GREMLIN Database
Q97YM8 - Uncharacterized protein
UniProt: Q97YM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (212)
Sequences: 5250 (3033)
Seq/√Len: 208.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_A118_I4.6441.00
191_G194_Q4.1911.00
193_I196_E3.9771.00
31_Y116_V3.7291.00
189_Q198_N3.6901.00
207_V211_D3.5751.00
34_L114_Y3.2391.00
20_A35_Y2.6281.00
77_T112_K2.5151.00
21_L48_L2.4571.00
3_I147_T2.4551.00
78_L83_S2.4331.00
207_V220_K2.4301.00
27_L118_I2.3701.00
45_S82_Y2.3691.00
217_F220_K2.3351.00
27_L116_V2.1731.00
48_L78_L2.1701.00
199_Q203_E2.0891.00
188_P197_I2.0391.00
98_M130_P2.0181.00
154_T206_E2.0071.00
190_I197_I1.9641.00
34_L117_I1.9601.00
208_V212_I1.9491.00
21_L44_G1.9171.00
41_L128_N1.9091.00
50_F78_L1.8461.00
226_N229_E1.8371.00
21_L47_I1.8211.00
165_V212_I1.7991.00
169_L173_N1.7771.00
62_G66_E1.7481.00
208_V211_D1.7321.00
152_G164_V1.7101.00
17_T47_I1.7101.00
152_G168_F1.6931.00
47_I159_N1.6871.00
19_I153_I1.6351.00
7_I118_I1.6121.00
46_L162_T1.5691.00
194_Q198_N1.5681.00
18_T227_M1.5531.00
43_M163_D1.4871.00
63_L66_E1.4821.00
104_R108_D1.4721.00
62_G67_Q1.4621.00
32_K113_G1.4161.00
189_Q192_D1.4121.00
90_E169_L1.4071.00
209_K212_I1.4061.00
26_Y30_R1.3931.00
24_A118_I1.3901.00
209_K213_L1.3891.00
38_K119_V1.3831.00
193_I198_N1.3701.00
25_L29_K1.3691.00
79_F109_V1.3631.00
27_L33_V1.3531.00
101_K105_A1.3511.00
77_T114_Y1.3091.00
114_Y117_I1.2941.00
19_I183_V1.2911.00
72_V75_N1.2891.00
207_V217_F1.2841.00
8_I121_Y1.2551.00
62_G65_N1.2531.00
50_F83_S1.2471.00
8_I167_Y1.2461.00
5_V180_L1.2451.00
204_I207_V1.2361.00
186_M223_Q1.2351.00
72_V77_T1.2311.00
189_Q200_I1.2161.00
154_T160_D1.2121.00
81_L84_D1.2011.00
99_G133_Y1.1891.00
149_A180_L1.1861.00
17_T44_G1.1841.00
121_Y131_L1.1811.00
25_L74_N1.1711.00
48_L76_L1.1551.00
36_I119_V1.1511.00
97_G100_E1.1441.00
93_H101_K1.1401.00
79_F83_S1.1361.00
149_A178_K1.1291.00
32_K115_D1.1291.00
6_D121_Y1.1281.00
225_A228_G1.1191.00
3_I149_A1.1131.00
206_E217_F1.0981.00
72_V76_L1.0791.00
187_V220_K1.0581.00
71_K77_T1.0561.00
19_I221_L1.0371.00
162_T166_K1.0371.00
86_V89_R1.0351.00
146_Y149_A1.0191.00
92_Q171_T1.0171.00
168_F213_L1.0111.00
90_E93_H1.0001.00
25_L76_L1.0001.00
188_P199_Q0.9981.00
89_R169_L0.9921.00
150_A172_I0.9861.00
61_E66_E0.9771.00
88_E165_V0.9701.00
35_Y44_G0.9691.00
197_I200_I0.9661.00
200_I223_Q0.9571.00
3_I31_Y0.9540.99
58_A63_L0.9490.99
6_D146_Y0.9440.99
28_S76_L0.9310.99
60_V64_G0.9270.99
192_D198_N0.9260.99
103_E107_V0.9250.99
89_R174_R0.9200.99
36_I117_I0.9190.99
197_I220_K0.9020.99
191_G198_N0.8990.99
224_Y227_M0.8920.99
102_A105_A0.8920.99
173_N214_T0.8890.99
63_L67_Q0.8860.99
79_F84_D0.8840.99
204_I208_V0.8820.99
7_I23_T0.8710.99
158_R161_V0.8680.99
206_E209_K0.8670.99
3_I116_V0.8610.99
64_G67_Q0.8600.99
199_Q202_R0.8560.99
28_S74_N0.8520.99
119_V139_F0.8390.99
155_D186_M0.8390.99
26_Y29_K0.8380.99
184_I187_V0.8340.99
93_H97_G0.8340.99
102_A130_P0.8290.99
206_E210_C0.8260.99
99_G142_N0.8240.99
22_N25_L0.8170.98
20_A44_G0.8120.98
90_E94_K0.8110.98
94_K98_M0.8090.98
192_D196_E0.8030.98
23_T151_A0.8010.98
97_G101_K0.7990.98
22_N26_Y0.7990.98
154_T182_F0.7970.98
59_I66_E0.7960.98
165_V213_L0.7950.98
25_L48_L0.7900.98
46_L51_N0.7850.98
210_C217_F0.7850.98
100_E103_E0.7840.98
168_F179_P0.7830.98
19_I23_T0.7830.98
8_I172_I0.7790.98
44_G78_L0.7760.98
103_E142_N0.7680.98
205_S208_V0.7630.98
100_E105_A0.7540.97
162_T169_L0.7530.97
182_F215_I0.7520.97
60_V63_L0.7520.97
17_T43_M0.7510.97
129_D132_V0.7480.97
5_V116_V0.7460.97
196_E199_Q0.7460.97
225_A229_E0.7460.97
4_R119_V0.7430.97
140_K177_A0.7410.97
58_A61_E0.7410.97
5_V151_A0.7340.97
12_G15_G0.7330.97
95_V129_D0.7300.97
169_L213_L0.7300.97
46_L158_R0.7290.97
204_I217_F0.7260.97
91_L94_K0.7170.96
60_V67_Q0.7120.96
207_V210_C0.7110.96
158_R162_T0.7080.96
218_N222_V0.7070.96
10_L167_Y0.7030.96
72_V78_L0.6990.96
155_D163_D0.6990.96
69_E72_V0.6900.96
59_I79_F0.6880.96
133_Y141_K0.6870.95
99_G103_E0.6810.95
149_A181_A0.6810.95
73_N77_T0.6800.95
121_Y160_D0.6790.95
139_F142_N0.6780.95
188_P220_K0.6770.95
121_Y167_Y0.6740.95
94_K97_G0.6730.95
128_N131_L0.6720.95
140_K175_I0.6700.95
18_T47_I0.6680.95
191_G195_K0.6580.94
197_I201_V0.6550.94
60_V66_E0.6550.94
92_Q132_V0.6490.94
4_R147_T0.6460.94
90_E95_V0.6450.94
210_C216_P0.6430.94
12_G16_K0.6400.93
190_I194_Q0.6400.93
24_A76_L0.6400.93
119_V143_F0.6380.93
200_I204_I0.6380.93
6_D177_A0.6380.93
51_N87_N0.6370.93
131_L139_F0.6360.93
98_M105_A0.6350.93
82_Y86_V0.6320.93
198_N202_R0.6320.93
67_Q110_V0.6310.93
203_E220_K0.6280.93
201_V204_I0.6250.93
169_L174_R0.6230.93
61_E65_N0.6220.92
94_K129_D0.6200.92
221_L227_M0.6150.92
92_Q105_A0.6150.92
31_Y115_D0.6140.92
71_K75_N0.6130.92
13_G16_K0.6110.92
28_S75_N0.6080.92
41_L98_M0.6070.92
158_R165_V0.6070.92
182_F209_K0.6040.91
18_T163_D0.6030.91
25_L28_S0.6020.91
76_L80_K0.6010.91
205_S210_C0.6000.91
98_M171_T0.5970.91
8_I150_A0.5950.91
43_M157_I0.5900.90
151_A218_N0.5900.90
94_K105_A0.5850.90
94_K103_E0.5830.90
99_G131_L0.5830.90
173_N178_K0.5820.90
33_V38_K0.5810.90
22_N41_L0.5740.89
8_I152_G0.5730.89
46_L87_N0.5700.89
124_I163_D0.5700.89
49_G73_N0.5690.89
131_L167_Y0.5660.88
22_N163_D0.5650.88
181_A216_P0.5600.88
98_M101_K0.5590.88
74_N77_T0.5570.88
93_H108_D0.5560.88
42_S125_F0.5560.88
91_L98_M0.5550.88
184_I220_K0.5540.87
43_M159_N0.5530.87
150_A163_D0.5530.87
160_D163_D0.5520.87
106_Y143_F0.5520.87
38_K102_A0.5480.87
144_P147_T0.5470.87
184_I204_I0.5450.87
156_A187_V0.5440.86
88_E209_K0.5440.86
28_S33_V0.5410.86
59_I67_Q0.5360.86
33_V116_V0.5340.85
218_N227_M0.5340.85
206_E216_P0.5330.85
59_I62_G0.5320.85
105_A109_V0.5320.85
199_Q220_K0.5290.85
198_N225_A0.5270.85
38_K139_F0.5270.85
191_G196_E0.5270.85
8_I23_T0.5240.84
60_V65_N0.5240.84
23_T27_L0.5240.84
150_A177_A0.5230.84
155_D160_D0.5230.84
97_G104_R0.5230.84
32_K214_T0.5220.84
41_L130_P0.5220.84
96_K105_A0.5220.84
187_V204_I0.5220.84
163_D172_I0.5200.84
28_S73_N0.5200.84
154_T209_K0.5200.84
103_E109_V0.5190.84
95_V98_M0.5190.84
42_S123_R0.5160.83
66_E110_V0.5160.83
203_E229_E0.5150.83
33_V118_I0.5140.83
224_Y229_E0.5130.83
32_K112_K0.5130.83
10_L164_V0.5100.83
43_M130_P0.5090.83
98_M102_A0.5090.83
21_L78_L0.5060.82
4_R106_Y0.5060.82
197_I203_E0.5050.82
6_D119_V0.5050.82
92_Q95_V0.5050.82
37_D42_S0.5050.82
11_K16_K0.5040.82
110_V113_G0.5010.82
158_R166_K0.5010.82
11_K15_G0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wojA 2 0.9271 100 0.445 Contact Map
3io3A 2 0.7611 100 0.445 Contact Map
3iqwA 2 0.8704 100 0.448 Contact Map
2wooA 5 0.9636 100 0.46 Contact Map
3ug7A 4 0.9595 100 0.494 Contact Map
3zq6A 2 0.9312 100 0.494 Contact Map
3igfA 2 0.8745 100 0.504 Contact Map
2ph1A 2 0.9312 100 0.506 Contact Map
1ihuA 3 0.8704 100 0.507 Contact Map
5aunB 2 0.8543 100 0.521 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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