GREMLIN Database
Q97YN5 - Uncharacterized protein
UniProt: Q97YN5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (365)
Sequences: 4124 (3390)
Seq/√Len: 177.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_F140_L3.8371.00
79_A157_R3.3871.00
280_R284_N3.3771.00
93_F189_V3.2471.00
350_V384_V3.2081.00
85_P88_A3.1951.00
301_S308_F3.1861.00
96_Q99_K3.0771.00
153_V164_V2.9001.00
273_I348_N2.8991.00
95_V105_R2.7361.00
94_T165_T2.6691.00
101_K135_I2.5551.00
65_I93_F2.5521.00
193_S356_K2.4291.00
94_T163_I2.4251.00
82_I94_T2.4201.00
354_L374_F2.3481.00
67_T71_N2.2861.00
346_I434_L2.2821.00
70_Y100_G2.2631.00
351_F374_F2.2401.00
78_N230_E2.2391.00
410_K430_T2.1741.00
403_S411_L2.0901.00
79_A153_V2.0871.00
270_L328_V2.0581.00
223_L349_L2.0291.00
400_V427_K2.0281.00
154_S158_E2.0041.00
67_T70_Y1.9741.00
110_D159_I1.9611.00
288_L293_V1.9491.00
201_K221_N1.9421.00
243_L247_I1.9341.00
98_T139_I1.9151.00
94_T139_I1.9031.00
244_Y247_I1.8941.00
298_Y301_S1.8531.00
120_E123_K1.8491.00
301_S306_F1.8171.00
380_F412_I1.8051.00
279_T294_E1.8001.00
374_F384_V1.7991.00
353_E357_R1.7911.00
372_V402_F1.7891.00
85_P329_I1.7831.00
307_L355_Y1.7691.00
370_A401_R1.7531.00
298_Y302_N1.7381.00
381_A411_L1.7381.00
240_L332_G1.7351.00
327_Y348_N1.7091.00
413_I431_L1.6931.00
192_F200_Y1.6831.00
83_T304_Y1.6711.00
194_F222_Y1.6631.00
375_I381_A1.6531.00
269_L306_F1.6381.00
77_N157_R1.6301.00
350_V434_L1.6271.00
351_F362_V1.6131.00
85_P228_F1.6121.00
312_F375_I1.6091.00
198_L218_E1.5881.00
92_I96_Q1.5851.00
197_Y232_F1.5811.00
367_N370_A1.5811.00
64_R193_S1.5771.00
308_F324_R1.5621.00
412_I432_I1.5581.00
286_F293_V1.5401.00
361_E377_K1.5381.00
241_R245_S1.5231.00
308_F326_V1.5231.00
382_I414_I1.5201.00
239_Y243_L1.5161.00
106_V113_L1.5121.00
230_E234_F1.5091.00
88_A189_V1.5061.00
146_V149_W1.4791.00
307_L329_I1.4731.00
318_E321_T1.4701.00
382_I412_I1.4521.00
64_R195_K1.4521.00
414_I432_I1.4501.00
365_Y370_A1.4471.00
393_D397_K1.4311.00
237_N241_R1.4281.00
238_E241_R1.4221.00
266_A300_L1.4181.00
352_L356_K1.4151.00
62_K65_I1.4131.00
309_V327_Y1.4101.00
249_T253_I1.4031.00
194_F215_L1.3831.00
68_R71_N1.3461.00
389_G393_D1.3441.00
98_T137_V1.3331.00
218_E221_N1.3291.00
238_E242_N1.3281.00
74_I78_N1.3231.00
245_S249_T1.3171.00
194_F197_Y1.3161.00
265_L296_Y1.3091.00
237_N244_Y1.3091.00
102_E134_K1.3081.00
268_F272_N1.3021.00
348_N352_L1.3011.00
138_I162_V1.2861.00
81_L184_H1.2821.00
309_V351_F1.2801.00
98_T103_I1.2781.00
241_R244_Y1.2751.00
370_A397_K1.2711.00
182_G371_E1.2681.00
242_N246_D1.2611.00
153_V162_V1.2591.00
281_R284_N1.2561.00
353_E356_K1.2561.00
297_F326_V1.2551.00
245_S263_K1.2541.00
214_R217_E1.2461.00
241_R336_T1.2451.00
223_L345_M1.2431.00
283_G293_V1.2391.00
158_E183_R1.2361.00
222_Y227_G1.2291.00
363_Y377_K1.2291.00
145_N151_L1.2131.00
203_V218_E1.1971.00
105_R139_I1.1961.00
242_N245_S1.1951.00
63_E67_T1.1911.00
82_I189_V1.1911.00
219_L349_L1.1901.00
372_V398_G1.1871.00
225_Q231_T1.1871.00
292_S296_Y1.1781.00
290_H294_E1.1651.00
414_I434_L1.1641.00
142_E167_S1.1601.00
276_E323_P1.1541.00
96_Q100_G1.1521.00
88_A228_F1.1441.00
65_I189_V1.1411.00
142_E183_R1.1401.00
166_G183_R1.1371.00
342_M386_Y1.1321.00
264_G267_D1.1291.00
194_F218_E1.1271.00
220_R224_Q1.1121.00
188_L304_Y1.1081.00
421_K430_T1.1021.00
237_N243_L1.1011.00
109_D154_S1.0991.00
346_I384_V1.0971.00
309_V364_Y1.0931.00
289_S292_S1.0901.00
351_F355_Y1.0891.00
121_L128_G1.0881.00
83_T186_D1.0861.00
190_F307_L1.0851.00
124_F128_G1.0841.00
309_V362_V1.0741.00
87_R182_G1.0741.00
231_T240_L1.0731.00
396_Y400_V1.0721.00
403_S428_E1.0701.00
114_S151_L1.0671.00
144_Q166_G1.0671.00
197_Y218_E1.0641.00
217_E221_N1.0641.00
265_L293_V1.0601.00
403_S408_D1.0491.00
95_V159_I1.0471.00
104_L107_D1.0451.00
118_A121_L1.0451.00
269_L297_F1.0411.00
121_L124_F1.0401.00
279_T297_F1.0371.00
216_K220_R1.0350.99
334_F341_Q1.0340.99
283_G290_H1.0310.99
282_V286_F1.0300.99
380_F410_K1.0240.99
181_T254_I1.0180.99
402_F406_F1.0160.99
325_K347_E1.0160.99
219_L223_L1.0090.99
381_A403_S1.0080.99
265_L282_V0.9970.99
122_N126_E0.9900.99
66_I69_H0.9890.99
359_G362_V0.9890.99
400_V411_L0.9880.99
140_L153_V0.9810.99
139_I163_I0.9800.99
197_Y221_N0.9800.99
191_P329_I0.9770.99
280_R290_H0.9760.99
111_E114_S0.9710.99
397_K401_R0.9700.99
123_K126_E0.9690.99
244_Y266_A0.9660.99
166_G343_G0.9650.99
256_C299_C0.9640.99
311_R322_L0.9530.99
275_K344_K0.9520.99
63_E66_I0.9510.99
66_I70_Y0.9450.99
140_L162_V0.9440.99
73_S97_L0.9430.99
225_Q236_K0.9340.99
139_I165_T0.9340.99
194_F198_L0.9320.99
86_R142_E0.9230.99
307_L352_L0.9230.99
190_F356_K0.9180.99
174_S302_N0.9110.99
80_Y163_I0.9070.99
119_N122_N0.9050.99
138_I160_Y0.9030.99
195_K199_R0.9030.99
198_L215_L0.9020.99
334_F345_M0.8990.99
191_P227_G0.8990.99
220_R342_M0.8950.99
142_E383_Q0.8940.99
263_K267_D0.8920.98
250_R254_I0.8870.98
270_L337_Y0.8870.98
102_E132_K0.8860.98
262_V300_L0.8840.98
236_K244_Y0.8840.98
279_T290_H0.8830.98
131_I134_K0.8790.98
174_S177_A0.8710.98
183_R373_D0.8690.98
335_N345_M0.8690.98
222_Y349_L0.8690.98
223_L342_M0.8690.98
280_R283_G0.8680.98
192_F197_Y0.8670.98
371_E383_Q0.8660.98
219_L434_L0.8660.98
88_A191_P0.8620.98
327_Y374_F0.8580.98
150_E184_H0.8570.98
347_E371_E0.8560.98
79_A164_V0.8560.98
398_G402_F0.8550.98
125_L152_F0.8520.98
371_E385_T0.8520.98
354_L362_V0.8510.98
297_F308_F0.8470.98
243_L248_I0.8460.98
103_I137_V0.8450.98
312_F377_K0.8450.98
354_L382_I0.8440.98
158_E179_Y0.8440.98
87_R180_L0.8430.98
64_R67_T0.8430.98
347_E383_Q0.8410.98
86_R166_G0.8390.98
108_F149_W0.8380.98
142_E343_G0.8370.98
82_I93_F0.8360.98
267_D337_Y0.8350.98
143_I150_E0.8350.98
126_E129_Y0.8340.98
110_D158_E0.8320.98
83_T188_L0.8310.98
73_S185_M0.8310.98
69_H97_L0.8310.98
408_D411_L0.8300.98
384_V414_I0.8240.97
193_S196_E0.8240.97
115_G119_N0.8210.97
166_G182_G0.8190.97
103_I139_I0.8180.97
110_D155_R0.8180.97
102_E108_F0.8160.97
269_L326_V0.8130.97
307_L351_F0.8100.97
196_E199_R0.8080.97
372_V381_A0.8060.97
175_E255_R0.8050.97
142_E166_G0.8020.97
267_D271_E0.8010.97
398_G401_R0.8010.97
111_E115_G0.8010.97
253_I258_T0.7980.97
188_L355_Y0.7960.97
225_Q232_F0.7950.97
66_I93_F0.7950.97
343_G385_T0.7940.97
80_Y185_M0.7910.97
331_T335_N0.7860.97
387_D391_I0.7860.97
421_K431_L0.7850.97
295_N299_C0.7840.97
415_T419_E0.7830.97
262_V299_C0.7790.96
181_T184_H0.7790.96
392_D396_Y0.7770.96
175_E178_T0.7760.96
262_V296_Y0.7750.96
266_A328_V0.7750.96
241_R247_I0.7730.96
426_G431_L0.7710.96
386_Y416_W0.7690.96
197_Y200_Y0.7680.96
125_L156_I0.7680.96
221_N225_Q0.7650.96
391_I394_R0.7620.96
350_V414_I0.7610.96
111_E155_R0.7610.96
185_M242_N0.7580.96
425_N431_L0.7580.96
328_V348_N0.7560.96
343_G347_E0.7520.96
137_V163_I0.7520.96
351_F384_V0.7510.96
411_L428_E0.7500.96
365_Y402_F0.7490.96
412_I430_T0.7480.96
77_N185_M0.7470.96
273_I334_F0.7470.96
420_G431_L0.7450.95
404_E407_K0.7440.95
62_K67_T0.7420.95
117_K121_L0.7420.95
142_E371_E0.7400.95
372_V399_L0.7400.95
94_T98_T0.7390.95
381_A406_F0.7380.95
108_F146_V0.7380.95
252_V256_C0.7370.95
237_N245_S0.7360.95
291_Q294_E0.7350.95
140_L143_I0.7350.95
236_K240_L0.7340.95
260_K295_N0.7290.95
231_T239_Y0.7280.95
64_R68_R0.7270.95
151_L154_S0.7230.95
331_T352_L0.7170.94
78_N157_R0.7160.94
366_S369_N0.7140.94
244_Y337_Y0.7130.94
349_L353_E0.7130.94
181_T246_D0.7120.94
87_R166_G0.7120.94
331_T348_N0.7120.94
68_R185_M0.7120.94
79_A162_V0.7110.94
262_V265_L0.7040.94
327_Y351_F0.7030.94
397_K400_V0.7020.94
244_Y248_I0.7010.94
145_N179_Y0.7010.94
274_G327_Y0.7000.94
276_E364_Y0.6980.94
214_R218_E0.6970.94
85_P190_F0.6970.94
268_F282_V0.6960.94
103_I107_D0.6960.94
121_L125_L0.6960.94
254_I257_K0.6950.93
249_T267_D0.6940.93
264_G294_E0.6940.93
272_N275_K0.6930.93
376_I380_F0.6920.93
258_T262_V0.6910.93
117_K120_E0.6900.93
190_F355_Y0.6890.93
132_K135_I0.6870.93
148_G151_L0.6870.93
401_R404_E0.6860.93
426_G430_T0.6830.93
387_D390_G0.6820.93
201_K218_E0.6820.93
373_D383_Q0.6800.93
268_F285_A0.6790.93
276_E279_T0.6770.93
107_D158_E0.6740.92
400_V404_E0.6730.92
87_R371_E0.6680.92
391_I398_G0.6680.92
313_T318_E0.6680.92
256_C259_R0.6660.92
200_Y232_F0.6650.92
258_T299_C0.6650.92
315_K318_E0.6630.92
415_T418_R0.6570.91
315_K322_L0.6570.91
81_L164_V0.6560.91
109_D155_R0.6550.91
374_F382_I0.6530.91
166_G373_D0.6520.91
71_N97_L0.6510.91
265_L297_F0.6500.91
215_L218_E0.6500.91
360_Q376_I0.6500.91
198_L222_Y0.6470.91
392_D413_I0.6460.91
81_L186_D0.6460.91
98_T105_R0.6420.90
155_R159_I0.6420.90
192_F229_P0.6390.90
74_I163_I0.6380.90
182_G385_T0.6360.90
69_H80_Y0.6310.90
426_G429_I0.6300.90
339_R343_G0.6280.89
253_I256_C0.6270.89
228_F329_I0.6250.89
191_P330_D0.6240.89
123_K127_A0.6240.89
248_I266_A0.6240.89
197_Y222_Y0.6180.89
216_K416_W0.6180.89
210_R213_A0.6180.89
77_N242_N0.6170.89
64_R70_Y0.6150.88
319_R377_K0.6150.88
393_D400_V0.6130.88
277_V282_V0.6070.88
396_Y413_I0.6070.88
117_K124_F0.6060.88
167_S182_G0.6050.88
300_L306_F0.6040.88
111_E152_F0.6030.88
297_F306_F0.6020.87
221_N236_K0.6010.87
333_L337_Y0.6010.87
261_D264_G0.5990.87
82_I163_I0.5990.87
345_M349_L0.5980.87
399_L403_S0.5960.87
145_N254_I0.5950.87
108_F113_L0.5940.87
178_T255_R0.5940.87
213_A217_E0.5930.87
168_N173_S0.5920.87
228_F331_T0.5920.87
403_S406_F0.5910.86
388_E391_I0.5900.86
171_L175_E0.5890.86
65_I68_R0.5890.86
367_N401_R0.5860.86
238_E243_L0.5860.86
354_L358_Y0.5860.86
331_T345_M0.5860.86
265_L286_F0.5850.86
144_Q251_D0.5850.86
402_F408_D0.5810.86
384_V434_L0.5800.85
273_I328_V0.5780.85
293_V297_F0.5760.85
110_D113_L0.5760.85
151_L178_T0.5760.85
230_E233_K0.5760.85
154_S157_R0.5740.85
63_E199_R0.5740.85
343_G373_D0.5730.85
401_R405_R0.5720.85
249_T258_T0.5720.85
228_F231_T0.5710.85
343_G383_Q0.5710.85
169_A172_M0.5690.84
269_L328_V0.5690.84
193_S197_Y0.5690.84
240_L243_L0.5680.84
346_I416_W0.5660.84
281_R338_K0.5630.84
367_N398_G0.5630.84
92_I95_V0.5620.84
381_A409_Y0.5610.84
292_S295_N0.5610.84
122_N155_R0.5580.83
80_Y187_F0.5570.83
194_F435_W0.5510.82
256_C302_N0.5510.82
93_F192_F0.5490.82
240_L244_Y0.5480.82
311_R323_P0.5480.82
67_T100_G0.5460.82
188_L307_L0.5460.82
125_L210_R0.5460.82
325_K364_Y0.5450.82
70_Y73_S0.5450.82
122_N125_L0.5440.82
194_F349_L0.5440.82
62_K70_Y0.5430.82
412_I418_R0.5430.82
329_I352_L0.5430.82
373_D385_T0.5420.81
288_L295_N0.5410.81
268_F286_F0.5410.81
197_Y225_Q0.5400.81
251_D325_K0.5400.81
415_T431_L0.5390.81
104_L108_F0.5370.81
387_D416_W0.5350.81
332_G335_N0.5350.81
400_V426_G0.5340.80
231_T234_F0.5340.80
265_L288_L0.5340.80
281_R285_A0.5330.80
87_R183_R0.5320.80
128_G131_I0.5320.80
142_E385_T0.5310.80
131_I136_E0.5310.80
154_S170_R0.5290.80
385_T391_I0.5260.79
309_V374_F0.5250.79
167_S183_R0.5240.79
305_L328_V0.5230.79
331_T349_L0.5230.79
253_I263_K0.5220.79
203_V214_R0.5220.79
284_N290_H0.5210.79
82_I198_L0.5180.78
118_A125_L0.5180.78
297_F301_S0.5180.78
193_S352_L0.5160.78
150_E178_T0.5130.78
347_E385_T0.5130.78
168_N172_M0.5120.78
338_K341_Q0.5110.78
78_N161_P0.5110.78
419_E431_L0.5110.78
191_P228_F0.5100.77
72_Y235_D0.5090.77
251_D255_R0.5080.77
192_F196_E0.5070.77
72_Y78_N0.5070.77
283_G286_F0.5060.77
237_N242_N0.5040.77
365_Y406_F0.5040.77
182_G383_Q0.5030.76
362_V374_F0.5030.76
282_V293_V0.5020.76
368_G405_R0.5010.76
306_F326_V0.5000.76
343_G386_Y0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.5973 100 0.716 Contact Map
2qenA 1 0.6106 100 0.724 Contact Map
3pfiA 3 0.5929 99.8 0.816 Contact Map
1hqcA 1 0.5951 99.7 0.827 Contact Map
1w5sA 1 0.6549 99.6 0.838 Contact Map
1fnnA 1 0.6416 99.6 0.841 Contact Map
1in4A 1 0.5973 99.4 0.856 Contact Map
2qbyA 1 0.6305 99.4 0.858 Contact Map
3te6A 1 0.5509 99.4 0.86 Contact Map
2v1uA 1 0.6704 99.4 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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