Q97YL9 - SULSO - GREMLIN Contacts

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Q97YL9 - Mandelate racemase /muconate lactonizing enzyme related protein (MR/MLE)

UniProt:	Q97YL9	Sequences: MIKGCSDKCYSMTAKIDKIYVVTTERISRQNFPYVKPTDYYREYLGSLSPFQSAFMDKVCFIRMDLDDNVTYSILETSESVCNFVMSNLADLVRGLPVSRINMVWDLLYRYTLPIGRSGIAIHAISVINLLMYDAYAKLLGVPVYELLGGKARDKIRAYASHLHPTSKDELEKEARSYVEEGYAAMKMRFCCGPSDPLGVDKNVELVKVIRDSVGYSVDLAGDAWMSWNLNFALKMARRLEKYELSWIEEPLLPDDFESYSYLSKRTDIPISAGEHHYHVYDFKRLLDSGVRILQPDAVWVGGITPMKRITGLAEAYGGVVIPHTSNIYNLHFIISEPESVSPMAEYLTKYKWLEDRMINPPKPIKGYFELGEEKGFGLKYDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	383 (327)
Sequences:	12053 (7053)
Seq/√Len:	390.0

ECOLI - RHMD GUDX GUDD RSPA DGOD AEEP MENC
BACSU - GUDD AEEP YITF MENC
HALSA - Q9HS20 Q9HP25 Q9HQN7
SULSO - Q97YL9 GAD Q97VG1 ARAD Q97YR3 Q97UK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_L	107_L	3.582	1.00
285_R	289_S	3.486	1.00
155_K	368_Y	3.396	1.00
264_S	292_R	3.259	1.00
229_N	232_F	3.176	1.00
261_S	265_K	3.004	1.00
100_R	103_M	2.962	1.00
256_D	259_S	2.722	1.00
284_K	288_D	2.482	1.00
238_R	241_E	2.460	1.00
83_N	87_S	2.361	1.00
262_Y	265_K	2.349	1.00
66_L	135_A	2.327	1.00
280_V	306_P	2.293	1.00
238_R	266_R	2.266	1.00
176_R	213_S	2.252	1.00
237_A	248_I	2.231	1.00
241_E	268_D	2.196	1.00
129_N	305_T	2.196	1.00
176_R	180_E	2.177	1.00
102_N	309_R	2.163	1.00
287_L	319_G	2.127	1.00
219_D	246_S	2.126	1.00
262_Y	266_R	2.111	1.00
70_V	135_A	2.103	1.00
261_S	289_S	2.099	1.00
301_V	310_I	2.015	1.00
365_I	370_E	2.000	1.00
293_I	320_V	1.994	1.00
66_L	70_V	1.993	1.00
205_E	208_K	1.974	1.00
65_D	71_T	1.953	1.00
157_R	184_A	1.935	1.00
258_E	289_S	1.922	1.00
234_L	266_R	1.904	1.00
237_A	267_T	1.900	1.00
239_R	242_K	1.894	1.00
104_V	132_M	1.861	1.00
208_K	243_Y	1.858	1.00
137_A	144_V	1.850	1.00
168_K	172_E	1.841	1.00
328_I	332_H	1.839	1.00
96_L	103_M	1.816	1.00
283_F	310_I	1.811	1.00
236_M	240_L	1.808	1.00
142_V	146_E	1.783	1.00
167_S	170_E	1.766	1.00
313_L	317_Y	1.745	1.00
143_P	146_E	1.710	1.00
172_E	213_S	1.693	1.00
288_D	317_Y	1.681	1.00
182_G	186_M	1.664	1.00
312_G	315_E	1.612	1.00
231_N	262_Y	1.612	1.00
176_R	179_V	1.610	1.00
61_F	282_D	1.594	1.00
173_K	176_R	1.590	1.00
204_V	239_R	1.554	1.00
286_L	291_V	1.534	1.00
209_V	212_D	1.520	1.00
287_L	313_L	1.520	1.00
208_K	212_D	1.514	1.00
88_N	119_G	1.514	1.00
252_L	263_L	1.509	1.00
155_K	370_E	1.502	1.00
202_K	205_E	1.488	1.00
230_L	262_Y	1.476	1.00
179_V	218_V	1.475	1.00
308_K	312_G	1.454	1.00
63_R	71_T	1.447	1.00
230_L	263_L	1.446	1.00
335_I	371_L	1.442	1.00
90_A	94_R	1.440	1.00
182_G	188_M	1.424	1.00
129_N	133_Y	1.421	1.00
82_C	86_M	1.418	1.00
144_V	377_F	1.417	1.00
234_L	262_Y	1.406	1.00
99_S	139_L	1.406	1.00
70_V	139_L	1.399	1.00
177_S	181_E	1.381	1.00
211_R	215_G	1.375	1.00
151_K	154_D	1.371	1.00
162_H	203_N	1.367	1.00
284_K	313_L	1.361	1.00
199_G	202_K	1.355	1.00
208_K	242_K	1.347	1.00
230_L	259_S	1.339	1.00
177_S	180_E	1.339	1.00
205_E	209_V	1.334	1.00
222_G	245_L	1.333	1.00
287_L	317_Y	1.329	1.00
272_S	293_I	1.325	1.00
170_E	173_K	1.320	1.00
80_S	83_N	1.316	1.00
134_D	138_K	1.303	1.00
285_R	288_D	1.293	1.00
134_D	329_Y	1.292	1.00
235_K	239_R	1.289	1.00
137_A	147_L	1.285	1.00
106_D	110_R	1.283	1.00
173_K	177_S	1.282	1.00
103_M	107_L	1.281	1.00
235_K	238_R	1.281	1.00
221_A	247_W	1.277	1.00
130_L	304_I	1.275	1.00
142_V	147_L	1.271	1.00
306_P	309_R	1.268	1.00
96_L	104_V	1.267	1.00
221_A	246_S	1.262	1.00
136_Y	140_L	1.257	1.00
252_L	259_S	1.254	1.00
166_T	170_E	1.250	1.00
283_F	294_L	1.243	1.00
62_I	127_V	1.241	1.00
238_R	268_D	1.239	1.00
311_T	337_E	1.228	1.00
204_V	243_Y	1.219	1.00
48_L	53_S	1.211	1.00
234_L	263_L	1.206	1.00
64_M	132_M	1.203	1.00
66_L	139_L	1.203	1.00
108_L	125_I	1.203	1.00
157_R	368_Y	1.201	1.00
261_S	290_G	1.194	1.00
232_F	235_K	1.192	1.00
214_V	220_L	1.190	1.00
309_R	312_G	1.187	1.00
60_C	255_D	1.179	1.00
251_P	271_I	1.178	1.00
251_P	263_L	1.170	1.00
186_M	218_V	1.166	1.00
75_L	127_V	1.161	1.00
213_S	216_Y	1.158	1.00
282_D	285_R	1.156	1.00
189_R	225_W	1.151	1.00
88_N	91_D	1.138	1.00
280_V	313_L	1.135	1.00
279_H	282_D	1.133	1.00
204_V	208_K	1.130	1.00
360_N	374_E	1.123	1.00
241_E	269_I	1.123	1.00
87_S	91_D	1.118	1.00
63_R	72_Y	1.110	1.00
294_L	314_A	1.109	1.00
224_A	248_I	1.107	1.00
329_Y	333_F	1.107	1.00
210_I	214_V	1.099	1.00
174_E	177_S	1.096	1.00
133_Y	305_T	1.095	1.00
175_A	179_V	1.091	1.00
332_H	338_P	1.090	1.00
189_R	192_C	1.089	1.00
312_G	316_A	1.089	1.00
233_A	237_A	1.084	1.00
182_G	187_K	1.079	1.00
273_A	286_L	1.073	1.00
307_M	333_F	1.072	1.00
329_Y	332_H	1.063	1.00
309_R	315_E	1.058	1.00
313_L	316_A	1.053	1.00
102_N	308_K	1.052	1.00
308_K	337_E	1.051	1.00
263_L	271_I	1.046	1.00
99_S	136_Y	1.044	1.00
228_W	236_M	1.041	1.00
272_S	295_Q	1.040	1.00
183_Y	188_M	1.037	1.00
207_V	243_Y	1.037	1.00
188_M	210_I	1.036	1.00
323_P	339_E	1.034	1.00
298_A	307_M	1.033	1.00
89_L	128_I	1.030	1.00
68_D	71_T	1.029	1.00
97_P	100_R	1.026	1.00
175_A	186_M	1.025	1.00
328_I	333_F	1.024	1.00
182_G	185_A	1.019	1.00
140_L	147_L	1.014	1.00
228_W	233_A	1.005	1.00
101_I	136_Y	1.004	1.00
211_R	220_L	1.002	1.00
161_S	164_H	0.992	1.00
184_A	187_K	0.991	1.00
169_D	173_K	0.989	1.00
182_G	218_V	0.983	1.00
284_K	317_Y	0.981	1.00
65_D	68_D	0.981	1.00
255_D	282_D	0.979	1.00
191_C	203_N	0.976	1.00
148_L	308_K	0.969	1.00
183_Y	186_M	0.962	1.00
179_V	186_M	0.960	1.00
61_F	255_D	0.958	1.00
168_K	205_E	0.953	1.00
297_D	324_H	0.946	1.00
201_D	205_E	0.944	1.00
175_A	214_V	0.943	1.00
172_E	212_D	0.942	1.00
99_S	140_L	0.937	1.00
105_W	109_Y	0.936	1.00
181_E	186_M	0.935	1.00
301_V	307_M	0.934	1.00
200_V	204_V	0.933	1.00
245_L	269_I	0.932	1.00
352_K	356_D	0.927	1.00
92_L	107_L	0.923	1.00
204_V	214_V	0.921	1.00
68_D	139_L	0.917	1.00
250_E	295_Q	0.908	1.00
70_V	138_K	0.905	1.00
332_H	339_E	0.905	1.00
258_E	261_S	0.904	1.00
328_I	331_L	0.904	1.00
207_V	240_L	0.902	1.00
172_E	214_V	0.899	1.00
330_N	333_F	0.894	1.00
200_V	236_M	0.894	1.00
146_E	373_E	0.892	1.00
230_L	234_L	0.891	1.00
185_A	221_A	0.889	1.00
105_W	129_N	0.888	1.00
343_P	346_E	0.887	1.00
79_E	83_N	0.884	1.00
104_V	108_L	0.881	1.00
168_K	209_V	0.881	1.00
224_A	237_A	0.879	1.00
77_T	80_S	0.879	1.00
201_D	239_R	0.873	1.00
252_L	260_Y	0.872	1.00
204_V	242_K	0.871	1.00
148_L	336_S	0.870	1.00
287_L	294_L	0.867	1.00
172_E	176_R	0.862	1.00
259_S	262_Y	0.861	1.00
144_V	304_I	0.858	1.00
136_Y	147_L	0.858	1.00
258_E	285_R	0.855	1.00
207_V	222_G	0.854	1.00
257_F	290_G	0.851	1.00
178_Y	181_E	0.845	1.00
214_V	218_V	0.844	1.00
311_T	321_V	0.844	1.00
96_L	100_R	0.841	1.00
209_V	213_S	0.838	1.00
233_A	252_L	0.837	1.00
87_S	90_A	0.837	1.00
278_Y	282_D	0.835	1.00
291_V	294_L	0.834	1.00
211_R	217_S	0.830	1.00
311_T	323_P	0.828	1.00
280_V	309_R	0.827	1.00
241_E	267_T	0.824	1.00
185_A	188_M	0.818	1.00
173_K	180_E	0.817	1.00
133_Y	304_I	0.815	1.00
153_R	156_I	0.815	1.00
231_N	235_K	0.813	1.00
311_T	315_E	0.813	1.00
98_V	136_Y	0.810	1.00
184_A	188_M	0.809	1.00
328_I	338_P	0.809	1.00
98_V	132_M	0.808	1.00
273_A	291_V	0.807	1.00
144_V	148_L	0.806	1.00
67_D	98_V	0.805	1.00
106_D	309_R	0.803	1.00
67_D	71_T	0.801	1.00
315_E	338_P	0.800	1.00
145_Y	371_L	0.792	1.00
181_E	184_A	0.789	1.00
364_P	369_F	0.785	1.00
329_Y	338_P	0.783	1.00
224_A	228_W	0.783	1.00
104_V	107_L	0.782	1.00
175_A	180_E	0.781	1.00
277_H	283_F	0.781	1.00
92_L	96_L	0.781	1.00
230_L	252_L	0.778	1.00
61_F	72_Y	0.775	1.00
76_E	80_S	0.768	1.00
294_L	319_G	0.766	1.00
46_G	53_S	0.765	1.00
233_A	263_L	0.763	1.00
260_Y	273_A	0.763	1.00
84_F	88_N	0.761	1.00
274_G	297_D	0.758	1.00
181_E	188_M	0.757	1.00
105_W	108_L	0.756	1.00
181_E	187_K	0.754	1.00
91_D	94_R	0.753	1.00
141_G	375_K	0.753	1.00
348_L	351_Y	0.750	1.00
76_E	79_E	0.750	1.00
140_L	143_P	0.750	1.00
277_H	282_D	0.750	1.00
296_P	307_M	0.750	1.00
370_E	373_E	0.742	1.00
298_A	330_N	0.738	1.00
98_V	139_L	0.737	1.00
93_V	96_L	0.736	1.00
304_I	308_K	0.736	1.00
264_S	271_I	0.735	1.00
260_Y	271_I	0.735	1.00
203_N	228_W	0.726	1.00
106_D	109_Y	0.723	1.00
174_E	178_Y	0.722	1.00
211_R	244_E	0.722	1.00
60_C	227_S	0.721	1.00
234_L	238_R	0.721	1.00
216_Y	244_E	0.719	1.00
328_I	339_E	0.716	1.00
294_L	310_I	0.714	1.00
146_E	151_K	0.714	1.00
228_W	248_I	0.712	1.00
109_Y	306_P	0.710	1.00
257_F	285_R	0.709	1.00
363_K	370_E	0.709	1.00
296_P	311_T	0.704	1.00
173_K	213_S	0.704	1.00
172_E	175_A	0.696	1.00
234_L	267_T	0.696	1.00
211_R	216_Y	0.696	1.00
323_P	334_I	0.696	1.00
283_F	319_G	0.695	1.00
102_N	305_T	0.692	0.99
89_L	108_L	0.691	0.99
277_H	286_L	0.688	0.99
76_E	81_V	0.686	0.99
86_M	90_A	0.685	0.99
66_L	69_N	0.681	0.99
329_Y	339_E	0.681	0.99
130_L	329_Y	0.680	0.99
281_Y	284_K	0.679	0.99
257_F	286_L	0.678	0.99
105_W	305_T	0.678	0.99
334_I	340_S	0.676	0.99
155_K	366_K	0.676	0.99
203_N	206_L	0.675	0.99
328_I	340_S	0.675	0.99
296_P	321_V	0.674	0.99
144_V	147_L	0.673	0.99
78_S	81_V	0.671	0.99
358_M	361_P	0.661	0.99
52_Q	127_V	0.659	0.99
260_Y	263_L	0.657	0.99
329_Y	377_F	0.653	0.99
365_I	368_Y	0.651	0.99
235_K	266_R	0.650	0.99
133_Y	144_V	0.646	0.99
345_A	348_L	0.645	0.99
308_K	336_S	0.644	0.99
185_A	219_D	0.644	0.99
145_Y	332_H	0.642	0.99
82_C	85_V	0.641	0.99
188_M	207_V	0.639	0.99
43_E	46_G	0.639	0.99
280_V	310_I	0.639	0.99
155_K	365_I	0.638	0.99
125_I	303_G	0.638	0.99
135_A	139_L	0.636	0.99
136_Y	139_L	0.633	0.99
160_A	178_Y	0.632	0.99
137_A	142_V	0.629	0.99
65_D	72_Y	0.625	0.99
208_K	213_S	0.624	0.99
295_Q	324_H	0.622	0.99
160_A	183_Y	0.620	0.99
107_L	110_R	0.619	0.99
333_F	338_P	0.618	0.99
172_E	209_V	0.616	0.99
173_K	178_Y	0.616	0.99
346_E	349_T	0.613	0.99
175_A	210_I	0.612	0.99
332_H	340_S	0.610	0.99
148_L	304_I	0.609	0.99
202_K	206_L	0.608	0.99
353_W	356_D	0.606	0.99
151_K	373_E	0.606	0.99
336_S	340_S	0.605	0.99
68_D	98_V	0.604	0.99
67_D	70_V	0.602	0.99
320_V	343_P	0.601	0.99
184_A	366_K	0.599	0.99
80_S	84_F	0.597	0.99
101_I	132_M	0.597	0.99
257_F	289_S	0.593	0.98
314_A	321_V	0.593	0.98
234_L	252_L	0.592	0.98
304_I	329_Y	0.592	0.98
133_Y	148_L	0.588	0.98
198_L	202_K	0.587	0.98
333_F	339_E	0.585	0.98
314_A	319_G	0.585	0.98
77_T	84_F	0.584	0.98
344_M	347_Y	0.581	0.98
93_V	128_I	0.581	0.98
134_D	328_I	0.581	0.98
247_W	322_I	0.580	0.98
169_D	172_E	0.580	0.98
173_K	179_V	0.580	0.98
343_P	347_Y	0.579	0.98
281_Y	285_R	0.577	0.98
137_A	375_K	0.577	0.98
102_N	106_D	0.576	0.98
190_F	228_W	0.576	0.98
315_E	321_V	0.574	0.98
207_V	220_L	0.572	0.98
250_E	276_H	0.572	0.98
85_V	90_A	0.572	0.98
283_F	296_P	0.571	0.98
114_P	117_R	0.570	0.98
75_L	123_H	0.570	0.98
88_N	92_L	0.570	0.98
263_L	267_T	0.569	0.98
307_M	323_P	0.568	0.98
176_R	214_V	0.568	0.98
85_V	128_I	0.567	0.98
186_M	214_V	0.567	0.98
336_S	339_E	0.564	0.98
175_A	178_Y	0.563	0.98
109_Y	125_I	0.562	0.98
291_V	319_G	0.562	0.98
283_F	314_A	0.561	0.98
250_E	275_E	0.560	0.98
355_E	359_I	0.560	0.98
308_K	333_F	0.559	0.98
98_V	135_A	0.558	0.98
64_M	93_V	0.556	0.98
349_T	352_K	0.556	0.98
101_I	305_T	0.555	0.98
332_H	337_E	0.554	0.98
290_G	319_G	0.550	0.97
190_F	224_A	0.548	0.97
237_A	269_I	0.548	0.97
299_V	326_S	0.548	0.97
331_L	372_G	0.546	0.97
250_E	274_G	0.545	0.97
347_Y	350_K	0.545	0.97
163_L	171_L	0.545	0.97
97_P	146_E	0.544	0.97
298_A	333_F	0.543	0.97
236_M	239_R	0.541	0.97
215_G	218_V	0.540	0.97
137_A	140_L	0.539	0.97
333_F	336_S	0.537	0.97
103_M	106_D	0.536	0.97
102_N	154_D	0.536	0.97
246_S	270_P	0.533	0.97
154_D	373_E	0.533	0.97
298_A	304_I	0.532	0.97
212_D	216_Y	0.529	0.97
163_L	175_A	0.529	0.97
207_V	245_L	0.528	0.97
142_V	150_G	0.528	0.97
345_A	350_K	0.527	0.97
160_A	322_I	0.527	0.97
74_I	185_A	0.526	0.97
78_S	82_C	0.526	0.97
172_E	210_I	0.526	0.97
45_L	139_L	0.526	0.97
333_F	337_E	0.525	0.97
267_T	271_I	0.525	0.97
156_I	159_Y	0.525	0.97
204_V	207_V	0.525	0.97
92_L	111_Y	0.522	0.97
79_E	87_S	0.521	0.97
145_Y	373_E	0.521	0.97
162_H	165_P	0.520	0.96
179_V	214_V	0.517	0.96
116_G	119_G	0.516	0.96
280_V	284_K	0.515	0.96
157_R	219_D	0.514	0.96
304_I	333_F	0.514	0.96
321_V	339_E	0.514	0.96
132_M	136_Y	0.513	0.96
130_L	299_V	0.512	0.96
201_D	216_Y	0.512	0.96
84_F	120_I	0.510	0.96
204_V	240_L	0.507	0.96
158_A	369_F	0.507	0.96
73_S	127_V	0.507	0.96
264_S	290_G	0.507	0.96
237_A	240_L	0.507	0.96
138_K	141_G	0.506	0.96
81_V	84_F	0.505	0.96
171_L	206_L	0.504	0.96
79_E	82_C	0.502	0.96
332_H	336_S	0.501	0.96
101_I	104_V	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cyjA	5	0.9008	100	0.212	Contact Map
3dgbA	5	0.8982	100	0.227	Contact Map
3fcpA	5	0.859	100	0.228	Contact Map
3s5sA	2	0.8877	100	0.229	Contact Map
2pp0A	5	0.9556	100	0.229	Contact Map
3i4kA	4	0.893	100	0.232	Contact Map
3ugvA	5	0.8956	100	0.233	Contact Map
3u9iA	2	0.8747	100	0.235	Contact Map
3tj4A	5	0.8721	100	0.235	Contact Map
2og9A	5	0.8877	100	0.236	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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