GREMLIN Database
Q97YL9 - Mandelate racemase /muconate lactonizing enzyme related protein (MR/MLE)
UniProt: Q97YL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 383 (327)
Sequences: 12053 (7053)
Seq/√Len: 390.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_L107_L3.5821.00
285_R289_S3.4861.00
155_K368_Y3.3961.00
264_S292_R3.2591.00
229_N232_F3.1761.00
261_S265_K3.0041.00
100_R103_M2.9621.00
256_D259_S2.7221.00
284_K288_D2.4821.00
238_R241_E2.4601.00
83_N87_S2.3611.00
262_Y265_K2.3491.00
66_L135_A2.3271.00
280_V306_P2.2931.00
238_R266_R2.2661.00
176_R213_S2.2521.00
237_A248_I2.2311.00
241_E268_D2.1961.00
129_N305_T2.1961.00
176_R180_E2.1771.00
102_N309_R2.1631.00
287_L319_G2.1271.00
219_D246_S2.1261.00
262_Y266_R2.1111.00
70_V135_A2.1031.00
261_S289_S2.0991.00
301_V310_I2.0151.00
365_I370_E2.0001.00
293_I320_V1.9941.00
66_L70_V1.9931.00
205_E208_K1.9741.00
65_D71_T1.9531.00
157_R184_A1.9351.00
258_E289_S1.9221.00
234_L266_R1.9041.00
237_A267_T1.9001.00
239_R242_K1.8941.00
104_V132_M1.8611.00
208_K243_Y1.8581.00
137_A144_V1.8501.00
168_K172_E1.8411.00
328_I332_H1.8391.00
96_L103_M1.8161.00
283_F310_I1.8111.00
236_M240_L1.8081.00
142_V146_E1.7831.00
167_S170_E1.7661.00
313_L317_Y1.7451.00
143_P146_E1.7101.00
172_E213_S1.6931.00
288_D317_Y1.6811.00
182_G186_M1.6641.00
312_G315_E1.6121.00
231_N262_Y1.6121.00
176_R179_V1.6101.00
61_F282_D1.5941.00
173_K176_R1.5901.00
204_V239_R1.5541.00
286_L291_V1.5341.00
209_V212_D1.5201.00
287_L313_L1.5201.00
208_K212_D1.5141.00
88_N119_G1.5141.00
252_L263_L1.5091.00
155_K370_E1.5021.00
202_K205_E1.4881.00
230_L262_Y1.4761.00
179_V218_V1.4751.00
308_K312_G1.4541.00
63_R71_T1.4471.00
230_L263_L1.4461.00
335_I371_L1.4421.00
90_A94_R1.4401.00
182_G188_M1.4241.00
129_N133_Y1.4211.00
82_C86_M1.4181.00
144_V377_F1.4171.00
234_L262_Y1.4061.00
99_S139_L1.4061.00
70_V139_L1.3991.00
177_S181_E1.3811.00
211_R215_G1.3751.00
151_K154_D1.3711.00
162_H203_N1.3671.00
284_K313_L1.3611.00
199_G202_K1.3551.00
208_K242_K1.3471.00
230_L259_S1.3391.00
177_S180_E1.3391.00
205_E209_V1.3341.00
222_G245_L1.3331.00
287_L317_Y1.3291.00
272_S293_I1.3251.00
170_E173_K1.3201.00
80_S83_N1.3161.00
134_D138_K1.3031.00
285_R288_D1.2931.00
134_D329_Y1.2921.00
235_K239_R1.2891.00
137_A147_L1.2851.00
106_D110_R1.2831.00
173_K177_S1.2821.00
103_M107_L1.2811.00
235_K238_R1.2811.00
221_A247_W1.2771.00
130_L304_I1.2751.00
142_V147_L1.2711.00
306_P309_R1.2681.00
96_L104_V1.2671.00
221_A246_S1.2621.00
136_Y140_L1.2571.00
252_L259_S1.2541.00
166_T170_E1.2501.00
283_F294_L1.2431.00
62_I127_V1.2411.00
238_R268_D1.2391.00
311_T337_E1.2281.00
204_V243_Y1.2191.00
48_L53_S1.2111.00
234_L263_L1.2061.00
64_M132_M1.2031.00
66_L139_L1.2031.00
108_L125_I1.2031.00
157_R368_Y1.2011.00
261_S290_G1.1941.00
232_F235_K1.1921.00
214_V220_L1.1901.00
309_R312_G1.1871.00
60_C255_D1.1791.00
251_P271_I1.1781.00
251_P263_L1.1701.00
186_M218_V1.1661.00
75_L127_V1.1611.00
213_S216_Y1.1581.00
282_D285_R1.1561.00
189_R225_W1.1511.00
88_N91_D1.1381.00
280_V313_L1.1351.00
279_H282_D1.1331.00
204_V208_K1.1301.00
360_N374_E1.1231.00
241_E269_I1.1231.00
87_S91_D1.1181.00
63_R72_Y1.1101.00
294_L314_A1.1091.00
224_A248_I1.1071.00
329_Y333_F1.1071.00
210_I214_V1.0991.00
174_E177_S1.0961.00
133_Y305_T1.0951.00
175_A179_V1.0911.00
332_H338_P1.0901.00
189_R192_C1.0891.00
312_G316_A1.0891.00
233_A237_A1.0841.00
182_G187_K1.0791.00
273_A286_L1.0731.00
307_M333_F1.0721.00
329_Y332_H1.0631.00
309_R315_E1.0581.00
313_L316_A1.0531.00
102_N308_K1.0521.00
308_K337_E1.0511.00
263_L271_I1.0461.00
99_S136_Y1.0441.00
228_W236_M1.0411.00
272_S295_Q1.0401.00
183_Y188_M1.0371.00
207_V243_Y1.0371.00
188_M210_I1.0361.00
323_P339_E1.0341.00
298_A307_M1.0331.00
89_L128_I1.0301.00
68_D71_T1.0291.00
97_P100_R1.0261.00
175_A186_M1.0251.00
328_I333_F1.0241.00
182_G185_A1.0191.00
140_L147_L1.0141.00
228_W233_A1.0051.00
101_I136_Y1.0041.00
211_R220_L1.0021.00
161_S164_H0.9921.00
184_A187_K0.9911.00
169_D173_K0.9891.00
182_G218_V0.9831.00
284_K317_Y0.9811.00
65_D68_D0.9811.00
255_D282_D0.9791.00
191_C203_N0.9761.00
148_L308_K0.9691.00
183_Y186_M0.9621.00
179_V186_M0.9601.00
61_F255_D0.9581.00
168_K205_E0.9531.00
297_D324_H0.9461.00
201_D205_E0.9441.00
175_A214_V0.9431.00
172_E212_D0.9421.00
99_S140_L0.9371.00
105_W109_Y0.9361.00
181_E186_M0.9351.00
301_V307_M0.9341.00
200_V204_V0.9331.00
245_L269_I0.9321.00
352_K356_D0.9271.00
92_L107_L0.9231.00
204_V214_V0.9211.00
68_D139_L0.9171.00
250_E295_Q0.9081.00
70_V138_K0.9051.00
332_H339_E0.9051.00
258_E261_S0.9041.00
328_I331_L0.9041.00
207_V240_L0.9021.00
172_E214_V0.8991.00
330_N333_F0.8941.00
200_V236_M0.8941.00
146_E373_E0.8921.00
230_L234_L0.8911.00
185_A221_A0.8891.00
105_W129_N0.8881.00
343_P346_E0.8871.00
79_E83_N0.8841.00
104_V108_L0.8811.00
168_K209_V0.8811.00
224_A237_A0.8791.00
77_T80_S0.8791.00
201_D239_R0.8731.00
252_L260_Y0.8721.00
204_V242_K0.8711.00
148_L336_S0.8701.00
287_L294_L0.8671.00
172_E176_R0.8621.00
259_S262_Y0.8611.00
144_V304_I0.8581.00
136_Y147_L0.8581.00
258_E285_R0.8551.00
207_V222_G0.8541.00
257_F290_G0.8511.00
178_Y181_E0.8451.00
214_V218_V0.8441.00
311_T321_V0.8441.00
96_L100_R0.8411.00
209_V213_S0.8381.00
233_A252_L0.8371.00
87_S90_A0.8371.00
278_Y282_D0.8351.00
291_V294_L0.8341.00
211_R217_S0.8301.00
311_T323_P0.8281.00
280_V309_R0.8271.00
241_E267_T0.8241.00
185_A188_M0.8181.00
173_K180_E0.8171.00
133_Y304_I0.8151.00
153_R156_I0.8151.00
231_N235_K0.8131.00
311_T315_E0.8131.00
98_V136_Y0.8101.00
184_A188_M0.8091.00
328_I338_P0.8091.00
98_V132_M0.8081.00
273_A291_V0.8071.00
144_V148_L0.8061.00
67_D98_V0.8051.00
106_D309_R0.8031.00
67_D71_T0.8011.00
315_E338_P0.8001.00
145_Y371_L0.7921.00
181_E184_A0.7891.00
364_P369_F0.7851.00
329_Y338_P0.7831.00
224_A228_W0.7831.00
104_V107_L0.7821.00
175_A180_E0.7811.00
277_H283_F0.7811.00
92_L96_L0.7811.00
230_L252_L0.7781.00
61_F72_Y0.7751.00
76_E80_S0.7681.00
294_L319_G0.7661.00
46_G53_S0.7651.00
233_A263_L0.7631.00
260_Y273_A0.7631.00
84_F88_N0.7611.00
274_G297_D0.7581.00
181_E188_M0.7571.00
105_W108_L0.7561.00
181_E187_K0.7541.00
91_D94_R0.7531.00
141_G375_K0.7531.00
348_L351_Y0.7501.00
76_E79_E0.7501.00
140_L143_P0.7501.00
277_H282_D0.7501.00
296_P307_M0.7501.00
370_E373_E0.7421.00
298_A330_N0.7381.00
98_V139_L0.7371.00
93_V96_L0.7361.00
304_I308_K0.7361.00
264_S271_I0.7351.00
260_Y271_I0.7351.00
203_N228_W0.7261.00
106_D109_Y0.7231.00
174_E178_Y0.7221.00
211_R244_E0.7221.00
60_C227_S0.7211.00
234_L238_R0.7211.00
216_Y244_E0.7191.00
328_I339_E0.7161.00
294_L310_I0.7141.00
146_E151_K0.7141.00
228_W248_I0.7121.00
109_Y306_P0.7101.00
257_F285_R0.7091.00
363_K370_E0.7091.00
296_P311_T0.7041.00
173_K213_S0.7041.00
172_E175_A0.6961.00
234_L267_T0.6961.00
211_R216_Y0.6961.00
323_P334_I0.6961.00
283_F319_G0.6951.00
102_N305_T0.6920.99
89_L108_L0.6910.99
277_H286_L0.6880.99
76_E81_V0.6860.99
86_M90_A0.6850.99
66_L69_N0.6810.99
329_Y339_E0.6810.99
130_L329_Y0.6800.99
281_Y284_K0.6790.99
257_F286_L0.6780.99
105_W305_T0.6780.99
334_I340_S0.6760.99
155_K366_K0.6760.99
203_N206_L0.6750.99
328_I340_S0.6750.99
296_P321_V0.6740.99
144_V147_L0.6730.99
78_S81_V0.6710.99
358_M361_P0.6610.99
52_Q127_V0.6590.99
260_Y263_L0.6570.99
329_Y377_F0.6530.99
365_I368_Y0.6510.99
235_K266_R0.6500.99
133_Y144_V0.6460.99
345_A348_L0.6450.99
308_K336_S0.6440.99
185_A219_D0.6440.99
145_Y332_H0.6420.99
82_C85_V0.6410.99
188_M207_V0.6390.99
43_E46_G0.6390.99
280_V310_I0.6390.99
155_K365_I0.6380.99
125_I303_G0.6380.99
135_A139_L0.6360.99
136_Y139_L0.6330.99
160_A178_Y0.6320.99
137_A142_V0.6290.99
65_D72_Y0.6250.99
208_K213_S0.6240.99
295_Q324_H0.6220.99
160_A183_Y0.6200.99
107_L110_R0.6190.99
333_F338_P0.6180.99
172_E209_V0.6160.99
173_K178_Y0.6160.99
346_E349_T0.6130.99
175_A210_I0.6120.99
332_H340_S0.6100.99
148_L304_I0.6090.99
202_K206_L0.6080.99
353_W356_D0.6060.99
151_K373_E0.6060.99
336_S340_S0.6050.99
68_D98_V0.6040.99
67_D70_V0.6020.99
320_V343_P0.6010.99
184_A366_K0.5990.99
80_S84_F0.5970.99
101_I132_M0.5970.99
257_F289_S0.5930.98
314_A321_V0.5930.98
234_L252_L0.5920.98
304_I329_Y0.5920.98
133_Y148_L0.5880.98
198_L202_K0.5870.98
333_F339_E0.5850.98
314_A319_G0.5850.98
77_T84_F0.5840.98
344_M347_Y0.5810.98
93_V128_I0.5810.98
134_D328_I0.5810.98
247_W322_I0.5800.98
169_D172_E0.5800.98
173_K179_V0.5800.98
343_P347_Y0.5790.98
281_Y285_R0.5770.98
137_A375_K0.5770.98
102_N106_D0.5760.98
190_F228_W0.5760.98
315_E321_V0.5740.98
207_V220_L0.5720.98
250_E276_H0.5720.98
85_V90_A0.5720.98
283_F296_P0.5710.98
114_P117_R0.5700.98
75_L123_H0.5700.98
88_N92_L0.5700.98
263_L267_T0.5690.98
307_M323_P0.5680.98
176_R214_V0.5680.98
85_V128_I0.5670.98
186_M214_V0.5670.98
336_S339_E0.5640.98
175_A178_Y0.5630.98
109_Y125_I0.5620.98
291_V319_G0.5620.98
283_F314_A0.5610.98
250_E275_E0.5600.98
355_E359_I0.5600.98
308_K333_F0.5590.98
98_V135_A0.5580.98
64_M93_V0.5560.98
349_T352_K0.5560.98
101_I305_T0.5550.98
332_H337_E0.5540.98
290_G319_G0.5500.97
190_F224_A0.5480.97
237_A269_I0.5480.97
299_V326_S0.5480.97
331_L372_G0.5460.97
250_E274_G0.5450.97
347_Y350_K0.5450.97
163_L171_L0.5450.97
97_P146_E0.5440.97
298_A333_F0.5430.97
236_M239_R0.5410.97
215_G218_V0.5400.97
137_A140_L0.5390.97
333_F336_S0.5370.97
103_M106_D0.5360.97
102_N154_D0.5360.97
246_S270_P0.5330.97
154_D373_E0.5330.97
298_A304_I0.5320.97
212_D216_Y0.5290.97
163_L175_A0.5290.97
207_V245_L0.5280.97
142_V150_G0.5280.97
345_A350_K0.5270.97
160_A322_I0.5270.97
74_I185_A0.5260.97
78_S82_C0.5260.97
172_E210_I0.5260.97
45_L139_L0.5260.97
333_F337_E0.5250.97
267_T271_I0.5250.97
156_I159_Y0.5250.97
204_V207_V0.5250.97
92_L111_Y0.5220.97
79_E87_S0.5210.97
145_Y373_E0.5210.97
162_H165_P0.5200.96
179_V214_V0.5170.96
116_G119_G0.5160.96
280_V284_K0.5150.96
157_R219_D0.5140.96
304_I333_F0.5140.96
321_V339_E0.5140.96
132_M136_Y0.5130.96
130_L299_V0.5120.96
201_D216_Y0.5120.96
84_F120_I0.5100.96
204_V240_L0.5070.96
158_A369_F0.5070.96
73_S127_V0.5070.96
264_S290_G0.5070.96
237_A240_L0.5070.96
138_K141_G0.5060.96
81_V84_F0.5050.96
171_L206_L0.5040.96
79_E82_C0.5020.96
332_H336_S0.5010.96
101_I104_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cyjA 5 0.9008 100 0.212 Contact Map
3dgbA 5 0.8982 100 0.227 Contact Map
3fcpA 5 0.859 100 0.228 Contact Map
3s5sA 2 0.8877 100 0.229 Contact Map
2pp0A 5 0.9556 100 0.229 Contact Map
3i4kA 4 0.893 100 0.232 Contact Map
3ugvA 5 0.8956 100 0.233 Contact Map
3u9iA 2 0.8747 100 0.235 Contact Map
3tj4A 5 0.8721 100 0.235 Contact Map
2og9A 5 0.8877 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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