GREMLIN Database
Q97YR4 - Transcriptional regulator
UniProt: Q97YR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (198)
Sequences: 23554 (17400)
Seq/√Len: 1236.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_I180_K3.8221.00
88_K188_Y3.3391.00
183_S186_L2.9711.00
110_R173_E2.8111.00
21_K24_N2.7271.00
14_Y19_K2.7271.00
14_Y34_L2.4211.00
81_N85_L2.3321.00
28_E39_R2.2791.00
101_K130_A2.2141.00
74_Q138_K2.1981.00
80_I196_E2.1221.00
8_Y48_R2.0891.00
12_L52_E1.9951.00
77_E89_L1.9821.00
7_A37_I1.9661.00
92_I184_P1.9611.00
133_E141_V1.8251.00
99_I180_K1.8081.00
98_E136_H1.8051.00
7_A35_L1.8051.00
178_A186_L1.7991.00
95_S98_E1.7491.00
56_V62_F1.7331.00
130_A133_E1.7251.00
106_L176_V1.7081.00
116_D119_T1.7071.00
10_K14_Y1.7021.00
84_S192_R1.6911.00
171_E197_K1.6331.00
88_K184_P1.6251.00
78_V143_I1.5991.00
186_L190_M1.5821.00
84_S188_Y1.5791.00
188_Y192_R1.5741.00
85_L88_K1.5471.00
13_E17_T1.5471.00
128_H172_H1.5121.00
174_S190_M1.4861.00
132_A144_L1.4371.00
87_A187_A1.4351.00
108_E123_L1.4311.00
8_Y52_E1.4291.00
142_D146_S1.4201.00
80_I192_R1.4181.00
139_Y150_K1.4121.00
129_R145_D1.4111.00
110_R169_F1.4051.00
177_I181_N1.4021.00
103_I176_V1.3981.00
98_E134_A1.3901.00
57_K60_K1.3741.00
105_V123_L1.3691.00
29_E33_S1.3671.00
80_I199_L1.3431.00
181_N186_L1.3371.00
74_Q139_Y1.3151.00
94_A99_I1.3111.00
173_E177_I1.3031.00
103_I107_N1.2721.00
184_P188_Y1.2631.00
104_N108_E1.2511.00
25_T63_T1.2471.00
30_E34_L1.2381.00
108_E126_N1.2381.00
189_D193_M1.2311.00
27_K30_E1.2271.00
171_E194_H1.2161.00
31_L42_I1.1991.00
106_L173_E1.1961.00
80_I84_S1.1931.00
105_V130_A1.1871.00
6_I10_K1.1701.00
79_R83_E1.1701.00
10_K13_E1.1641.00
14_Y35_L1.1491.00
186_L189_D1.1461.00
10_K35_L1.1421.00
192_R196_E1.1311.00
126_N130_A1.1301.00
129_R133_E1.1281.00
94_A182_R1.1281.00
84_S88_K1.1191.00
94_A134_A1.1181.00
131_I179_I1.1151.00
124_N128_H1.1141.00
74_Q137_N1.1141.00
99_I176_V1.1121.00
88_K185_D1.1041.00
87_A191_M1.1001.00
119_T122_N1.0971.00
177_I180_K1.0831.00
105_V126_N1.0821.00
106_L109_I1.0801.00
50_E56_V1.0781.00
20_Y64_V1.0771.00
87_A91_A1.0731.00
94_A98_E1.0661.00
106_L110_R1.0581.00
176_V180_K1.0571.00
86_S132_A1.0571.00
130_A134_A1.0551.00
103_I173_E1.0511.00
77_E137_N1.0411.00
101_K133_E1.0271.00
99_I182_R1.0261.00
57_K63_T1.0231.00
73_L199_L1.0221.00
50_E55_I1.0131.00
44_E47_A1.0051.00
107_N110_R0.9981.00
123_L126_N0.9921.00
143_I146_S0.9911.00
178_A183_S0.9801.00
101_K104_N0.9761.00
172_H194_H0.9761.00
85_L188_Y0.9711.00
127_L176_V0.9711.00
128_H194_H0.9661.00
89_L93_R0.9591.00
46_L62_F0.9581.00
174_S186_L0.9581.00
135_S141_V0.9571.00
174_S193_M0.9561.00
170_R174_S0.9551.00
91_A184_P0.9481.00
14_Y20_Y0.9421.00
122_N126_N0.9381.00
83_E128_H0.9371.00
101_K105_V0.9361.00
15_I64_V0.9281.00
25_T61_S0.9211.00
174_S177_I0.9181.00
55_I62_F0.9091.00
100_N104_N0.9091.00
57_K61_S0.9061.00
175_I191_M0.8991.00
28_E43_R0.8991.00
141_V145_D0.8991.00
185_D189_D0.8941.00
48_R51_K0.8941.00
91_A179_I0.8921.00
78_V139_Y0.8911.00
68_T71_D0.8891.00
8_Y12_L0.8861.00
60_K63_T0.8801.00
93_R136_H0.8741.00
4_S48_R0.8681.00
99_I103_I0.8621.00
85_L89_L0.8591.00
103_I177_I0.8511.00
79_R195_E0.8451.00
38_S41_P0.8441.00
94_A179_I0.8431.00
71_D139_Y0.8431.00
12_L54_V0.8411.00
32_A42_I0.8411.00
169_F173_E0.8391.00
105_V108_E0.8381.00
185_D188_Y0.8321.00
108_E111_G0.8301.00
96_Q100_N0.8211.00
12_L16_I0.8161.00
91_A182_R0.8101.00
98_E101_K0.8101.00
30_E33_S0.8051.00
107_N111_G0.8001.00
124_N172_H0.7971.00
112_S119_T0.7971.00
175_I190_M0.7961.00
47_A50_E0.7961.00
37_I42_I0.7871.00
90_A134_A0.7851.00
139_Y143_I0.7851.00
174_S178_A0.7831.00
46_L55_I0.7801.00
102_I130_A0.7761.00
96_Q182_R0.7761.00
5_Q48_R0.7741.00
31_L46_L0.7721.00
91_A187_A0.7691.00
178_A190_M0.7691.00
77_E199_L0.7661.00
102_I176_V0.7651.00
70_S136_H0.7611.00
109_I120_L0.7541.00
129_R148_R0.7531.00
88_K92_I0.7511.00
70_S74_Q0.7501.00
90_A94_A0.7451.00
139_Y142_D0.7431.00
166_D170_R0.7371.00
107_N173_E0.7371.00
100_N180_K0.7311.00
89_L92_I0.7271.00
100_N103_I0.7251.00
78_V140_I0.7241.00
196_E200_D0.7211.00
190_M193_M0.7181.00
77_E93_R0.7171.00
76_Y198_V0.7171.00
89_L137_N0.7141.00
119_T123_L0.7141.00
108_E112_S0.7071.00
47_A56_V0.7031.00
78_V86_S0.7031.00
101_K126_N0.6991.00
189_D192_R0.6941.00
125_G148_R0.6871.00
175_I187_A0.6861.00
106_L169_F0.6831.00
4_S8_Y0.6821.00
108_E119_T0.6791.00
19_K34_L0.6781.00
41_P45_A0.6761.00
129_R141_V0.6731.00
48_R52_E0.6721.00
112_S123_L0.6671.00
196_E199_L0.6631.00
193_M197_K0.6581.00
77_E85_L0.6571.00
99_I179_I0.6491.00
98_E130_A0.6461.00
98_E133_E0.6461.00
125_G152_K0.6451.00
171_E174_S0.6451.00
126_N129_R0.6441.00
197_K201_Y0.6311.00
104_N107_N0.6301.00
20_Y24_N0.6301.00
78_V82_L0.6291.00
81_N140_I0.6271.00
175_I194_H0.6221.00
87_A184_P0.6211.00
112_S115_A0.6191.00
153_I157_T0.6171.00
120_L168_E0.6141.00
71_D138_K0.6121.00
83_E172_H0.6091.00
14_Y18_G0.6061.00
86_S135_S0.6021.00
86_S140_I0.5961.00
90_A135_S0.5941.00
80_I195_E0.5941.00
23_G66_P0.5821.00
112_S116_D0.5801.00
59_G62_F0.5801.00
84_S184_P0.5751.00
142_D150_K0.5681.00
81_N84_S0.5631.00
84_S191_M0.5611.00
22_P66_P0.5591.00
102_I134_A0.5591.00
35_L42_I0.5581.00
111_G114_N0.5571.00
97_D101_K0.5561.00
82_L144_L0.5521.00
29_E32_A0.5521.00
153_I156_I0.5491.00
90_A131_I0.5431.00
78_V81_N0.5421.00
109_I169_F0.5411.00
63_T66_P0.5391.00
164_R167_E0.5371.00
47_A51_K0.5361.00
20_Y26_L0.5361.00
102_I106_L0.5321.00
4_S44_E0.5321.00
164_R201_Y0.5281.00
33_S36_K0.5271.00
102_I105_V0.5251.00
142_D145_D0.5231.00
11_I31_L0.5231.00
88_K192_R0.5221.00
16_I54_V0.5201.00
87_A131_I0.5191.00
26_L55_I0.5171.00
28_E62_F0.5141.00
118_L156_I0.5141.00
77_E80_I0.5131.00
96_Q180_K0.5131.00
70_S73_L0.5121.00
175_I178_A0.5111.00
14_Y17_T0.5111.00
170_R173_E0.5101.00
191_M195_E0.5101.00
154_V158_L0.5081.00
91_A188_Y0.5081.00
167_E170_R0.5071.00
85_L140_I0.5071.00
20_Y34_L0.5051.00
114_N117_P0.5021.00
171_E193_M0.5021.00
83_E195_E0.5021.00
132_A148_R0.5021.00
122_N152_K0.5001.00
138_K141_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sxyA 2 0.9387 100 0.133 Contact Map
3c7jA 4 0.9906 100 0.139 Contact Map
4p9fA 1 0.9764 100 0.146 Contact Map
3ihuA 1 0.9528 100 0.148 Contact Map
2hs5A 1 0.967 100 0.152 Contact Map
4p96A 2 1 100 0.167 Contact Map
2di3A 2 0.967 100 0.174 Contact Map
1hw1A 2 0.9623 100 0.2 Contact Map
3ic7A 2 0.5142 99.8 0.545 Contact Map
3by6A 2 0.533 99.8 0.548 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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