GREMLIN Database
Q97YN4 - Uncharacterized protein
UniProt: Q97YN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (259)
Sequences: 3147 (3057)
Seq/√Len: 190.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_R122_L4.5151.00
34_D58_R3.6471.00
9_V41_T3.5301.00
12_N85_L3.4301.00
13_A40_S3.0511.00
72_K126_S2.8581.00
7_A23_V2.6601.00
17_E47_E2.6431.00
69_Y73_H2.6261.00
42_W58_R2.6071.00
137_E141_R2.5591.00
17_E21_K2.5011.00
21_K48_L2.4761.00
32_I45_L2.4721.00
81_T93_F2.3381.00
46_L58_R2.3371.00
57_Y73_H2.3201.00
59_L65_K2.2831.00
59_L69_Y2.2521.00
18_E156_L2.1891.00
57_Y69_Y2.1151.00
3_Y115_V2.1051.00
61_S65_K2.1021.00
40_S43_E2.0911.00
3_Y93_F2.0781.00
42_W56_L2.0561.00
9_V32_I2.0321.00
3_Y97_L2.0281.00
94_H98_E1.9811.00
89_Y92_S1.9791.00
95_K150_A1.9781.00
7_A30_I1.9711.00
11_N38_T1.9521.00
18_E88_R1.9481.00
33_T70_S1.9201.00
67_R84_D1.9181.00
6_Y70_S1.8921.00
59_L62_T1.8721.00
42_W46_L1.8631.00
121_I138_I1.8581.00
29_T55_V1.8251.00
20_V48_L1.7861.00
29_T76_E1.7851.00
30_I54_L1.7841.00
4_C29_T1.7741.00
7_A19_S1.7661.00
74_C118_R1.7501.00
92_S96_I1.7491.00
119_E123_E1.7181.00
23_V83_F1.7061.00
34_D42_W1.6991.00
4_C76_E1.6841.00
67_R82_Y1.6601.00
36_Y62_T1.6571.00
59_L66_G1.6481.00
81_T92_S1.6311.00
83_F89_Y1.6051.00
149_P153_H1.5881.00
28_V93_F1.5611.00
36_Y59_L1.5381.00
120_T142_V1.5291.00
71_L80_T1.5291.00
45_L56_L1.4841.00
79_I100_A1.4801.00
71_L74_C1.4541.00
19_S83_F1.4081.00
138_I142_V1.4021.00
81_T89_Y1.4001.00
96_I115_V1.3951.00
11_N37_S1.3951.00
46_L56_L1.3921.00
128_R137_E1.3911.00
69_Y72_K1.3881.00
55_V73_H1.3611.00
17_E48_L1.3601.00
20_V32_I1.3311.00
13_A44_R1.3241.00
34_D37_S1.3241.00
81_T115_V1.3221.00
116_V139_V1.3201.00
20_V24_W1.3121.00
67_R134_E1.3111.00
90_N154_A1.2961.00
153_H157_R1.2891.00
55_V75_P1.2651.00
77_N117_K1.2611.00
16_L45_L1.2591.00
120_T146_Y1.2581.00
20_V30_I1.2451.00
9_V45_L1.2431.00
9_V12_N1.2371.00
46_L49_R1.2341.00
16_L41_T1.2031.00
24_W48_L1.2031.00
74_C80_T1.1981.00
153_H156_L1.1881.00
100_A115_V1.1781.00
44_R48_L1.1741.00
96_I100_A1.1701.00
33_T66_G1.1671.00
80_T118_R1.1631.00
24_W54_L1.1601.00
9_V16_L1.1541.00
130_L133_A1.1501.00
42_W45_L1.1431.00
43_E46_L1.1301.00
142_V146_Y1.1301.00
49_R54_L1.1051.00
49_R56_L1.1001.00
147_F153_H1.1001.00
64_G68_G1.0951.00
47_E51_D1.0771.00
12_N15_T1.0771.00
38_T41_T1.0751.00
149_P157_R1.0741.00
68_G127_W1.0691.00
17_E44_R1.0661.00
65_K129_D1.0631.00
29_T74_C1.0551.00
19_S88_R1.0541.00
32_I41_T1.0511.00
160_L163_E1.0441.00
63_R134_E1.0441.00
29_T75_P1.0431.00
35_N59_L1.0401.00
24_W52_Y1.0391.00
27_D97_L1.0291.00
82_Y127_W1.0201.00
19_S22_S1.0151.00
149_P156_L1.0141.00
148_V155_E0.9960.99
7_A83_F0.9950.99
71_L126_S0.9950.99
149_P155_E0.9820.99
162_R165_R0.9800.99
8_T67_R0.9730.99
23_V89_Y0.9720.99
49_R52_Y0.9630.99
63_R66_G0.9600.99
109_N112_N0.9520.99
23_V30_I0.9440.99
5_I93_F0.9440.99
5_I28_V0.9250.99
21_K25_R0.9240.99
8_T85_L0.9230.99
19_S89_Y0.9220.99
80_T121_I0.9220.99
150_A153_H0.9180.99
35_N66_G0.9180.99
97_L100_A0.9160.99
155_E158_N0.9130.99
71_L82_Y0.9120.99
82_Y134_E0.9120.99
10_F35_N0.9120.99
28_V53_N0.9070.99
3_Y96_I0.9060.99
89_Y93_F0.9030.99
8_T35_N0.9000.99
9_V34_D0.8910.99
65_K69_Y0.8840.99
124_K142_V0.8830.99
148_V153_H0.8710.99
71_L121_I0.8650.99
95_K152_I0.8540.98
4_C74_C0.8530.98
23_V32_I0.8510.98
133_A136_W0.8470.98
9_V85_L0.8450.98
119_E122_L0.8420.98
81_T96_I0.8400.98
152_I156_L0.8370.98
16_L44_R0.8370.98
61_S66_G0.8340.98
35_N62_T0.8310.98
68_G71_L0.8290.98
42_W49_R0.8280.98
161_A164_K0.8260.98
33_T69_Y0.8260.98
21_K51_D0.8170.98
116_V142_V0.8150.98
11_N41_T0.8140.98
4_C31_V0.8130.98
3_Y81_T0.8110.98
24_W30_I0.8080.98
166_Y169_G0.8080.98
20_V54_L0.8060.98
20_V44_R0.8060.98
48_L51_D0.8030.98
147_F150_A0.8000.98
59_L63_R0.7970.98
8_T66_G0.7960.97
64_G134_E0.7960.97
128_R138_I0.7940.97
3_Y100_A0.7940.97
147_F151_L0.7870.97
37_S41_T0.7810.97
5_I23_V0.7810.97
79_I117_K0.7790.97
6_Y82_Y0.7770.97
147_F155_E0.7760.97
99_W148_V0.7710.97
45_L49_R0.7710.97
150_A156_L0.7680.97
13_A16_L0.7630.97
114_F139_V0.7600.97
3_Y28_V0.7590.97
12_N19_S0.7590.97
154_A157_R0.7540.97
148_V152_I0.7480.96
10_F62_T0.7360.96
107_L112_N0.7310.96
77_N119_E0.7280.96
123_E145_D0.7260.96
82_Y121_I0.7190.95
13_A39_D0.7190.95
66_G69_Y0.7190.95
8_T70_S0.7130.95
148_V151_L0.7130.95
163_E167_A0.7130.95
31_V73_H0.7110.95
47_E50_K0.7100.95
177_F181_L0.7080.95
68_G138_I0.7080.95
31_V55_V0.7030.95
79_I115_V0.6980.95
84_D134_E0.6980.95
176_R180_K0.6970.95
121_I142_V0.6960.95
63_R133_A0.6940.94
35_N87_M0.6940.94
159_E162_R0.6920.94
27_D53_N0.6910.94
67_R127_W0.6880.94
104_K107_L0.6870.94
45_L58_R0.6810.94
25_R91_E0.6800.94
122_L126_S0.6800.94
6_Y33_T0.6800.94
83_F92_S0.6780.94
63_R111_V0.6690.93
41_T44_R0.6680.93
147_F158_N0.6640.93
95_K99_W0.6570.93
32_I54_L0.6550.93
41_T85_L0.6510.92
169_G172_Y0.6480.92
116_V121_I0.6480.92
120_T145_D0.6470.92
165_R168_K0.6460.92
137_E140_S0.6440.92
88_R154_A0.6430.92
161_A167_A0.6370.92
16_L32_I0.6370.92
159_E165_R0.6340.91
150_A154_A0.6330.91
13_A43_E0.6310.91
95_K98_E0.6310.91
154_A158_N0.6310.91
117_K120_T0.6310.91
64_G67_R0.6300.91
68_G126_S0.6280.91
37_S42_W0.6270.91
24_W53_N0.6250.91
7_A85_L0.6250.91
84_D87_M0.6230.91
107_L110_L0.6230.91
109_N136_W0.6210.91
153_H158_N0.6200.90
40_S44_R0.6200.90
118_R121_I0.6190.90
71_L138_I0.6190.90
43_E47_E0.6190.90
6_Y74_C0.6180.90
128_R141_R0.6160.90
256_F261_Y0.6160.90
10_F38_T0.6130.90
177_F180_K0.6110.90
19_S23_V0.6100.90
92_S113_G0.6100.90
26_S53_N0.6090.90
79_I97_L0.6060.89
81_T113_G0.6060.89
23_V28_V0.6010.89
15_T156_L0.6000.89
148_V156_L0.6000.89
254_K259_G0.6000.89
12_N41_T0.5990.89
66_G70_S0.5990.89
13_A41_T0.5970.89
126_S141_R0.5970.89
175_R179_N0.5960.89
149_P152_I0.5930.88
24_W28_V0.5920.88
63_R67_R0.5910.88
93_F115_V0.5890.88
3_Y26_S0.5880.88
61_S64_G0.5880.88
62_T66_G0.5870.88
163_E166_Y0.5860.88
64_G80_T0.5850.88
79_I87_M0.5850.88
139_V143_G0.5830.88
7_A82_Y0.5820.88
33_T84_D0.5810.87
130_L140_S0.5800.87
21_K24_W0.5780.87
15_T158_N0.5770.87
68_G125_G0.5740.87
178_K182_D0.5720.87
41_T45_L0.5690.86
180_K187_L0.5690.86
137_E146_Y0.5670.86
129_D133_A0.5650.86
28_V75_P0.5640.86
67_R112_N0.5610.86
160_L165_R0.5610.86
6_Y67_R0.5600.85
236_I239_A0.5600.85
7_A32_I0.5600.85
162_R166_Y0.5590.85
45_L54_L0.5590.85
35_N84_D0.5570.85
183_V187_L0.5570.85
63_R130_L0.5560.85
120_T124_K0.5560.85
31_V74_C0.5550.85
138_I141_R0.5530.85
5_I81_T0.5530.85
19_S85_L0.5510.85
83_F153_H0.5490.84
172_Y176_R0.5490.84
18_E160_L0.5480.84
70_S74_C0.5470.84
64_G130_L0.5460.84
147_F157_R0.5440.84
3_Y27_D0.5440.84
108_V111_V0.5440.84
31_V76_E0.5430.84
89_Y96_I0.5430.84
87_M143_G0.5430.84
15_T19_S0.5430.84
159_E167_A0.5410.83
36_Y66_G0.5410.83
10_F59_L0.5400.83
222_I226_Y0.5400.83
103_D106_I0.5400.83
159_E166_Y0.5390.83
12_N84_D0.5360.83
165_R169_G0.5360.83
12_N63_R0.5350.83
26_S52_Y0.5350.83
27_D93_F0.5350.83
259_G262_W0.5340.83
183_V186_G0.5340.83
151_L154_A0.5320.82
64_G127_W0.5320.82
206_K211_A0.5310.82
76_E79_I0.5310.82
206_K209_V0.5300.82
8_T134_E0.5280.82
212_P229_Y0.5270.82
111_V134_E0.5240.82
166_Y170_L0.5240.82
121_I126_S0.5220.81
8_T84_D0.5220.81
67_R138_I0.5220.81
36_Y58_R0.5210.81
61_S69_Y0.5170.81
143_G146_Y0.5170.81
8_T19_S0.5160.81
221_G224_R0.5110.80
92_S114_F0.5110.80
113_G139_V0.5110.80
24_W91_E0.5080.80
174_G178_K0.5070.79
67_R85_L0.5070.79
180_K183_V0.5060.79
176_R179_N0.5060.79
149_P154_A0.5060.79
36_Y65_K0.5050.79
252_N255_Y0.5050.79
5_I83_F0.5050.79
9_V67_R0.5040.79
48_L54_L0.5020.79
197_A200_Q0.5010.79
97_L115_V0.5010.79
36_Y64_G0.5000.78
184_I188_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.4568 100 0.49 Contact Map
3l7iA 4 0.1636 100 0.507 Contact Map
1qg8A 1 0.5617 100 0.511 Contact Map
2z86A 2 0.642 100 0.529 Contact Map
2d7iA 1 0.8056 100 0.565 Contact Map
3ckjA 2 0.6728 99.9 0.58 Contact Map
1xhbA 1 0.8765 99.9 0.586 Contact Map
2nxvA 4 0.5586 99.9 0.591 Contact Map
5ajoA 1 0.7901 99.9 0.592 Contact Map
3f1yA 2 0.7068 99.9 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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