GREMLIN Database
Q97YQ2 - Uncharacterized protein
UniProt: Q97YQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (321)
Sequences: 640 (514)
Seq/√Len: 28.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_N224_Y4.5681.00
257_K270_C4.1521.00
288_K325_K3.6371.00
8_F25_L3.3311.00
154_V294_R3.1351.00
294_R310_Y3.0611.00
205_A230_V3.0581.00
120_T144_R3.0011.00
160_S265_E2.9611.00
209_F215_V2.9551.00
161_K207_Y2.9241.00
39_G42_P2.8371.00
108_S111_E2.8241.00
25_L67_L2.7041.00
65_N99_K2.6751.00
25_L36_I2.6541.00
11_F151_Y2.6511.00
27_N31_L2.5930.99
26_K63_E2.5590.99
116_S145_I2.5330.99
277_Y296_R2.5230.99
196_L207_Y2.4070.99
73_V98_F2.4070.99
292_A301_F2.4060.99
228_R232_E2.3490.99
292_A310_Y2.3420.99
154_V310_Y2.2880.99
184_N226_S2.2850.99
26_K67_L2.2750.99
286_L301_F2.2330.98
155_L198_Y2.2300.98
169_R173_E2.1940.98
252_K255_D2.1900.98
178_I212_V2.1110.98
22_I59_E2.1090.98
242_R320_N2.0800.97
8_F28_A2.0640.97
103_A107_F2.0630.97
258_F272_T2.0590.97
156_Y266_F2.0510.97
287_F304_D2.0390.97
195_V207_Y2.0290.97
191_T218_G2.0220.97
164_F180_A1.9920.97
261_E330_I1.9920.97
286_L292_A1.9390.96
149_H159_I1.9230.96
8_F69_Y1.9100.96
31_L228_R1.9070.96
28_A222_P1.8640.95
177_E214_R1.8540.95
279_G296_R1.8330.94
161_K195_V1.8010.94
72_F100_G1.7880.94
243_I291_V1.7770.93
315_E318_D1.7770.93
31_L224_Y1.7470.93
21_Q221_I1.7080.92
206_N320_N1.7030.92
182_I205_A1.7020.92
164_F212_V1.6770.91
172_K213_D1.6670.91
147_A171_F1.6330.90
286_L312_L1.5600.88
295_G311_R1.5590.88
252_K256_K1.5440.87
224_Y228_R1.5440.87
22_I63_E1.5410.87
22_I26_K1.5400.87
258_F271_Y1.5350.87
245_V249_S1.5170.86
223_D226_S1.4910.85
46_W52_E1.4700.85
241_I327_S1.4670.84
17_I59_E1.4540.84
157_S267_A1.4540.84
55_S59_E1.4390.83
156_Y305_L1.4380.83
24_L257_K1.4370.83
130_E137_A1.4340.83
290_A315_E1.4330.83
39_G79_I1.4250.83
267_A305_L1.4060.82
154_V292_A1.3890.81
31_L231_S1.3640.80
15_K21_Q1.3570.79
136_I174_R1.3510.79
182_I217_I1.3430.79
109_K112_I1.3220.78
127_E171_F1.3220.78
288_K304_D1.2910.76
287_F290_A1.2780.75
182_I230_V1.2520.74
139_N328_S1.2470.73
148_C191_T1.2470.73
302_T324_V1.2460.73
110_E113_V1.2270.72
133_V174_R1.2260.72
41_G105_Y1.2130.71
19_D23_S1.2010.70
162_E166_E1.1990.70
122_E148_C1.1970.70
205_A208_L1.1930.70
284_T312_L1.1860.69
141_N144_R1.1780.69
91_S95_E1.1590.68
128_I170_I1.1470.67
83_L151_Y1.1340.66
24_L222_P1.1340.66
154_V308_G1.1330.66
125_P178_I1.1330.66
150_N274_D1.1300.66
104_D150_N1.1280.65
160_S266_F1.1280.65
293_V313_V1.1270.65
35_E216_L1.1260.65
270_C293_V1.1260.65
207_Y322_E1.1260.65
241_I316_I1.1080.64
182_I215_V1.1080.64
44_T185_P1.1070.64
109_K135_F1.1070.64
154_V299_W1.1050.64
288_K302_T1.1050.64
217_I230_V1.1030.64
66_K215_V1.0920.63
286_L310_Y1.0910.63
10_I60_I1.0810.62
42_P53_A1.0740.62
132_E176_I1.0690.61
76_N79_I1.0680.61
148_C216_L1.0660.61
265_E268_I1.0630.61
183_S191_T1.0630.61
130_E134_D1.0540.60
278_E295_G1.0500.60
259_A327_S1.0480.60
180_A323_I1.0360.59
24_L270_C1.0350.59
101_V121_V1.0330.59
16_E20_E1.0260.58
133_V170_I1.0240.58
290_A301_F1.0180.57
161_K193_L1.0130.57
40_I73_V1.0050.56
13_G16_E1.0040.56
248_E268_I1.0030.56
85_A92_M1.0030.56
202_F229_Q0.9980.56
100_G122_E0.9960.56
145_I176_I0.9900.55
263_Y273_R0.9880.55
26_K66_K0.9850.55
75_I157_S0.9800.54
33_F231_S0.9790.54
161_K326_M0.9760.54
20_E23_S0.9760.54
286_L305_L0.9710.54
244_K317_D0.9710.54
36_I64_A0.9700.54
165_I169_R0.9690.54
171_F299_W0.9590.53
12_P122_E0.9580.53
148_C257_K0.9570.53
266_F303_R0.9570.53
36_I69_Y0.9560.53
283_Y312_L0.9520.52
26_K30_D0.9510.52
42_P79_I0.9440.52
142_L145_I0.9400.51
26_K215_V0.9370.51
125_P286_L0.9320.51
163_I191_T0.9320.51
252_K276_I0.9280.50
132_E140_A0.9270.50
112_I135_F0.9210.50
38_M73_V0.9190.50
156_Y264_R0.9170.50
154_V286_L0.9150.49
123_L140_A0.9140.49
64_A71_A0.9120.49
294_R299_W0.9100.49
125_P147_A0.9030.49
195_V241_I0.9010.48
74_D104_D0.9000.48
62_K316_I0.9000.48
103_A112_I0.8990.48
247_D313_V0.8950.48
63_E66_K0.8940.48
168_N208_L0.8940.48
13_G65_N0.8930.48
140_A145_I0.8920.48
201_P204_S0.8920.48
113_V140_A0.8870.47
150_N190_R0.8850.47
33_F79_I0.8840.47
8_F64_A0.8830.47
75_I279_G0.8750.46
35_E103_A0.8750.46
77_P103_A0.8670.46
16_E21_Q0.8660.46
200_E288_K0.8660.46
322_E326_M0.8640.46
125_P167_K0.8640.46
291_V314_G0.8640.46
205_A209_F0.8630.45
112_I131_E0.8630.45
260_V269_V0.8620.45
259_A264_R0.8610.45
134_D291_V0.8590.45
63_E67_L0.8500.44
215_V235_K0.8490.44
30_D282_C0.8480.44
164_F193_L0.8470.44
208_L230_V0.8450.44
21_Q218_G0.8430.44
182_I325_K0.8400.44
29_R67_L0.8350.43
9_S37_F0.8350.43
51_N241_I0.8350.43
31_L227_L0.8330.43
136_I140_A0.8310.43
35_E214_R0.8290.43
183_S218_G0.8220.42
54_L58_K0.8210.42
302_T309_P0.8150.42
74_D150_N0.8130.42
70_Y196_L0.8100.41
23_S27_N0.8100.41
60_I201_P0.8090.41
286_L304_D0.8080.41
11_F103_A0.8060.41
262_N269_V0.8020.41
90_L115_M0.8000.41
105_Y273_R0.7990.41
203_D320_N0.7820.39
27_N30_D0.7810.39
253_R257_K0.7800.39
35_E122_E0.7790.39
263_Y329_E0.7780.39
80_L85_A0.7710.38
184_N206_N0.7700.38
280_E295_G0.7650.38
76_N105_Y0.7620.38
90_L118_Q0.7620.38
154_V301_F0.7600.38
53_A79_I0.7580.38
150_N260_V0.7570.37
39_G56_V0.7550.37
68_D225_E0.7520.37
39_G191_T0.7520.37
104_D274_D0.7520.37
321_M324_V0.7500.37
12_P40_I0.7500.37
168_N178_I0.7490.37
126_F159_I0.7450.37
57_A133_V0.7450.37
326_M331_M0.7430.36
25_L253_R0.7410.36
201_P205_A0.7400.36
114_E316_I0.7380.36
126_F149_H0.7360.36
257_K293_V0.7330.36
207_Y305_L0.7310.36
150_N269_V0.7220.35
42_P219_D0.7190.35
250_V295_G0.7190.35
242_R293_V0.7190.35
291_V316_I0.7180.35
134_D137_A0.7170.35
183_S196_L0.7170.35
254_L314_G0.7150.34
190_R274_D0.7150.34
278_E314_G0.7150.34
16_E19_D0.7140.34
282_C312_L0.7130.34
11_F83_L0.7110.34
259_A301_F0.7100.34
163_I263_Y0.7090.34
148_C192_T0.7070.34
106_G111_E0.7040.34
54_L316_I0.7030.34
30_D224_Y0.7010.33
125_P171_F0.6960.33
8_F222_P0.6930.33
30_D34_S0.6880.33
283_Y296_R0.6840.32
66_K231_S0.6840.32
19_D22_I0.6830.32
89_N92_M0.6810.32
246_Y249_S0.6800.32
108_S180_A0.6790.32
100_G119_M0.6780.32
80_L107_F0.6760.32
55_S155_L0.6750.32
36_I327_S0.6750.32
33_F80_L0.6720.32
154_V188_N0.6720.32
150_N262_N0.6710.31
292_A299_W0.6710.31
223_D247_D0.6700.31
301_F304_D0.6700.31
15_K221_I0.6690.31
299_W310_Y0.6680.31
123_L136_I0.6680.31
100_G148_C0.6650.31
41_G98_F0.6650.31
269_V274_D0.6640.31
160_S163_I0.6630.31
39_G53_A0.6610.31
36_I60_I0.6600.31
78_Q198_Y0.6580.31
93_F118_Q0.6570.31
73_V93_F0.6560.30
233_V298_V0.6530.30
217_I289_N0.6530.30
186_K273_R0.6500.30
287_F301_F0.6490.30
64_A69_Y0.6460.30
161_K165_I0.6430.30
19_D68_D0.6410.29
15_K41_G0.6370.29
104_D190_R0.6350.29
58_K314_G0.6330.29
94_M118_Q0.6310.29
148_C270_C0.6300.29
317_D320_N0.6300.29
222_P230_V0.6290.29
305_L310_Y0.6290.29
242_R317_D0.6290.29
173_E225_E0.6280.29
40_I129_S0.6280.29
220_P295_G0.6280.29
117_K258_F0.6270.29
62_K66_K0.6250.28
130_E170_I0.6240.28
70_Y100_G0.6230.28
235_K239_T0.6230.28
257_K273_R0.6230.28
61_L71_A0.6200.28
267_A309_P0.6200.28
165_I168_N0.6190.28
58_K95_E0.6180.28
250_V281_T0.6170.28
134_D326_M0.6170.28
32_G84_N0.6170.28
41_G103_A0.6170.28
248_E293_V0.6170.28
228_R255_D0.6170.28
34_S157_S0.6160.28
38_M129_S0.6160.28
241_I268_I0.6110.28
92_M98_F0.6110.28
254_L313_V0.6110.28
262_N274_D0.6100.28
6_I31_L0.6100.28
126_F260_V0.6100.28
35_E179_G0.6080.27
34_S285_K0.6060.27
150_N191_T0.6060.27
264_R267_A0.6050.27
287_F312_L0.6030.27
280_E311_R0.6020.27
41_G76_N0.6020.27
185_P190_R0.6010.27
45_H53_A0.6010.27
218_G222_P0.5990.27
72_F75_I0.5990.27
184_N222_P0.5980.27
182_I199_V0.5970.27
30_D66_K0.5960.27
57_A79_I0.5960.27
202_F210_K0.5960.27
98_F119_M0.5920.26
308_G316_I0.5910.26
17_I22_I0.5910.26
17_I21_Q0.5910.26
127_E147_A0.5900.26
183_S219_D0.5900.26
108_S310_Y0.5900.26
41_G116_S0.5900.26
286_L294_R0.5890.26
62_K97_G0.5890.26
278_E311_R0.5850.26
200_E203_D0.5850.26
316_I327_S0.5850.26
123_L157_S0.5840.26
99_K206_N0.5830.26
227_L302_T0.5810.26
125_P259_A0.5810.26
43_G46_W0.5800.26
90_L145_I0.5800.26
12_P93_F0.5790.26
91_S118_Q0.5780.26
240_K265_E0.5770.26
8_F17_I0.5770.26
35_E182_I0.5770.26
185_P264_R0.5770.26
35_E146_K0.5750.25
122_E179_G0.5750.25
185_P196_L0.5750.25
146_K264_R0.5750.25
251_G325_K0.5750.25
205_A222_P0.5750.25
218_G295_G0.5740.25
136_I205_A0.5730.25
253_R313_V0.5730.25
185_P305_L0.5710.25
25_L39_G0.5690.25
142_L251_G0.5690.25
63_E182_I0.5670.25
28_A230_V0.5650.25
291_V331_M0.5620.25
122_E184_N0.5590.24
112_I191_T0.5590.24
24_L67_L0.5580.24
318_D321_M0.5580.24
172_K216_L0.5570.24
81_K121_V0.5570.24
129_S170_I0.5550.24
34_S69_Y0.5520.24
35_E107_F0.5510.24
218_G286_L0.5500.24
258_F273_R0.5490.24
77_P83_L0.5490.24
263_Y330_I0.5480.24
70_Y120_T0.5480.24
219_D305_L0.5460.24
215_V304_D0.5440.24
79_I239_T0.5430.24
77_P107_F0.5420.24
95_E158_G0.5420.24
230_V233_V0.5420.24
43_G53_A0.5410.23
154_V295_G0.5410.23
98_F135_F0.5400.23
128_I140_A0.5400.23
50_V291_V0.5390.23
163_I170_I0.5380.23
253_R292_A0.5360.23
260_V274_D0.5360.23
155_L228_R0.5360.23
113_V209_F0.5360.23
180_A326_M0.5350.23
14_W43_G0.5350.23
167_K170_I0.5340.23
151_Y273_R0.5320.23
10_I245_V0.5280.23
168_N212_V0.5220.22
209_F235_K0.5220.22
9_S107_F0.5220.22
166_E245_V0.5210.22
41_G219_D0.5210.22
68_D318_D0.5210.22
316_I321_M0.5210.22
190_R262_N0.5200.22
68_D103_A0.5200.22
103_A227_L0.5190.22
191_T273_R0.5190.22
280_E283_Y0.5190.22
286_L307_I0.5180.22
50_V82_E0.5170.22
163_I264_R0.5170.22
189_L219_D0.5170.22
188_N245_V0.5150.22
253_R256_K0.5140.22
268_I288_K0.5140.22
31_L232_E0.5130.22
182_I318_D0.5130.22
162_E182_I0.5130.22
168_N292_A0.5120.22
156_Y286_L0.5110.22
11_F221_I0.5090.22
246_Y273_R0.5080.22
182_I212_V0.5070.22
32_G78_Q0.5060.22
123_L273_R0.5060.22
156_Y307_I0.5050.22
25_L69_Y0.5030.21
38_M61_L0.5010.21
268_I302_T0.5010.21
130_E133_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p0oA 1 0.9522 100 0.113 Contact Map
1x7fA 1 0.9373 100 0.121 Contact Map
4s1aA 2 0.4179 96.1 0.944 Contact Map
2r6oA 2 0.4746 92.6 0.953 Contact Map
4rniA 2 0.4627 92.6 0.953 Contact Map
4rnhA 2 0.4597 92 0.954 Contact Map
4fojA 1 0.4537 90.9 0.955 Contact Map
2g0wA 1 0.7433 90 0.956 Contact Map
3lmzA 2 0.6896 89.4 0.957 Contact Map
1yx1A 3 0.6925 88.8 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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