GREMLIN Database
Q97YQ3 - Alanyl-tRNA synthetase truncated homolog (AlaS-like2)
UniProt: Q97YQ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (141)
Sequences: 4446 (2400)
Seq/√Len: 202.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_N121_F4.2361.00
10_T106_I3.1251.00
76_P79_E2.9421.00
63_K66_K2.5951.00
17_G21_K2.4331.00
21_K59_L2.4221.00
77_R81_E2.4191.00
60_A128_I2.3331.00
74_V100_E2.3251.00
119_T125_I2.1271.00
25_A44_F2.1151.00
67_N123_S2.1091.00
46_R52_E2.0491.00
48_P56_V2.0241.00
70_I106_I1.9571.00
120_K124_E1.8911.00
49_S52_E1.8721.00
79_E82_R1.8451.00
22_V59_L1.7221.00
105_V111_I1.7191.00
54_D58_E1.7131.00
73_E83_K1.7071.00
71_I105_V1.7011.00
78_E82_R1.7001.00
3_Q6_I1.6971.00
83_K111_I1.6911.00
55_K58_E1.6581.00
73_E105_V1.6441.00
72_I104_V1.6231.00
59_L62_E1.6091.00
138_S141_L1.5531.00
63_K109_W1.5371.00
7_R65_R1.5361.00
75_L83_K1.5151.00
67_N124_E1.5091.00
48_P53_M1.5051.00
34_N37_H1.4821.00
63_K68_L1.4601.00
69_P121_F1.4381.00
29_A43_K1.4101.00
14_V60_A1.4041.00
20_R27_W1.3571.00
76_P100_E1.3391.00
62_E66_K1.2931.00
20_R86_D1.2861.00
52_E55_K1.2831.00
6_I117_Q1.2781.00
58_E62_E1.2711.00
105_V108_D1.2631.00
133_W142_L1.2431.00
57_F129_I1.2281.00
78_E81_E1.1961.00
59_L63_K1.1881.00
55_K59_L1.1831.00
14_V63_K1.1821.00
64_V128_I1.1791.00
5_E35_S1.1731.00
134_R145_S1.1551.00
53_M130_K1.1441.00
10_T70_I1.1321.00
18_A59_L1.1211.00
12_L31_T1.1161.00
22_V55_K1.1151.00
38_G146_F1.1051.00
4_V7_R1.0771.00
19_V56_V1.0721.00
50_D54_D1.0681.00
75_L79_E1.0651.00
119_T124_E1.0161.00
72_I102_S1.0101.00
37_H145_S1.0071.00
103_I111_I1.0051.00
65_R127_E1.0021.00
12_L38_G1.0011.00
16_K86_D1.0011.00
25_A45_E0.9981.00
70_I119_T0.9851.00
3_Q7_R0.9801.00
17_G109_W0.9660.99
12_L28_T0.9610.99
68_L107_P0.9510.99
4_V8_T0.9450.99
106_I122_T0.9380.99
89_Y92_F0.9340.99
75_L103_I0.9300.99
64_V125_I0.9220.99
11_A128_I0.9190.99
121_F124_E0.9100.99
11_A125_I0.8900.99
51_Q55_K0.8850.99
14_V125_I0.8750.99
96_A100_E0.8650.99
77_R95_S0.8610.99
22_V52_E0.8430.99
21_K63_K0.8420.99
88_I91_L0.8350.99
70_I104_V0.8310.98
15_V128_I0.8230.98
19_V42_V0.8180.98
69_P120_K0.8140.98
48_P52_E0.8120.98
27_W43_K0.8060.98
16_K88_I0.8060.98
131_D147_D0.8000.98
87_E91_L0.7970.98
18_A22_V0.7960.98
61_N127_E0.7960.98
68_L122_T0.7950.98
27_W86_D0.7930.98
21_K109_W0.7920.98
59_L109_W0.7850.98
44_F52_E0.7810.98
14_V122_T0.7770.98
17_G68_L0.7730.98
33_V38_G0.7540.97
14_V64_V0.7530.97
87_E90_D0.7470.97
47_K136_R0.7460.97
28_T112_N0.7440.97
41_T143_E0.7410.97
10_T119_T0.7390.97
83_K105_V0.7340.97
3_Q124_E0.7300.97
17_G63_K0.7260.96
129_I147_D0.7230.96
26_K43_K0.7200.96
17_G86_D0.7190.96
54_D57_F0.7090.96
8_T38_G0.7080.96
6_I120_K0.7050.96
2_D5_E0.6990.96
65_R123_S0.6980.96
29_A141_L0.6980.96
73_E79_E0.6970.95
31_T38_G0.6930.95
6_I72_I0.6880.95
89_Y93_L0.6780.95
95_S100_E0.6740.95
18_A56_V0.6700.94
74_V95_S0.6550.94
15_V19_V0.6530.94
80_A113_A0.6520.94
67_N122_T0.6480.93
123_S126_G0.6460.93
66_K122_T0.6430.93
72_I120_K0.6390.93
20_R26_K0.6390.93
11_A38_G0.6380.93
30_S41_T0.6380.93
130_K144_I0.6370.93
28_T31_T0.6340.93
69_P107_P0.6330.93
15_V60_A0.6300.92
7_R124_E0.6190.92
12_L146_F0.6180.92
12_L112_N0.6170.92
17_G59_L0.6120.91
6_I119_T0.6100.91
48_P133_W0.6030.91
23_L44_F0.6030.91
27_W46_R0.6020.91
70_I122_T0.6000.90
16_K112_N0.5990.90
18_A109_W0.5990.90
72_I117_Q0.5960.90
3_Q120_K0.5910.90
30_S143_E0.5870.89
80_A84_Y0.5870.89
2_D117_Q0.5830.89
75_L80_A0.5820.89
79_E100_E0.5800.89
66_K69_P0.5800.89
68_L106_I0.5790.89
16_K26_K0.5790.89
9_H13_H0.5740.88
14_V109_W0.5730.88
65_R126_G0.5730.88
77_R80_A0.5700.88
45_E129_I0.5660.88
71_I74_V0.5650.88
62_E69_P0.5650.88
47_K50_D0.5640.88
71_I107_P0.5610.87
6_I124_E0.5610.87
27_W81_E0.5600.87
64_V127_E0.5590.87
8_T33_V0.5550.87
25_A46_R0.5510.86
19_V26_K0.5480.86
15_V38_G0.5420.85
80_A85_G0.5410.85
6_I70_I0.5400.85
5_E8_T0.5400.85
23_L48_P0.5360.85
83_K103_I0.5360.85
24_G44_F0.5350.85
75_L84_Y0.5320.84
53_M133_W0.5320.84
81_E87_E0.5310.84
8_T132_Y0.5260.84
90_D95_S0.5170.83
28_T40_L0.5170.83
11_A146_F0.5160.83
26_K44_F0.5160.83
5_E34_N0.5160.83
7_R119_T0.5120.82
32_Y136_R0.5110.82
136_R139_K0.5100.82
77_R100_E0.5040.81
79_E83_K0.5020.81
60_A63_K0.5020.81
51_Q54_D0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zzeA 1 0.9267 100 0.229 Contact Map
3wqyA 2 0.96 100 0.233 Contact Map
2ztgA 1 0.96 100 0.24 Contact Map
3kewA 1 0.9333 100 0.303 Contact Map
2e1bA 1 0.8267 100 0.329 Contact Map
1v4pA 2 1 100 0.373 Contact Map
1nyrA 2 0.9667 100 0.41 Contact Map
1tkeA 1 0.9667 100 0.425 Contact Map
1qf6A 1 0.9667 100 0.442 Contact Map
4ce4c 1 0.9667 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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