GREMLIN Database
Q97YL4 - Uncharacterized protein
UniProt: Q97YL4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (254)
Sequences: 3311 (2415)
Seq/√Len: 151.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_T203_V4.0381.00
146_K164_Y3.9601.00
117_I142_K3.3201.00
8_I73_E2.9151.00
132_I205_V2.9101.00
38_S79_V2.9051.00
138_F142_K2.8481.00
183_I205_V2.8251.00
204_E214_D2.8011.00
10_I73_E2.7901.00
12_E71_R2.6671.00
4_K77_K2.5221.00
8_I75_Y2.4811.00
24_L242_V2.4011.00
10_I71_R2.3961.00
159_A173_I2.3701.00
144_I164_Y2.2811.00
117_I177_L2.2641.00
142_K163_G2.2571.00
137_N220_G2.2561.00
127_T130_E2.2271.00
139_V143_I2.2011.00
143_I170_Y2.1971.00
175_L203_V2.1221.00
37_I81_T2.0831.00
54_D58_N2.0591.00
117_I160_Y2.0481.00
6_E77_K2.0451.00
74_I242_V2.0351.00
137_N141_K2.0101.00
116_K120_E1.9791.00
4_K79_V1.9371.00
106_T109_V1.9171.00
145_Y218_T1.9101.00
113_Q161_S1.9081.00
24_L63_I1.8961.00
190_G202_W1.8951.00
146_K149_I1.8841.00
35_V81_T1.8801.00
158_E162_L1.8661.00
42_G75_Y1.8001.00
37_I79_V1.7011.00
121_L138_F1.6851.00
178_L205_V1.6761.00
115_Q180_A1.6761.00
240_S243_I1.6681.00
140_R220_G1.6201.00
143_I173_I1.5891.00
136_V215_V1.5861.00
224_N227_Y1.5701.00
174_T178_L1.5611.00
126_K134_T1.5471.00
6_E75_Y1.5331.00
229_K232_V1.5181.00
203_V217_P1.5091.00
171_T175_L1.4781.00
175_L185_A1.4711.00
221_R227_Y1.4381.00
113_Q157_F1.4301.00
40_E77_K1.4181.00
115_Q119_K1.3881.00
117_I121_L1.3821.00
135_I181_L1.3641.00
171_T203_V1.3601.00
150_T154_T1.3521.00
192_V219_R1.3421.00
160_Y173_I1.3381.00
16_D70_R1.3181.00
248_S254_L1.3151.00
102_F106_T1.3121.00
51_S61_Y1.3081.00
178_L203_V1.3021.00
131_V181_L1.3001.00
89_T127_T1.2911.00
8_I258_R1.2901.00
139_V174_T1.2881.00
114_F176_G1.2721.00
105_P111_P1.2651.00
236_F240_S1.2561.00
30_N35_V1.2331.00
156_A159_A1.2321.00
139_V173_I1.2311.00
210_G213_I1.2241.00
49_K61_Y1.2161.00
52_Y60_V1.2131.00
42_G77_K1.1991.00
186_R204_E1.1801.00
134_T137_N1.1711.00
177_L180_A1.1591.00
207_T213_I1.1481.00
143_I159_A1.1471.00
36_L39_H1.1451.00
114_F177_L1.1411.00
168_Q187_Y1.1381.00
149_I164_Y1.1301.00
155_T158_E1.1241.00
234_R238_D1.1231.00
166_V187_Y1.0990.99
118_A181_L1.0940.99
7_Y191_V1.0900.99
145_Y167_C1.0890.99
29_Y232_V1.0860.99
39_H78_S1.0850.99
55_I101_E1.0830.99
132_I215_V1.0820.99
130_E134_T1.0800.99
11_Y22_N1.0700.99
136_V174_T1.0690.99
178_L215_V1.0660.99
133_E137_N1.0590.99
88_K95_Y1.0590.99
27_V39_H1.0590.99
167_C201_A1.0590.99
113_Q116_K1.0540.99
145_Y200_H1.0510.99
5_V228_I1.0510.99
84_K225_L1.0390.99
45_P48_Y1.0200.99
244_G248_S1.0170.99
150_T166_V1.0160.99
99_F206_L1.0140.99
139_V170_Y1.0120.99
5_V80_V1.0120.99
172_H235_D1.0120.99
27_V61_Y1.0060.99
233_G238_D1.0000.99
88_K96_N0.9990.99
3_Y193_N0.9990.99
106_T235_D0.9970.99
132_I207_T0.9940.99
201_A218_T0.9920.99
94_P97_Y0.9850.99
150_T168_Q0.9770.99
166_V201_A0.9740.99
92_E95_Y0.9680.99
44_I75_Y0.9680.99
74_I78_S0.9670.98
51_S59_I0.9660.98
68_L74_I0.9640.98
246_F252_G0.9590.98
82_L227_Y0.9550.98
145_Y170_Y0.9520.98
135_I178_L0.9520.98
129_G213_I0.9440.98
109_V176_G0.9420.98
205_V215_V0.9420.98
175_L187_Y0.9420.98
90_D94_P0.9400.98
107_R237_N0.9360.98
41_V76_S0.9320.98
190_G227_Y0.9320.98
121_L134_T0.9320.98
246_F249_S0.9310.98
139_V177_L0.9270.98
174_T215_V0.9250.98
167_C218_T0.9250.98
7_Y13_Y0.9250.98
116_K119_K0.9200.98
82_L225_L0.9180.98
105_P110_D0.9180.98
154_T166_V0.9170.98
187_Y239_V0.9130.98
106_T172_H0.9070.98
88_K93_F0.9020.98
152_I236_F0.9020.98
18_I68_L0.9010.98
13_Y17_V0.8950.98
132_I136_V0.8880.97
27_V51_S0.8840.97
193_N259_I0.8740.97
117_I138_F0.8740.97
122_T126_K0.8730.97
130_E133_E0.8730.97
25_K60_V0.8700.97
118_A180_A0.8660.97
109_V172_H0.8650.97
27_V59_I0.8630.97
176_G180_A0.8600.97
157_F161_S0.8590.97
6_E258_R0.8470.97
123_K126_K0.8450.96
89_T93_F0.8410.96
166_V219_R0.8300.96
5_V10_I0.8170.96
15_A249_S0.8170.96
91_Y94_P0.8120.96
214_D229_K0.8120.96
44_I71_R0.8090.95
254_L257_V0.8090.95
112_E116_K0.8090.95
23_T60_V0.8080.95
160_Y163_G0.8080.95
43_T47_G0.8060.95
88_K91_Y0.8050.95
88_K94_P0.8030.95
147_P170_Y0.8030.95
45_P69_H0.8020.95
145_Y166_V0.7990.95
126_K130_E0.7920.95
233_G239_V0.7910.95
107_R110_D0.7870.95
166_V169_D0.7790.94
145_Y192_V0.7780.94
150_T187_Y0.7750.94
118_A122_T0.7710.94
168_Q198_A0.7700.94
120_E142_K0.7690.94
18_I247_V0.7670.94
108_L235_D0.7660.94
27_V41_V0.7650.94
168_Q199_T0.7640.94
171_T201_A0.7630.94
117_I120_E0.7590.94
156_A172_H0.7570.94
34_Q80_V0.7540.93
170_Y217_P0.7490.93
187_Y219_R0.7480.93
187_Y201_A0.7440.93
122_T131_V0.7410.93
132_I178_L0.7370.93
250_G253_W0.7350.93
141_K220_G0.7340.93
73_E137_N0.7340.93
168_Q201_A0.7320.92
169_D201_A0.7320.92
202_W227_Y0.7270.92
90_D93_F0.7240.92
168_Q236_F0.7240.92
120_E138_F0.7240.92
168_Q219_R0.7220.92
41_V61_Y0.7200.92
125_L134_T0.7170.92
103_L106_T0.7100.91
145_Y171_T0.7100.91
43_T63_I0.7090.91
109_V156_A0.7020.91
167_C219_R0.6960.90
253_W258_R0.6940.90
166_V233_G0.6930.90
88_K92_E0.6930.90
35_V83_D0.6920.90
101_E108_L0.6910.90
63_I72_L0.6890.90
102_F107_R0.6880.90
89_T96_N0.6860.90
200_H218_T0.6840.90
166_V172_H0.6840.90
149_I162_L0.6790.89
144_I163_G0.6790.89
151_N154_T0.6770.89
44_I47_G0.6760.89
166_V198_A0.6750.89
84_K87_I0.6680.89
128_L205_V0.6650.88
102_F109_V0.6620.88
214_D223_Y0.6610.88
121_L135_I0.6610.88
7_Y244_G0.6600.88
170_Y218_T0.6600.88
93_F96_N0.6540.87
110_D157_F0.6510.87
34_Q229_K0.6500.87
9_S13_Y0.6470.87
200_H219_R0.6450.87
188_V229_K0.6440.87
56_F238_D0.6430.87
154_T201_A0.6420.87
167_C200_H0.6420.87
42_G46_N0.6410.86
96_N109_V0.6410.86
143_I163_G0.6390.86
135_I183_I0.6390.86
118_A177_L0.6370.86
114_F160_Y0.6370.86
53_V59_I0.6350.86
99_F102_F0.6330.86
202_W241_P0.6320.86
189_M241_P0.6310.86
150_T167_C0.6310.86
134_T138_F0.6300.85
144_I170_Y0.6270.85
150_T159_A0.6250.85
189_M231_A0.6240.85
237_N243_I0.6210.85
204_E232_V0.6210.85
21_E24_L0.6170.84
136_V220_G0.6160.84
231_A243_I0.6070.83
3_Y82_L0.6070.83
13_Y81_T0.6060.83
44_I73_E0.6050.83
189_M200_H0.6040.83
13_Y20_N0.6010.83
7_Y11_Y0.5900.82
19_S69_H0.5890.81
194_D219_R0.5860.81
247_V253_W0.5850.81
154_T159_A0.5800.80
99_F103_L0.5780.80
159_A168_Q0.5780.80
254_L258_R0.5770.80
122_T181_L0.5750.80
111_P180_A0.5730.80
114_F156_A0.5700.79
5_V249_S0.5690.79
158_E161_S0.5690.79
246_F250_G0.5690.79
129_G215_V0.5680.79
227_Y244_G0.5680.79
199_T219_R0.5630.79
89_T92_E0.5600.78
71_R163_G0.5600.78
173_I187_Y0.5590.78
241_P244_G0.5590.78
13_Y244_G0.5580.78
203_V215_V0.5580.78
11_Y242_V0.5570.78
114_F117_I0.5560.78
26_I74_I0.5550.78
154_T158_E0.5530.77
67_E70_R0.5510.77
9_S199_T0.5510.77
152_I168_Q0.5490.77
9_S17_V0.5490.77
172_H238_D0.5490.77
17_V72_L0.5490.77
7_Y241_P0.5480.77
213_I222_F0.5470.77
31_G229_K0.5460.76
119_K122_T0.5450.76
67_E113_Q0.5430.76
95_Y206_L0.5430.76
151_N162_L0.5430.76
88_K209_D0.5420.76
9_S191_V0.5420.76
154_T168_Q0.5420.76
43_T49_K0.5380.75
92_E209_D0.5380.75
104_L234_R0.5370.75
116_K141_K0.5370.75
133_E215_V0.5360.75
16_D46_N0.5320.75
29_Y229_K0.5320.75
199_T236_F0.5310.74
166_V170_Y0.5280.74
172_H175_L0.5280.74
57_G207_T0.5270.74
166_V199_T0.5270.74
126_K131_V0.5260.74
168_Q189_M0.5260.74
167_C244_G0.5250.74
192_V202_W0.5240.73
247_V250_G0.5230.73
28_P190_G0.5230.73
177_L181_L0.5230.73
28_P202_W0.5220.73
5_V259_I0.5220.73
169_D191_V0.5200.73
106_T110_D0.5180.73
129_G206_L0.5180.73
135_I174_T0.5140.72
48_Y66_Q0.5140.72
42_G50_T0.5140.72
152_I159_A0.5140.72
56_F101_E0.5130.72
21_E64_K0.5130.72
251_R254_L0.5080.71
249_S254_L0.5080.71
138_F177_L0.5080.71
84_K224_N0.5070.71
131_V134_T0.5070.71
101_E104_L0.5060.71
26_I61_Y0.5060.71
54_D57_G0.5040.71
58_N202_W0.5020.70
152_I160_Y0.5020.70
145_Y201_A0.5020.70
107_R111_P0.5010.70
39_H45_P0.5010.70
24_L74_I0.5010.70
246_F253_W0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isrA 3 0.9624 100 0.212 Contact Map
4xz7A 2 0.9474 100 0.494 Contact Map
4ktyA 1 0.8985 100 0.593 Contact Map
1g0dA 1 0.9436 100 0.594 Contact Map
2f4mA 2 0.6767 100 0.603 Contact Map
2q3zA 2 0.9624 100 0.603 Contact Map
3kd4A 3 0.906 100 0.606 Contact Map
1l9mA 2 0.9549 100 0.61 Contact Map
4fgqA 1 0.6015 99.9 0.639 Contact Map
1x3zA 1 0.8233 99.9 0.655 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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