GREMLIN Database
Q97YR0 - Uncharacterized protein
UniProt: Q97YR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (163)
Sequences: 4403 (2880)
Seq/√Len: 225.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_I41_I2.9741.00
132_T138_T2.4741.00
25_A53_V2.3121.00
146_P154_I2.3091.00
141_F159_Y2.2941.00
38_C171_C2.2791.00
33_R37_P2.1981.00
12_S102_G2.1911.00
71_I75_N2.0971.00
34_S164_E2.0511.00
104_L170_I2.0071.00
160_F169_E2.0041.00
112_V122_Y1.9921.00
129_Y166_M1.9361.00
162_N165_R1.8871.00
41_I64_K1.8761.00
168_E172_E1.8721.00
97_I101_S1.8641.00
118_I130_A1.8571.00
158_K169_E1.8431.00
27_K30_K1.8381.00
160_F165_R1.8011.00
34_S38_C1.7671.00
107_S118_I1.7641.00
31_F106_V1.7581.00
135_G138_T1.7531.00
36_K63_I1.7241.00
34_S37_P1.6351.00
23_E134_T1.6181.00
35_I40_P1.5541.00
56_D78_I1.5281.00
53_V57_E1.5141.00
37_P61_E1.4591.00
78_I81_E1.4521.00
29_R57_E1.4401.00
41_I66_V1.4321.00
29_R53_V1.4271.00
33_R61_E1.4161.00
29_R60_R1.4131.00
139_D142_A1.4071.00
18_E150_D1.3791.00
26_E29_R1.3661.00
29_R56_D1.3641.00
131_L166_M1.3521.00
87_S91_F1.3451.00
96_V100_R1.3211.00
59_L82_V1.3151.00
34_S163_V1.3141.00
151_D155_V1.3091.00
38_C168_E1.2901.00
36_K61_E1.2561.00
25_A29_R1.2431.00
91_F124_M1.2421.00
87_S90_E1.2191.00
13_I54_V1.2141.00
22_H26_E1.2141.00
27_K131_L1.2121.00
160_F166_M1.1981.00
58_A63_I1.1981.00
64_K82_V1.1921.00
30_K33_R1.1921.00
23_E27_K1.1871.00
129_Y160_F1.1741.00
29_R33_R1.1481.00
19_E25_A1.1341.00
84_C97_I1.1331.00
66_V101_S1.1271.00
119_M140_Y1.1271.00
13_I32_V1.1241.00
30_K34_S1.1241.00
97_I100_R1.1211.00
11_I35_I1.1101.00
28_A108_L1.1071.00
32_V36_K1.1051.00
27_K133_N1.1041.00
95_S116_I1.0881.00
9_M40_P1.0811.00
26_E30_K1.0701.00
28_A32_V1.0641.00
83_I89_C1.0631.00
89_C93_C1.0611.00
139_D144_S1.0611.00
30_K164_E1.0571.00
58_A61_E1.0521.00
56_D80_R1.0521.00
88_G93_C1.0481.00
57_E61_E1.0431.00
52_R56_D1.0421.00
11_I40_P1.0371.00
85_I97_I1.0331.00
106_V166_M1.0251.00
56_D60_R1.0221.00
42_L58_A0.9971.00
15_A47_Y0.9891.00
139_D147_D0.9851.00
15_A54_V0.9841.00
32_V57_E0.9831.00
118_I128_I0.9811.00
69_L76_I0.9661.00
12_S98_L0.9611.00
88_G91_F0.9601.00
129_Y169_E0.9581.00
90_E124_M0.9541.00
71_I88_G0.9491.00
165_R169_E0.9441.00
138_T142_A0.9301.00
68_I97_I0.9291.00
115_E119_M0.9251.00
163_V167_A0.9231.00
83_I90_E0.9140.99
33_R60_R0.9120.99
12_S105_L0.9100.99
35_I58_A0.8980.99
36_K58_A0.8980.99
11_I104_L0.8940.99
34_S167_A0.8880.99
58_A65_T0.8830.99
105_L126_K0.8810.99
112_V149_I0.8800.99
35_I42_L0.8800.99
28_A50_L0.8680.99
24_L148_Y0.8670.99
84_C90_E0.8660.99
23_E26_E0.8630.99
141_F157_V0.8580.99
125_G156_K0.8530.99
19_E53_V0.8500.99
116_I120_M0.8410.99
55_V65_T0.8400.99
142_A146_P0.8380.99
32_V58_A0.8340.99
144_S147_D0.8330.99
118_I157_V0.8270.99
130_A141_F0.8260.99
129_Y170_I0.8250.99
31_F108_L0.8210.99
99_V121_A0.8050.99
83_I87_S0.8040.99
153_K156_K0.8020.99
57_E60_R0.8010.99
16_H20_S0.8000.99
168_E171_C0.7970.99
99_V124_M0.7950.99
82_V90_E0.7940.99
44_L65_T0.7900.99
119_M123_A0.7810.98
41_I63_I0.7800.98
95_S120_M0.7750.98
122_Y156_K0.7730.98
125_G173_D0.7730.98
47_Y69_L0.7670.98
145_F154_I0.7660.98
32_V42_L0.7530.98
71_I74_E0.7520.98
104_L127_P0.7510.98
105_L121_A0.7460.98
108_L131_L0.7410.98
122_Y157_V0.7390.98
33_R57_E0.7390.98
85_I89_C0.7310.98
99_V105_L0.7300.98
112_V153_K0.7280.97
160_F163_V0.7270.97
115_E137_S0.7190.97
134_T138_T0.7180.97
73_K77_E0.7120.97
131_L160_F0.7080.97
59_L65_T0.7070.97
10_I101_S0.7050.97
119_M145_F0.7030.97
136_L139_D0.6990.97
31_F35_I0.6970.97
48_W52_R0.6930.97
161_D165_R0.6920.97
83_I91_F0.6830.96
104_L129_Y0.6720.96
40_P171_C0.6690.96
81_E84_C0.6670.96
30_K162_N0.6670.96
64_K83_I0.6600.96
116_I123_A0.6570.95
22_H25_A0.6570.95
10_I43_L0.6520.95
131_L163_V0.6510.95
98_L107_S0.6470.95
53_V56_D0.6450.95
16_H148_Y0.6440.95
13_I31_F0.6420.95
71_I87_S0.6370.95
66_V85_I0.6360.95
24_L50_L0.6320.94
125_G153_K0.6320.94
19_E148_Y0.6290.94
120_M123_A0.6280.94
129_Y167_A0.6270.94
91_F96_V0.6270.94
56_D59_L0.6260.94
84_C89_C0.6260.94
130_A159_Y0.6240.94
68_I98_L0.6240.94
44_L55_V0.6210.94
69_L77_E0.6200.94
59_L78_I0.6180.94
102_G105_L0.6160.94
139_D145_F0.6120.93
68_I101_S0.6090.93
59_L81_E0.6090.93
164_E168_E0.6040.93
27_K31_F0.6030.93
50_L108_L0.5990.93
152_R155_V0.5920.92
38_C167_A0.5910.92
156_K173_D0.5850.92
165_R168_E0.5850.92
72_E122_Y0.5840.92
120_M124_M0.5800.91
107_S114_T0.5760.91
137_S144_S0.5740.91
28_A54_V0.5700.91
84_C87_S0.5700.91
82_V91_F0.5660.90
10_I66_V0.5650.90
36_K57_E0.5630.90
13_I42_L0.5620.90
66_V83_I0.5540.89
54_V58_A0.5460.89
69_L84_C0.5440.89
103_D126_K0.5430.88
141_F145_F0.5370.88
166_M170_I0.5330.88
107_S130_A0.5290.87
121_A126_K0.5240.87
169_E172_E0.5220.86
99_V116_I0.5180.86
86_K89_C0.5150.86
150_D153_K0.5140.86
154_I157_V0.5140.86
43_L98_L0.5090.85
44_L49_G0.5090.85
82_V87_S0.5080.85
82_V89_C0.5080.85
27_K108_L0.5050.85
84_C91_F0.5030.84
112_V123_A0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajtA 2 0.9508 100 0.209 Contact Map
3bq9A 3 0.9891 100 0.226 Contact Map
3gh1A 3 0.9891 100 0.233 Contact Map
1ydhA 2 0.9235 100 0.248 Contact Map
2a33A 2 0.8962 100 0.263 Contact Map
1t35A 5 0.918 100 0.284 Contact Map
3sbxA 2 0.8907 100 0.296 Contact Map
1wekA 5 0.929 100 0.315 Contact Map
3quaA 2 0.9016 100 0.338 Contact Map
1rcuA 3 0.8852 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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