GREMLIN Database
Q97YN3 - Uncharacterized protein
UniProt: Q97YN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (406)
Sequences: 24752 (16039)
Seq/√Len: 796.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_T337_T4.1681.00
320_G331_V4.0551.00
376_R380_K3.3801.00
325_K328_E3.2551.00
63_T250_G3.0161.00
236_K240_K2.9281.00
323_K331_V2.9101.00
383_L386_L2.8851.00
233_T237_T2.6041.00
383_L387_H2.4821.00
87_Y314_D2.4621.00
103_G311_M2.4561.00
189_F259_S2.4451.00
325_K330_L2.3991.00
320_G323_K2.3921.00
312_A322_S2.3921.00
27_F244_S2.2941.00
23_F244_S2.2841.00
150_L341_A2.2541.00
187_L191_Y2.2451.00
280_I284_V2.2171.00
75_S378_A2.1921.00
231_G313_E2.1011.00
91_F99_G2.0881.00
23_F237_T2.0611.00
198_Y201_I2.0601.00
368_I396_S2.0321.00
334_V338_S2.0261.00
26_V233_T2.0251.00
158_S162_A2.0231.00
271_D274_L1.9991.00
309_K313_E1.9901.00
232_E306_R1.9821.00
154_I341_A1.9771.00
23_F27_F1.9631.00
161_L330_L1.9501.00
165_Q169_K1.9491.00
419_F423_I1.9251.00
157_T333_L1.9231.00
72_V371_N1.9121.00
384_K387_H1.8981.00
150_L344_Y1.8911.00
240_K244_S1.8701.00
176_I180_L1.8661.00
391_I395_A1.8571.00
22_T25_D1.8561.00
94_L376_R1.8491.00
426_F430_E1.8341.00
149_A344_Y1.8291.00
197_F201_I1.8161.00
91_F96_S1.8131.00
107_L336_I1.7981.00
321_L335_F1.7961.00
427_I431_A1.7951.00
425_G428_Y1.7941.00
271_D275_F1.7771.00
17_T324_V1.7771.00
47_M50_K1.7601.00
315_K319_S1.7591.00
243_I247_L1.7511.00
193_S197_F1.7281.00
94_L372_S1.7261.00
47_M55_A1.7191.00
64_L68_F1.7141.00
197_F200_P1.7091.00
25_D172_I1.6681.00
194_R197_F1.6541.00
90_A102_T1.6531.00
388_E391_I1.6331.00
402_V405_Y1.6031.00
160_V298_M1.6001.00
420_G423_I1.5971.00
114_G340_T1.5891.00
154_I337_T1.5861.00
234_N237_T1.5851.00
196_N201_I1.5831.00
27_F248_F1.5821.00
416_Y419_F1.5721.00
194_R198_Y1.5711.00
399_S402_V1.5701.00
390_F394_F1.5691.00
58_A212_A1.5661.00
161_L334_V1.5651.00
144_D147_F1.5611.00
102_T369_S1.5591.00
376_R379_S1.5591.00
153_G340_T1.5391.00
180_L184_L1.5131.00
416_Y420_G1.5111.00
118_L297_G1.5021.00
104_W425_G1.4781.00
30_S245_V1.4781.00
194_R199_N1.4771.00
392_G396_S1.4611.00
48_I52_G1.4511.00
331_V335_F1.4431.00
143_Y147_F1.4411.00
95_T98_L1.4401.00
247_L251_L1.4371.00
125_L148_Y1.4331.00
21_L25_D1.4321.00
118_L153_G1.4301.00
121_G152_I1.4191.00
196_N199_N1.4181.00
415_V419_F1.4021.00
229_L302_L1.4001.00
54_Q209_L1.3961.00
234_N240_K1.3851.00
421_W425_G1.3831.00
403_F406_S1.3811.00
395_A399_S1.3721.00
397_L401_S1.3701.00
393_I397_L1.3631.00
150_L154_I1.3611.00
388_E392_G1.3411.00
308_L332_G1.3361.00
17_T309_K1.3361.00
157_T334_V1.3361.00
181_I288_I1.3331.00
305_S333_L1.3321.00
121_G290_L1.3291.00
304_N336_I1.3281.00
190_L259_S1.3271.00
70_G246_L1.3261.00
283_L287_L1.3221.00
186_S255_F1.3211.00
25_D168_A1.3171.00
388_E395_A1.3141.00
309_K324_V1.3111.00
193_S196_N1.3101.00
62_A216_G1.3081.00
319_S322_S1.3081.00
274_L282_T1.3041.00
372_S376_R1.2971.00
64_L394_F1.2941.00
90_A369_S1.2921.00
319_S323_K1.2891.00
153_G337_T1.2881.00
94_L98_L1.2851.00
80_F92_Y1.2781.00
35_A38_I1.2761.00
79_R384_K1.2701.00
237_T240_K1.2641.00
398_V402_V1.2601.00
189_F263_M1.2561.00
323_K330_L1.2541.00
70_G242_A1.2511.00
23_F240_K1.2481.00
235_P239_G1.2441.00
274_L279_L1.2431.00
392_G395_A1.2421.00
83_G231_G1.2401.00
402_V406_S1.2361.00
251_L255_F1.2361.00
197_F202_P1.2351.00
410_F413_Y1.2331.00
179_I183_S1.2301.00
198_Y202_P1.2261.00
431_A434_I1.2231.00
199_N202_P1.2091.00
417_L420_G1.2091.00
21_L168_A1.2081.00
428_Y432_L1.1911.00
34_Q249_G1.1911.00
88_T92_Y1.1851.00
24_K28_F1.1671.00
71_L243_I1.1671.00
21_L26_V1.1651.00
156_A297_G1.1631.00
195_W200_P1.1561.00
193_S262_A1.1471.00
47_M52_G1.1441.00
117_L296_G1.1421.00
379_S382_A1.1411.00
390_F395_A1.1411.00
69_N371_N1.1411.00
420_G424_L1.1341.00
185_L189_F1.1341.00
277_F281_G1.1301.00
267_G271_D1.1281.00
324_V328_E1.1261.00
93_S373_S1.1221.00
313_E322_S1.1201.00
107_L308_L1.1181.00
68_F394_F1.1161.00
82_R88_T1.1151.00
404_L408_P1.1141.00
308_L317_M1.1121.00
72_V392_G1.1111.00
372_S396_S1.1081.00
56_P258_Y1.1071.00
401_S405_Y1.1041.00
430_E434_I1.0971.00
378_A382_A1.0941.00
331_V334_V1.0921.00
428_Y431_A1.0911.00
196_N200_P1.0911.00
159_I170_Y1.0891.00
400_I404_L1.0861.00
75_S78_G1.0811.00
73_I86_Y1.0781.00
26_V241_A1.0751.00
30_S226_I1.0741.00
195_W198_Y1.0711.00
205_I208_T1.0611.00
396_S399_S1.0571.00
415_V421_W1.0491.00
92_Y381_R1.0491.00
415_V418_F1.0481.00
399_S403_F1.0471.00
90_A98_L1.0461.00
29_I229_L1.0441.00
77_S89_Y1.0441.00
193_S198_Y1.0431.00
184_L188_L1.0391.00
31_F248_F1.0361.00
169_K173_G1.0321.00
390_F393_I1.0321.00
125_L129_I1.0311.00
146_W150_L1.0271.00
407_L411_N1.0241.00
60_L254_T1.0201.00
100_L104_W1.0061.00
403_F407_L1.0001.00
122_A148_Y1.0001.00
157_T161_L1.0001.00
87_Y310_A0.9931.00
170_Y174_A0.9931.00
409_T413_Y0.9921.00
258_Y262_A0.9861.00
419_F430_E0.9861.00
368_I400_I0.9841.00
411_N414_I0.9831.00
171_A298_M0.9821.00
195_W199_N0.9811.00
416_Y430_E0.9791.00
174_A295_L0.9781.00
97_R426_F0.9741.00
338_S342_M0.9731.00
147_F151_I0.9691.00
183_S187_L0.9681.00
398_V405_Y0.9671.00
46_V50_K0.9671.00
154_I158_S0.9531.00
31_F249_G0.9521.00
151_I155_I0.9521.00
211_S215_F0.9491.00
402_V407_L0.9481.00
419_F425_G0.9441.00
41_L120_G0.9411.00
186_S259_S0.9401.00
361_L418_F0.9381.00
82_R92_Y0.9371.00
97_R429_A0.9361.00
375_V393_I0.9271.00
162_A328_E0.9271.00
125_L290_L0.9241.00
56_P261_A0.9221.00
230_G238_I0.9191.00
203_S207_P0.9161.00
368_I372_S0.9131.00
416_Y425_G0.9091.00
386_L392_G0.9081.00
164_V302_L0.9071.00
396_S400_I0.9051.00
221_T363_N0.9021.00
186_S190_L0.8991.00
416_Y426_F0.8971.00
116_T218_G0.8931.00
415_V429_A0.8901.00
104_W317_M0.8891.00
423_I427_I0.8811.00
28_F172_I0.8791.00
195_W201_I0.8721.00
250_G254_T0.8711.00
116_T356_G0.8691.00
224_G228_P0.8681.00
161_L328_E0.8641.00
17_T306_R0.8631.00
179_I252_I0.8551.00
63_T220_P0.8551.00
388_E394_F0.8541.00
84_G88_T0.8531.00
419_F434_I0.8531.00
392_G407_L0.8521.00
25_D169_K0.8481.00
155_I294_T0.8481.00
193_S201_I0.8471.00
330_L334_V0.8401.00
193_S200_P0.8391.00
404_L407_L0.8331.00
122_A149_A0.8321.00
323_K326_Y0.8311.00
301_I337_T0.8291.00
161_L325_K0.8281.00
185_L273_L0.8231.00
20_K165_Q0.8211.00
203_S206_T0.8191.00
156_A298_M0.8151.00
256_F260_L0.8131.00
98_L369_S0.8131.00
84_G87_Y0.8121.00
393_I396_S0.8091.00
321_L331_V0.8071.00
419_F422_I0.8071.00
17_T232_E0.8061.00
35_A40_L0.8051.00
317_M321_L0.8031.00
238_I242_A0.8031.00
76_L374_L0.8021.00
244_S248_F0.7971.00
91_F314_D0.7961.00
389_V393_I0.7941.00
24_K172_I0.7941.00
422_I425_G0.7931.00
374_L378_A0.7921.00
415_V430_E0.7901.00
67_L71_L0.7901.00
225_S303_A0.7891.00
398_V401_S0.7881.00
371_N395_A0.7871.00
90_A373_S0.7841.00
148_Y151_I0.7831.00
121_G294_T0.7801.00
178_E292_D0.7791.00
162_A166_V0.7741.00
407_L410_F0.7721.00
401_S404_L0.7691.00
337_T341_A0.7691.00
68_F72_V0.7691.00
416_Y421_W0.7681.00
126_Y145_Q0.7681.00
194_R202_P0.7671.00
23_F241_A0.7671.00
153_G344_Y0.7641.00
60_L64_L0.7631.00
204_S207_P0.7621.00
169_K172_I0.7621.00
415_V425_G0.7601.00
358_L362_N0.7591.00
194_R201_I0.7581.00
20_K164_V0.7541.00
422_I426_F0.7541.00
111_L339_L0.7541.00
362_N366_I0.7511.00
409_T412_K0.7501.00
326_Y330_L0.7481.00
391_I394_F0.7471.00
389_V392_G0.7461.00
374_L392_G0.7441.00
67_L243_I0.7431.00
419_F426_F0.7421.00
375_V379_S0.7381.00
94_L97_R0.7361.00
122_A145_Q0.7351.00
430_E433_E0.7331.00
255_F259_S0.7331.00
421_W424_L0.7321.00
35_A39_S0.7311.00
379_S389_V0.7311.00
46_V55_A0.7291.00
158_S161_L0.7281.00
415_V434_I0.7281.00
399_S405_Y0.7281.00
146_W344_Y0.7261.00
121_G293_G0.7261.00
398_V407_L0.7251.00
57_F61_I0.7251.00
27_F241_A0.7211.00
278_G281_G0.7191.00
410_F414_I0.7191.00
194_R200_P0.7191.00
57_F209_L0.7171.00
338_S341_A0.7171.00
279_L283_L0.7161.00
424_L427_I0.7151.00
40_L44_G0.7141.00
415_V420_G0.7131.00
33_G299_T0.7071.00
156_A301_I0.7051.00
248_F252_I0.7051.00
425_G429_A0.7021.00
280_I283_L0.7011.00
97_R101_N0.7011.00
73_I370_A0.6981.00
198_Y262_A0.6971.00
248_F255_F0.6961.00
417_L421_W0.6951.00
320_G335_F0.6941.00
190_L255_F0.6931.00
39_S44_G0.6891.00
429_A433_E0.6881.00
160_V302_L0.6851.00
424_L428_Y0.6811.00
39_S43_F0.6811.00
34_Q245_V0.6781.00
36_P253_A0.6761.00
122_A125_L0.6761.00
160_V333_L0.6761.00
429_A432_L0.6751.00
263_M272_Y0.6741.00
221_T367_H0.6741.00
420_G427_I0.6731.00
32_G175_S0.6731.00
415_V428_Y0.6731.00
236_K239_G0.6711.00
427_I430_E0.6701.00
186_S256_F0.6671.00
196_N202_P0.6661.00
66_V223_Y0.6651.00
106_Y110_G0.6631.00
24_K169_K0.6631.00
124_V289_A0.6611.00
57_F60_L0.6611.00
110_G300_Y0.6611.00
418_F422_I0.6601.00
94_L373_S0.6601.00
36_P39_S0.6591.00
416_Y428_Y0.6591.00
168_A172_I0.6561.00
396_S407_L0.6551.00
273_L277_F0.6541.00
127_T286_A0.6531.00
87_Y91_F0.6521.00
308_L335_F0.6501.00
55_A257_F0.6491.00
109_Y363_N0.6491.00
56_P60_L0.6491.00
419_F428_Y0.6491.00
43_F46_V0.6471.00
35_A178_E0.6471.00
203_S208_T0.6461.00
419_F429_A0.6461.00
150_L345_T0.6461.00
239_G242_A0.6451.00
112_A358_L0.6441.00
113_Y359_A0.6431.00
377_I382_A0.6431.00
373_S377_I0.6431.00
17_T20_K0.6411.00
111_L336_I0.6381.00
210_I405_Y0.6371.00
312_A321_L0.6371.00
321_L332_G0.6321.00
76_L89_Y0.6321.00
425_G430_E0.6301.00
421_W428_Y0.6281.00
161_L333_L0.6271.00
125_L152_I0.6261.00
419_F431_A0.6251.00
405_Y409_T0.6251.00
188_L192_D0.6241.00
327_S330_L0.6231.00
78_G385_H0.6231.00
143_Y146_W0.6231.00
423_I430_E0.6231.00
93_S377_I0.6221.00
395_A398_V0.6211.00
156_A294_T0.6191.00
74_Y78_G0.6191.00
43_F257_F0.6181.00
65_V398_V0.6171.00
20_K24_K0.6171.00
234_N239_G0.6161.00
79_R382_A0.6161.00
59_M219_I0.6151.00
416_Y423_I0.6151.00
416_Y432_L0.6131.00
305_S332_G0.6111.00
87_Y99_G0.6111.00
105_N365_F0.6111.00
27_F30_S0.6101.00
105_N366_I0.6101.00
87_Y103_G0.6101.00
301_I305_S0.6081.00
399_S407_L0.6071.00
154_I157_T0.6061.00
56_P254_T0.6061.00
164_V229_L0.6041.00
395_A410_F0.6031.00
269_L273_L0.6031.00
166_V169_K0.6011.00
31_F175_S0.6011.00
77_S227_A0.6011.00
93_S376_R0.6001.00
76_L93_S0.5991.00
428_Y433_E0.5981.00
273_L278_G0.5981.00
287_L291_S0.5971.00
119_T355_L0.5951.00
61_I213_V0.5931.00
418_F428_Y0.5931.00
416_Y422_I0.5921.00
417_L422_I0.5901.00
146_W149_A0.5881.00
97_R430_E0.5881.00
399_S406_S0.5871.00
54_Q202_P0.5871.00
420_G430_E0.5851.00
188_L278_G0.5851.00
128_I286_A0.5851.00
377_I381_R0.5851.00
86_Y224_G0.5841.00
70_G223_Y0.5841.00
33_G300_Y0.5831.00
231_G309_K0.5811.00
421_W429_A0.5801.00
83_G309_K0.5801.00
113_Y116_T0.5801.00
415_V422_I0.5791.00
79_R385_H0.5791.00
418_F429_A0.5781.00
168_A298_M0.5771.00
181_I284_V0.5771.00
115_G343_T0.5761.00
348_L354_I0.5751.00
221_T224_G0.5751.00
227_A242_A0.5741.00
306_R309_K0.5731.00
233_T238_I0.5731.00
375_V392_G0.5711.00
386_L389_V0.5711.00
228_P303_A0.5691.00
152_I297_G0.5681.00
330_L333_L0.5661.00
153_G341_A0.5661.00
423_I431_A0.5641.00
244_S247_L0.5641.00
115_G355_L0.5621.00
194_R262_A0.5611.00
329_L332_G0.5591.00
36_P40_L0.5581.00
85_G227_A0.5571.00
45_T353_T0.5571.00
77_S238_I0.5561.00
172_I176_I0.5561.00
121_G125_L0.5551.00
375_V389_V0.5541.00
95_T99_G0.5541.00
180_L183_S0.5521.00
75_S79_R0.5511.00
167_S302_L0.5511.00
42_T356_G0.5511.00
253_A257_F0.5501.00
418_F423_I0.5501.00
145_Q149_A0.5491.00
47_M51_V0.5491.00
117_L297_G0.5491.00
177_V288_I0.5481.00
406_S410_F0.5481.00
39_S256_F0.5471.00
273_L276_R0.5471.00
304_N308_L0.5451.00
152_I294_T0.5451.00
177_V181_I0.5411.00
342_M345_T0.5401.00
423_I426_F0.5401.00
62_A220_P0.5391.00
335_F339_L0.5391.00
51_V54_Q0.5391.00
425_G433_E0.5391.00
120_G124_V0.5371.00
256_F259_S0.5371.00
59_M257_F0.5371.00
292_D295_L0.5341.00
426_F429_A0.5331.00
110_G303_A0.5321.00
43_F47_M0.5301.00
17_T83_G0.5291.00
86_Y228_P0.5291.00
24_K27_F0.5241.00
195_W202_P0.5241.00
406_S411_N0.5231.00
128_I287_L0.5221.00
44_G47_M0.5211.00
50_K53_T0.5211.00
70_G74_Y0.5201.00
405_Y408_P0.5191.00
175_S178_E0.5191.00
151_I154_I0.5191.00
242_A245_V0.5181.00
90_A99_G0.5181.00
416_Y431_A0.5181.00
259_S262_A0.5181.00
353_T356_G0.5161.00
16_K19_K0.5151.00
163_G166_V0.5141.00
320_G324_V0.5131.00
396_S406_S0.5121.00
396_S403_F0.5111.00
388_E398_V0.5111.00
173_G176_I0.5111.00
425_G432_L0.5101.00
62_A217_L0.5101.00
109_Y362_N0.5101.00
232_E329_L0.5101.00
415_V423_I0.5101.00
166_V170_Y0.5091.00
117_L293_G0.5081.00
39_S182_I0.5071.00
58_A61_I0.5061.00
206_T210_I0.5061.00
86_Y370_A0.5051.00
284_V288_I0.5051.00
75_S389_V0.5031.00
371_N399_S0.5021.00
248_F251_L0.5021.00
22_T165_Q0.5011.00
264_N275_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.9305 100 0.355 Contact Map
3l1lA 2 0.917 100 0.357 Contact Map
4djkA 2 0.8857 100 0.423 Contact Map
2jlnA 1 0.9126 99 0.848 Contact Map
3dh4A 3 0.8969 98.8 0.86 Contact Map
2xq2A 2 0.9036 98.6 0.867 Contact Map
2a65A 2 0.9283 97.6 0.897 Contact Map
4xp4A 1 0.935 97.5 0.9 Contact Map
4us3A 1 0.8386 96.9 0.909 Contact Map
4wgvA 2 0.7937 96.8 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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