GREMLIN Database
Q97YL7 - Uncharacterized protein
UniProt: Q97YL7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (205)
Sequences: 1834 (1470)
Seq/√Len: 102.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_Y211_E4.5461.00
187_I192_L4.2371.00
174_H178_L3.7871.00
202_T206_Y3.2861.00
103_I108_T3.2791.00
171_A196_M3.2731.00
108_T126_M3.1461.00
199_S202_T3.0731.00
178_L195_I3.0251.00
174_H192_L2.9781.00
178_L192_L2.9781.00
188_N191_E2.7621.00
167_Q206_Y2.7211.00
182_E186_R2.7141.00
187_I191_E2.7071.00
176_I216_S2.6911.00
24_S118_G2.4851.00
48_D89_I2.4751.00
167_Q170_N2.4251.00
12_E119_N2.3711.00
189_L203_L2.2331.00
167_Q171_A2.2291.00
23_T68_E2.2001.00
183_Y204_E2.1961.00
50_V61_F2.1731.00
127_P130_D1.9531.00
111_I125_I1.9491.00
169_R173_L1.9401.00
62_L87_Y1.9161.00
189_L204_E1.8221.00
172_V215_M1.8101.00
198_I203_L1.8091.00
206_Y209_K1.8001.00
200_K204_E1.7731.00
185_R208_R1.6941.00
57_V60_D1.6681.00
194_K197_G1.6641.00
34_F37_P1.6601.00
192_L203_L1.6541.00
12_E145_H1.5821.00
172_V181_Y1.5781.00
178_L187_I1.5491.00
9_V131_V1.4851.00
171_A206_Y1.4821.00
46_G91_F1.4231.00
171_A198_I1.3931.00
187_I195_I1.3670.99
179_G186_R1.3230.99
215_M218_I1.3220.99
35_A49_E1.3100.99
189_L206_Y1.3030.99
171_A192_L1.3000.99
206_Y213_K1.2980.99
12_E147_F1.2920.99
205_E209_K1.2870.99
76_Q87_Y1.2750.99
176_I219_F1.2610.99
19_W23_T1.2400.99
183_Y205_E1.2120.99
75_I187_I1.2120.99
202_T207_L1.2090.99
202_T205_E1.2030.99
133_M136_R1.1870.99
201_P205_E1.1870.99
212_K216_S1.1760.98
11_F124_L1.1690.98
58_F62_L1.1680.98
58_F85_G1.1570.98
191_E194_K1.1560.98
193_G203_L1.1540.98
171_A210_A1.1520.98
59_K221_E1.1490.98
161_F218_I1.1420.98
171_A203_L1.1410.98
190_E200_K1.1360.98
180_Y185_R1.1350.98
77_I115_I1.1140.98
67_K82_S1.1090.98
62_L74_I1.1060.98
153_N157_F1.1050.98
181_Y207_L1.0930.98
176_I181_Y1.0910.97
196_M203_L1.0900.97
52_T56_R1.0890.97
183_Y206_Y1.0700.97
183_Y201_P1.0580.97
58_F61_F1.0360.97
121_R147_F1.0350.97
71_I74_I1.0340.97
164_F210_A1.0280.96
76_Q85_G1.0250.96
214_I218_I1.0180.96
183_Y212_K1.0100.96
51_K84_R0.9930.96
34_F48_D0.9900.96
113_D181_Y0.9870.95
142_G202_T0.9670.95
125_I181_Y0.9660.95
180_Y189_L0.9630.95
183_Y190_E0.9610.95
108_T112_K0.9530.95
199_S208_R0.9510.94
207_L211_E0.9500.94
126_M145_H0.9420.94
149_A180_Y0.9360.94
215_M219_F0.9210.93
135_K144_I0.9200.93
65_F209_K0.9180.93
181_Y189_L0.9160.93
189_L200_K0.9120.93
131_V170_N0.9110.93
107_M127_P0.9090.93
60_D63_K0.9050.93
85_G88_R0.9030.93
62_L79_E0.9010.93
11_F135_K0.9010.93
110_Y124_L0.8980.93
181_Y210_A0.8960.92
163_D217_K0.8890.92
17_D198_I0.8700.91
132_T135_K0.8630.91
101_S105_N0.8610.91
173_L177_R0.8590.91
102_I188_N0.8560.91
133_M186_R0.8510.90
92_K146_Y0.8500.90
202_T210_A0.8490.90
192_L196_M0.8470.90
60_D64_S0.8430.90
135_K202_T0.8420.90
21_K71_I0.8380.90
136_R140_S0.8370.90
183_Y208_R0.8360.90
68_E210_A0.8280.89
145_H153_N0.8270.89
84_R166_E0.8210.89
45_L119_N0.8210.89
146_Y149_A0.8130.88
198_I201_P0.8090.88
190_E208_R0.8010.88
170_N173_L0.7890.87
106_Y137_D0.7850.86
174_H196_M0.7820.86
67_K157_F0.7820.86
49_E135_K0.7800.86
30_V44_I0.7770.86
189_L202_T0.7760.86
18_C120_E0.7740.86
22_L70_S0.7660.85
200_K209_K0.7620.85
167_Q205_E0.7620.85
32_T50_V0.7580.85
19_W22_L0.7570.84
50_V85_G0.7550.84
88_R144_I0.7510.84
182_E212_K0.7510.84
34_F47_M0.7460.84
9_V12_E0.7410.83
210_A215_M0.7400.83
129_S177_R0.7380.83
173_L219_F0.7370.83
209_K212_K0.7280.82
32_T209_K0.7280.82
134_L200_K0.7270.82
115_I120_E0.7260.82
167_Q211_E0.7210.81
52_T130_D0.7200.81
189_L210_A0.7200.81
138_L142_G0.7120.81
33_I36_K0.7090.80
110_Y133_M0.7060.80
130_D133_M0.7020.80
184_P208_R0.7010.80
30_V52_T0.6990.79
56_R67_K0.6930.79
187_I203_L0.6910.79
63_K67_K0.6870.78
18_C122_L0.6860.78
23_T30_V0.6830.78
126_M181_Y0.6820.78
103_I122_L0.6810.78
18_C99_I0.6810.78
104_E192_L0.6780.77
160_T214_I0.6750.77
180_Y207_L0.6740.77
70_S111_I0.6740.77
73_E130_D0.6730.77
62_L131_V0.6730.77
73_E76_Q0.6670.76
100_M126_M0.6600.75
112_K181_Y0.6560.75
148_N192_L0.6560.75
34_F125_I0.6560.75
8_L150_K0.6530.75
202_T209_K0.6520.75
154_F182_E0.6520.75
119_N158_V0.6510.74
24_S119_N0.6490.74
178_L203_L0.6440.74
86_I90_L0.6440.74
49_E84_R0.6390.73
47_M88_R0.6370.73
170_N174_H0.6370.73
34_F39_K0.6360.73
214_I217_K0.6310.72
84_R89_I0.6300.72
179_G204_E0.6280.72
90_L200_K0.6260.72
9_V164_F0.6260.72
59_K72_Y0.6220.71
100_M203_L0.6220.71
14_D21_K0.6180.71
98_M101_S0.6180.71
80_L133_M0.6160.70
118_G191_E0.6160.70
100_M110_Y0.6160.70
17_D48_D0.6130.70
15_H18_C0.6110.70
21_K24_S0.6100.70
50_V65_F0.6080.69
60_D194_K0.6080.69
113_D126_M0.6040.69
16_E58_F0.6030.69
169_R218_I0.6020.69
61_F152_V0.6020.69
9_V15_H0.6000.68
80_L218_I0.5990.68
72_Y92_K0.5980.68
162_F218_I0.5960.68
190_E194_K0.5940.68
14_D118_G0.5940.68
114_L121_R0.5920.67
37_P98_M0.5920.67
174_H195_I0.5920.67
28_V32_T0.5900.67
79_E101_S0.5900.67
29_Q32_T0.5890.67
34_F98_M0.5890.67
18_C21_K0.5880.67
9_V124_L0.5860.67
209_K214_I0.5850.66
116_K119_N0.5840.66
103_I144_I0.5820.66
70_S81_D0.5800.66
20_S89_I0.5800.66
51_K101_S0.5800.66
60_D82_S0.5800.66
20_S120_E0.5780.65
192_L197_G0.5760.65
36_K46_G0.5730.65
180_Y214_I0.5710.65
163_D216_S0.5700.64
96_E103_I0.5680.64
174_H187_I0.5670.64
25_S70_S0.5660.64
42_D195_I0.5660.64
41_K148_N0.5650.64
132_T202_T0.5610.63
131_V148_N0.5600.63
124_L134_L0.5600.63
109_L125_I0.5580.63
196_M204_E0.5570.63
68_E71_I0.5570.63
35_A38_S0.5560.63
91_F100_M0.5560.63
15_H20_S0.5550.62
77_I86_I0.5540.62
10_T121_R0.5520.62
168_E213_K0.5450.61
202_T218_I0.5440.61
179_G182_E0.5440.61
33_I216_S0.5430.61
160_T209_K0.5410.60
63_K219_F0.5400.60
11_F122_L0.5380.60
172_V210_A0.5350.60
66_K133_M0.5330.59
15_H120_E0.5300.59
91_F161_F0.5290.59
43_Y90_L0.5290.59
11_F118_G0.5270.58
121_R195_I0.5270.58
106_Y165_S0.5250.58
187_I208_R0.5250.58
34_F115_I0.5240.58
172_V214_I0.5210.58
67_K178_L0.5210.58
186_R217_K0.5200.57
11_F205_E0.5200.57
89_I92_K0.5190.57
107_M137_D0.5180.57
183_Y202_T0.5180.57
78_L131_V0.5160.57
169_R217_K0.5120.56
151_L154_F0.5120.56
176_I215_M0.5120.56
45_L147_F0.5120.56
170_N203_L0.5120.56
32_T154_F0.5110.56
63_K101_S0.5110.56
35_A181_Y0.5090.56
180_Y188_N0.5090.56
132_T136_R0.5060.55
144_I204_E0.5050.55
129_S149_A0.5030.55
123_L147_F0.5020.55
50_V64_S0.5020.55
13_I144_I0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s7oA 3 0.3504 97.6 0.85 Contact Map
1ku3A 1 0.2607 97.4 0.854 Contact Map
2o8xA 7 0.2607 97.4 0.855 Contact Map
4wszA 2 0.2521 97.4 0.856 Contact Map
3hugA 3 0.3419 97.3 0.857 Contact Map
2lfwA 1 0.6709 97.2 0.859 Contact Map
1xsvA 2 0.3462 97.1 0.862 Contact Map
1ttyA 1 0.3376 97.1 0.862 Contact Map
1je8A 2 0.2564 97.1 0.863 Contact Map
3c57A 2 0.2009 96.9 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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