Q97YQ2 - SULSO - GREMLIN Contacts

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Q97YQ2 - Uncharacterized protein

UniProt:	Q97YQ2	Sequences: MTKRRIGFSIFPGWKEIKDEQISLLKNARDLGFSEIFMGIGPGTHWRTPVNEALSVAKEILKEANKLDYYAFVDINPQILKELNASPRNLSMFMEIGFKGVRADYGFSKEEIVEMSKQMTVELNPFEISEEEVDFIARNANLERIKACHNYYPVLYSGISKEIFIEKNRIFKERGIEIGAFISNPKFNLRTTLEVLRYVEPFDSANYLFKFVDRVLIGDPIPDYESLRQVSEVFKSDITKIRIKVYDESVGKRLDKKFAVENYREFAIVCYTRDNIYEGETCYTKLFKNAVAVRGREVWIFTRDLGIGPYRLVGEIDDINMEIVKMSSEIMLISK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (321)
Sequences:	640 (514)
Seq/√Len:	28.7

SULSO - Q97YQ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_N	224_Y	4.568	1.00
257_K	270_C	4.152	1.00
288_K	325_K	3.637	1.00
8_F	25_L	3.331	1.00
154_V	294_R	3.135	1.00
294_R	310_Y	3.061	1.00
205_A	230_V	3.058	1.00
120_T	144_R	3.001	1.00
160_S	265_E	2.961	1.00
209_F	215_V	2.955	1.00
161_K	207_Y	2.924	1.00
39_G	42_P	2.837	1.00
108_S	111_E	2.824	1.00
25_L	67_L	2.704	1.00
65_N	99_K	2.675	1.00
25_L	36_I	2.654	1.00
11_F	151_Y	2.651	1.00
27_N	31_L	2.593	0.99
26_K	63_E	2.559	0.99
116_S	145_I	2.533	0.99
277_Y	296_R	2.523	0.99
196_L	207_Y	2.407	0.99
73_V	98_F	2.407	0.99
292_A	301_F	2.406	0.99
228_R	232_E	2.349	0.99
292_A	310_Y	2.342	0.99
154_V	310_Y	2.288	0.99
184_N	226_S	2.285	0.99
26_K	67_L	2.275	0.99
286_L	301_F	2.233	0.98
155_L	198_Y	2.230	0.98
169_R	173_E	2.194	0.98
252_K	255_D	2.190	0.98
178_I	212_V	2.111	0.98
22_I	59_E	2.109	0.98
242_R	320_N	2.080	0.97
8_F	28_A	2.064	0.97
103_A	107_F	2.063	0.97
258_F	272_T	2.059	0.97
156_Y	266_F	2.051	0.97
287_F	304_D	2.039	0.97
195_V	207_Y	2.029	0.97
191_T	218_G	2.022	0.97
164_F	180_A	1.992	0.97
261_E	330_I	1.992	0.97
286_L	292_A	1.939	0.96
149_H	159_I	1.923	0.96
8_F	69_Y	1.910	0.96
31_L	228_R	1.907	0.96
28_A	222_P	1.864	0.95
177_E	214_R	1.854	0.95
279_G	296_R	1.833	0.94
161_K	195_V	1.801	0.94
72_F	100_G	1.788	0.94
243_I	291_V	1.777	0.93
315_E	318_D	1.777	0.93
31_L	224_Y	1.747	0.93
21_Q	221_I	1.708	0.92
206_N	320_N	1.703	0.92
182_I	205_A	1.702	0.92
164_F	212_V	1.677	0.91
172_K	213_D	1.667	0.91
147_A	171_F	1.633	0.90
286_L	312_L	1.560	0.88
295_G	311_R	1.559	0.88
252_K	256_K	1.544	0.87
224_Y	228_R	1.544	0.87
22_I	63_E	1.541	0.87
22_I	26_K	1.540	0.87
258_F	271_Y	1.535	0.87
245_V	249_S	1.517	0.86
223_D	226_S	1.491	0.85
46_W	52_E	1.470	0.85
241_I	327_S	1.467	0.84
17_I	59_E	1.454	0.84
157_S	267_A	1.454	0.84
55_S	59_E	1.439	0.83
156_Y	305_L	1.438	0.83
24_L	257_K	1.437	0.83
130_E	137_A	1.434	0.83
290_A	315_E	1.433	0.83
39_G	79_I	1.425	0.83
267_A	305_L	1.406	0.82
154_V	292_A	1.389	0.81
31_L	231_S	1.364	0.80
15_K	21_Q	1.357	0.79
136_I	174_R	1.351	0.79
182_I	217_I	1.343	0.79
109_K	112_I	1.322	0.78
127_E	171_F	1.322	0.78
288_K	304_D	1.291	0.76
287_F	290_A	1.278	0.75
182_I	230_V	1.252	0.74
139_N	328_S	1.247	0.73
148_C	191_T	1.247	0.73
302_T	324_V	1.246	0.73
110_E	113_V	1.227	0.72
133_V	174_R	1.226	0.72
41_G	105_Y	1.213	0.71
19_D	23_S	1.201	0.70
162_E	166_E	1.199	0.70
122_E	148_C	1.197	0.70
205_A	208_L	1.193	0.70
284_T	312_L	1.186	0.69
141_N	144_R	1.178	0.69
91_S	95_E	1.159	0.68
128_I	170_I	1.147	0.67
83_L	151_Y	1.134	0.66
24_L	222_P	1.134	0.66
154_V	308_G	1.133	0.66
125_P	178_I	1.133	0.66
150_N	274_D	1.130	0.66
104_D	150_N	1.128	0.65
160_S	266_F	1.128	0.65
293_V	313_V	1.127	0.65
35_E	216_L	1.126	0.65
270_C	293_V	1.126	0.65
207_Y	322_E	1.126	0.65
241_I	316_I	1.108	0.64
182_I	215_V	1.108	0.64
44_T	185_P	1.107	0.64
109_K	135_F	1.107	0.64
154_V	299_W	1.105	0.64
288_K	302_T	1.105	0.64
217_I	230_V	1.103	0.64
66_K	215_V	1.092	0.63
286_L	310_Y	1.091	0.63
10_I	60_I	1.081	0.62
42_P	53_A	1.074	0.62
132_E	176_I	1.069	0.61
76_N	79_I	1.068	0.61
148_C	216_L	1.066	0.61
265_E	268_I	1.063	0.61
183_S	191_T	1.063	0.61
130_E	134_D	1.054	0.60
278_E	295_G	1.050	0.60
259_A	327_S	1.048	0.60
180_A	323_I	1.036	0.59
24_L	270_C	1.035	0.59
101_V	121_V	1.033	0.59
16_E	20_E	1.026	0.58
133_V	170_I	1.024	0.58
290_A	301_F	1.018	0.57
161_K	193_L	1.013	0.57
40_I	73_V	1.005	0.56
13_G	16_E	1.004	0.56
248_E	268_I	1.003	0.56
85_A	92_M	1.003	0.56
202_F	229_Q	0.998	0.56
100_G	122_E	0.996	0.56
145_I	176_I	0.990	0.55
263_Y	273_R	0.988	0.55
26_K	66_K	0.985	0.55
75_I	157_S	0.980	0.54
33_F	231_S	0.979	0.54
161_K	326_M	0.976	0.54
20_E	23_S	0.976	0.54
286_L	305_L	0.971	0.54
244_K	317_D	0.971	0.54
36_I	64_A	0.970	0.54
165_I	169_R	0.969	0.54
171_F	299_W	0.959	0.53
12_P	122_E	0.958	0.53
148_C	257_K	0.957	0.53
266_F	303_R	0.957	0.53
36_I	69_Y	0.956	0.53
283_Y	312_L	0.952	0.52
26_K	30_D	0.951	0.52
42_P	79_I	0.944	0.52
142_L	145_I	0.940	0.51
26_K	215_V	0.937	0.51
125_P	286_L	0.932	0.51
163_I	191_T	0.932	0.51
252_K	276_I	0.928	0.50
132_E	140_A	0.927	0.50
112_I	135_F	0.921	0.50
38_M	73_V	0.919	0.50
156_Y	264_R	0.917	0.50
154_V	286_L	0.915	0.49
123_L	140_A	0.914	0.49
64_A	71_A	0.912	0.49
294_R	299_W	0.910	0.49
125_P	147_A	0.903	0.49
195_V	241_I	0.901	0.48
74_D	104_D	0.900	0.48
62_K	316_I	0.900	0.48
103_A	112_I	0.899	0.48
247_D	313_V	0.895	0.48
63_E	66_K	0.894	0.48
168_N	208_L	0.894	0.48
13_G	65_N	0.893	0.48
140_A	145_I	0.892	0.48
201_P	204_S	0.892	0.48
113_V	140_A	0.887	0.47
150_N	190_R	0.885	0.47
33_F	79_I	0.884	0.47
8_F	64_A	0.883	0.47
75_I	279_G	0.875	0.46
35_E	103_A	0.875	0.46
77_P	103_A	0.867	0.46
16_E	21_Q	0.866	0.46
200_E	288_K	0.866	0.46
322_E	326_M	0.864	0.46
125_P	167_K	0.864	0.46
291_V	314_G	0.864	0.46
205_A	209_F	0.863	0.45
112_I	131_E	0.863	0.45
260_V	269_V	0.862	0.45
259_A	264_R	0.861	0.45
134_D	291_V	0.859	0.45
63_E	67_L	0.850	0.44
215_V	235_K	0.849	0.44
30_D	282_C	0.848	0.44
164_F	193_L	0.847	0.44
208_L	230_V	0.845	0.44
21_Q	218_G	0.843	0.44
182_I	325_K	0.840	0.44
29_R	67_L	0.835	0.43
9_S	37_F	0.835	0.43
51_N	241_I	0.835	0.43
31_L	227_L	0.833	0.43
136_I	140_A	0.831	0.43
35_E	214_R	0.829	0.43
183_S	218_G	0.822	0.42
54_L	58_K	0.821	0.42
302_T	309_P	0.815	0.42
74_D	150_N	0.813	0.42
70_Y	196_L	0.810	0.41
23_S	27_N	0.810	0.41
60_I	201_P	0.809	0.41
286_L	304_D	0.808	0.41
11_F	103_A	0.806	0.41
262_N	269_V	0.802	0.41
90_L	115_M	0.800	0.41
105_Y	273_R	0.799	0.41
203_D	320_N	0.782	0.39
27_N	30_D	0.781	0.39
253_R	257_K	0.780	0.39
35_E	122_E	0.779	0.39
263_Y	329_E	0.778	0.39
80_L	85_A	0.771	0.38
184_N	206_N	0.770	0.38
280_E	295_G	0.765	0.38
76_N	105_Y	0.762	0.38
90_L	118_Q	0.762	0.38
154_V	301_F	0.760	0.38
53_A	79_I	0.758	0.38
150_N	260_V	0.757	0.37
39_G	56_V	0.755	0.37
68_D	225_E	0.752	0.37
39_G	191_T	0.752	0.37
104_D	274_D	0.752	0.37
321_M	324_V	0.750	0.37
12_P	40_I	0.750	0.37
168_N	178_I	0.749	0.37
126_F	159_I	0.745	0.37
57_A	133_V	0.745	0.37
326_M	331_M	0.743	0.36
25_L	253_R	0.741	0.36
201_P	205_A	0.740	0.36
114_E	316_I	0.738	0.36
126_F	149_H	0.736	0.36
257_K	293_V	0.733	0.36
207_Y	305_L	0.731	0.36
150_N	269_V	0.722	0.35
42_P	219_D	0.719	0.35
250_V	295_G	0.719	0.35
242_R	293_V	0.719	0.35
291_V	316_I	0.718	0.35
134_D	137_A	0.717	0.35
183_S	196_L	0.717	0.35
254_L	314_G	0.715	0.34
190_R	274_D	0.715	0.34
278_E	314_G	0.715	0.34
16_E	19_D	0.714	0.34
282_C	312_L	0.713	0.34
11_F	83_L	0.711	0.34
259_A	301_F	0.710	0.34
163_I	263_Y	0.709	0.34
148_C	192_T	0.707	0.34
106_G	111_E	0.704	0.34
54_L	316_I	0.703	0.34
30_D	224_Y	0.701	0.33
125_P	171_F	0.696	0.33
8_F	222_P	0.693	0.33
30_D	34_S	0.688	0.33
283_Y	296_R	0.684	0.32
66_K	231_S	0.684	0.32
19_D	22_I	0.683	0.32
89_N	92_M	0.681	0.32
246_Y	249_S	0.680	0.32
108_S	180_A	0.679	0.32
100_G	119_M	0.678	0.32
80_L	107_F	0.676	0.32
55_S	155_L	0.675	0.32
36_I	327_S	0.675	0.32
33_F	80_L	0.672	0.32
154_V	188_N	0.672	0.32
150_N	262_N	0.671	0.31
292_A	299_W	0.671	0.31
223_D	247_D	0.670	0.31
301_F	304_D	0.670	0.31
15_K	221_I	0.669	0.31
299_W	310_Y	0.668	0.31
123_L	136_I	0.668	0.31
100_G	148_C	0.665	0.31
41_G	98_F	0.665	0.31
269_V	274_D	0.664	0.31
160_S	163_I	0.663	0.31
39_G	53_A	0.661	0.31
36_I	60_I	0.660	0.31
78_Q	198_Y	0.658	0.31
93_F	118_Q	0.657	0.31
73_V	93_F	0.656	0.30
233_V	298_V	0.653	0.30
217_I	289_N	0.653	0.30
186_K	273_R	0.650	0.30
287_F	301_F	0.649	0.30
64_A	69_Y	0.646	0.30
161_K	165_I	0.643	0.30
19_D	68_D	0.641	0.29
15_K	41_G	0.637	0.29
104_D	190_R	0.635	0.29
58_K	314_G	0.633	0.29
94_M	118_Q	0.631	0.29
148_C	270_C	0.630	0.29
317_D	320_N	0.630	0.29
222_P	230_V	0.629	0.29
305_L	310_Y	0.629	0.29
242_R	317_D	0.629	0.29
173_E	225_E	0.628	0.29
40_I	129_S	0.628	0.29
220_P	295_G	0.628	0.29
117_K	258_F	0.627	0.29
62_K	66_K	0.625	0.28
130_E	170_I	0.624	0.28
70_Y	100_G	0.623	0.28
235_K	239_T	0.623	0.28
257_K	273_R	0.623	0.28
61_L	71_A	0.620	0.28
267_A	309_P	0.620	0.28
165_I	168_N	0.619	0.28
58_K	95_E	0.618	0.28
250_V	281_T	0.617	0.28
134_D	326_M	0.617	0.28
32_G	84_N	0.617	0.28
41_G	103_A	0.617	0.28
248_E	293_V	0.617	0.28
228_R	255_D	0.617	0.28
34_S	157_S	0.616	0.28
38_M	129_S	0.616	0.28
241_I	268_I	0.611	0.28
92_M	98_F	0.611	0.28
254_L	313_V	0.611	0.28
262_N	274_D	0.610	0.28
6_I	31_L	0.610	0.28
126_F	260_V	0.610	0.28
35_E	179_G	0.608	0.27
34_S	285_K	0.606	0.27
150_N	191_T	0.606	0.27
264_R	267_A	0.605	0.27
287_F	312_L	0.603	0.27
280_E	311_R	0.602	0.27
41_G	76_N	0.602	0.27
185_P	190_R	0.601	0.27
45_H	53_A	0.601	0.27
218_G	222_P	0.599	0.27
72_F	75_I	0.599	0.27
184_N	222_P	0.598	0.27
182_I	199_V	0.597	0.27
30_D	66_K	0.596	0.27
57_A	79_I	0.596	0.27
202_F	210_K	0.596	0.27
98_F	119_M	0.592	0.26
308_G	316_I	0.591	0.26
17_I	22_I	0.591	0.26
17_I	21_Q	0.591	0.26
127_E	147_A	0.590	0.26
183_S	219_D	0.590	0.26
108_S	310_Y	0.590	0.26
41_G	116_S	0.590	0.26
286_L	294_R	0.589	0.26
62_K	97_G	0.589	0.26
278_E	311_R	0.585	0.26
200_E	203_D	0.585	0.26
316_I	327_S	0.585	0.26
123_L	157_S	0.584	0.26
99_K	206_N	0.583	0.26
227_L	302_T	0.581	0.26
125_P	259_A	0.581	0.26
43_G	46_W	0.580	0.26
90_L	145_I	0.580	0.26
12_P	93_F	0.579	0.26
91_S	118_Q	0.578	0.26
240_K	265_E	0.577	0.26
8_F	17_I	0.577	0.26
35_E	182_I	0.577	0.26
185_P	264_R	0.577	0.26
35_E	146_K	0.575	0.25
122_E	179_G	0.575	0.25
185_P	196_L	0.575	0.25
146_K	264_R	0.575	0.25
251_G	325_K	0.575	0.25
205_A	222_P	0.575	0.25
218_G	295_G	0.574	0.25
136_I	205_A	0.573	0.25
253_R	313_V	0.573	0.25
185_P	305_L	0.571	0.25
25_L	39_G	0.569	0.25
142_L	251_G	0.569	0.25
63_E	182_I	0.567	0.25
28_A	230_V	0.565	0.25
291_V	331_M	0.562	0.25
122_E	184_N	0.559	0.24
112_I	191_T	0.559	0.24
24_L	67_L	0.558	0.24
318_D	321_M	0.558	0.24
172_K	216_L	0.557	0.24
81_K	121_V	0.557	0.24
129_S	170_I	0.555	0.24
34_S	69_Y	0.552	0.24
35_E	107_F	0.551	0.24
218_G	286_L	0.550	0.24
258_F	273_R	0.549	0.24
77_P	83_L	0.549	0.24
263_Y	330_I	0.548	0.24
70_Y	120_T	0.548	0.24
219_D	305_L	0.546	0.24
215_V	304_D	0.544	0.24
79_I	239_T	0.543	0.24
77_P	107_F	0.542	0.24
95_E	158_G	0.542	0.24
230_V	233_V	0.542	0.24
43_G	53_A	0.541	0.23
154_V	295_G	0.541	0.23
98_F	135_F	0.540	0.23
128_I	140_A	0.540	0.23
50_V	291_V	0.539	0.23
163_I	170_I	0.538	0.23
253_R	292_A	0.536	0.23
260_V	274_D	0.536	0.23
155_L	228_R	0.536	0.23
113_V	209_F	0.536	0.23
180_A	326_M	0.535	0.23
14_W	43_G	0.535	0.23
167_K	170_I	0.534	0.23
151_Y	273_R	0.532	0.23
10_I	245_V	0.528	0.23
168_N	212_V	0.522	0.22
209_F	235_K	0.522	0.22
9_S	107_F	0.522	0.22
166_E	245_V	0.521	0.22
41_G	219_D	0.521	0.22
68_D	318_D	0.521	0.22
316_I	321_M	0.521	0.22
190_R	262_N	0.520	0.22
68_D	103_A	0.520	0.22
103_A	227_L	0.519	0.22
191_T	273_R	0.519	0.22
280_E	283_Y	0.519	0.22
286_L	307_I	0.518	0.22
50_V	82_E	0.517	0.22
163_I	264_R	0.517	0.22
189_L	219_D	0.517	0.22
188_N	245_V	0.515	0.22
253_R	256_K	0.514	0.22
268_I	288_K	0.514	0.22
31_L	232_E	0.513	0.22
182_I	318_D	0.513	0.22
162_E	182_I	0.513	0.22
168_N	292_A	0.512	0.22
156_Y	286_L	0.511	0.22
11_F	221_I	0.509	0.22
246_Y	273_R	0.508	0.22
182_I	212_V	0.507	0.22
32_G	78_Q	0.506	0.22
123_L	273_R	0.506	0.22
156_Y	307_I	0.505	0.22
25_L	69_Y	0.503	0.21
38_M	61_L	0.501	0.21
268_I	302_T	0.501	0.21
130_E	133_V	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p0oA	1	0.9522	100	0.113	Contact Map
1x7fA	1	0.9373	100	0.121	Contact Map
4s1aA	2	0.4179	96.1	0.944	Contact Map
2r6oA	2	0.4746	92.6	0.953	Contact Map
4rniA	2	0.4627	92.6	0.953	Contact Map
4rnhA	2	0.4597	92	0.954	Contact Map
4fojA	1	0.4537	90.9	0.955	Contact Map
2g0wA	1	0.7433	90	0.956	Contact Map
3lmzA	2	0.6896	89.4	0.957	Contact Map
1yx1A	3	0.6925	88.8	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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