GREMLIN Database
Q97YP3 - Oligo/dipeptide transport, ATP binding protein . (DppD-2)
UniProt: Q97YP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (256)
Sequences: 59317 (36216)
Seq/√Len: 2263.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D221_K3.8791.00
89_K171_E3.2031.00
7_D24_R3.1471.00
4_Q28_Q3.0541.00
6_R65_S2.9611.00
20_R23_N2.8321.00
35_L223_L2.7931.00
10_I51_A2.6531.00
65_S72_D2.5541.00
36_G219_A2.5411.00
235_D238_K2.4981.00
30_E33_D2.4331.00
221_K233_F2.4051.00
69_N171_E2.3851.00
11_S20_R2.3851.00
144_I147_K2.3571.00
223_L230_I2.3261.00
4_Q67_F2.3221.00
123_D126_K2.2241.00
23_N229_E2.2161.00
137_Q201_K2.2041.00
9_N63_S2.1551.00
9_N24_R2.0721.00
196_R200_D2.0601.00
5_V8_L2.0471.00
31_K171_E1.9681.00
6_R67_F1.9481.00
216_A237_R1.9381.00
72_D75_K1.8971.00
49_A208_I1.8911.00
12_Y47_T1.8721.00
77_D80_T1.8561.00
132_F145_Y1.8481.00
9_N20_R1.8211.00
105_K109_E1.8191.00
130_R133_Y1.8141.00
130_R169_D1.7881.00
134_L167_L1.7471.00
137_Q200_D1.7451.00
223_L233_F1.7331.00
234_G239_I1.7141.00
49_A174_I1.7011.00
136_N142_P1.6791.00
234_G238_K1.6681.00
209_T215_V1.6451.00
54_R81_Y1.6431.00
147_K151_E1.6361.00
12_Y21_A1.6311.00
133_Y137_Q1.5831.00
10_I56_L1.5741.00
36_G215_V1.5591.00
108_G146_K1.5431.00
132_F142_P1.5371.00
195_K217_G1.5311.00
69_N89_K1.5201.00
11_S62_Y1.5161.00
10_I62_Y1.4981.00
7_D26_Y1.4851.00
11_S18_S1.4831.00
238_K242_E1.4761.00
108_G145_Y1.4681.00
112_V127_A1.4561.00
195_K198_I1.4531.00
71_K80_T1.4521.00
112_V131_I1.4491.00
169_D201_K1.4391.00
5_V27_F1.4051.00
108_G112_V1.3821.00
144_I152_L1.3821.00
9_N23_N1.3811.00
8_L58_E1.3481.00
76_M80_T1.3411.00
116_M127_A1.3401.00
175_A205_L1.3391.00
128_S132_F1.3121.00
33_D220_K1.2921.00
106_R109_E1.2911.00
5_V52_I1.2701.00
137_Q196_R1.2581.00
27_F223_L1.2371.00
98_M157_R1.2291.00
54_R57_P1.2261.00
35_L233_F1.2201.00
34_S198_I1.2181.00
6_R28_Q1.2151.00
111_L135_F1.2101.00
53_M92_I1.1971.00
27_F48_I1.1921.00
29_L35_L1.1861.00
6_R26_Y1.1661.00
93_I175_A1.1611.00
125_S129_E1.1561.00
143_E147_K1.1531.00
25_V48_I1.1531.00
109_E112_V1.1521.00
237_R241_K1.1491.00
246_P249_K1.1491.00
67_F72_D1.1481.00
30_E221_K1.1471.00
135_F145_Y1.1471.00
35_L221_K1.1451.00
191_I214_V1.1431.00
104_I150_D1.1411.00
106_R146_K1.1401.00
34_S205_L1.1341.00
124_T127_A1.1321.00
37_V206_I1.1231.00
71_K76_M1.1211.00
108_G128_S1.1201.00
129_E133_Y1.1081.00
34_S219_A1.1071.00
249_K253_S1.1061.00
31_K69_N1.1041.00
169_D203_K1.0921.00
128_S145_Y1.0711.00
76_M81_Y1.0641.00
136_N141_P1.0581.00
152_L160_V1.0571.00
126_K129_E1.0561.00
194_I205_L1.0531.00
132_F136_N1.0511.00
139_S196_R1.0301.00
238_K241_K1.0271.00
110_Q164_S1.0241.00
222_V236_S1.0241.00
31_K202_Q1.0231.00
51_A58_E1.0231.00
246_P250_G1.0161.00
112_V116_M0.9961.00
48_I225_L0.9941.00
105_K113_K0.9891.00
123_D127_A0.9831.00
141_P144_I0.9811.00
52_I206_I0.9741.00
7_D63_S0.9711.00
182_L190_V0.9671.00
133_Y136_N0.9651.00
173_V203_K0.9641.00
111_L167_L0.9631.00
124_T128_S0.9611.00
127_A131_I0.9591.00
108_G131_I0.9581.00
122_I127_A0.9571.00
22_I51_A0.9501.00
173_V205_L0.9481.00
245_H248_S0.9411.00
30_E204_T0.9311.00
10_I47_T0.9231.00
115_M167_L0.9221.00
230_I233_F0.9091.00
248_S252_L0.9071.00
50_N56_L0.9021.00
236_S240_F0.8981.00
11_S23_N0.8981.00
37_V48_I0.8971.00
29_L172_L0.8951.00
37_V223_L0.8911.00
91_S170_P0.8901.00
53_M174_I0.8891.00
240_F243_P0.8891.00
134_L163_A0.8891.00
226_Y231_M0.8881.00
207_Y218_V0.8871.00
122_I126_K0.8841.00
107_V160_V0.8811.00
187_Q211_D0.8801.00
50_N55_A0.8781.00
91_S165_A0.8771.00
175_A194_I0.8711.00
198_I205_L0.8701.00
187_Q214_V0.8691.00
107_V152_L0.8671.00
5_V66_I0.8671.00
148_L151_E0.8641.00
198_I220_K0.8611.00
236_S247_Y0.8611.00
58_E62_Y0.8601.00
43_S225_L0.8581.00
112_V128_S0.8571.00
239_I248_S0.8511.00
21_A47_T0.8491.00
106_R148_L0.8491.00
257_D260_F0.8401.00
125_S128_S0.8401.00
72_D76_M0.8291.00
126_K130_R0.8241.00
71_K89_K0.8171.00
177_E210_H0.8171.00
105_K110_Q0.8121.00
34_S195_K0.8101.00
93_I162_I0.8091.00
34_S218_V0.8081.00
214_V218_V0.8071.00
90_I172_L0.8061.00
193_L196_R0.8051.00
51_A56_L0.8021.00
134_L137_Q0.8011.00
130_R134_L0.8001.00
8_L51_A0.7981.00
138_L163_A0.7971.00
68_F89_K0.7941.00
22_I25_V0.7941.00
38_I215_V0.7831.00
266_V270_P0.7811.00
221_K232_E0.7811.00
101_F157_R0.7801.00
188_A192_S0.7781.00
78_Q81_Y0.7771.00
29_L204_T0.7731.00
139_S189_R0.7711.00
10_I22_I0.7701.00
51_A66_I0.7691.00
24_R229_E0.7651.00
152_L156_Q0.7641.00
174_I206_I0.7641.00
149_P160_V0.7561.00
114_I164_S0.7551.00
195_K218_V0.7551.00
224_T243_P0.7531.00
172_L204_T0.7531.00
192_S217_G0.7531.00
25_V230_I0.7501.00
207_Y219_A0.7491.00
128_S146_K0.7481.00
219_A222_V0.7451.00
101_F110_Q0.7431.00
7_D10_I0.7431.00
114_I168_L0.7421.00
88_K120_S0.7411.00
231_M245_H0.7391.00
226_Y250_G0.7381.00
268_Y272_D0.7381.00
102_N105_K0.7311.00
29_L206_I0.7261.00
24_R63_S0.7181.00
93_I165_A0.7111.00
227_A271_G0.7091.00
250_G254_S0.7081.00
226_Y229_E0.7081.00
253_S267_H0.7071.00
116_M124_T0.7061.00
219_A236_S0.7051.00
140_L144_I0.7001.00
22_I48_I0.7001.00
65_S75_K0.7001.00
34_S220_K0.6971.00
144_I156_Q0.6941.00
254_S257_D0.6941.00
192_S196_R0.6901.00
128_S131_I0.6901.00
247_Y250_G0.6861.00
131_I145_Y0.6841.00
40_E226_Y0.6831.00
106_R110_Q0.6831.00
250_G253_S0.6791.00
192_S195_K0.6781.00
3_L52_I0.6781.00
120_S130_R0.6751.00
115_M121_N0.6751.00
195_K199_V0.6741.00
255_V258_I0.6711.00
172_L206_I0.6701.00
134_L166_L0.6691.00
35_L206_I0.6691.00
5_V48_I0.6671.00
118_N168_L0.6651.00
111_L131_I0.6641.00
179_T214_V0.6591.00
118_N121_N0.6581.00
38_I224_T0.6581.00
212_I240_F0.6581.00
270_P273_P0.6571.00
79_E82_R0.6571.00
50_N92_I0.6561.00
78_Q82_R0.6551.00
55_A94_P0.6551.00
68_F172_L0.6521.00
239_I243_P0.6511.00
53_M90_I0.6511.00
110_Q149_P0.6471.00
73_I90_I0.6471.00
114_I117_E0.6471.00
67_F70_N0.6461.00
11_S63_S0.6461.00
129_E136_N0.6451.00
243_P248_S0.6451.00
198_I201_K0.6441.00
108_G132_F0.6411.00
197_E203_K0.6351.00
224_T239_I0.6341.00
255_V259_R0.6291.00
65_S74_L0.6281.00
259_R262_K0.6261.00
238_K244_L0.6261.00
46_T50_N0.6261.00
120_S127_A0.6251.00
120_S123_D0.6231.00
237_R240_F0.6191.00
52_I66_I0.6171.00
34_S207_Y0.6171.00
32_G204_T0.6171.00
11_S21_A0.6161.00
12_Y56_L0.6121.00
162_I190_V0.6111.00
265_K268_Y0.6091.00
154_G159_R0.6041.00
158_Q181_A0.6031.00
268_Y273_P0.6021.00
260_F263_V0.5981.00
108_G111_L0.5971.00
3_L172_L0.5971.00
3_L68_F0.5971.00
215_V219_A0.5971.00
113_K117_E0.5961.00
179_T190_V0.5931.00
28_Q233_F0.5891.00
31_K204_T0.5871.00
142_P145_Y0.5871.00
77_D81_Y0.5871.00
236_S239_I0.5851.00
40_E247_Y0.5841.00
66_I74_L0.5831.00
247_Y251_L0.5821.00
127_A132_F0.5781.00
215_V222_V0.5751.00
51_A62_Y0.5721.00
216_A240_F0.5721.00
140_L156_Q0.5711.00
166_L203_K0.5691.00
252_L256_P0.5661.00
33_D233_F0.5611.00
9_N62_Y0.5581.00
253_S256_P0.5571.00
101_F160_V0.5561.00
112_V145_Y0.5521.00
171_E203_K0.5511.00
234_G243_P0.5501.00
232_E243_P0.5501.00
40_E43_S0.5481.00
7_D64_G0.5471.00
216_A236_S0.5461.00
115_M118_N0.5461.00
269_I273_P0.5451.00
266_V269_I0.5441.00
122_I130_R0.5441.00
267_H271_G0.5431.00
96_Y157_R0.5381.00
111_L114_I0.5371.00
264_K268_Y0.5361.00
244_L249_K0.5351.00
129_E132_F0.5341.00
20_R24_R0.5341.00
191_I195_K0.5341.00
265_K269_I0.5321.00
41_T177_E0.5321.00
115_M168_L0.5311.00
68_F73_I0.5301.00
234_G240_F0.5301.00
115_M120_S0.5291.00
95_Q154_G0.5281.00
267_H270_P0.5281.00
213_A217_G0.5271.00
189_R192_S0.5261.00
54_R74_L0.5261.00
249_K252_L0.5261.00
107_V111_L0.5221.00
209_T214_V0.5201.00
135_F144_I0.5191.00
215_V236_S0.5191.00
37_V225_L0.5181.00
147_K152_L0.5171.00
153_S156_Q0.5131.00
4_Q26_Y0.5111.00
198_I203_K0.5111.00
73_I76_M0.5101.00
49_A53_M0.5091.00
57_P74_L0.5091.00
242_E246_P0.5081.00
232_E242_E0.5061.00
115_M127_A0.5061.00
130_R137_Q0.5051.00
243_P252_L0.5021.00
226_Y245_H0.5011.00
268_Y271_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9598 100 0.211 Contact Map
4fwiB 1 0.9474 100 0.219 Contact Map
4ry2A 2 0.7368 100 0.224 Contact Map
1v43A 2 0.9102 100 0.226 Contact Map
4mkiB 2 0.8669 100 0.227 Contact Map
2yyzA 1 0.9288 100 0.229 Contact Map
2it1A 1 0.9412 100 0.229 Contact Map
4f4cA 1 0.7028 100 0.23 Contact Map
1z47A 2 0.9412 100 0.231 Contact Map
4ymuJ 2 0.7368 100 0.233 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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