GREMLIN Database
Q97YR3 - Mandelate racemase /muconate lactonizing enzyme related protein (MR/MLE)
UniProt: Q97YR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (313)
Sequences: 12195 (7289)
Seq/√Len: 412.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_V80_I3.4071.00
128_S338_Y3.3751.00
251_K255_S3.2621.00
230_T258_T3.1461.00
193_D197_V2.9581.00
227_S231_E2.8771.00
73_E76_D2.7811.00
222_D225_L2.6931.00
37_D108_L2.6781.00
33_E38_Y2.6741.00
30_V100_A2.6731.00
250_K254_E2.5971.00
31_K38_Y2.5331.00
203_D206_H2.3571.00
228_K231_E2.3291.00
56_S60_D2.2321.00
203_D232_F2.1801.00
246_L272_K2.1801.00
206_H234_P2.1411.00
227_S255_S2.1051.00
75_I275_E2.0941.00
149_R178_N2.0881.00
202_V213_I2.0831.00
228_K232_F2.0581.00
102_E271_T2.0541.00
253_I285_V2.0521.00
55_L59_N2.0171.00
224_D255_S2.0131.00
183_K211_E1.9881.00
259_Y286_R1.9821.00
267_V276_I1.9591.00
149_R153_E1.9291.00
31_K40_W1.9251.00
69_V76_D1.9141.00
37_D112_K1.9131.00
110_A117_L1.9031.00
35_E112_K1.9011.00
170_A173_K1.9001.00
145_L178_N1.8981.00
202_V233_S1.8781.00
173_K208_Y1.8701.00
204_K207_K1.8461.00
130_K157_D1.8431.00
335_K340_S1.8381.00
199_K232_F1.8301.00
141_I145_L1.8031.00
279_L283_Y1.7871.00
201_F205_V1.7791.00
140_K143_D1.7751.00
77_V105_L1.7651.00
249_F276_I1.7591.00
254_E283_Y1.7231.00
88_A247_Y1.7091.00
37_D111_R1.6831.00
32_V105_L1.6781.00
115_V119_K1.6781.00
150_K154_R1.6611.00
116_E119_K1.6231.00
174_A177_E1.6111.00
43_A100_A1.6101.00
169_L204_K1.5871.00
217_L229_L1.5841.00
278_D281_S1.5611.00
150_K153_E1.5471.00
128_S340_S1.5381.00
196_D228_K1.5311.00
195_L228_K1.5201.00
61_I92_G1.5071.00
63_I67_S1.5061.00
274_L278_D1.4891.00
152_L182_V1.4711.00
72_S112_K1.4711.00
167_T170_A1.4691.00
253_I279_L1.4401.00
250_K279_L1.4321.00
199_K228_K1.4281.00
107_S111_R1.4151.00
59_N63_I1.4081.00
248_G251_K1.4051.00
277_L310_K1.4031.00
76_D80_I1.3971.00
252_L257_I1.3911.00
102_E106_W1.3821.00
173_K177_E1.3821.00
195_L229_L1.3791.00
308_L341_P1.3751.00
124_K127_D1.3641.00
173_K207_K1.3631.00
221_N248_G1.3531.00
200_E203_D1.3261.00
29_Y40_W1.3241.00
103_M270_V1.3211.00
195_L225_L1.3181.00
69_V77_V1.3171.00
186_I210_I1.3091.00
238_A259_Y1.2921.00
81_L98_I1.2921.00
251_K254_E1.2861.00
143_D146_I1.2851.00
107_S302_Y1.2831.00
218_W221_N1.2831.00
253_I283_Y1.2731.00
273_F306_I1.2631.00
130_K338_Y1.2621.00
169_L208_Y1.2601.00
272_K275_E1.2521.00
136_P168_V1.2491.00
217_L225_L1.2401.00
274_L310_K1.2361.00
146_I149_R1.2361.00
79_T83_K1.2181.00
109_K113_S1.2171.00
115_V120_L1.2151.00
110_A120_L1.2141.00
149_R152_L1.2121.00
175_I179_Y1.2071.00
216_P237_I1.2031.00
245_S248_G1.2001.00
159_V182_V1.1841.00
249_F260_L1.1821.00
185_A211_E1.1811.00
139_G143_D1.1791.00
203_D234_P1.1741.00
103_M302_Y1.1701.00
53_S56_S1.1681.00
200_E204_K1.1641.00
147_A150_K1.1611.00
286_R314_E1.1511.00
176_R181_E1.1471.00
170_A174_A1.1441.00
216_P229_L1.1341.00
275_E278_D1.1271.00
206_H235_I1.1251.00
260_L280_A1.1251.00
148_T159_V1.1241.00
146_I150_K1.1241.00
324_P327_L1.1231.00
279_L282_K1.1221.00
278_D282_K1.1111.00
145_L177_E1.1081.00
264_I273_F1.1051.00
246_L279_L1.1041.00
29_Y298_I1.1001.00
162_H189_N1.0991.00
148_T179_Y1.0951.00
199_K229_L1.0891.00
60_D64_P1.0781.00
239_A252_L1.0781.00
197_V200_E1.0771.00
106_W271_T1.0771.00
74_P109_K1.0771.00
70_E73_E1.0751.00
185_A212_W1.0641.00
42_E298_I1.0611.00
145_L149_R1.0461.00
198_A202_V1.0441.00
161_L175_I1.0411.00
179_Y184_I1.0371.00
75_I274_L1.0311.00
151_S154_R1.0221.00
119_K343_E1.0161.00
34_D71_L1.0061.00
169_L173_K1.0021.00
250_K283_Y1.0011.00
72_S109_K0.9991.00
192_F198_A0.9971.00
238_A261_Q0.9951.00
113_S120_L0.9881.00
69_V73_E0.9861.00
275_E281_S0.9831.00
281_S311_S0.9811.00
72_S113_S0.9721.00
215_E261_Q0.9591.00
229_L237_I0.9581.00
166_S170_A0.9511.00
142_D146_I0.9511.00
172_V186_I0.9501.00
192_F201_F0.9501.00
152_L159_V0.9431.00
176_R184_I0.9391.00
217_L226_L0.9381.00
195_L199_K0.9321.00
174_A178_N0.9311.00
263_D290_H0.9271.00
145_L179_Y0.9261.00
289_P312_Q0.9221.00
210_I235_I0.9191.00
224_D227_S0.9141.00
267_V273_F0.9121.00
121_I274_L0.9101.00
264_I303_T0.9091.00
253_I260_L0.9061.00
77_V80_I0.9061.00
277_L287_V0.9011.00
52_N56_S0.9001.00
172_V208_Y0.8961.00
106_W270_V0.8931.00
55_L58_I0.8911.00
132_Y135_F0.8901.00
179_Y182_V0.8891.00
340_S343_E0.8861.00
198_A217_L0.8771.00
188_L213_I0.8761.00
246_L275_E0.8751.00
109_K120_L0.8721.00
117_L270_V0.8701.00
131_V134_S0.8671.00
65_L80_I0.8671.00
165_P201_F0.8671.00
225_L228_K0.8651.00
117_L121_I0.8641.00
169_L179_Y0.8611.00
270_V302_Y0.8501.00
56_S59_N0.8501.00
158_L185_A0.8481.00
78_R81_L0.8421.00
82_E272_K0.8401.00
77_V81_L0.8391.00
141_I170_A0.8381.00
71_L105_L0.8361.00
165_P169_L0.8361.00
257_I260_L0.8361.00
226_L237_I0.8331.00
192_F213_I0.8301.00
274_L309_V0.8271.00
169_L207_K0.8261.00
118_Y305_N0.8221.00
66_L69_V0.8211.00
277_L281_S0.8201.00
78_R82_E0.8201.00
52_N60_D0.8171.00
28_L55_L0.8161.00
244_Y248_G0.8151.00
304_L339_I0.8151.00
236_P314_E0.8131.00
224_D251_K0.8121.00
33_E36_K0.8121.00
196_D200_E0.8121.00
264_I306_I0.8101.00
243_E249_F0.8051.00
40_W298_I0.8031.00
334_F339_I0.8011.00
277_L289_P0.8011.00
240_G263_D0.7991.00
239_A257_I0.7991.00
64_P67_S0.7981.00
163_Q188_L0.7961.00
118_Y341_P0.7941.00
188_L192_F0.7931.00
247_Y250_K0.7921.00
172_V205_V0.7921.00
44_L47_G0.7911.00
198_A229_L0.7891.00
226_L239_A0.7881.00
262_P277_L0.7871.00
33_E40_W0.7831.00
57_I61_I0.7811.00
246_L276_I0.7811.00
108_L112_K0.7801.00
61_I64_P0.7801.00
256_G285_V0.7771.00
113_S116_E0.7761.00
141_I174_A0.7741.00
61_I65_L0.7691.00
71_L112_K0.7681.00
78_R271_T0.7671.00
193_D196_D0.7661.00
78_R102_E0.7631.00
206_H233_S0.7591.00
154_R174_A0.7591.00
58_I101_V0.7581.00
281_S312_Q0.7571.00
223_Y252_L0.7541.00
262_P273_F0.7511.00
119_K124_K0.7491.00
106_W117_L0.7471.00
58_I63_I0.7461.00
32_V66_L0.7421.00
243_E248_G0.7421.00
123_D126_R0.7401.00
65_L84_I0.7381.00
166_S204_K0.7381.00
304_L341_P0.7371.00
270_V274_L0.7331.00
260_L285_V0.7311.00
74_P77_V0.7281.00
223_Y251_K0.7251.00
115_V123_D0.7241.00
71_L109_K0.7241.00
333_K340_S0.7231.00
134_S141_I0.7221.00
41_G44_L0.7201.00
243_E252_L0.7201.00
79_T275_E0.7191.00
176_R209_E0.7171.00
318_Y321_A0.7161.00
180_K209_E0.7141.00
195_L217_L0.7131.00
73_E119_K0.7131.00
335_K338_Y0.7111.00
148_T175_I0.7111.00
54_Y58_I0.7101.00
172_V179_Y0.7031.00
128_S336_D0.6971.00
57_I93_V0.6961.00
249_F285_V0.6951.00
169_L172_V0.6881.00
53_S57_I0.6841.00
145_L174_A0.6811.00
57_I60_D0.6801.00
289_P307_G0.6781.00
176_R179_Y0.6761.00
145_L175_I0.6751.00
107_S301_I0.6730.99
145_L148_T0.6730.99
199_K233_S0.6710.99
260_L276_I0.6710.99
249_F280_A0.6700.99
117_L120_L0.6680.99
164_S168_V0.6680.99
98_I269_G0.6670.99
41_G100_A0.6650.99
75_I127_D0.6640.99
274_L306_I0.6630.99
158_L183_K0.6620.99
32_V39_G0.6610.99
308_L342_P0.6610.99
199_K217_L0.6570.99
133_A156_F0.6560.99
261_Q290_H0.6550.99
307_G316_V0.6510.99
230_T237_I0.6500.99
280_A285_V0.6490.99
176_R180_K0.6480.99
110_A115_V0.6480.99
161_L172_V0.6470.99
75_I79_T0.6470.99
109_K112_K0.6460.99
106_W121_I0.6460.99
65_L69_V0.6450.99
39_G107_S0.6450.99
200_E232_F0.6430.99
75_I271_T0.6420.99
199_K203_D0.6410.99
291_D300_L0.6400.99
149_R179_Y0.6370.99
229_L233_S0.6360.99
137_R144_V0.6340.99
202_V235_I0.6290.99
212_W288_L0.6270.99
133_A151_S0.6260.99
124_K343_E0.6260.99
167_T171_A0.6260.99
48_S51_I0.6250.99
121_I270_V0.6250.99
287_V312_Q0.6240.99
226_L229_L0.6230.99
316_V321_A0.6220.99
223_Y255_S0.6210.99
121_I309_V0.6180.99
295_A299_S0.6160.99
38_Y111_R0.6150.99
145_L160_K0.6140.99
80_I83_K0.6110.99
117_L305_N0.6090.99
79_T82_E0.6080.99
262_P287_V0.6080.99
188_L202_V0.6050.99
247_Y251_K0.6020.99
42_E45_V0.6020.99
63_I101_V0.6000.99
332_P339_I0.5990.99
53_S60_D0.5990.99
270_V306_I0.5940.99
39_G104_A0.5930.99
76_D79_T0.5930.99
111_R114_N0.5920.99
281_S287_V0.5910.99
316_V319_T0.5900.99
196_D199_K0.5890.99
277_L312_Q0.5880.99
280_A287_V0.5850.99
148_T174_A0.5850.99
70_E119_K0.5850.99
151_S156_F0.5850.99
58_I64_P0.5820.99
105_L109_K0.5820.99
230_T256_G0.5810.99
168_V189_N0.5810.99
146_I178_N0.5800.98
66_L101_V0.5800.98
265_A292_R0.5790.98
51_I55_L0.5790.98
41_G47_G0.5770.98
130_K183_K0.5770.98
246_L250_K0.5760.98
317_E321_A0.5760.98
57_I97_A0.5740.98
211_E236_P0.5740.98
323_F328_F0.5700.98
82_E98_I0.5700.98
152_L179_Y0.5690.98
41_G45_V0.5690.98
287_V310_K0.5690.98
273_F289_P0.5650.98
168_V192_F0.5620.98
257_I285_V0.5620.98
302_Y306_I0.5600.98
227_S256_G0.5590.98
147_A151_S0.5580.98
142_D145_L0.5570.98
157_D336_D0.5570.98
215_E240_G0.5560.98
172_V184_I0.5550.98
301_I305_N0.5540.98
122_G126_R0.5530.98
249_F262_P0.5530.98
81_L269_G0.5520.98
74_P105_L0.5520.98
159_V179_Y0.5490.98
163_Q192_F0.5470.98
317_E320_I0.5470.98
126_R129_V0.5450.98
74_P271_T0.5440.98
30_V101_V0.5440.98
135_F151_S0.5440.98
215_E241_E0.5430.98
89_G92_G0.5430.98
45_V96_G0.5420.98
131_V339_I0.5400.98
128_S335_K0.5400.98
215_E242_N0.5390.98
34_D37_D0.5360.98
233_S237_I0.5360.98
166_S169_L0.5320.97
74_P120_L0.5320.97
166_S180_K0.5320.97
77_V82_E0.5280.97
116_E122_G0.5270.97
297_P328_F0.5260.97
198_A213_I0.5240.97
71_L108_L0.5240.97
148_T178_N0.5230.97
177_E180_K0.5220.97
163_Q186_I0.5220.97
103_M265_A0.5200.97
304_L342_P0.5200.97
330_S333_K0.5180.97
168_V176_R0.5170.97
152_L178_N0.5160.97
133_A288_L0.5150.97
186_I205_V0.5150.97
102_E269_G0.5120.97
144_V147_A0.5120.97
134_S137_R0.5110.97
139_G144_V0.5110.97
66_L77_V0.5110.97
30_V58_I0.5110.97
202_V205_V0.5100.97
203_D207_K0.5090.97
201_F204_K0.5070.97
110_A113_S0.5050.96
144_V182_V0.5040.96
323_F326_D0.5040.96
166_S173_K0.5030.96
34_D112_K0.5030.96
52_N55_L0.5020.96
32_V104_A0.5010.96
226_L257_I0.5000.96
236_P259_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9074 100 0.237 Contact Map
1r0mA 2 0.9048 100 0.237 Contact Map
2zc8A 5 0.9286 100 0.244 Contact Map
3i6eA 4 0.8915 100 0.246 Contact Map
1wueA 2 0.9233 100 0.246 Contact Map
1wufA 2 0.9312 100 0.248 Contact Map
1sjdA 5 0.9259 100 0.25 Contact Map
3qldA 2 0.9444 100 0.251 Contact Map
3u9iA 2 0.8677 100 0.252 Contact Map
3dgbA 5 0.918 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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