GREMLIN Database
Q97YP8 - Oligo/dipeptide transport, ATP binding protein (DppD-1)
UniProt: Q97YP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (242)
Sequences: 78819 (46256)
Seq/√Len: 2973.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E223_R3.6111.00
94_K173_E3.1131.00
8_E32_Y3.0831.00
11_N28_G3.0261.00
24_K27_D2.9021.00
10_R70_E2.8721.00
40_G221_S2.7381.00
39_V225_Y2.7321.00
223_R235_S2.6621.00
70_E77_N2.6461.00
146_L149_K2.5211.00
34_D37_E2.4751.00
14_V55_A2.4431.00
15_Y24_K2.4291.00
8_E72_L2.3801.00
237_P240_V2.3571.00
139_M203_L2.3531.00
27_D231_K2.2531.00
74_K173_E2.2271.00
13_K68_S2.1761.00
225_Y232_V2.1421.00
13_K28_G2.1061.00
10_R72_L2.0741.00
13_K24_K2.0541.00
9_V12_L2.0141.00
236_G240_V1.9871.00
225_Y235_S1.9151.00
134_K147_A1.8961.00
132_R171_N1.8961.00
35_K173_E1.8531.00
53_G210_I1.8111.00
110_F114_D1.8021.00
16_F51_T1.7701.00
218_S239_E1.7461.00
82_D85_A1.7041.00
132_R135_E1.6881.00
61_P66_I1.6811.00
53_G176_I1.6561.00
236_G241_I1.6391.00
211_T217_L1.6241.00
14_V60_V1.6131.00
197_K219_E1.5981.00
16_F25_A1.5881.00
113_K148_E1.5631.00
15_Y67_E1.5371.00
136_L169_A1.5361.00
77_N80_K1.5351.00
14_V67_E1.5311.00
130_E134_K1.5061.00
135_E139_M1.5051.00
11_N30_N1.5021.00
149_K153_E1.4951.00
113_K147_A1.4801.00
117_I129_Y1.4701.00
113_K117_I1.4611.00
74_K94_K1.4291.00
171_N203_L1.4171.00
40_G217_L1.4091.00
12_L66_I1.3911.00
13_K27_D1.3851.00
58_R86_F1.3821.00
37_E222_D1.3761.00
9_V31_L1.3721.00
31_L225_Y1.3611.00
240_V244_K1.3561.00
117_I133_I1.3321.00
171_N205_L1.3291.00
177_A207_I1.3131.00
247_H250_T1.3011.00
146_L154_L1.2951.00
6_L74_K1.2741.00
138_K143_D1.2701.00
33_L39_V1.2671.00
144_P147_A1.2611.00
72_L77_N1.2561.00
9_V56_I1.2421.00
39_V235_S1.2401.00
137_F147_A1.2281.00
15_Y22_I1.2221.00
121_R129_Y1.2171.00
34_D223_R1.2171.00
113_K130_E1.2121.00
58_R61_P1.2101.00
10_R32_Y1.2081.00
134_K138_K1.2071.00
38_I200_R1.2001.00
31_L52_I1.1941.00
111_K114_D1.1921.00
39_V223_R1.1901.00
81_L85_A1.1861.00
131_E135_E1.1751.00
76_E85_A1.1631.00
116_I137_F1.1521.00
248_P252_L1.1491.00
29_V52_I1.1411.00
115_Q166_M1.1271.00
57_M97_M1.1261.00
55_A66_I1.1211.00
248_P251_S1.1161.00
228_Y233_M1.1131.00
193_L216_L1.1071.00
134_K142_M1.1021.00
56_I208_I1.0981.00
10_R30_N1.0941.00
112_I154_L1.0911.00
239_E243_K1.0891.00
145_Q149_K1.0741.00
98_V177_A1.0711.00
35_K74_K1.0661.00
38_I207_I1.0621.00
111_K148_E1.0561.00
197_K200_R1.0431.00
52_I227_L1.0431.00
113_K133_I1.0381.00
251_S255_E1.0281.00
26_V55_A1.0281.00
126_N130_E1.0251.00
126_N129_Y1.0201.00
128_D131_E1.0131.00
41_L52_I1.0071.00
154_L162_A1.0041.00
114_D117_I1.0021.00
132_R136_L0.9971.00
117_I130_E0.9961.00
38_I221_S0.9921.00
200_R207_I0.9891.00
41_L208_I0.9841.00
116_I169_A0.9831.00
175_L205_L0.9791.00
233_M247_H0.9791.00
135_E138_K0.9741.00
224_D238_S0.9641.00
127_G131_E0.9631.00
184_L192_I0.9621.00
130_E147_A0.9571.00
177_A196_L0.9551.00
250_T254_I0.9541.00
139_M198_K0.9511.00
54_Y60_V0.9371.00
120_L169_A0.9371.00
111_K150_Y0.9261.00
129_Y133_I0.9151.00
240_V243_K0.9131.00
9_V52_I0.9111.00
41_L225_Y0.9081.00
96_A172_P0.9081.00
11_N68_S0.9051.00
238_S249_Y0.9051.00
136_L165_A0.9021.00
190_E194_N0.9001.00
189_Q216_L0.9001.00
195_L198_K0.8961.00
228_Y252_L0.8921.00
196_L207_I0.8911.00
175_L207_I0.8891.00
81_L86_F0.8871.00
141_N198_K0.8851.00
14_V51_T0.8851.00
109_V152_H0.8841.00
106_F159_K0.8781.00
117_I121_R0.8761.00
200_R222_D0.8751.00
9_V71_I0.8741.00
179_E212_H0.8721.00
35_K204_N0.8661.00
6_L35_K0.8641.00
120_L124_G0.8581.00
76_E81_L0.8581.00
76_E94_K0.8531.00
98_V164_I0.8471.00
143_D146_L0.8421.00
150_Y153_E0.8421.00
123_H170_L0.8411.00
12_L55_A0.8361.00
241_I250_T0.8311.00
6_L34_D0.8311.00
189_Q213_D0.8301.00
15_Y27_D0.8281.00
38_I197_K0.8241.00
112_I162_A0.8211.00
136_L140_V0.8181.00
57_M176_I0.8171.00
96_A167_A0.8151.00
83_E87_R0.8151.00
38_I220_I0.8121.00
259_T262_K0.8101.00
34_D206_S0.8071.00
141_N191_H0.8021.00
194_N197_K0.7971.00
140_V165_A0.7931.00
83_E86_F0.7861.00
55_A71_I0.7831.00
136_L139_M0.7801.00
118_E122_I0.7791.00
7_L56_I0.7771.00
234_E244_K0.7761.00
33_L174_V0.7741.00
138_K144_P0.7691.00
113_K134_K0.7681.00
28_G231_K0.7681.00
44_E228_Y0.7661.00
125_W129_Y0.7651.00
234_E245_P0.7641.00
128_D132_R0.7581.00
26_V29_V0.7561.00
121_R126_N0.7541.00
193_L219_E0.7521.00
55_A60_V0.7491.00
252_L256_S0.7491.00
54_Y59_L0.7441.00
47_S227_L0.7411.00
38_I209_F0.7411.00
42_A217_L0.7381.00
134_K144_P0.7361.00
25_A51_T0.7351.00
194_N219_E0.7321.00
6_L32_Y0.7311.00
216_L220_I0.7271.00
15_Y25_A0.7261.00
110_F118_E0.7251.00
119_V122_I0.7231.00
256_S259_T0.7211.00
176_I208_I0.7171.00
130_E133_I0.7161.00
214_L242_F0.7151.00
125_W128_D0.7141.00
33_L206_S0.7141.00
7_L174_V0.7101.00
238_S242_F0.7091.00
194_N198_K0.7051.00
245_P250_T0.7031.00
197_K220_I0.7021.00
29_V232_V0.7011.00
232_V235_S0.7011.00
242_F245_P0.6971.00
11_N14_V0.6961.00
14_V26_V0.6951.00
95_I174_V0.6951.00
252_L255_E0.6941.00
221_S238_S0.6921.00
131_E134_K0.6911.00
199_L205_L0.6881.00
120_L123_H0.6871.00
228_Y231_K0.6871.00
110_F115_Q0.6871.00
209_F221_S0.6851.00
6_L73_F0.6841.00
151_P162_A0.6831.00
154_L158_Q0.6811.00
146_L158_Q0.6811.00
39_V208_I0.6771.00
221_S224_D0.6771.00
136_L168_L0.6761.00
240_V246_R0.6761.00
258_A261_D0.6751.00
234_E246_R0.6751.00
15_Y68_S0.6711.00
73_F94_K0.6711.00
209_F220_I0.6711.00
33_L208_I0.6661.00
119_V170_L0.6651.00
7_L73_F0.6641.00
72_L75_G0.6631.00
197_K201_K0.6621.00
226_T241_I0.6591.00
28_G68_S0.6591.00
181_T192_I0.6581.00
174_V206_S0.6561.00
98_V167_A0.6541.00
127_G130_E0.6531.00
133_I136_L0.6521.00
66_I79_L0.6491.00
119_V166_M0.6461.00
42_A226_T0.6441.00
116_I133_I0.6401.00
173_E205_L0.6401.00
77_N81_L0.6371.00
181_T216_L0.6351.00
130_E148_E0.6341.00
70_E79_L0.6331.00
156_G161_R0.6311.00
174_V208_I0.6311.00
6_L174_V0.6301.00
249_Y252_L0.6281.00
26_V52_I0.6231.00
107_T110_F0.6181.00
234_E241_I0.6131.00
15_Y21_G0.6121.00
135_E171_N0.6101.00
111_K115_Q0.6101.00
226_T245_P0.6031.00
70_E80_K0.6031.00
84_E87_R0.6021.00
50_S54_Y0.6021.00
60_V66_I0.6021.00
141_N144_P0.6001.00
160_Q183_A0.5981.00
100_Q156_G0.5931.00
42_A214_L0.5921.00
191_H194_N0.5921.00
115_Q151_P0.5911.00
38_I222_D0.5901.00
57_M95_I0.5891.00
54_Y97_M0.5891.00
258_A262_K0.5871.00
44_E249_Y0.5861.00
82_D86_F0.5841.00
45_S179_E0.5821.00
124_G132_R0.5801.00
101_G159_K0.5791.00
37_E235_S0.5751.00
120_L129_Y0.5751.00
73_F174_V0.5741.00
61_P79_L0.5741.00
24_K28_G0.5741.00
196_L209_F0.5731.00
32_Y235_S0.5711.00
218_S242_F0.5691.00
128_D137_F0.5681.00
6_L206_S0.5661.00
228_Y247_H0.5641.00
16_F60_V0.5641.00
131_E138_K0.5631.00
218_S238_S0.5621.00
55_A67_E0.5591.00
211_T216_L0.5591.00
106_F162_A0.5591.00
129_Y134_K0.5581.00
217_L221_S0.5551.00
229_A252_L0.5551.00
234_E250_T0.5541.00
36_G206_S0.5511.00
128_D142_M0.5491.00
56_I71_I0.5461.00
35_K206_S0.5431.00
228_Y249_Y0.5421.00
251_S254_I0.5411.00
257_I260_L0.5411.00
59_L99_F0.5401.00
102_S163_F0.5401.00
236_G245_P0.5381.00
137_F142_M0.5321.00
168_L205_L0.5291.00
217_L224_D0.5291.00
47_S229_A0.5281.00
142_M158_Q0.5281.00
8_E75_G0.5241.00
113_K116_I0.5231.00
142_M146_L0.5231.00
58_R79_L0.5191.00
155_S158_Q0.5171.00
108_P159_K0.5161.00
133_I147_A0.5161.00
193_L220_I0.5111.00
238_S241_I0.5081.00
241_I245_P0.5071.00
137_F146_L0.5061.00
233_M248_P0.5051.00
223_R237_P0.5031.00
106_F115_Q0.5021.00
143_D147_A0.5021.00
200_R205_L0.5011.00
260_L263_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fwiB 1 0.9494 100 0.181 Contact Map
3tuiC 2 0.9399 100 0.218 Contact Map
4f4cA 1 0.712 100 0.238 Contact Map
4u00A 1 0.7532 100 0.24 Contact Map
4ry2A 2 0.731 100 0.24 Contact Map
4mkiB 2 0.8861 100 0.241 Contact Map
1v43A 2 0.8513 100 0.242 Contact Map
2it1A 1 0.8892 100 0.242 Contact Map
1b0uA 2 0.7658 100 0.242 Contact Map
2oljA 2 0.7532 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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