GREMLIN Database
Q97YP9 - Oligo/dipeptide transport, permease protein (DppC-1)
UniProt: Q97YP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (437)
Sequences: 308 (269)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
440_F447_L4.2771.00
337_I342_Y3.7070.99
234_D238_R3.6750.99
269_V284_I3.4590.99
12_I16_L3.3720.98
225_G229_G3.0960.97
384_A393_A2.9620.96
247_G266_G2.6210.93
436_V443_E2.6170.93
371_A436_V2.6020.92
270_G360_H2.5360.91
428_V435_F2.5040.91
286_W289_L2.4900.90
266_G270_G2.4490.90
17_S279_N2.3940.89
49_W55_W2.3540.88
425_G428_V2.3240.87
351_I447_L2.3110.87
275_Y323_W2.2300.85
384_A391_G2.2230.84
322_S385_Q2.2120.84
378_P435_F2.1900.84
287_V291_F2.1640.83
384_A439_G2.1150.81
11_Y446_T2.1140.81
343_V361_F2.0660.80
351_I355_R2.0510.79
28_L254_I2.0060.78
333_M368_I2.0060.78
443_E447_L2.0020.77
28_L318_I1.9970.77
384_A388_A1.9840.77
323_W390_L1.9760.76
281_D331_R1.9740.76
239_P286_W1.9650.76
332_S371_A1.9550.76
337_I361_F1.9460.75
21_G441_A1.9430.75
286_W385_Q1.9250.75
326_Y389_F1.9230.74
390_L424_P1.9170.74
125_P147_G1.9020.74
332_S374_V1.8940.73
324_P342_Y1.8900.73
281_D439_G1.8800.73
284_I327_A1.8690.72
331_R393_A1.8500.71
281_D384_A1.8420.71
420_W424_P1.8250.70
254_I270_G1.8170.70
274_G323_W1.8050.70
371_A374_V1.8040.69
229_G378_P1.8030.69
364_R440_F1.8010.69
286_W363_P1.7780.68
374_V396_N1.7710.68
346_D356_V1.7700.68
261_V316_L1.7550.67
322_S383_L1.7450.67
399_T445_V1.7420.67
405_D417_W1.7250.66
335_L371_A1.7130.65
332_S398_V1.6960.64
28_L35_T1.6960.64
338_K363_P1.6730.63
374_V447_L1.6500.62
334_A342_Y1.6430.62
245_L294_L1.6230.61
259_S447_L1.6030.60
334_A371_A1.5940.59
342_Y361_F1.5900.59
231_M423_F1.5840.59
18_S445_V1.5610.58
367_P423_F1.5550.58
59_P225_G1.5470.57
335_L384_A1.5460.57
374_V378_P1.5450.57
432_A443_E1.5430.57
108_K113_Y1.5410.57
345_A363_P1.5210.56
81_L260_L1.5200.56
337_I368_I1.5170.56
441_A445_V1.5070.55
418_W425_G1.5050.55
345_A387_L1.5020.55
341_S396_N1.5010.55
374_V440_F1.5000.55
233_T247_G1.5000.55
384_A399_T1.4950.54
393_A440_F1.4930.54
299_F382_L1.4840.54
21_G446_T1.4800.54
352_P356_V1.4790.54
363_P401_G1.4770.54
285_Q328_I1.4750.53
298_P418_W1.4610.53
246_L381_I1.4590.53
247_G331_R1.4500.52
352_P449_E1.4100.50
108_K112_A1.4100.50
401_G424_P1.4040.50
263_V273_S1.4010.50
38_A246_L1.4000.50
295_P350_G1.3950.49
396_N447_L1.3920.49
257_L370_V1.3790.48
231_M427_M1.3790.48
274_G445_V1.3720.48
355_R358_F1.3680.48
329_I428_V1.3660.48
330_A436_V1.3650.48
255_G311_I1.3630.48
256_V283_I1.3630.48
325_F384_A1.3590.47
261_V272_I1.3500.47
156_T168_S1.3480.47
299_F446_T1.3480.47
356_V361_F1.3470.47
86_M89_Y1.3410.46
14_D21_G1.3410.46
24_G437_L1.3400.46
270_G389_F1.3390.46
374_V388_A1.3380.46
14_D446_T1.3350.46
177_V283_I1.3340.46
85_N88_L1.3220.45
36_G161_D1.3120.45
271_G373_M1.3100.45
277_G439_G1.3030.44
266_G326_Y1.3030.44
21_G368_I1.2880.44
393_A447_L1.2850.44
299_F321_L1.2800.43
336_S371_A1.2780.43
64_P229_G1.2750.43
232_G237_G1.2670.43
322_S325_F1.2670.43
260_L280_K1.2670.43
425_G435_F1.2620.42
298_P365_L1.2610.42
318_I449_E1.2570.42
363_P424_P1.2560.42
182_L188_N1.2540.42
19_K117_F1.2500.42
335_L393_A1.2430.41
232_G350_G1.2430.41
256_V343_V1.2390.41
393_A439_G1.2380.41
327_A361_F1.2380.41
240_L252_L1.2300.41
66_W229_G1.2190.40
254_I332_S1.2090.40
161_D165_Y1.2070.40
387_L400_W1.2070.40
286_W447_L1.2040.39
375_L378_P1.2030.39
377_V423_F1.2010.39
13_R16_L1.2000.39
273_S329_I1.1990.39
297_L399_T1.1970.39
373_M432_A1.1950.39
244_I399_T1.1880.39
267_V422_V1.1730.38
244_I423_F1.1710.38
442_I448_G1.1700.38
150_N430_I1.1690.38
273_S289_L1.1690.38
275_Y363_P1.1560.37
390_L401_G1.1520.37
346_D442_I1.1430.36
393_A402_G1.1370.36
273_S362_M1.1350.36
339_S343_V1.1340.36
292_L324_P1.1270.36
377_V418_W1.1270.36
35_T249_P1.1260.36
88_L96_F1.1260.36
289_L292_L1.1250.36
42_P431_V1.1230.36
261_V348_L1.1230.36
390_L441_A1.1200.35
269_V283_I1.1140.35
439_G443_E1.1070.35
274_G390_L1.1060.35
38_A249_P1.1030.35
251_A293_A1.0970.34
371_A432_A1.0960.34
276_L407_A1.0940.34
400_W427_M1.0920.34
16_L20_I1.0920.34
298_P367_P1.0890.34
337_I435_F1.0850.34
297_L420_W1.0850.34
225_G298_P1.0830.34
124_T130_I1.0830.34
370_V445_V1.0830.34
274_G290_V1.0820.34
421_V445_V1.0790.33
396_N402_G1.0740.33
364_R399_T1.0740.33
407_A420_W1.0730.33
303_V325_F1.0700.33
308_E343_V1.0690.33
185_A189_S1.0690.33
299_F428_V1.0690.33
266_G389_F1.0680.33
285_Q332_S1.0680.33
273_S285_Q1.0670.33
289_L425_G1.0660.33
13_R27_I1.0650.33
249_P389_F1.0630.33
136_D140_L1.0630.33
302_A408_E1.0610.33
298_P400_W1.0610.33
173_T188_N1.0600.33
306_V438_I1.0590.33
259_S272_I1.0490.32
364_R369_T1.0480.32
160_G185_A1.0480.32
49_W333_M1.0470.32
350_G360_H1.0460.32
179_S183_S1.0450.32
231_M237_G1.0420.32
371_A443_E1.0340.31
402_G406_A1.0340.31
378_P424_P1.0330.31
271_G341_S1.0300.31
255_G380_G1.0280.31
335_L359_T1.0280.31
432_A436_V1.0270.31
128_E280_K1.0200.31
198_E230_L1.0190.31
324_P382_L1.0180.31
311_I366_I1.0160.31
29_I215_N1.0130.30
375_L432_A1.0100.30
254_I371_A1.0030.30
318_I346_D0.9990.30
29_I426_A0.9960.30
345_A439_G0.9940.30
118_I121_S0.9900.29
211_S214_M0.9900.29
81_L167_S0.9840.29
368_I419_W0.9830.29
83_P89_Y0.9820.29
40_S422_V0.9770.29
314_E357_F0.9750.29
206_I215_N0.9750.29
302_A349_L0.9740.29
436_V440_F0.9720.29
277_G345_A0.9670.28
327_A385_Q0.9640.28
347_K356_V0.9630.28
276_L353_S0.9620.28
264_L268_F0.9610.28
314_E424_P0.9600.28
286_W443_E0.9600.28
363_P390_L0.9560.28
81_L256_V0.9560.28
318_I376_G0.9540.28
64_P420_W0.9510.28
45_V56_N0.9510.28
299_F342_Y0.9500.28
440_F443_E0.9480.28
271_G334_A0.9480.28
371_A418_W0.9470.28
207_E210_S0.9450.28
18_S446_T0.9450.28
175_N190_P0.9390.27
225_G378_P0.9330.27
307_A351_I0.9330.27
337_I340_N0.9330.27
101_T147_G0.9310.27
325_F386_T0.9310.27
178_N187_F0.9280.27
11_Y14_D0.9260.27
31_L427_M0.9240.27
137_G203_V0.9230.27
183_S210_S0.9220.27
180_T184_S0.9220.27
243_G402_G0.9190.26
380_G449_E0.9190.26
255_G337_I0.9120.26
238_R419_W0.9100.26
277_G363_P0.9100.26
403_I432_A0.9090.26
243_G436_V0.9090.26
302_A431_V0.9070.26
302_A311_I0.9050.26
329_I383_L0.9010.26
333_M337_I0.8990.26
335_L385_Q0.8980.26
391_G439_G0.8960.26
233_T266_G0.8950.26
237_G419_W0.8940.25
385_Q437_L0.8930.25
176_I186_L0.8920.25
290_V353_S0.8910.25
265_V268_F0.8900.25
286_W290_V0.8890.25
12_I397_I0.8860.25
158_I175_N0.8850.25
351_I440_F0.8840.25
334_A432_A0.8800.25
303_V433_I0.8790.25
254_I359_T0.8790.25
102_Y106_W0.8770.25
271_G371_A0.8770.25
249_P446_T0.8750.25
15_F19_K0.8740.25
317_L321_L0.8740.25
345_A401_G0.8740.25
124_T137_G0.8690.25
293_A343_V0.8660.24
272_I290_V0.8650.24
274_G338_K0.8650.24
74_K78_T0.8630.24
304_S403_I0.8620.24
407_A424_P0.8590.24
355_R390_L0.8590.24
330_A445_V0.8570.24
244_I281_D0.8570.24
108_K114_N0.8550.24
336_S432_A0.8540.24
107_S261_V0.8530.24
200_G204_V0.8530.24
338_K351_I0.8530.24
321_L324_P0.8520.24
251_A445_V0.8520.24
242_L305_F0.8510.24
305_F393_A0.8490.24
341_S344_E0.8490.24
337_I378_P0.8490.24
364_R384_A0.8490.24
29_I209_V0.8460.24
285_Q335_L0.8420.23
334_A367_P0.8410.23
255_G318_I0.8400.23
284_I335_L0.8390.23
331_R439_G0.8380.23
252_L392_I0.8370.23
298_P317_L0.8360.23
370_V446_T0.8350.23
94_N158_I0.8340.23
241_D276_L0.8330.23
101_T138_Y0.8320.23
334_A365_L0.8310.23
55_W66_W0.8310.23
371_A399_T0.8300.23
393_A448_G0.8300.23
237_G436_V0.8290.23
200_G206_I0.8250.23
329_I425_G0.8230.23
115_V178_N0.8220.23
388_A436_V0.8220.23
19_K22_L0.8210.23
432_A447_L0.8210.23
338_K424_P0.8190.23
269_V278_G0.8180.23
30_I176_I0.8180.23
256_V404_L0.8150.23
315_A329_I0.8100.22
248_L259_S0.8090.22
87_S90_S0.8080.22
86_M353_S0.8070.22
132_W270_G0.8040.22
20_I396_N0.8040.22
387_L390_L0.8040.22
176_I209_V0.8030.22
144_V149_F0.8030.22
76_F261_V0.8000.22
232_G295_P0.7990.22
301_V435_F0.7980.22
290_V331_R0.7970.22
315_A321_L0.7950.22
369_T433_I0.7930.22
15_F386_T0.7880.22
381_I417_W0.7850.21
93_K98_A0.7850.21
232_G360_H0.7850.21
364_R448_G0.7850.21
105_N145_P0.7830.21
21_G447_L0.7790.21
21_G380_G0.7760.21
95_I176_I0.7750.21
229_G432_A0.7730.21
323_W371_A0.7700.21
371_A393_A0.7690.21
161_D168_S0.7690.21
16_L22_L0.7670.21
244_I388_A0.7650.21
229_G243_G0.7640.21
270_G295_P0.7640.21
382_L432_A0.7630.21
110_L113_Y0.7610.21
348_L421_V0.7590.21
250_N315_A0.7590.21
259_S378_P0.7590.21
273_S414_V0.7580.20
243_G396_N0.7560.20
299_F322_S0.7560.20
44_K414_V0.7550.20
289_L436_V0.7540.20
186_L189_S0.7530.20
202_Y208_I0.7500.20
102_Y105_N0.7490.20
21_G28_L0.7470.20
182_L186_L0.7470.20
66_W225_G0.7460.20
285_Q293_A0.7450.20
289_L363_P0.7440.20
64_P135_P0.7430.20
151_V160_G0.7420.20
292_L337_I0.7420.20
280_K430_I0.7400.20
231_M360_H0.7370.20
105_N111_P0.7340.20
133_S147_G0.7330.20
370_V374_V0.7330.20
199_Q202_Y0.7300.20
323_W327_A0.7280.20
246_L431_V0.7280.20
122_N359_T0.7280.20
289_L443_E0.7260.19
135_P229_G0.7260.19
102_Y113_Y0.7250.19
310_N338_K0.7250.19
393_A400_W0.7240.19
281_D393_A0.7240.19
255_G367_P0.7220.19
261_V389_F0.7200.19
320_F409_T0.7180.19
378_P432_A0.7150.19
368_I425_G0.7140.19
106_W111_P0.7120.19
262_A380_G0.7120.19
176_I192_S0.7100.19
296_A300_L0.7090.19
265_V385_Q0.7080.19
160_G317_L0.7070.19
241_D439_G0.7040.19
33_I136_D0.7030.19
341_S443_E0.7020.19
105_N108_K0.7020.19
274_G381_I0.7010.19
125_P129_V0.7000.19
112_A202_Y0.7000.19
29_I283_I0.6990.19
124_T127_E0.6990.19
298_P321_L0.6980.19
240_L392_I0.6980.19
18_S341_S0.6980.19
247_G286_W0.6970.19
198_E202_Y0.6960.18
52_P249_P0.6950.18
254_I380_G0.6920.18
254_I267_V0.6920.18
11_Y341_S0.6920.18
103_Q106_W0.6920.18
348_L372_Y0.6900.18
297_L379_A0.6890.18
229_G234_D0.6870.18
327_A417_W0.6820.18
365_L374_V0.6820.18
171_G174_P0.6800.18
259_S266_G0.6790.18
225_G432_A0.6770.18
229_G425_G0.6760.18
392_I435_F0.6730.18
122_N154_D0.6730.18
243_G416_G0.6720.18
371_A440_F0.6720.18
70_F228_Y0.6710.18
251_A256_V0.6690.18
381_I392_I0.6660.18
335_L418_W0.6660.18
21_G329_I0.6650.18
274_G363_P0.6650.18
282_S364_R0.6640.17
225_G399_T0.6630.17
238_R289_L0.6630.17
30_I69_I0.6620.17
305_F437_L0.6620.17
435_F441_A0.6590.17
15_F360_H0.6590.17
436_V444_R0.6580.17
130_I142_V0.6580.17
151_V211_S0.6560.17
328_I400_W0.6550.17
299_F336_S0.6540.17
329_I338_K0.6530.17
374_V443_E0.6520.17
158_I268_F0.6520.17
336_S403_I0.6500.17
319_A340_N0.6500.17
402_G428_V0.6470.17
254_I318_I0.6460.17
371_A425_G0.6450.17
275_Y401_G0.6440.17
28_L216_I0.6430.17
37_I40_S0.6430.17
275_Y338_K0.6430.17
346_D448_G0.6430.17
286_W335_L0.6430.17
244_I346_D0.6420.17
281_D448_G0.6420.17
321_L400_W0.6420.17
340_N442_I0.6420.17
367_P374_V0.6410.17
62_V66_W0.6400.17
16_L334_A0.6380.17
293_A296_A0.6370.17
81_L263_V0.6360.17
243_G403_I0.6330.17
11_Y394_P0.6310.17
348_L440_F0.6300.16
371_A447_L0.6300.16
364_R383_L0.6270.16
321_L333_M0.6270.16
364_R436_V0.6260.16
418_W423_F0.6260.16
257_L322_S0.6240.16
250_N299_F0.6230.16
386_T390_L0.6200.16
330_A364_R0.6200.16
335_L432_A0.6180.16
119_T294_L0.6170.16
323_W381_I0.6170.16
330_A370_V0.6150.16
270_G275_Y0.6140.16
200_G208_I0.6140.16
344_E407_A0.6130.16
329_I385_Q0.6120.16
66_W135_P0.6120.16
24_G57_Q0.6100.16
17_S421_V0.6090.16
401_G441_A0.6070.16
259_S440_F0.6070.16
225_G234_D0.6060.16
316_L346_D0.6040.16
244_I286_W0.6030.16
341_S380_G0.6020.16
163_L185_A0.6020.16
344_E420_W0.5990.16
380_G394_P0.5980.16
231_M317_L0.5980.16
160_G167_S0.5950.16
285_Q327_A0.5950.16
391_G448_G0.5940.15
23_V172_K0.5930.15
343_V347_K0.5930.15
338_K402_G0.5920.15
118_I128_E0.5920.15
370_V377_V0.5910.15
268_F358_F0.5900.15
277_G443_E0.5890.15
158_I184_S0.5870.15
117_F130_I0.5870.15
300_L420_W0.5860.15
418_W441_A0.5860.15
266_G279_N0.5820.15
286_W388_A0.5810.15
344_E367_P0.5810.15
239_P242_L0.5790.15
260_L437_L0.5790.15
109_V112_A0.5790.15
256_V441_A0.5770.15
289_L293_A0.5730.15
293_A373_M0.5730.15
249_P294_L0.5720.15
107_S111_P0.5720.15
292_L326_Y0.5720.15
381_I435_F0.5710.15
259_S449_E0.5680.15
328_I443_E0.5680.15
145_P149_F0.5680.15
134_K140_L0.5670.15
277_G286_W0.5660.15
281_D325_F0.5630.15
167_S190_P0.5620.15
364_R443_E0.5600.15
29_I347_K0.5590.15
229_G399_T0.5570.15
335_L388_A0.5560.14
380_G429_V0.5560.14
111_P121_S0.5550.14
102_Y108_K0.5520.14
115_V137_G0.5510.14
229_G443_E0.5490.14
277_G323_W0.5480.14
385_Q402_G0.5480.14
156_T186_L0.5470.14
28_L275_Y0.5460.14
368_I447_L0.5460.14
27_I63_P0.5450.14
99_I182_L0.5450.14
243_G371_A0.5440.14
334_A425_G0.5430.14
219_S223_L0.5420.14
133_S150_N0.5410.14
340_N369_T0.5400.14
64_P399_T0.5400.14
321_L385_Q0.5400.14
251_A341_S0.5400.14
74_K338_K0.5390.14
180_T186_L0.5390.14
21_G254_I0.5370.14
333_M399_T0.5370.14
244_I384_A0.5370.14
23_V346_D0.5370.14
364_R371_A0.5350.14
33_I175_N0.5350.14
344_E380_G0.5320.14
24_G61_H0.5310.14
240_L360_H0.5310.14
20_I440_F0.5300.14
137_G143_N0.5290.14
29_I155_L0.5270.14
42_P335_L0.5270.14
56_N347_K0.5240.14
439_G448_G0.5240.14
394_P447_L0.5230.14
330_A342_Y0.5230.14
248_L333_M0.5220.14
393_A406_A0.5210.14
162_I203_V0.5200.14
266_G360_H0.5200.14
323_W363_P0.5200.14
15_F438_I0.5190.14
336_S420_W0.5190.14
101_T119_T0.5190.14
253_E359_T0.5190.14
371_A396_N0.5180.14
105_N294_L0.5170.14
259_S332_S0.5170.14
112_A116_Y0.5160.13
399_T443_E0.5150.13
134_K338_K0.5150.13
238_R245_L0.5130.13
114_N121_S0.5110.13
261_V375_L0.5090.13
249_P393_A0.5090.13
112_A135_P0.5090.13
249_P328_I0.5090.13
161_D176_I0.5080.13
116_Y123_V0.5080.13
278_G288_T0.5070.13
248_L286_W0.5050.13
156_T159_R0.5050.13
318_I383_L0.5040.13
288_T335_L0.5030.13
247_G389_F0.5020.13
293_A395_A0.5010.13
367_P447_L0.5010.13
345_A441_A0.5000.13
278_G430_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.4511 99.9 0.789 Contact Map
4tquM 1 0.56 99.9 0.794 Contact Map
4ymuD 2 0.4622 99.9 0.81 Contact Map
3d31C 2 0.5089 99.9 0.817 Contact Map
3rlfF 1 0.8756 99.9 0.819 Contact Map
2onkC 2 0.5156 99.9 0.823 Contact Map
3rlfG 1 0.5689 99.8 0.827 Contact Map
4tquN 1 0.5822 99.8 0.842 Contact Map
2kogA 1 0.0911 11.2 0.978 Contact Map
3hd7A 1 0.0889 9.1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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