GREMLIN Database
Q97YQ4 - Uncharacterized protein
UniProt: Q97YQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 464 (387)
Sequences: 8089 (6436)
Seq/√Len: 327.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E21_I5.6381.00
52_N65_L4.4941.00
49_P80_F4.4861.00
245_C253_C3.6651.00
69_V76_T3.5521.00
52_N106_I3.5271.00
223_V229_A3.3091.00
226_W250_S3.2461.00
223_V232_L3.1551.00
28_I133_I3.1081.00
242_T255_V2.7721.00
20_E36_L2.7511.00
307_T311_L2.6761.00
236_L257_I2.6061.00
233_Y257_I2.5521.00
232_L257_I2.4961.00
147_I152_R2.4131.00
282_S291_I2.3501.00
77_Q81_S2.2921.00
262_M266_F2.2791.00
67_R80_F2.2741.00
308_L311_L2.2681.00
230_L246_L2.2641.00
304_T311_L2.2471.00
171_G174_C2.2451.00
372_T378_D2.2181.00
223_V257_I2.2081.00
198_D201_D2.1871.00
303_V310_L2.1761.00
11_L86_N2.1701.00
303_V311_L2.1661.00
233_Y237_R2.1051.00
303_V306_S2.0901.00
371_V374_D2.0781.00
89_S92_I2.0531.00
382_I388_E2.0171.00
32_V157_V1.9911.00
17_T21_I1.9591.00
36_L135_S1.9571.00
371_V377_T1.9501.00
168_A171_G1.9431.00
243_E254_K1.9381.00
303_V307_T1.9261.00
233_Y244_V1.9211.00
25_K28_I1.9191.00
307_T312_S1.9011.00
48_S76_T1.8761.00
372_T379_K1.8531.00
31_D131_N1.8371.00
105_V122_A1.8251.00
21_I28_I1.8141.00
271_E293_V1.8101.00
373_V377_T1.7531.00
21_I24_R1.7451.00
233_Y246_L1.7431.00
148_V152_R1.7421.00
166_G169_V1.7411.00
170_E174_C1.7241.00
366_V369_D1.7031.00
199_I203_D1.6971.00
147_I150_R1.6921.00
171_G176_K1.6741.00
371_V379_K1.6541.00
166_G170_E1.6541.00
17_T20_E1.6481.00
374_D377_T1.6371.00
166_G171_G1.6281.00
14_C46_V1.6221.00
374_D378_D1.6221.00
69_V73_Y1.6061.00
307_T310_L1.5911.00
372_T377_T1.5801.00
344_L347_R1.5751.00
48_S135_S1.5281.00
374_D379_K1.5201.00
258_T262_M1.5081.00
378_D381_K1.4941.00
16_E21_I1.4921.00
148_V151_F1.4871.00
371_V378_D1.4751.00
236_L244_V1.4591.00
170_E173_D1.4581.00
79_H82_K1.4571.00
24_R28_I1.4551.00
90_S94_E1.4481.00
147_I151_F1.4481.00
382_I386_P1.4421.00
90_S93_S1.4391.00
373_V378_D1.4341.00
20_E28_I1.4201.00
303_V312_S1.4151.00
173_D176_K1.4121.00
304_T312_S1.4051.00
88_Y91_A1.3941.00
15_K18_E1.3901.00
111_R264_T1.3841.00
18_E28_I1.3711.00
221_L255_V1.3641.00
14_C17_T1.3591.00
13_N21_I1.3401.00
23_R27_S1.3401.00
229_A246_L1.3331.00
17_T22_N1.3291.00
383_T387_P1.3251.00
376_F379_K1.3181.00
371_V375_L1.3111.00
306_S311_L1.3061.00
361_E365_E1.3011.00
327_K330_Y1.2971.00
47_I51_E1.2931.00
188_Y278_I1.2861.00
383_T388_E1.2821.00
175_V178_G1.2781.00
347_R350_E1.2661.00
375_L378_D1.2611.00
149_S152_R1.2581.00
412_G416_S1.2571.00
11_L85_L1.2521.00
13_N18_E1.2461.00
308_L312_S1.2451.00
20_E24_R1.2191.00
349_S353_H1.2191.00
64_R103_S1.2181.00
382_I390_V1.2161.00
219_F255_V1.2101.00
116_K119_I1.2101.00
378_D382_I1.2101.00
412_G415_C1.2021.00
306_S309_N1.1901.00
120_A123_D1.1861.00
377_T388_E1.1831.00
348_L352_S1.1731.00
377_T380_E1.1671.00
361_E364_T1.1581.00
304_T310_L1.1581.00
89_S93_S1.1581.00
327_K331_A1.1561.00
78_L82_K1.1501.00
328_M331_A1.1481.00
28_I34_F1.1461.00
357_R360_F1.1431.00
105_V132_A1.1421.00
112_M115_D1.1411.00
304_T308_L1.1401.00
20_E26_F1.1381.00
65_L104_L1.1381.00
52_N104_L1.1291.00
316_V321_P1.1231.00
228_K270_S1.1231.00
174_C178_G1.1191.00
385_V388_E1.1161.00
304_T307_T1.1141.00
382_I387_P1.1061.00
367_F370_F1.1031.00
19_R23_R1.1001.00
172_R176_K1.0991.00
306_S310_L1.0981.00
326_G330_Y1.0981.00
387_P390_V1.0961.00
364_T370_F1.0941.00
377_T381_K1.0901.00
324_C327_K1.0881.00
328_M332_N1.0871.00
146_E152_R1.0861.00
363_V366_V1.0811.00
372_T375_L1.0791.00
222_F262_M1.0731.00
410_T414_K1.0701.00
380_E388_E1.0661.00
14_C18_E1.0641.00
228_K232_L1.0631.00
337_K340_I1.0621.00
322_F331_A1.0621.00
63_S102_T1.0611.00
318_L324_C1.0601.00
362_K370_F1.0541.00
375_L379_K1.0541.00
220_T258_T1.0511.00
325_N329_G1.0511.00
27_S159_I1.0461.00
222_F281_R1.0431.00
364_T368_S1.0411.00
91_A94_E1.0381.00
324_C331_A1.0361.00
198_D203_D1.0341.00
231_R235_K1.0281.00
321_P326_G1.0231.00
382_I385_V1.0181.00
347_R351_I1.0171.00
244_V257_I1.0171.00
294_W297_R1.0151.00
326_G329_G1.0141.00
324_C328_M1.0131.00
234_R238_E1.0121.00
121_A124_E1.0071.00
201_D205_E1.0001.00
88_Y93_S1.0001.00
415_C418_I0.9921.00
169_V173_D0.9901.00
18_E22_N0.9861.00
365_E369_D0.9841.00
305_E308_L0.9821.00
396_K399_Y0.9771.00
36_L47_I0.9741.00
18_E24_R0.9721.00
409_F415_C0.9681.00
89_S94_E0.9671.00
156_V159_I0.9641.00
379_K382_I0.9611.00
409_F412_G0.9611.00
56_K64_R0.9601.00
402_N407_T0.9571.00
188_Y282_S0.9571.00
375_L381_K0.9521.00
10_E15_K0.9491.00
21_I26_F0.9481.00
23_R26_F0.9471.00
381_K385_V0.9471.00
264_T280_A0.9451.00
146_E150_R0.9441.00
198_D202_L0.9371.00
169_V172_R0.9361.00
366_V370_F0.9311.00
20_E23_R0.9301.00
206_I292_Y0.9261.00
272_I281_R0.9231.00
221_L232_L0.9221.00
46_V79_H0.9221.00
383_T386_P0.9181.00
408_Y411_D0.9171.00
71_N75_D0.9151.00
10_E13_N0.9141.00
378_D385_V0.9131.00
143_F146_E0.9111.00
38_L42_Y0.9111.00
49_P79_H0.9081.00
358_R361_E0.9031.00
338_P345_I0.9031.00
22_N26_F0.9021.00
318_L325_N0.8991.00
48_S69_V0.8991.00
383_T390_V0.8941.00
382_I389_F0.8911.00
249_S262_M0.8901.00
53_Y84_F0.8901.00
172_R175_V0.8791.00
405_V408_Y0.8741.00
356_D360_F0.8731.00
169_V174_C0.8721.00
315_K321_P0.8711.00
71_N264_T0.8681.00
401_G404_C0.8681.00
198_D270_S0.8621.00
320_H327_K0.8601.00
197_F200_R0.8591.00
359_E362_K0.8581.00
167_Q170_E0.8571.00
373_V379_K0.8561.00
391_Y396_K0.8511.00
66_T100_I0.8491.00
394_K397_I0.8471.00
414_K418_I0.8451.00
27_S157_V0.8441.00
95_I98_F0.8411.00
235_K239_E0.8361.00
365_E368_S0.8361.00
402_N406_Y0.8351.00
411_D415_C0.8311.00
360_F364_T0.8291.00
397_I400_Y0.8281.00
303_V308_L0.8281.00
365_E370_F0.8251.00
347_R353_H0.8251.00
343_R347_R0.8241.00
33_N132_A0.8231.00
340_I348_L0.8221.00
398_L408_Y0.8211.00
408_Y412_G0.8201.00
381_K388_E0.8191.00
194_I197_F0.8191.00
411_D417_K0.8171.00
372_T376_F0.8161.00
411_D414_K0.8141.00
354_L357_R0.8121.00
377_T385_V0.8111.00
344_L351_I0.8101.00
111_R280_A0.8041.00
118_L121_A0.8011.00
229_A248_N0.7991.00
291_I295_I0.7991.00
170_E176_K0.7991.00
334_T340_I0.7981.00
251_D254_K0.7961.00
166_G173_D0.7951.00
399_Y403_S0.7951.00
348_L351_I0.7901.00
378_D384_T0.7881.00
364_T367_F0.7861.00
318_L321_P0.7841.00
318_L323_G0.7841.00
381_K384_T0.7841.00
305_E309_N0.7821.00
79_H83_F0.7821.00
407_T413_E0.7821.00
401_G416_S0.7751.00
339_N344_L0.7751.00
355_M360_F0.7721.00
88_Y92_I0.7721.00
229_A257_I0.7721.00
118_L122_A0.7701.00
400_Y404_C0.7691.00
325_N330_Y0.7681.00
55_S103_S0.7671.00
345_I349_S0.7661.00
323_G331_A0.7651.00
49_P67_R0.7641.00
408_Y414_K0.7631.00
117_A120_A0.7631.00
338_P342_E0.7611.00
408_Y416_S0.7591.00
399_Y402_N0.7550.99
143_F147_I0.7550.99
346_K349_S0.7550.99
373_V381_K0.7500.99
27_S30_D0.7490.99
146_E149_S0.7490.99
110_Y134_F0.7480.99
290_K293_V0.7460.99
200_R203_D0.7450.99
236_L255_V0.7440.99
355_M358_R0.7440.99
401_G408_Y0.7430.99
343_R349_S0.7420.99
270_S294_W0.7420.99
116_K121_A0.7410.99
404_C411_D0.7400.99
48_S51_E0.7390.99
380_E383_T0.7390.99
203_D206_I0.7390.99
176_K188_Y0.7360.99
49_P84_F0.7360.99
232_L235_K0.7330.99
168_A172_R0.7320.99
340_I344_L0.7310.99
350_E353_H0.7290.99
17_T28_I0.7280.99
293_V296_D0.7270.99
380_E385_V0.7230.99
392_E395_K0.7230.99
407_T411_D0.7220.99
391_Y395_K0.7210.99
404_C414_K0.7200.99
381_K387_P0.7200.99
174_C177_K0.7160.99
354_L361_E0.7160.99
223_V228_K0.7130.99
405_V409_F0.7120.99
414_K417_K0.7120.99
406_Y411_D0.7110.99
171_G175_V0.7090.99
28_I104_L0.7090.99
304_T309_N0.7090.99
20_E25_K0.7090.99
119_I125_L0.7070.99
409_F416_S0.7070.99
229_A233_Y0.7070.99
359_E364_T0.7060.99
340_I347_R0.7050.99
49_P83_F0.7050.99
395_K399_Y0.7030.99
374_D382_I0.7030.99
291_I296_D0.7030.99
354_L358_R0.7020.99
341_D349_S0.7020.99
338_P341_D0.7010.99
374_D385_V0.6990.99
394_K398_L0.6990.99
225_S228_K0.6980.99
335_V339_N0.6980.99
351_I355_M0.6950.99
168_A173_D0.6920.99
315_K320_H0.6920.99
203_D239_E0.6900.99
371_V376_F0.6900.99
140_S143_F0.6890.99
234_R237_R0.6880.99
116_K122_A0.6880.99
122_A125_L0.6870.99
362_K366_V0.6850.99
18_E26_F0.6830.99
406_Y413_E0.6820.99
400_Y403_S0.6810.99
247_L262_M0.6810.99
384_T387_P0.6800.99
342_E346_K0.6800.99
12_L17_T0.6790.99
308_L315_K0.6780.99
54_L58_M0.6770.99
260_K263_P0.6760.99
398_L401_G0.6730.99
111_R276_P0.6700.99
15_K20_E0.6670.99
373_V398_L0.6660.99
334_T341_D0.6650.99
373_V380_E0.6640.99
339_N343_R0.6620.99
408_Y413_E0.6610.99
344_L358_R0.6600.99
390_V394_K0.6600.99
356_D363_V0.6590.99
319_K325_N0.6580.99
322_F326_G0.6580.99
21_I25_K0.6580.99
22_N25_K0.6570.99
317_C322_F0.6560.99
377_T387_P0.6560.99
19_R22_N0.6550.99
380_E384_T0.6540.99
339_N352_S0.6530.99
410_T413_E0.6530.99
321_P324_C0.6520.98
378_D387_P0.6510.98
75_D79_H0.6500.98
377_T383_T0.6490.98
320_H323_G0.6470.98
363_V369_D0.6460.98
388_E393_N0.6460.98
406_Y418_I0.6410.98
391_Y394_K0.6390.98
405_V414_K0.6390.98
227_E231_R0.6370.98
320_H324_C0.6360.98
24_R27_S0.6350.98
15_K21_I0.6330.98
399_Y404_C0.6330.98
300_Y303_V0.6320.98
406_Y416_S0.6310.98
413_E418_I0.6290.98
381_K389_F0.6260.98
389_F393_N0.6230.98
222_F266_F0.6230.98
235_K238_E0.6230.98
371_V382_I0.6220.98
33_N156_V0.6220.98
16_E22_N0.6200.98
377_T389_F0.6190.98
16_E20_E0.6180.98
395_K398_L0.6180.98
386_P389_F0.6150.98
39_P42_Y0.6140.98
384_T389_F0.6130.98
361_E369_D0.6120.98
274_S277_T0.6120.98
379_K388_E0.6110.98
118_L123_D0.6110.98
403_S415_C0.6100.98
107_L113_M0.6060.98
392_E398_L0.6060.98
228_K231_R0.6040.98
80_F84_F0.6000.97
343_R353_H0.6000.97
355_M361_E0.5990.97
402_N405_V0.5980.97
319_K323_G0.5980.97
35_I139_P0.5980.97
260_K281_R0.5970.97
378_D388_E0.5970.97
313_N319_K0.5950.97
269_V272_I0.5950.97
317_C320_H0.5950.97
409_F418_I0.5930.97
170_E175_V0.5920.97
373_V376_F0.5890.97
316_V327_K0.5890.97
357_R361_E0.5890.97
335_V338_P0.5890.97
303_V309_N0.5880.97
374_D381_K0.5880.97
376_F381_K0.5870.97
409_F413_E0.5860.97
363_V368_S0.5850.97
413_E416_S0.5850.97
407_T414_K0.5850.97
197_F203_D0.5850.97
306_S312_S0.5840.97
87_L90_S0.5840.97
17_T26_F0.5830.97
376_F385_V0.5830.97
410_T417_K0.5830.97
377_T390_V0.5820.97
363_V370_F0.5820.97
22_N28_I0.5780.97
389_F395_K0.5730.97
396_K400_Y0.5720.97
86_N90_S0.5710.97
378_D389_F0.5690.96
343_R346_K0.5670.96
356_D359_E0.5670.96
340_I351_I0.5670.96
324_C330_Y0.5660.96
77_Q92_I0.5640.96
384_T388_E0.5620.96
404_C407_T0.5610.96
78_L81_S0.5600.96
293_V297_R0.5590.96
354_L368_S0.5590.96
323_G326_G0.5590.96
398_L413_E0.5580.96
55_S104_L0.5580.96
76_T263_P0.5580.96
408_Y415_C0.5570.96
397_I401_G0.5570.96
159_I162_V0.5540.96
338_P352_S0.5540.96
407_T410_T0.5540.96
172_R177_K0.5520.96
322_F330_Y0.5520.96
410_T416_S0.5510.96
167_Q171_G0.5510.96
407_T416_S0.5490.96
13_N17_T0.5480.96
166_G174_C0.5470.96
45_D76_T0.5460.96
376_F388_E0.5450.96
244_V255_V0.5430.95
243_E253_C0.5430.95
404_C408_Y0.5430.95
342_E350_E0.5380.95
342_E353_H0.5380.95
230_L248_N0.5370.95
409_F417_K0.5360.95
176_K282_S0.5360.95
339_N342_E0.5350.95
316_V323_G0.5340.95
320_H325_N0.5330.95
141_V144_E0.5310.95
404_C417_K0.5310.95
373_V383_T0.5290.95
362_K365_E0.5290.95
36_L133_I0.5280.95
336_L339_N0.5270.95
364_T369_D0.5250.95
315_K318_L0.5250.95
363_V367_F0.5240.94
409_F414_K0.5230.94
168_A174_C0.5230.94
392_E396_K0.5220.94
349_S352_S0.5200.94
400_Y413_E0.5200.94
199_I235_K0.5200.94
74_E78_L0.5190.94
377_T382_I0.5190.94
335_V350_E0.5190.94
116_K123_D0.5180.94
378_D383_T0.5170.94
323_G329_G0.5160.94
63_S103_S0.5140.94
404_C412_G0.5140.94
326_G331_A0.5140.94
307_T314_I0.5120.94
313_N316_V0.5120.94
383_T389_F0.5110.94
391_Y399_Y0.5110.94
198_D205_E0.5110.94
405_V412_G0.5110.94
344_L348_L0.5110.94
372_T385_V0.5100.94
356_D361_E0.5100.94
87_L91_A0.5090.94
193_L201_D0.5080.94
291_I294_W0.5070.93
403_S417_K0.5070.93
344_L352_S0.5060.93
319_K332_N0.5050.93
345_I351_I0.5040.93
111_R114_P0.5040.93
399_Y413_E0.5020.93
357_R363_V0.5000.93
112_M264_T0.5000.93
355_M364_T0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d25A 1 0.6466 100 0.486 Contact Map
3fmpB 1 0.3427 100 0.487 Contact Map
4pxaA 1 0.6552 100 0.488 Contact Map
2db3A 1 0.6444 100 0.492 Contact Map
4nhoA 1 0.653 100 0.5 Contact Map
4w7sA 2 0.6875 100 0.5 Contact Map
4ljyA 1 0.681 100 0.501 Contact Map
3fhtA 1 0.6358 100 0.503 Contact Map
3eiqA 1 0.6099 100 0.503 Contact Map
4c9bA 1 0.6444 100 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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