GREMLIN Database
Q97YL5 - Uncharacterized protein
UniProt: Q97YL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 449 (435)
Sequences: 1463 (827)
Seq/√Len: 39.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
345_Q348_R7.6131.00
253_V268_I6.7201.00
316_E322_L6.6901.00
215_V268_I6.5351.00
216_I238_I5.7561.00
252_E264_H5.2521.00
109_S317_K5.2491.00
247_Y262_E4.8201.00
341_K345_Q4.4471.00
339_L376_I4.2781.00
335_E338_N3.9491.00
90_L413_T3.8001.00
424_S445_L3.7661.00
251_K288_R3.5751.00
333_L342_V3.2971.00
251_K284_K3.2661.00
123_F128_M3.2181.00
336_K339_L3.1391.00
106_Q131_S3.1101.00
102_R106_Q3.0911.00
89_Y325_V3.0131.00
268_I291_V2.8421.00
168_S419_A2.7761.00
215_V265_V2.7631.00
278_L284_K2.7561.00
74_I402_F2.7341.00
340_E344_T2.7191.00
283_M297_P2.6271.00
373_L377_Y2.5561.00
311_I314_L2.5471.00
251_K254_V2.5271.00
306_A354_R2.5041.00
19_Y23_L2.4341.00
253_V285_A2.4121.00
365_V368_D2.4071.00
92_A321_K2.3791.00
200_Y204_R2.3431.00
341_K344_T2.3381.00
215_V291_V2.3071.00
365_V369_N2.2571.00
379_E382_N2.2030.99
87_S91_V2.1490.99
53_A58_F2.1400.99
275_L297_P2.1270.99
313_Y316_E2.1230.99
309_V332_C2.0920.99
372_V383_F2.0840.99
253_V291_V2.0780.99
151_V326_I2.0570.99
371_N375_E2.0370.99
63_S223_N2.0140.99
159_L311_I2.0120.99
95_Y321_K1.9900.99
338_N341_K1.9900.99
132_P135_D1.9660.99
285_A290_W1.9650.99
207_S212_P1.9610.99
212_P266_D1.9510.99
31_L77_I1.9500.99
346_P373_L1.9290.99
286_Y293_L1.9260.99
102_R135_D1.9180.98
29_S33_E1.8820.98
370_I374_K1.8720.98
104_V314_L1.8640.98
252_E290_W1.8090.98
95_Y99_K1.8030.98
108_G114_D1.7930.98
27_I79_T1.7930.98
116_I306_A1.7880.98
17_N28_Y1.7690.97
86_I152_P1.7110.97
114_D118_K1.7050.97
69_T442_V1.7050.97
346_P351_I1.7030.97
39_K42_V1.6960.97
252_E285_A1.6690.96
213_I263_V1.6570.96
393_T404_E1.6460.96
208_G292_T1.6390.96
394_V407_A1.6270.96
336_K340_E1.6230.96
206_V292_T1.6180.96
202_I414_Y1.6100.95
343_I373_L1.6080.95
339_L377_Y1.6030.95
108_G128_M1.5940.95
79_T152_P1.5720.95
310_W335_E1.5520.94
374_K377_Y1.5480.94
323_E326_I1.5260.94
331_I341_K1.5080.94
94_S141_Y1.5070.94
370_I373_L1.4920.93
138_I141_Y1.4490.92
254_V264_H1.4470.92
132_P297_P1.4390.92
388_V432_R1.4120.91
195_G199_L1.3960.91
342_V385_A1.3950.91
94_S415_Y1.3700.90
339_L343_I1.3680.90
398_V401_S1.3560.89
374_K378_K1.3550.89
254_V285_A1.3510.89
425_R439_G1.3340.88
13_L393_T1.3290.88
153_F329_Y1.3230.88
146_V389_L1.3190.88
241_A255_V1.3140.88
398_V403_Y1.3100.88
137_Y299_T1.3100.88
284_K288_R1.2990.87
53_A69_T1.2970.87
140_V199_L1.2930.87
91_V418_V1.2740.86
102_R131_S1.2720.86
332_C335_E1.2700.86
60_F224_S1.2660.86
132_P137_Y1.2580.85
341_K349_Y1.2450.85
72_D443_K1.2410.85
205_Y417_K1.2410.85
171_A442_V1.2400.84
343_I376_I1.2340.84
50_N58_F1.2320.84
203_L294_A1.2310.84
127_M130_F1.2170.83
153_F326_I1.2040.83
127_M306_A1.2040.83
63_S437_S1.1930.82
191_L196_L1.1870.82
313_Y335_E1.1720.81
98_N137_Y1.1710.81
79_T82_L1.1630.80
346_P376_I1.1460.79
38_L42_V1.1380.79
158_N435_N1.1280.78
229_H440_G1.1270.78
265_V291_V1.1230.78
108_G118_K1.1230.78
310_W334_Y1.1150.77
148_V153_F1.1120.77
251_K290_W1.1080.77
257_T261_G1.1020.77
15_K404_E1.1010.77
192_Q235_K1.0950.76
173_E192_Q1.0920.76
80_S448_I1.0910.76
406_Y432_R1.0890.76
215_V253_V1.0850.76
149_N153_F1.0850.76
219_D277_Y1.0820.75
265_V268_I1.0750.75
96_V315_A1.0500.73
104_V301_V1.0500.73
343_I346_P1.0500.73
362_L372_V1.0360.72
69_T299_T1.0300.72
102_R107_E1.0290.72
353_K362_L1.0270.71
206_V294_A1.0230.71
86_I280_P1.0220.71
96_V100_F1.0220.71
335_E339_L1.0200.71
223_N440_G1.0170.71
249_K262_E1.0150.70
329_Y338_N1.0130.70
146_V391_F1.0130.70
80_S84_F1.0110.70
49_V174_Y1.0100.70
163_S225_A1.0090.70
331_I338_N1.0060.70
45_L179_L1.0030.70
47_K50_N0.9980.69
138_I415_Y0.9950.69
85_K324_N0.9890.68
352_K359_G0.9870.68
345_Q349_Y0.9850.68
88_N324_N0.9840.68
45_L180_P0.9830.68
123_F244_N0.9780.68
203_L267_V0.9740.67
437_S440_G0.9740.67
306_A381_E0.9690.67
306_A309_V0.9640.66
84_F87_S0.9610.66
203_L214_I0.9560.66
88_N321_K0.9560.66
66_Y70_P0.9500.65
102_R137_Y0.9470.65
389_L414_Y0.9450.65
148_V151_V0.9430.65
316_E320_I0.9420.65
90_L411_I0.9420.65
347_T373_L0.9420.65
80_S189_R0.9410.65
98_N383_F0.9400.64
355_E382_N0.9400.64
49_V71_I0.9380.64
338_N342_V0.9330.64
251_K278_L0.9280.63
283_M286_Y0.9260.63
24_T28_Y0.9230.63
136_I139_H0.9150.62
115_W334_Y0.9110.62
342_V351_I0.9100.62
326_I329_Y0.9100.62
43_F397_V0.9060.62
160_R302_A0.9050.62
337_E341_K0.9040.61
278_L287_L0.9020.61
340_E377_Y0.9020.61
253_V265_V0.8980.61
241_A246_I0.8930.60
72_D423_L0.8930.60
131_S135_D0.8890.60
139_H228_E0.8830.60
66_Y327_Q0.8820.60
315_A318_Y0.8810.59
337_E340_E0.8780.59
225_A229_H0.8770.59
111_P317_K0.8750.59
31_L182_L0.8740.59
120_T355_E0.8740.59
106_Q130_F0.8730.59
14_N383_F0.8720.59
277_Y421_A0.8690.58
52_Q177_R0.8660.58
12_K22_F0.8660.58
369_N373_L0.8650.58
69_T120_T0.8620.58
352_K433_I0.8570.57
150_G234_E0.8530.57
423_L443_K0.8520.57
216_I236_L0.8470.56
314_L332_C0.8470.56
313_Y332_C0.8410.56
98_N136_I0.8330.55
158_N225_A0.8300.55
67_R242_E0.8280.55
27_I152_P0.8270.55
86_I411_I0.8260.55
127_M333_L0.8220.54
373_L376_I0.8200.54
209_N266_D0.8180.54
427_G434_T0.8160.54
363_A368_D0.8150.54
158_N163_S0.8140.53
165_I196_L0.8120.53
173_E235_K0.8110.53
306_A334_Y0.8090.53
127_M137_Y0.8090.53
15_K393_T0.8040.53
85_K151_V0.8030.52
250_D374_K0.8020.52
283_M293_L0.8020.52
134_K417_K0.8020.52
343_I377_Y0.8010.52
97_L100_F0.7990.52
127_M283_M0.7970.52
84_F88_N0.7960.52
42_V45_L0.7960.52
315_A323_E0.7940.52
108_G123_F0.7930.52
26_P326_I0.7920.51
168_S414_Y0.7920.51
311_I332_C0.7900.51
395_I420_S0.7880.51
330_T384_I0.7880.51
344_T373_L0.7870.51
218_T226_Y0.7870.51
306_A328_P0.7860.51
250_D340_E0.7790.50
94_S413_T0.7790.50
219_D223_N0.7760.50
66_Y218_T0.7760.50
138_I334_Y0.7750.50
396_S426_V0.7740.50
340_E370_I0.7730.50
141_Y415_Y0.7730.50
205_Y416_D0.7690.49
364_I367_D0.7680.49
98_N231_F0.7670.49
352_K435_N0.7660.49
316_E335_E0.7650.49
89_Y324_N0.7640.49
129_G135_D0.7590.48
26_P81_E0.7590.48
208_G426_V0.7590.48
91_V413_T0.7590.48
352_K386_Q0.7570.48
213_I255_V0.7560.48
351_I383_F0.7530.48
336_K374_K0.7520.48
86_I403_Y0.7520.48
340_E345_Q0.7480.47
165_I195_G0.7470.47
332_C338_N0.7460.47
256_R262_E0.7460.47
35_V74_I0.7450.47
239_I255_V0.7380.46
392_D407_A0.7370.46
349_Y385_A0.7360.46
329_Y387_E0.7340.46
214_I238_I0.7320.46
175_V396_S0.7320.46
391_F440_G0.7320.46
404_E412_F0.7300.46
158_N224_S0.7270.45
51_L124_R0.7220.45
78_I409_M0.7210.45
29_S371_N0.7200.45
171_A242_E0.7200.45
197_D280_P0.7150.44
328_P391_F0.7140.44
143_A413_T0.7110.44
427_G439_G0.7110.44
434_T445_L0.7090.44
163_S224_S0.7060.44
95_Y136_I0.7050.44
175_V179_L0.7030.43
320_I340_E0.7030.43
64_S356_G0.7020.43
112_I314_L0.7020.43
353_K393_T0.7020.43
147_R392_D0.7010.43
86_I145_I0.6990.43
97_L311_I0.6990.43
205_Y209_N0.6980.43
167_Y232_I0.6970.43
77_I348_R0.6970.43
329_Y335_E0.6960.43
366_K388_V0.6960.43
366_K369_N0.6960.43
41_K45_L0.6910.42
16_D25_D0.6890.42
91_V321_K0.6870.42
114_D249_K0.6860.42
279_T422_V0.6850.42
363_A372_V0.6850.42
171_A257_T0.6840.42
150_G226_Y0.6840.42
363_A433_I0.6840.42
156_E269_Y0.6830.42
227_F376_I0.6830.42
386_Q425_R0.6830.42
224_S437_S0.6810.41
347_T369_N0.6800.41
137_Y234_E0.6800.41
350_V423_L0.6760.41
269_Y304_D0.6760.41
44_H194_N0.6750.41
56_E69_T0.6730.41
91_V95_Y0.6720.41
41_K44_H0.6690.40
254_V287_L0.6670.40
69_T170_K0.6670.40
123_F442_V0.6660.40
44_H79_T0.6660.40
228_E255_V0.6660.40
352_K423_L0.6660.40
294_A346_P0.6650.40
46_S397_V0.6650.40
96_V311_I0.6640.40
159_L297_P0.6630.40
26_P29_S0.6630.40
86_I216_I0.6630.40
45_L297_P0.6610.40
60_F225_A0.6610.40
254_V290_W0.6600.40
158_N408_D0.6580.39
78_I154_I0.6570.39
51_L216_I0.6570.39
140_V195_G0.6560.39
141_Y159_L0.6550.39
142_G158_N0.6550.39
12_K20_N0.6550.39
120_T231_F0.6540.39
175_V183_K0.6540.39
337_E344_T0.6530.39
137_Y296_A0.6520.39
82_L182_L0.6520.39
408_D435_N0.6520.39
46_S90_L0.6510.39
314_L319_G0.6510.39
223_N437_S0.6480.38
391_F406_Y0.6480.38
277_Y422_V0.6460.38
364_I368_D0.6430.38
331_I348_R0.6420.38
49_V52_Q0.6400.38
276_D281_G0.6400.38
138_I412_F0.6400.38
156_E358_G0.6390.38
122_Y284_K0.6390.38
368_D376_I0.6380.38
304_D408_D0.6370.38
315_A321_K0.6330.37
386_Q439_G0.6320.37
299_T345_Q0.6320.37
141_Y285_A0.6310.37
331_I349_Y0.6310.37
306_A330_T0.6300.37
170_K261_G0.6300.37
350_V438_S0.6290.37
168_S418_V0.6280.37
236_L447_I0.6260.37
117_V307_T0.6250.37
100_F314_L0.6240.36
356_G382_N0.6240.36
169_Y196_L0.6230.36
138_I159_L0.6210.36
340_E371_N0.6210.36
13_L77_I0.6210.36
107_E201_D0.6200.36
153_F283_M0.6190.36
213_I239_I0.6190.36
161_I225_A0.6190.36
168_S387_E0.6180.36
56_E68_S0.6180.36
17_N111_P0.6180.36
84_F91_V0.6170.36
53_A66_Y0.6170.36
219_D421_A0.6170.36
117_V393_T0.6160.36
132_P136_I0.6140.36
169_Y414_Y0.6130.35
158_N437_S0.6120.35
37_K41_K0.6110.35
155_L391_F0.6110.35
290_W412_F0.6110.35
347_T370_I0.6110.35
90_L124_R0.6110.35
207_S267_V0.6110.35
201_D205_Y0.6100.35
111_P316_E0.6090.35
379_E383_F0.6080.35
434_T439_G0.6080.35
80_S180_P0.6080.35
63_S229_H0.6070.35
100_F311_I0.6060.35
108_G217_L0.6060.35
69_T353_K0.6050.35
152_P186_Y0.6050.35
285_A288_R0.6040.35
190_V235_K0.6030.35
140_V228_E0.6030.35
159_L234_E0.6020.35
435_N439_G0.6020.35
156_E305_K0.6010.35
214_I267_V0.6000.34
81_E377_Y0.6000.34
26_P180_P0.6000.34
158_N303_D0.5980.34
55_M183_K0.5980.34
86_I125_P0.5970.34
124_R132_P0.5940.34
200_Y213_I0.5930.34
334_Y415_Y0.5920.34
173_E320_I0.5920.34
145_I152_P0.5920.34
39_K117_V0.5920.34
13_L404_E0.5920.34
68_S447_I0.5910.34
372_V376_I0.5910.34
364_I369_N0.5910.34
120_T306_A0.5900.34
211_D288_R0.5890.34
194_N198_Y0.5890.34
354_R384_I0.5880.33
94_S143_A0.5850.33
130_F429_M0.5850.33
191_L195_G0.5830.33
28_Y323_E0.5830.33
344_T370_I0.5820.33
184_E402_F0.5810.33
351_I364_I0.5810.33
361_G364_I0.5810.33
204_R211_D0.5810.33
139_H296_A0.5810.33
134_K205_Y0.5800.33
338_N376_I0.5780.33
23_L29_S0.5770.33
90_L292_T0.5770.33
138_I326_I0.5760.32
112_I117_V0.5760.32
209_N301_V0.5750.32
62_T427_G0.5750.32
133_P137_Y0.5740.32
311_I315_A0.5740.32
156_E359_G0.5740.32
212_P310_W0.5730.32
92_A324_N0.5720.32
114_D125_P0.5720.32
33_E41_K0.5720.32
86_I325_V0.5710.32
86_I447_I0.5700.32
132_P216_I0.5700.32
223_N439_G0.5690.32
98_N286_Y0.5680.32
169_Y218_T0.5660.32
41_K114_D0.5660.32
84_F189_R0.5660.32
308_F352_K0.5650.32
211_D215_V0.5650.32
38_L45_L0.5650.32
90_L206_V0.5650.32
129_G167_Y0.5650.32
155_L308_F0.5650.32
20_N340_E0.5640.32
58_F71_I0.5640.32
36_E429_M0.5630.31
142_G156_E0.5620.31
320_I448_I0.5610.31
351_I366_K0.5610.31
225_A303_D0.5610.31
338_N385_A0.5610.31
138_I297_P0.5600.31
360_I438_S0.5590.31
204_R214_I0.5590.31
125_P128_M0.5590.31
127_M419_A0.5590.31
129_G133_P0.5580.31
111_P313_Y0.5570.31
286_Y291_V0.5560.31
117_V209_N0.5550.31
313_Y322_L0.5550.31
305_K350_V0.5550.31
306_A407_A0.5550.31
340_E379_E0.5550.31
28_Y152_P0.5550.31
56_E138_I0.5540.31
178_F403_Y0.5530.31
136_I415_Y0.5530.31
396_S402_F0.5530.31
81_E399_N0.5530.31
26_P121_P0.5520.31
32_I36_E0.5520.31
148_V234_E0.5510.30
205_Y390_D0.5510.30
269_Y305_K0.5500.30
73_V251_K0.5490.30
60_F435_N0.5490.30
48_I52_Q0.5480.30
77_I447_I0.5480.30
349_Y380_Y0.5470.30
390_D432_R0.5470.30
182_L301_V0.5470.30
198_Y307_T0.5460.30
341_K348_R0.5460.30
305_K408_D0.5450.30
49_V310_W0.5440.30
166_S302_A0.5440.30
23_L370_I0.5440.30
212_P346_P0.5420.30
228_E442_V0.5420.30
159_L332_C0.5420.30
23_L33_E0.5410.30
23_L115_W0.5410.30
245_D277_Y0.5400.30
327_Q388_V0.5400.30
106_Q137_Y0.5380.30
117_V314_L0.5380.30
357_Y428_I0.5380.30
305_K435_N0.5380.30
300_G424_S0.5380.30
160_R225_A0.5370.29
66_Y155_L0.5360.29
21_E216_I0.5360.29
82_L147_R0.5360.29
54_Y73_V0.5360.29
20_N26_P0.5350.29
427_G440_G0.5340.29
224_S435_N0.5330.29
96_V323_E0.5330.29
167_Y223_N0.5330.29
125_P278_L0.5320.29
331_I387_E0.5320.29
305_K385_A0.5310.29
88_N211_D0.5310.29
156_E435_N0.5310.29
47_K185_G0.5300.29
101_I412_F0.5300.29
187_D263_V0.5300.29
90_L143_A0.5300.29
30_R340_E0.5290.29
76_R394_V0.5290.29
336_K376_I0.5290.29
160_R224_S0.5270.29
63_S163_S0.5260.29
348_R390_D0.5260.29
306_A332_C0.5260.29
16_D392_D0.5260.29
53_A422_V0.5260.29
111_P260_E0.5250.29
332_C419_A0.5240.28
107_E263_V0.5240.28
143_A207_S0.5240.28
85_K88_N0.5240.28
359_G433_I0.5230.28
24_T148_V0.5230.28
331_I342_V0.5230.28
338_N344_T0.5230.28
226_Y270_R0.5230.28
253_V267_V0.5210.28
219_D422_V0.5190.28
218_T273_E0.5170.28
248_V272_I0.5170.28
126_E189_R0.5160.28
126_E152_P0.5160.28
114_D344_T0.5160.28
189_R340_E0.5160.28
274_D445_L0.5150.28
269_Y315_A0.5150.28
347_T378_K0.5150.28
160_R303_D0.5140.28
29_S37_K0.5140.28
65_N364_I0.5130.28
215_V282_L0.5120.28
20_N23_L0.5120.28
225_A436_N0.5120.28
223_N357_Y0.5120.28
261_G268_I0.5110.27
24_T328_P0.5110.27
31_L183_K0.5110.27
339_L367_D0.5110.27
194_N297_P0.5100.27
53_A122_Y0.5100.27
51_L186_Y0.5100.27
60_F158_N0.5080.27
366_K373_L0.5080.27
163_S223_N0.5070.27
325_V403_Y0.5070.27
60_F437_S0.5070.27
99_K132_P0.5060.27
17_N20_N0.5060.27
41_K399_N0.5060.27
293_L368_D0.5050.27
96_V303_D0.5050.27
345_Q387_E0.5050.27
81_E84_F0.5040.27
350_V386_Q0.5040.27
146_V329_Y0.5040.27
90_L186_Y0.5030.27
80_S336_K0.5030.27
228_E294_A0.5020.27
100_F386_Q0.5020.27
15_K25_D0.5020.27
261_G281_G0.5000.27
376_I400_D0.5000.27
24_T400_D0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6xA 2 0.9443 100 0.359 Contact Map
2io8A 2 0.8575 100 0.709 Contact Map
2vobA 1 0.8018 100 0.711 Contact Map
1gsaA 3 0.4744 98.5 0.943 Contact Map
4iwxA 3 0.4833 97.6 0.954 Contact Map
3vpbA 3 0.4588 97.3 0.956 Contact Map
3r5xA 2 0.461 96.7 0.96 Contact Map
2p0aA 3 0.4633 95.6 0.964 Contact Map
4eg0A 2 0.4432 94.7 0.966 Contact Map
4ylrA 1 0.3831 93.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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