GREMLIN Database
Q97YN2 - Uncharacterized protein
UniProt: Q97YN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (157)
Sequences: 2927 (2077)
Seq/√Len: 165.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_I136_K3.3381.00
103_M132_A3.0781.00
114_A146_A2.9221.00
135_D138_K2.8861.00
160_F167_L2.8351.00
31_K47_L2.5611.00
46_Y160_F2.3951.00
89_V105_S2.3321.00
143_R165_E2.3181.00
84_V87_N2.2631.00
136_K140_K2.2611.00
52_F167_L2.1881.00
30_S55_L2.1521.00
163_V166_V2.1321.00
48_K69_D2.1121.00
46_Y163_V2.1071.00
122_A126_L2.0141.00
47_L163_V2.0021.00
34_G101_A1.9531.00
46_Y49_D1.9521.00
112_E165_E1.9341.00
36_G58_D1.8611.00
127_K131_Q1.8291.00
99_T128_R1.8271.00
45_R49_D1.8231.00
110_A113_I1.6981.00
103_M107_Y1.6181.00
33_T44_A1.6111.00
85_K109_G1.5821.00
89_V110_A1.5791.00
126_L139_L1.5721.00
31_K166_V1.5621.00
103_M134_I1.5311.00
122_A144_I1.4881.00
90_I146_A1.4541.00
102_I115_V1.3941.00
168_A172_G1.3761.00
126_L130_I1.3751.00
138_K141_K1.3701.00
74_G78_Q1.3641.00
152_A171_R1.3511.00
43_I90_I1.3431.00
42_F156_K1.3371.00
50_L163_V1.3241.00
126_L142_L1.2911.00
165_E168_A1.2801.00
143_R169_V1.2721.00
61_A71_V1.2581.00
53_H70_E1.2511.00
59_P94_R1.2501.00
30_S53_H1.2491.00
52_F88_Y1.2301.00
32_C83_V1.2291.00
83_V89_V1.2261.00
110_A141_K1.2111.00
31_K90_I1.2101.00
51_G156_K1.1991.00
105_S113_I1.1941.00
56_V66_Y1.1901.00
120_K124_V1.1731.00
113_I142_L1.1691.00
31_K88_Y1.1231.00
88_Y170_T1.1211.00
39_V116_I1.1151.00
44_A56_V1.1091.00
106_I134_I1.0951.00
50_L160_F1.0871.00
123_E127_K1.0851.00
99_T132_A1.0811.00
115_V122_A1.0690.99
93_T98_D1.0670.99
59_P97_Y1.0660.99
83_V87_N1.0640.99
30_S87_N1.0630.99
43_I162_I1.0570.99
102_I142_L1.0530.99
52_F170_T1.0520.99
108_G141_K1.0370.99
126_L140_K1.0230.99
20_C23_D1.0110.99
39_V118_S1.0050.99
34_G89_V0.9980.99
62_E65_Y0.9960.99
115_V125_I0.9720.99
122_A142_L0.9670.99
88_Y111_K0.9670.99
45_R67_E0.9490.99
44_A54_V0.9470.99
53_H69_D0.9280.99
91_V102_I0.9270.99
42_F45_R0.9150.98
60_F65_Y0.9130.98
77_F100_W0.9110.98
43_I163_V0.9060.98
74_G80_P0.9060.98
95_H121_R0.9040.98
105_S110_A0.9040.98
43_I92_A0.8980.98
107_Y134_I0.8900.98
30_S84_V0.8890.98
32_C89_V0.8830.98
88_Y112_E0.8780.98
99_T103_M0.8770.98
37_I146_A0.8750.98
42_F46_Y0.8690.98
83_V110_A0.8680.98
134_I138_K0.8660.98
137_E140_K0.8590.98
39_V92_A0.8570.98
32_C87_N0.8570.98
31_K52_F0.8540.97
39_V158_I0.8490.97
167_L171_R0.8490.97
29_A170_T0.8470.97
152_A157_E0.8460.97
94_R117_M0.8450.97
32_C57_V0.8340.97
29_A88_Y0.8340.97
28_D51_G0.8270.97
47_L54_V0.8250.97
148_L161_S0.8180.97
32_C55_L0.8080.96
62_E66_Y0.8070.96
107_Y138_K0.8020.96
95_H99_T0.8010.96
47_L51_G0.8000.96
164_A168_A0.7960.96
92_A118_S0.7870.96
115_V144_I0.7870.96
114_A166_V0.7810.96
75_T78_Q0.7750.96
154_N157_E0.7740.96
113_I134_I0.7650.95
121_R125_I0.7580.95
31_K163_V0.7580.95
91_V105_S0.7490.95
149_D174_M0.7490.95
41_P45_R0.7490.95
33_T40_A0.7490.95
95_H125_I0.7400.94
150_I158_I0.7400.94
49_D156_K0.7370.94
33_T43_I0.7330.94
148_L165_E0.7270.94
91_V115_V0.7190.93
55_L70_E0.7130.93
94_R116_I0.7110.93
129_L139_L0.7090.93
74_G79_I0.7070.93
92_A116_I0.7060.93
116_I146_A0.7040.93
20_C25_V0.6950.92
160_F164_A0.6890.92
97_Y125_I0.6840.92
95_H116_I0.6800.91
38_N121_R0.6780.91
58_D93_T0.6740.91
41_P65_Y0.6730.91
55_L72_I0.6730.91
112_E146_A0.6720.91
95_H128_R0.6700.91
91_V146_A0.6690.91
98_D101_A0.6660.91
165_E169_V0.6640.90
104_K108_G0.6590.90
46_Y156_K0.6570.90
149_D173_S0.6510.90
124_V128_R0.6450.89
102_I113_I0.6450.89
157_E167_L0.6430.89
42_F49_D0.6430.89
133_G139_L0.6430.89
157_E171_R0.6420.89
33_T54_V0.6380.89
150_I157_E0.6370.88
123_E126_L0.6360.88
92_A117_M0.6350.88
101_A121_R0.6320.88
20_C24_T0.6290.88
172_G175_G0.6280.88
115_V121_R0.6280.88
121_R144_I0.6250.88
48_K67_E0.6250.88
149_D175_G0.6240.87
39_V95_H0.6200.87
100_W132_A0.6150.87
60_F94_R0.6150.87
46_Y50_L0.6130.87
56_V71_V0.6120.86
166_V170_T0.6060.86
60_F64_S0.6050.86
61_A65_Y0.6020.86
48_K68_A0.6010.85
148_L151_G0.5990.85
130_I139_L0.5930.85
32_C81_D0.5930.85
21_D27_V0.5820.84
92_A146_A0.5810.84
90_I166_V0.5790.83
37_I95_H0.5730.83
114_A117_M0.5720.83
118_S122_A0.5700.82
100_W103_M0.5690.82
69_D74_G0.5600.81
45_R156_K0.5600.81
91_V98_D0.5600.81
26_K29_A0.5580.81
169_V172_G0.5580.81
52_F171_R0.5560.81
94_R97_Y0.5540.81
65_Y71_V0.5520.80
139_L142_L0.5520.80
19_F22_R0.5470.80
98_D155_E0.5470.80
76_T94_R0.5460.80
152_A158_I0.5410.79
22_R27_V0.5390.79
54_V69_D0.5380.79
66_Y71_V0.5370.78
109_G141_K0.5360.78
70_E73_K0.5360.78
39_V121_R0.5340.78
69_D73_K0.5320.78
116_I144_I0.5310.78
60_F66_Y0.5270.77
155_E167_L0.5220.77
124_V127_K0.5210.76
146_A162_I0.5190.76
150_I161_S0.5190.76
106_I138_K0.5180.76
52_F160_F0.5090.75
151_G172_G0.5080.75
100_W104_K0.5040.74
130_I135_D0.5040.74
69_D72_I0.5040.74
86_D120_K0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2we8A 2 0.9005 100 0.151 Contact Map
3on5A 4 0.9372 100 0.256 Contact Map
3fwzA 2 0.6911 96.5 0.876 Contact Map
1id1A 2 0.712 96.1 0.881 Contact Map
3l9wA 2 0.8115 96.1 0.881 Contact Map
2g1uA 2 0.6649 96 0.882 Contact Map
3ic5A 1 0.5759 95.4 0.887 Contact Map
3llvA 2 0.6545 95.3 0.888 Contact Map
3q2oA 2 0.8063 95.2 0.889 Contact Map
1lssA 3 0.644 94.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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