GREMLIN Database
Q97YR2 - Galactarate dehydratase, putative (GarD)
UniProt: Q97YR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (376)
Sequences: 1488 (846)
Seq/√Len: 43.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
361_R366_R5.3711.00
346_V354_R5.0081.00
10_I144_S4.6771.00
7_R139_E4.2541.00
166_T303_T4.2051.00
170_V180_V3.8051.00
142_L360_I3.6981.00
10_I138_T3.6881.00
201_D204_L3.4471.00
336_V355_I3.3101.00
202_P206_D3.2461.00
181_M297_S3.2151.00
10_I140_V3.1241.00
165_A355_I3.1131.00
78_A132_A2.8261.00
206_D210_R2.7801.00
38_V121_A2.7021.00
369_S372_I2.6551.00
358_Y366_R2.6301.00
144_S274_S2.6261.00
281_T295_K2.6171.00
340_D354_R2.4531.00
207_K261_C2.4311.00
337_D343_Q2.4191.00
340_D346_V2.3991.00
16_V140_V2.3631.00
357_N361_R2.3481.00
179_T277_C2.3311.00
9_Y17_G2.3281.00
293_A315_I2.2911.00
318_V362_V2.2571.00
217_A221_S2.2321.00
172_K353_E2.2231.00
173_L178_S2.2221.00
324_P328_A2.1461.00
346_V351_A2.1391.00
301_L320_I2.0780.99
18_V298_V2.0510.99
175_D257_K2.0490.99
200_Q260_T2.0000.99
23_A77_V1.9730.99
30_L54_R1.9370.99
341_L348_L1.9300.99
120_K123_R1.9160.99
200_Q258_P1.9070.99
5_I139_E1.9010.99
79_A128_F1.9010.99
140_V144_S1.8920.99
199_I208_F1.8510.99
168_Y349_K1.8470.99
30_L85_I1.8370.99
321_S334_I1.8280.98
165_A336_V1.8170.98
261_C271_K1.7940.98
54_R85_I1.7880.98
337_D340_D1.7810.98
148_S300_H1.7770.98
325_K328_A1.7770.98
324_P339_S1.7750.98
19_R371_E1.7650.98
351_A354_R1.7300.98
293_A312_H1.7130.98
131_E134_E1.7130.98
324_P337_D1.7110.98
35_S83_I1.6940.98
105_E127_E1.6760.97
260_T271_K1.6590.97
165_A341_L1.6510.97
22_V125_A1.6360.97
327_I334_I1.6360.97
263_L277_C1.6210.97
358_Y361_R1.6150.97
347_S350_E1.6040.97
320_I338_V1.5930.96
119_E123_R1.5770.96
147_L169_A1.5480.96
289_V312_H1.5240.95
169_A359_T1.5240.95
340_D351_A1.5240.95
169_A355_I1.5100.95
26_P35_S1.5050.95
213_N216_V1.4880.95
131_E135_K1.4830.95
38_V118_I1.4750.94
5_I141_D1.4450.94
72_G93_V1.4450.94
286_A310_V1.4380.94
168_Y348_L1.4330.93
22_V132_A1.4310.93
358_Y362_V1.4280.93
41_L122_S1.4190.93
85_I110_E1.4190.93
18_V299_L1.3980.93
200_Q271_K1.3930.92
181_M269_L1.3910.92
15_S268_P1.3910.92
30_L110_E1.3870.92
165_A352_G1.3860.92
321_S327_I1.3770.92
107_F117_V1.3750.92
261_C277_C1.3750.92
145_L363_A1.3680.92
150_K292_F1.3640.92
200_Q204_L1.3610.92
338_V351_A1.3470.91
150_K183_G1.3460.91
172_K356_F1.3440.91
328_A331_S1.3390.91
346_V350_E1.3260.90
54_R110_E1.3230.90
169_A173_L1.3100.90
172_K352_G1.3080.90
74_N298_V1.2970.89
327_I337_D1.2950.89
336_V358_Y1.2900.89
120_K124_K1.2850.89
6_I16_V1.2820.89
299_L359_T1.2810.89
325_K329_T1.2790.89
318_V358_Y1.2630.88
183_G292_F1.2580.88
73_A268_P1.2310.87
321_S326_T1.2200.86
208_F278_F1.2180.86
194_I248_L1.2070.86
22_V129_V1.2010.86
142_L356_F1.1920.85
115_L332_E1.1900.85
353_E357_N1.1890.85
129_V133_S1.1860.85
116_K119_E1.1840.85
176_Y356_F1.1800.84
22_V39_S1.1750.84
225_D228_G1.1680.84
6_I364_N1.1620.84
210_R214_E1.1620.84
72_G82_V1.1570.83
138_T144_S1.1540.83
207_K267_D1.1500.83
312_H317_V1.1450.83
217_A220_E1.1450.83
154_S240_L1.1440.83
141_D144_S1.1440.83
147_L299_L1.1140.81
348_L352_G1.1130.81
202_P205_R1.1090.81
331_S369_S1.1060.80
281_T291_L1.1050.80
7_R10_I1.1010.80
150_K289_V1.1000.80
327_I331_S1.1000.80
203_V207_K1.0950.80
191_A251_I1.0880.79
64_L380_P1.0880.79
165_A169_A1.0760.79
65_F88_N1.0750.78
259_I278_F1.0720.78
55_L87_E1.0560.77
264_D267_D1.0540.77
124_K127_E1.0440.76
148_S170_V1.0430.76
213_N217_A1.0400.76
7_R366_R1.0360.76
234_G285_A1.0330.76
149_I182_F1.0280.75
12_E101_G1.0270.75
168_Y352_G1.0270.75
38_V122_S1.0180.75
169_A352_G1.0150.74
7_R136_Q1.0140.74
191_A248_L1.0050.74
6_I145_L1.0050.74
81_I124_K0.9940.73
79_A103_P0.9910.73
169_A301_L0.9860.72
264_D280_N0.9850.72
123_R127_E0.9840.72
28_D54_R0.9830.72
341_L351_A0.9800.72
55_L284_A0.9760.71
15_S146_V0.9750.71
206_D213_N0.9740.71
357_N360_I0.9730.71
172_K176_Y0.9680.71
367_L372_I0.9650.70
153_E285_A0.9570.70
39_S45_T0.9560.70
157_T322_A0.9490.69
108_P111_G0.9470.69
263_L269_L0.9470.69
36_I49_P0.9460.69
135_K138_T0.9410.69
21_Y44_G0.9380.68
55_L233_E0.9320.68
56_Q64_L0.9310.68
26_P47_A0.9280.67
257_K260_T0.9250.67
38_V125_A0.9240.67
295_K322_A0.9240.67
162_S303_T0.9230.67
65_F96_K0.9230.67
166_T301_L0.9200.67
28_D85_I0.9140.66
157_T342_L0.9100.66
138_T357_N0.9090.66
15_S144_S0.9080.66
231_P236_I0.9070.66
301_L359_T0.9050.65
38_V83_I0.9020.65
28_D110_E0.9000.65
18_V363_A0.8970.65
55_L232_T0.8950.65
67_V266_L0.8910.64
251_I259_I0.8880.64
77_V80_A0.8840.64
196_A212_Y0.8830.64
238_G306_Q0.8830.64
33_S36_I0.8820.63
91_N95_D0.8790.63
224_V228_G0.8770.63
232_T243_I0.8760.63
78_A135_K0.8760.63
199_I204_L0.8720.63
279_V295_K0.8710.62
26_P49_P0.8680.62
204_L261_C0.8670.62
240_L336_V0.8660.62
336_V351_A0.8620.62
191_A231_P0.8600.61
22_V79_A0.8590.61
133_S136_Q0.8540.61
70_G74_N0.8530.61
261_C269_L0.8530.61
92_K95_D0.8510.61
344_L347_S0.8450.60
149_I166_T0.8450.60
355_I358_Y0.8450.60
97_I104_V0.8410.60
324_P343_Q0.8390.60
90_A94_A0.8390.60
31_S109_V0.8390.60
151_C184_E0.8360.59
172_K175_D0.8350.59
207_K210_R0.8330.59
247_A250_N0.8300.59
51_P379_S0.8300.59
81_I121_A0.8300.59
168_Y256_T0.8270.58
251_I288_A0.8260.58
254_L276_L0.8230.58
18_V364_N0.8220.58
188_L259_I0.8190.58
181_M292_F0.8180.58
261_C270_G0.8140.57
139_E360_I0.8120.57
216_V227_L0.8100.57
166_T355_I0.8080.57
328_A337_D0.8070.57
105_E124_K0.8030.56
352_G356_F0.7990.56
146_V297_S0.7990.56
149_I180_V0.7990.56
10_I16_V0.7980.56
207_K264_D0.7960.56
66_H267_D0.7930.55
121_A377_E0.7910.55
352_G355_I0.7910.55
69_S73_A0.7890.55
340_D344_L0.7890.55
289_V300_H0.7890.55
265_Y291_L0.7880.55
24_V39_S0.7870.55
56_Q60_D0.7870.55
36_I40_K0.7870.55
171_D256_T0.7860.55
348_L351_A0.7840.54
245_E248_L0.7820.54
165_A351_A0.7810.54
176_Y353_E0.7800.54
161_A342_L0.7780.54
297_S314_I0.7740.53
285_A308_N0.7720.53
9_Y135_K0.7720.53
171_D198_R0.7710.53
107_F120_K0.7700.53
62_D66_H0.7700.53
165_A348_L0.7680.53
196_A209_M0.7670.53
327_I339_S0.7670.53
300_H315_I0.7640.52
157_T161_A0.7590.52
290_T378_F0.7560.52
188_L278_F0.7530.51
7_R140_V0.7530.51
189_T216_V0.7480.51
72_G104_V0.7470.51
105_E128_F0.7430.50
69_S97_I0.7420.50
67_V70_G0.7410.50
179_T261_C0.7330.50
116_K332_E0.7320.49
193_D197_S0.7300.49
79_A377_E0.7290.49
298_V315_I0.7280.49
174_I258_P0.7280.49
154_S235_N0.7240.49
215_Y284_A0.7220.48
37_G40_K0.7180.48
15_S274_S0.7180.48
289_V310_V0.7170.48
42_I133_S0.7160.48
183_G281_T0.7160.48
150_K288_A0.7140.48
146_V269_L0.7130.48
75_P146_V0.7120.48
224_V243_I0.7120.48
199_I259_I0.7120.48
107_F124_K0.7110.47
184_E253_K0.7090.47
214_E280_N0.7050.47
93_V97_I0.6990.46
37_G41_L0.6990.46
368_T371_E0.6970.46
125_A129_V0.6950.46
152_G184_E0.6930.46
198_R276_L0.6910.46
147_L359_T0.6890.45
142_L173_L0.6880.45
132_A135_K0.6880.45
181_M279_V0.6840.45
89_W107_F0.6840.45
16_V173_L0.6840.45
63_L383_L0.6830.45
171_D257_K0.6820.45
30_L84_G0.6820.45
165_A172_K0.6810.45
204_L274_S0.6760.44
73_A101_G0.6710.44
54_R84_G0.6690.43
10_I274_S0.6680.43
350_E353_E0.6660.43
356_F360_I0.6640.43
69_S96_K0.6640.43
179_T269_L0.6640.43
17_G75_P0.6640.43
8_G140_V0.6620.43
67_V291_L0.6600.43
194_I251_I0.6600.43
152_G253_K0.6600.43
260_T263_L0.6590.42
82_V93_V0.6590.42
45_T129_V0.6570.42
134_E361_R0.6570.42
151_C253_K0.6560.42
351_A355_I0.6560.42
235_N249_G0.6550.42
150_K310_V0.6520.42
48_I129_V0.6520.42
8_G16_V0.6520.42
23_A314_I0.6520.42
161_A322_A0.6520.42
39_S47_A0.6520.42
7_R142_L0.6460.41
200_Q205_R0.6460.41
13_N298_V0.6460.41
81_I128_F0.6440.41
67_V294_A0.6440.41
84_G110_E0.6440.41
157_T321_S0.6440.41
313_P375_H0.6410.41
130_Q350_E0.6410.41
138_T320_I0.6400.41
68_L93_V0.6400.41
170_V257_K0.6390.41
102_K131_E0.6390.41
70_G268_P0.6390.41
266_L295_K0.6390.41
130_Q133_S0.6370.40
311_G377_E0.6370.40
321_S324_P0.6340.40
165_A338_V0.6330.40
154_S249_G0.6330.40
124_K128_F0.6330.40
18_V321_S0.6310.40
60_D382_K0.6310.40
232_T284_A0.6300.40
158_S163_N0.6300.40
147_L150_K0.6290.40
151_C163_N0.6280.40
146_V274_S0.6270.40
79_A132_A0.6230.39
324_P327_I0.6200.39
204_L262_V0.6190.39
343_Q346_V0.6170.39
159_G187_E0.6170.39
57_F87_E0.6170.39
25_I72_G0.6150.38
55_L230_Q0.6150.38
270_G274_S0.6130.38
25_I93_V0.6130.38
152_G187_E0.6120.38
157_T339_S0.6110.38
288_A297_S0.6110.38
249_G253_K0.6100.38
154_S190_G0.6090.38
265_Y288_A0.6080.38
53_G86_E0.6060.38
66_H266_L0.6050.38
95_D357_N0.6030.37
283_S291_L0.6030.37
101_G180_V0.6000.37
203_V206_D0.5990.37
6_I363_A0.5990.37
187_E253_K0.5980.37
114_D118_I0.5980.37
89_W92_K0.5970.37
42_I125_A0.5970.37
370_A373_L0.5960.37
33_S47_A0.5960.37
325_K343_Q0.5940.37
6_I140_V0.5940.37
83_I121_A0.5930.36
33_S375_H0.5920.36
161_A344_L0.5910.36
74_N379_S0.5910.36
300_H312_H0.5910.36
58_G384_Y0.5880.36
94_A106_V0.5860.36
50_H64_L0.5850.36
82_V94_A0.5850.36
243_I250_N0.5850.36
269_L277_C0.5850.36
151_C235_N0.5840.36
190_G235_N0.5830.36
40_K203_V0.5820.35
116_K120_K0.5800.35
182_F276_L0.5800.35
219_I243_I0.5780.35
146_V179_T0.5780.35
136_Q337_D0.5770.35
214_E264_D0.5760.35
139_E142_L0.5760.35
285_A306_Q0.5760.35
107_F276_L0.5760.35
178_S299_L0.5740.35
46_V376_E0.5740.35
230_Q236_I0.5730.35
24_V126_K0.5720.35
294_A356_F0.5720.35
208_F259_I0.5710.35
174_I260_T0.5710.35
146_V298_V0.5710.35
192_E302_F0.5700.34
62_D96_K0.5680.34
159_G253_K0.5680.34
322_A342_L0.5670.34
139_E361_R0.5660.34
205_R209_M0.5650.34
146_V223_G0.5640.34
186_S227_L0.5640.34
230_Q243_I0.5630.34
37_G118_I0.5610.34
239_G246_K0.5600.34
223_G328_A0.5600.34
266_L291_L0.5590.34
209_M213_N0.5580.33
201_D357_N0.5570.33
103_P135_K0.5560.33
116_K331_S0.5550.33
234_G306_Q0.5550.33
6_I141_D0.5540.33
134_E202_P0.5540.33
320_I362_V0.5530.33
79_A124_K0.5520.33
217_A271_K0.5520.33
122_S126_K0.5520.33
172_K348_L0.5520.33
112_N120_K0.5490.33
87_E243_I0.5490.33
113_G117_V0.5480.33
149_I257_K0.5480.33
342_L346_V0.5470.32
332_E373_L0.5450.32
151_C154_S0.5440.32
64_L250_N0.5440.32
129_V240_L0.5440.32
152_G235_N0.5430.32
72_G80_A0.5420.32
174_I179_T0.5400.32
34_A109_V0.5400.32
28_D230_Q0.5390.32
366_R372_I0.5390.32
12_E357_N0.5380.32
195_V254_L0.5370.32
184_E235_N0.5360.32
87_E224_V0.5350.31
215_Y219_I0.5340.31
83_I125_A0.5330.31
184_E187_E0.5330.31
115_L119_E0.5320.31
24_V83_I0.5310.31
310_V326_T0.5300.31
169_A180_V0.5300.31
279_V289_V0.5300.31
55_L61_L0.5290.31
180_V256_T0.5290.31
81_I125_A0.5290.31
38_V81_I0.5290.31
151_C190_G0.5290.31
318_V328_A0.5290.31
267_D270_G0.5280.31
118_I122_S0.5270.31
161_A321_S0.5270.31
219_I330_M0.5270.31
71_T293_A0.5270.31
134_E197_S0.5270.31
268_P295_K0.5260.31
17_G135_K0.5260.31
354_R369_S0.5260.31
71_T314_I0.5250.31
30_L306_Q0.5230.31
304_T307_G0.5230.31
142_L290_T0.5200.30
185_T280_N0.5200.30
34_A114_D0.5190.30
39_S245_E0.5190.30
103_P131_E0.5190.30
111_G329_T0.5190.30
48_I314_I0.5180.30
220_E224_V0.5180.30
212_Y227_L0.5170.30
50_H53_G0.5160.30
330_M333_H0.5160.30
23_A46_V0.5160.30
179_T281_T0.5160.30
199_I211_I0.5150.30
72_G100_T0.5140.30
111_G367_L0.5140.30
339_S354_R0.5130.30
274_S349_K0.5120.30
203_V366_R0.5120.30
179_T274_S0.5120.30
191_A194_I0.5120.30
160_L340_D0.5100.29
153_E308_N0.5100.29
230_Q284_A0.5090.29
203_V353_E0.5090.29
234_G283_S0.5080.29
103_P128_F0.5080.29
54_R308_N0.5080.29
27_V121_A0.5070.29
175_D349_K0.5070.29
35_S47_A0.5060.29
87_E230_Q0.5050.29
118_I348_L0.5050.29
182_F265_Y0.5050.29
147_L363_A0.5040.29
86_E110_E0.5040.29
212_Y216_V0.5030.29
349_K353_E0.5020.29
12_E138_T0.5010.29
112_N297_S0.5010.29
152_G190_G0.5000.29
310_V317_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.3359 47.7 0.977 Contact Map
3dmyA 2 0.447 33.7 0.978 Contact Map
3tqqA 1 0.2558 26.6 0.98 Contact Map
2fp4B 1 0.3049 25.9 0.98 Contact Map
1fmtA 1 0.2636 23.3 0.98 Contact Map
2blnA 1 0.2584 20.3 0.981 Contact Map
3q0iA 1 0.2558 15.6 0.982 Contact Map
3ufxB 2 0.3178 14.6 0.982 Contact Map
3o3mB 1 0.3178 14 0.982 Contact Map
4iqfA 1 0.2791 12.8 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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