
222_K226_E1.8531.00
142_L146_L1.8501.00
236_E262_K1.8501.00
46_E50_K1.8241.00
231_V248_L1.7981.00
196_K224_E1.7521.00
192_C217_V1.7361.00
76_K79_S1.7191.00
176_D203_K1.6761.00
103_Y131_G1.6591.00
12_T37_P1.5891.00
96_E118_K1.5791.00
225_I264_I1.5711.00
139_A177_K1.5631.00
109_S133_V1.5541.00
121_V169_T1.5291.00
123_I166_V1.5271.00
24_K60_R1.5051.00
248_L253_V1.4991.00
42_E76_K1.4881.00
6_Q27_S1.4811.00
136_S204_Q1.4781.00
226_E230_K1.4751.00
69_L74_S1.4641.00
140_A180_F1.4531.00
181_D184_N1.4471.00
95_A126_I1.4411.00
14_E47_S1.4331.00
8_Y204_Q1.4291.00
73_D76_K1.3891.00
38_P73_D1.3881.00
6_Q175_I1.3751.00
188_F213_I1.3681.00
13_S16_M1.3541.00
114_I123_I1.3421.00
118_K122_K1.3391.00
229_K233_E1.3301.00
167_A174_A1.3251.00
103_Y129_S1.3251.00
189_R217_V1.3191.00
186_D189_R1.3091.00
64_V81_I1.2961.00
192_C203_K1.2961.00
237_K241_E1.2931.00
149_D197_K1.2931.00
68_S71_L1.2881.00
263_R267_F1.2761.00
195_A218_F1.2651.00
227_W264_I1.2591.00
99_L112_P1.2531.00
84_E87_I1.2461.00
43_R47_S1.2401.00
183_K247_R1.2191.00
124_E162_L1.2141.00
120_L159_V1.2041.00
144_L259_K1.1971.00
114_I120_L1.1871.00
111_I136_S1.1841.00
91_V136_S1.1831.00
27_S63_C1.1681.00
50_K54_E1.1601.00
185_L189_R1.1471.00
258_Y262_K1.1391.00
49_I80_T1.1321.00
174_A201_V1.1291.00
233_E237_K1.1251.00
163_I174_A1.1241.00
100_S129_S1.1231.00
157_V161_T1.1221.00
184_N187_G1.1101.00
140_A256_V1.1081.00
262_K266_E1.1030.99
6_Q29_I1.0960.99
121_V124_E1.0910.99
112_P126_I1.0680.99
119_G123_I1.0640.99
124_E169_T1.0540.99
233_E236_E1.0510.99
255_Y262_K1.0360.99
168_R201_V1.0340.99
227_W249_D1.0330.99
160_K176_D1.0140.99
235_Y258_Y1.0130.99
34_D94_K1.0080.99
154_E157_V1.0070.99
142_L165_S1.0050.99
75_Y79_S1.0020.99
97_N122_K0.9970.99
227_W251_K0.9940.99
17_I30_F0.9940.99
220_P225_I0.9890.99
42_E46_E0.9850.99
17_I51_L0.9780.99
185_L209_S0.9740.99
71_L74_S0.9720.99
225_I265_I0.9720.99
48_L64_V0.9710.99
21_V51_L0.9680.99
149_D224_E0.9660.99
213_I217_V0.9590.99
175_I204_Q0.9520.99
180_F252_L0.9490.98
179_Y191_E0.9440.98
140_A257_H0.9430.98
123_I127_V0.9420.98
43_R46_E0.9390.98
154_E194_E0.9340.98
188_F192_C0.9290.98
157_V194_E0.9280.98
223_E226_E0.9270.98
118_K128_R0.9100.98
18_R21_V0.9090.98
105_A131_G0.9060.98
78_I102_L0.9050.98
124_E128_R0.9050.98
232_I235_Y0.9030.98
245_A254_D0.9030.98
190_K194_E0.8990.98
97_N126_I0.8900.98
49_I53_K0.8900.98
147_G263_R0.8870.98
162_L165_S0.8820.98
189_R213_I0.8790.97
188_F210_Q0.8750.97
14_E17_I0.8740.97
74_S102_L0.8740.97
114_I126_I0.8730.97
192_C218_F0.8710.97
8_Y178_V0.8700.97
36_V44_A0.8650.97
186_D190_K0.8640.97
47_S50_K0.8630.97
176_D195_A0.8600.97
164_V200_Y0.8590.97
157_V198_L0.8550.97
19_K22_E0.8550.97
117_A169_T0.8550.97
98_D101_F0.8540.97
225_I229_K0.8510.97
137_Y159_V0.8490.97
111_I134_A0.8420.97
118_K169_T0.8400.97
18_R54_E0.8360.97
66_V92_L0.8360.97
115_E141_D0.8330.97
158_Y161_T0.8290.96
24_K212_D0.8270.96
135_V167_A0.8210.96
128_R170_Y0.8190.96
136_S202_G0.8190.96
155_K158_Y0.8160.96
181_D251_K0.8150.96
102_L110_L0.8120.96
101_F104_K0.8090.96
134_A167_A0.8040.96
23_L211_I0.8030.96
120_L123_I0.7990.96
256_V260_I0.7980.96
100_S104_K0.7930.95
143_S148_G0.7900.95
6_Q63_C0.7890.95
83_R87_I0.7880.95
142_L159_V0.7820.95
179_Y203_K0.7800.95
111_I175_I0.7780.95
96_E119_G0.7750.95
133_V173_D0.7700.95
33_E94_K0.7690.95
99_L102_L0.7690.95
41_K67_N0.7680.95
120_L165_S0.7670.95
140_A254_D0.7610.94
116_T145_S0.7590.94
143_S156_N0.7530.94
20_S30_F0.7510.94
192_C214_S0.7500.94
211_I215_N0.7500.94
15_K18_R0.7500.94
140_A252_L0.7490.94
151_N197_K0.7490.94
247_R250_D0.7470.94
229_K265_I0.7470.94
9_V28_I0.7460.94
145_S168_R0.7430.94
78_I90_I0.7420.93
64_V80_T0.7390.93
29_I91_V0.7330.93
134_A175_I0.7300.93
226_E229_K0.7260.93
90_I110_L0.7230.93
66_V102_L0.7210.93
21_V62_L0.7190.92
33_E141_D0.7190.92
117_A146_L0.7170.92
37_P40_D0.7150.92
175_I202_G0.7140.92
176_D191_E0.7140.92
14_E18_R0.7130.92
254_D257_H0.7120.92
36_V41_K0.7090.92
10_P207_H0.7070.92
231_V249_D0.7060.92
174_A254_D0.7060.92
92_L95_A0.7050.92
196_K217_V0.7010.91
70_Q98_D0.6990.91
41_K45_R0.6980.91
158_Y165_S0.6980.91
161_T164_V0.6970.91
138_G141_D0.6960.91
45_R67_N0.6930.91
173_D201_V0.6890.91
182_L209_S0.6870.91
61_E88_T0.6860.91
17_I47_S0.6850.90
137_Y163_I0.6820.90
151_N155_K0.6750.90
6_Q111_I0.6750.90
193_E197_K0.6710.90
18_R22_E0.6690.89
179_Y210_Q0.6670.89
48_L87_I0.6670.89
70_Q74_S0.6650.89
155_K198_L0.6640.89
235_Y246_I0.6640.89
41_K73_D0.6640.89
6_Q202_G0.6580.89
120_L142_L0.6520.88
81_I87_I0.6510.88
24_K211_I0.6510.88
121_V158_Y0.6500.88
9_V16_M0.6490.88
226_E233_E0.6470.88
260_I264_I0.6470.88
114_I163_I0.6470.88
182_L206_I0.6440.88
8_Y139_A0.6420.87
164_V174_A0.6350.87
161_T198_L0.6340.87
127_V166_V0.6330.87
244_G254_D0.6320.87
33_E115_E0.6320.87
15_K23_L0.6310.87
119_G122_K0.6290.86
143_S150_Y0.6290.86
8_Y29_I0.6250.86
92_L99_L0.6250.86
98_D102_L0.6240.86
185_L213_I0.6240.86
134_A174_A0.6210.86
245_A252_L0.6200.86
70_Q75_Y0.6200.86
96_E116_T0.6170.85
114_I119_G0.6150.85
192_C196_K0.6140.85
122_K126_I0.6140.85
109_S131_G0.6120.85
246_I253_V0.6110.85
177_K204_Q0.6100.85
80_T83_R0.6090.85
79_S105_A0.6080.84
13_S17_I0.6060.84
234_A248_L0.6050.84
51_L55_L0.6040.84
52_V64_V0.6040.84
91_V111_I0.6020.84
227_W230_K0.6000.84
67_N77_D0.6000.84
234_A237_K0.5990.84
120_L163_I0.5990.84
52_V62_L0.5980.83
263_R266_E0.5980.83
216_E219_S0.5970.83
246_I255_Y0.5970.83
123_I162_L0.5970.83
5_S205_V0.5970.83
39_E42_E0.5940.83
17_I20_S0.5910.83
178_V191_E0.5900.83
227_W248_L0.5890.83
40_D47_S0.5890.83
115_E138_G0.5880.82
49_I84_E0.5840.82
232_I262_K0.5840.82
25_A211_I0.5820.82
117_A167_A0.5790.81
52_V84_E0.5770.81
63_C111_I0.5760.81
140_A177_K0.5750.81
82_A90_I0.5750.81
160_K200_Y0.5740.81
232_I236_E0.5720.81
179_Y188_F0.5710.81
125_D128_R0.5690.80
150_Y260_I0.5690.80
140_A144_L0.5670.80
166_V170_Y0.5650.80
78_I83_R0.5640.80
162_L166_V0.5630.80
113_L204_Q0.5610.79
92_L110_L0.5600.79
222_K229_K0.5590.79
89_C134_A0.5580.79
75_Y101_F0.5560.79
8_Y91_V0.5560.79
94_K116_T0.5550.79
21_V55_L0.5540.79
34_D141_D0.5540.79
256_V259_K0.5510.78
206_I252_L0.5490.78
243_R246_I0.5460.78
134_A140_A0.5450.77
148_G155_K0.5440.77
66_V75_Y0.5410.77
11_A17_I0.5410.77
64_V87_I0.5350.76
91_V113_L0.5320.76
193_E217_V0.5310.76
76_K80_T0.5310.76
203_K218_F0.5310.76
232_I258_Y0.5300.76
181_D187_G0.5300.76
136_S203_K0.5290.75
69_L98_D0.5280.75
37_P245_A0.5280.75
96_E117_A0.5260.75
5_S25_A0.5250.75
99_L110_L0.5240.75
156_N200_Y0.5240.75
79_S82_A0.5210.74
230_K233_E0.5200.74
81_I90_I0.5200.74
56_D88_T0.5170.74
100_S103_Y0.5160.74
33_E138_G0.5160.74
192_C195_A0.5150.73
55_L58_G0.5140.73
150_Y155_K0.5140.73
42_E72_L0.5120.73
224_E227_W0.5120.73
111_I133_V0.5110.73
118_K170_Y0.5110.73
137_Y174_A0.5100.73
216_E222_K0.5090.73
253_V258_Y0.5070.72
49_I81_I0.5060.72
132_V172_V0.5040.72
178_V195_A0.5040.72
14_E50_K0.5030.72
39_E242_G0.5020.72
207_H252_L0.5020.72
129_S132_V0.5010.71
205_V211_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sgjA 3 0.8067 100 0.229 Contact Map
4l9zA 5 1 100 0.236 Contact Map
1u5hA 3 0.7844 100 0.239 Contact Map
4l80A 5 0.9851 100 0.24 Contact Map
4roqA 5 0.9963 100 0.241 Contact Map
3qqwA 3 0.9182 100 0.249 Contact Map
3oyzA 5 0.9777 100 0.253 Contact Map
3qllA 3 0.7621 100 0.259 Contact Map
3r4iA 5 0.9814 100 0.262 Contact Map
3cuxA 1 0.9591 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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