Q97YR4 - SULSO - GREMLIN Contacts

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Q97YR4 - Transcriptional regulator

UniProt:	Q97YR4	Sequences: MSLSQIAYEKILEYIITGKYKPGNTLKEEELASLLKISRTPIREALARLEKEGVIVKNGKSFTVIPLTESDILQLYEVRINLESLSAKLAAIRASQDEINKIINVLNEIRGSANADPLTLANLNGNLHRAIAEASHNKYIVDILDSIRLKLKIVRITLFTSFQRRDEEFREHESIVIAIKNRSPDLAYDMMRMHEEKVLDYVKQNILPVMFR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	212 (198)
Sequences:	23554 (17400)
Seq/√Len:	1236.6

ECOLI - MCBR YJJM YDFH NANR DGOR CSIR GLCC PDHR YIEP EXUR LLDR UXUR FADR FRLR YIDP YEGW
BACSU - GNTR YDHC LUTR YCBG YMFC YURK YVOA YYDK TRER
SULSO - Q97YR4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_I	180_K	3.822	1.00
88_K	188_Y	3.339	1.00
183_S	186_L	2.971	1.00
110_R	173_E	2.811	1.00
21_K	24_N	2.727	1.00
14_Y	19_K	2.727	1.00
14_Y	34_L	2.421	1.00
81_N	85_L	2.332	1.00
28_E	39_R	2.279	1.00
101_K	130_A	2.214	1.00
74_Q	138_K	2.198	1.00
80_I	196_E	2.122	1.00
8_Y	48_R	2.089	1.00
12_L	52_E	1.995	1.00
77_E	89_L	1.982	1.00
7_A	37_I	1.966	1.00
92_I	184_P	1.961	1.00
133_E	141_V	1.825	1.00
99_I	180_K	1.808	1.00
98_E	136_H	1.805	1.00
7_A	35_L	1.805	1.00
178_A	186_L	1.799	1.00
95_S	98_E	1.749	1.00
56_V	62_F	1.733	1.00
130_A	133_E	1.725	1.00
106_L	176_V	1.708	1.00
116_D	119_T	1.707	1.00
10_K	14_Y	1.702	1.00
84_S	192_R	1.691	1.00
171_E	197_K	1.633	1.00
88_K	184_P	1.625	1.00
78_V	143_I	1.599	1.00
186_L	190_M	1.582	1.00
84_S	188_Y	1.579	1.00
188_Y	192_R	1.574	1.00
85_L	88_K	1.547	1.00
13_E	17_T	1.547	1.00
128_H	172_H	1.512	1.00
174_S	190_M	1.486	1.00
132_A	144_L	1.437	1.00
87_A	187_A	1.435	1.00
108_E	123_L	1.431	1.00
8_Y	52_E	1.429	1.00
142_D	146_S	1.420	1.00
80_I	192_R	1.418	1.00
139_Y	150_K	1.412	1.00
129_R	145_D	1.411	1.00
110_R	169_F	1.405	1.00
177_I	181_N	1.402	1.00
103_I	176_V	1.398	1.00
98_E	134_A	1.390	1.00
57_K	60_K	1.374	1.00
105_V	123_L	1.369	1.00
29_E	33_S	1.367	1.00
80_I	199_L	1.343	1.00
181_N	186_L	1.337	1.00
74_Q	139_Y	1.315	1.00
94_A	99_I	1.311	1.00
173_E	177_I	1.303	1.00
103_I	107_N	1.272	1.00
184_P	188_Y	1.263	1.00
104_N	108_E	1.251	1.00
25_T	63_T	1.247	1.00
30_E	34_L	1.238	1.00
108_E	126_N	1.238	1.00
189_D	193_M	1.231	1.00
27_K	30_E	1.227	1.00
171_E	194_H	1.216	1.00
31_L	42_I	1.199	1.00
106_L	173_E	1.196	1.00
80_I	84_S	1.193	1.00
105_V	130_A	1.187	1.00
6_I	10_K	1.170	1.00
79_R	83_E	1.170	1.00
10_K	13_E	1.164	1.00
14_Y	35_L	1.149	1.00
186_L	189_D	1.146	1.00
10_K	35_L	1.142	1.00
192_R	196_E	1.131	1.00
126_N	130_A	1.130	1.00
129_R	133_E	1.128	1.00
94_A	182_R	1.128	1.00
84_S	88_K	1.119	1.00
94_A	134_A	1.118	1.00
131_I	179_I	1.115	1.00
124_N	128_H	1.114	1.00
74_Q	137_N	1.114	1.00
99_I	176_V	1.112	1.00
88_K	185_D	1.104	1.00
87_A	191_M	1.100	1.00
119_T	122_N	1.097	1.00
177_I	180_K	1.083	1.00
105_V	126_N	1.082	1.00
106_L	109_I	1.080	1.00
50_E	56_V	1.078	1.00
20_Y	64_V	1.077	1.00
87_A	91_A	1.073	1.00
94_A	98_E	1.066	1.00
106_L	110_R	1.058	1.00
176_V	180_K	1.057	1.00
86_S	132_A	1.057	1.00
130_A	134_A	1.055	1.00
103_I	173_E	1.051	1.00
77_E	137_N	1.041	1.00
101_K	133_E	1.027	1.00
99_I	182_R	1.026	1.00
57_K	63_T	1.023	1.00
73_L	199_L	1.022	1.00
50_E	55_I	1.013	1.00
44_E	47_A	1.005	1.00
107_N	110_R	0.998	1.00
123_L	126_N	0.992	1.00
143_I	146_S	0.991	1.00
178_A	183_S	0.980	1.00
101_K	104_N	0.976	1.00
172_H	194_H	0.976	1.00
85_L	188_Y	0.971	1.00
127_L	176_V	0.971	1.00
128_H	194_H	0.966	1.00
89_L	93_R	0.959	1.00
46_L	62_F	0.958	1.00
174_S	186_L	0.958	1.00
135_S	141_V	0.957	1.00
174_S	193_M	0.956	1.00
170_R	174_S	0.955	1.00
91_A	184_P	0.948	1.00
14_Y	20_Y	0.942	1.00
122_N	126_N	0.938	1.00
83_E	128_H	0.937	1.00
101_K	105_V	0.936	1.00
15_I	64_V	0.928	1.00
25_T	61_S	0.921	1.00
174_S	177_I	0.918	1.00
55_I	62_F	0.909	1.00
100_N	104_N	0.909	1.00
57_K	61_S	0.906	1.00
175_I	191_M	0.899	1.00
28_E	43_R	0.899	1.00
141_V	145_D	0.899	1.00
185_D	189_D	0.894	1.00
48_R	51_K	0.894	1.00
91_A	179_I	0.892	1.00
78_V	139_Y	0.891	1.00
68_T	71_D	0.889	1.00
8_Y	12_L	0.886	1.00
60_K	63_T	0.880	1.00
93_R	136_H	0.874	1.00
4_S	48_R	0.868	1.00
99_I	103_I	0.862	1.00
85_L	89_L	0.859	1.00
103_I	177_I	0.851	1.00
79_R	195_E	0.845	1.00
38_S	41_P	0.844	1.00
94_A	179_I	0.843	1.00
71_D	139_Y	0.843	1.00
12_L	54_V	0.841	1.00
32_A	42_I	0.841	1.00
169_F	173_E	0.839	1.00
105_V	108_E	0.838	1.00
185_D	188_Y	0.832	1.00
108_E	111_G	0.830	1.00
96_Q	100_N	0.821	1.00
12_L	16_I	0.816	1.00
91_A	182_R	0.810	1.00
98_E	101_K	0.810	1.00
30_E	33_S	0.805	1.00
107_N	111_G	0.800	1.00
124_N	172_H	0.797	1.00
112_S	119_T	0.797	1.00
175_I	190_M	0.796	1.00
47_A	50_E	0.796	1.00
37_I	42_I	0.787	1.00
90_A	134_A	0.785	1.00
139_Y	143_I	0.785	1.00
174_S	178_A	0.783	1.00
46_L	55_I	0.780	1.00
102_I	130_A	0.776	1.00
96_Q	182_R	0.776	1.00
5_Q	48_R	0.774	1.00
31_L	46_L	0.772	1.00
91_A	187_A	0.769	1.00
178_A	190_M	0.769	1.00
77_E	199_L	0.766	1.00
102_I	176_V	0.765	1.00
70_S	136_H	0.761	1.00
109_I	120_L	0.754	1.00
129_R	148_R	0.753	1.00
88_K	92_I	0.751	1.00
70_S	74_Q	0.750	1.00
90_A	94_A	0.745	1.00
139_Y	142_D	0.743	1.00
166_D	170_R	0.737	1.00
107_N	173_E	0.737	1.00
100_N	180_K	0.731	1.00
89_L	92_I	0.727	1.00
100_N	103_I	0.725	1.00
78_V	140_I	0.724	1.00
196_E	200_D	0.721	1.00
190_M	193_M	0.718	1.00
77_E	93_R	0.717	1.00
76_Y	198_V	0.717	1.00
89_L	137_N	0.714	1.00
119_T	123_L	0.714	1.00
108_E	112_S	0.707	1.00
47_A	56_V	0.703	1.00
78_V	86_S	0.703	1.00
101_K	126_N	0.699	1.00
189_D	192_R	0.694	1.00
125_G	148_R	0.687	1.00
175_I	187_A	0.686	1.00
106_L	169_F	0.683	1.00
4_S	8_Y	0.682	1.00
108_E	119_T	0.679	1.00
19_K	34_L	0.678	1.00
41_P	45_A	0.676	1.00
129_R	141_V	0.673	1.00
48_R	52_E	0.672	1.00
112_S	123_L	0.667	1.00
196_E	199_L	0.663	1.00
193_M	197_K	0.658	1.00
77_E	85_L	0.657	1.00
99_I	179_I	0.649	1.00
98_E	130_A	0.646	1.00
98_E	133_E	0.646	1.00
125_G	152_K	0.645	1.00
171_E	174_S	0.645	1.00
126_N	129_R	0.644	1.00
197_K	201_Y	0.631	1.00
104_N	107_N	0.630	1.00
20_Y	24_N	0.630	1.00
78_V	82_L	0.629	1.00
81_N	140_I	0.627	1.00
175_I	194_H	0.622	1.00
87_A	184_P	0.621	1.00
112_S	115_A	0.619	1.00
153_I	157_T	0.617	1.00
120_L	168_E	0.614	1.00
71_D	138_K	0.612	1.00
83_E	172_H	0.609	1.00
14_Y	18_G	0.606	1.00
86_S	135_S	0.602	1.00
86_S	140_I	0.596	1.00
90_A	135_S	0.594	1.00
80_I	195_E	0.594	1.00
23_G	66_P	0.582	1.00
112_S	116_D	0.580	1.00
59_G	62_F	0.580	1.00
84_S	184_P	0.575	1.00
142_D	150_K	0.568	1.00
81_N	84_S	0.563	1.00
84_S	191_M	0.561	1.00
22_P	66_P	0.559	1.00
102_I	134_A	0.559	1.00
35_L	42_I	0.558	1.00
111_G	114_N	0.557	1.00
97_D	101_K	0.556	1.00
82_L	144_L	0.552	1.00
29_E	32_A	0.552	1.00
153_I	156_I	0.549	1.00
90_A	131_I	0.543	1.00
78_V	81_N	0.542	1.00
109_I	169_F	0.541	1.00
63_T	66_P	0.539	1.00
164_R	167_E	0.537	1.00
47_A	51_K	0.536	1.00
20_Y	26_L	0.536	1.00
102_I	106_L	0.532	1.00
4_S	44_E	0.532	1.00
164_R	201_Y	0.528	1.00
33_S	36_K	0.527	1.00
102_I	105_V	0.525	1.00
142_D	145_D	0.523	1.00
11_I	31_L	0.523	1.00
88_K	192_R	0.522	1.00
16_I	54_V	0.520	1.00
87_A	131_I	0.519	1.00
26_L	55_I	0.517	1.00
28_E	62_F	0.514	1.00
118_L	156_I	0.514	1.00
77_E	80_I	0.513	1.00
96_Q	180_K	0.513	1.00
70_S	73_L	0.512	1.00
175_I	178_A	0.511	1.00
14_Y	17_T	0.511	1.00
170_R	173_E	0.510	1.00
191_M	195_E	0.510	1.00
154_V	158_L	0.508	1.00
91_A	188_Y	0.508	1.00
167_E	170_R	0.507	1.00
85_L	140_I	0.507	1.00
20_Y	34_L	0.505	1.00
114_N	117_P	0.502	1.00
171_E	193_M	0.502	1.00
83_E	195_E	0.502	1.00
132_A	148_R	0.502	1.00
122_N	152_K	0.500	1.00
138_K	141_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3sxyA	2	0.9387	100	0.133	Contact Map
3c7jA	4	0.9906	100	0.139	Contact Map
4p9fA	1	0.9764	100	0.146	Contact Map
3ihuA	1	0.9528	100	0.148	Contact Map
2hs5A	1	0.967	100	0.152	Contact Map
4p96A	2	1	100	0.167	Contact Map
2di3A	2	0.967	100	0.174	Contact Map
1hw1A	2	0.9623	100	0.2	Contact Map
3ic7A	2	0.5142	99.8	0.545	Contact Map
3by6A	2	0.533	99.8	0.548	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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