Q97YL4 - SULSO - GREMLIN Contacts

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Q97YL4 - Uncharacterized protein

UniProt:	Q97YL4	Sequences: MDYKVEYISIYEYEADVISNENTLKIVPYNGDNQVLISHEVGTIPNGYKTSYVDIFGNIVYKIKVQELHRRLEIYSKSVVTLDKKVIKTDYEFPYNYGFNEFLLPTRLVDPEQFQKIAKELTKSLKTLGEVIETIVNFVRKKIIYKPGITNINTTAFEAYSLGYGVCQDYTHITLGLLRALGIPARYVMGVVNDNPRATHAWVEVLTPDGTYIDVDPTRGRFYNLDYIKFAVGRDFNDVSPVIGFFVSSGRGWLKEVRIKVEKSAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (254)
Sequences:	3311 (2415)
Seq/√Len:	151.5

SULSO - Q97YL4 Q7LX77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_T	203_V	4.038	1.00
146_K	164_Y	3.960	1.00
117_I	142_K	3.320	1.00
8_I	73_E	2.915	1.00
132_I	205_V	2.910	1.00
38_S	79_V	2.905	1.00
138_F	142_K	2.848	1.00
183_I	205_V	2.825	1.00
204_E	214_D	2.801	1.00
10_I	73_E	2.790	1.00
12_E	71_R	2.667	1.00
4_K	77_K	2.522	1.00
8_I	75_Y	2.481	1.00
24_L	242_V	2.401	1.00
10_I	71_R	2.396	1.00
159_A	173_I	2.370	1.00
144_I	164_Y	2.281	1.00
117_I	177_L	2.264	1.00
142_K	163_G	2.257	1.00
137_N	220_G	2.256	1.00
127_T	130_E	2.227	1.00
139_V	143_I	2.201	1.00
143_I	170_Y	2.197	1.00
175_L	203_V	2.122	1.00
37_I	81_T	2.083	1.00
54_D	58_N	2.059	1.00
117_I	160_Y	2.048	1.00
6_E	77_K	2.045	1.00
74_I	242_V	2.035	1.00
137_N	141_K	2.010	1.00
116_K	120_E	1.979	1.00
4_K	79_V	1.937	1.00
106_T	109_V	1.917	1.00
145_Y	218_T	1.910	1.00
113_Q	161_S	1.908	1.00
24_L	63_I	1.896	1.00
190_G	202_W	1.895	1.00
146_K	149_I	1.884	1.00
35_V	81_T	1.880	1.00
158_E	162_L	1.866	1.00
42_G	75_Y	1.800	1.00
37_I	79_V	1.701	1.00
121_L	138_F	1.685	1.00
178_L	205_V	1.676	1.00
115_Q	180_A	1.676	1.00
240_S	243_I	1.668	1.00
140_R	220_G	1.620	1.00
143_I	173_I	1.589	1.00
136_V	215_V	1.586	1.00
224_N	227_Y	1.570	1.00
174_T	178_L	1.561	1.00
126_K	134_T	1.547	1.00
6_E	75_Y	1.533	1.00
229_K	232_V	1.518	1.00
203_V	217_P	1.509	1.00
171_T	175_L	1.478	1.00
175_L	185_A	1.471	1.00
221_R	227_Y	1.438	1.00
113_Q	157_F	1.430	1.00
40_E	77_K	1.418	1.00
115_Q	119_K	1.388	1.00
117_I	121_L	1.382	1.00
135_I	181_L	1.364	1.00
171_T	203_V	1.360	1.00
150_T	154_T	1.352	1.00
192_V	219_R	1.342	1.00
160_Y	173_I	1.338	1.00
16_D	70_R	1.318	1.00
248_S	254_L	1.315	1.00
102_F	106_T	1.312	1.00
51_S	61_Y	1.308	1.00
178_L	203_V	1.302	1.00
131_V	181_L	1.300	1.00
89_T	127_T	1.291	1.00
8_I	258_R	1.290	1.00
139_V	174_T	1.288	1.00
114_F	176_G	1.272	1.00
105_P	111_P	1.265	1.00
236_F	240_S	1.256	1.00
30_N	35_V	1.233	1.00
156_A	159_A	1.232	1.00
139_V	173_I	1.231	1.00
210_G	213_I	1.224	1.00
49_K	61_Y	1.216	1.00
52_Y	60_V	1.213	1.00
42_G	77_K	1.199	1.00
186_R	204_E	1.180	1.00
134_T	137_N	1.171	1.00
177_L	180_A	1.159	1.00
207_T	213_I	1.148	1.00
143_I	159_A	1.147	1.00
36_L	39_H	1.145	1.00
114_F	177_L	1.141	1.00
168_Q	187_Y	1.138	1.00
149_I	164_Y	1.130	1.00
155_T	158_E	1.124	1.00
234_R	238_D	1.123	1.00
166_V	187_Y	1.099	0.99
118_A	181_L	1.094	0.99
7_Y	191_V	1.090	0.99
145_Y	167_C	1.089	0.99
29_Y	232_V	1.086	0.99
39_H	78_S	1.085	0.99
55_I	101_E	1.083	0.99
132_I	215_V	1.082	0.99
130_E	134_T	1.080	0.99
11_Y	22_N	1.070	0.99
136_V	174_T	1.069	0.99
178_L	215_V	1.066	0.99
133_E	137_N	1.059	0.99
88_K	95_Y	1.059	0.99
27_V	39_H	1.059	0.99
167_C	201_A	1.059	0.99
113_Q	116_K	1.054	0.99
145_Y	200_H	1.051	0.99
5_V	228_I	1.051	0.99
84_K	225_L	1.039	0.99
45_P	48_Y	1.020	0.99
244_G	248_S	1.017	0.99
150_T	166_V	1.016	0.99
99_F	206_L	1.014	0.99
139_V	170_Y	1.012	0.99
5_V	80_V	1.012	0.99
172_H	235_D	1.012	0.99
27_V	61_Y	1.006	0.99
233_G	238_D	1.000	0.99
88_K	96_N	0.999	0.99
3_Y	193_N	0.999	0.99
106_T	235_D	0.997	0.99
132_I	207_T	0.994	0.99
201_A	218_T	0.992	0.99
94_P	97_Y	0.985	0.99
150_T	168_Q	0.977	0.99
166_V	201_A	0.974	0.99
92_E	95_Y	0.968	0.99
44_I	75_Y	0.968	0.99
74_I	78_S	0.967	0.98
51_S	59_I	0.966	0.98
68_L	74_I	0.964	0.98
246_F	252_G	0.959	0.98
82_L	227_Y	0.955	0.98
145_Y	170_Y	0.952	0.98
135_I	178_L	0.952	0.98
129_G	213_I	0.944	0.98
109_V	176_G	0.942	0.98
205_V	215_V	0.942	0.98
175_L	187_Y	0.942	0.98
90_D	94_P	0.940	0.98
107_R	237_N	0.936	0.98
41_V	76_S	0.932	0.98
190_G	227_Y	0.932	0.98
121_L	134_T	0.932	0.98
246_F	249_S	0.931	0.98
139_V	177_L	0.927	0.98
174_T	215_V	0.925	0.98
167_C	218_T	0.925	0.98
7_Y	13_Y	0.925	0.98
116_K	119_K	0.920	0.98
82_L	225_L	0.918	0.98
105_P	110_D	0.918	0.98
154_T	166_V	0.917	0.98
187_Y	239_V	0.913	0.98
106_T	172_H	0.907	0.98
88_K	93_F	0.902	0.98
152_I	236_F	0.902	0.98
18_I	68_L	0.901	0.98
13_Y	17_V	0.895	0.98
132_I	136_V	0.888	0.97
27_V	51_S	0.884	0.97
193_N	259_I	0.874	0.97
117_I	138_F	0.874	0.97
122_T	126_K	0.873	0.97
130_E	133_E	0.873	0.97
25_K	60_V	0.870	0.97
118_A	180_A	0.866	0.97
109_V	172_H	0.865	0.97
27_V	59_I	0.863	0.97
176_G	180_A	0.860	0.97
157_F	161_S	0.859	0.97
6_E	258_R	0.847	0.97
123_K	126_K	0.845	0.96
89_T	93_F	0.841	0.96
166_V	219_R	0.830	0.96
5_V	10_I	0.817	0.96
15_A	249_S	0.817	0.96
91_Y	94_P	0.812	0.96
214_D	229_K	0.812	0.96
44_I	71_R	0.809	0.95
254_L	257_V	0.809	0.95
112_E	116_K	0.809	0.95
23_T	60_V	0.808	0.95
160_Y	163_G	0.808	0.95
43_T	47_G	0.806	0.95
88_K	91_Y	0.805	0.95
88_K	94_P	0.803	0.95
147_P	170_Y	0.803	0.95
45_P	69_H	0.802	0.95
145_Y	166_V	0.799	0.95
126_K	130_E	0.792	0.95
233_G	239_V	0.791	0.95
107_R	110_D	0.787	0.95
166_V	169_D	0.779	0.94
145_Y	192_V	0.778	0.94
150_T	187_Y	0.775	0.94
118_A	122_T	0.771	0.94
168_Q	198_A	0.770	0.94
120_E	142_K	0.769	0.94
18_I	247_V	0.767	0.94
108_L	235_D	0.766	0.94
27_V	41_V	0.765	0.94
168_Q	199_T	0.764	0.94
171_T	201_A	0.763	0.94
117_I	120_E	0.759	0.94
156_A	172_H	0.757	0.94
34_Q	80_V	0.754	0.93
170_Y	217_P	0.749	0.93
187_Y	219_R	0.748	0.93
187_Y	201_A	0.744	0.93
122_T	131_V	0.741	0.93
132_I	178_L	0.737	0.93
250_G	253_W	0.735	0.93
141_K	220_G	0.734	0.93
73_E	137_N	0.734	0.93
168_Q	201_A	0.732	0.92
169_D	201_A	0.732	0.92
202_W	227_Y	0.727	0.92
90_D	93_F	0.724	0.92
168_Q	236_F	0.724	0.92
120_E	138_F	0.724	0.92
168_Q	219_R	0.722	0.92
41_V	61_Y	0.720	0.92
125_L	134_T	0.717	0.92
103_L	106_T	0.710	0.91
145_Y	171_T	0.710	0.91
43_T	63_I	0.709	0.91
109_V	156_A	0.702	0.91
167_C	219_R	0.696	0.90
253_W	258_R	0.694	0.90
166_V	233_G	0.693	0.90
88_K	92_E	0.693	0.90
35_V	83_D	0.692	0.90
101_E	108_L	0.691	0.90
63_I	72_L	0.689	0.90
102_F	107_R	0.688	0.90
89_T	96_N	0.686	0.90
200_H	218_T	0.684	0.90
166_V	172_H	0.684	0.90
149_I	162_L	0.679	0.89
144_I	163_G	0.679	0.89
151_N	154_T	0.677	0.89
44_I	47_G	0.676	0.89
166_V	198_A	0.675	0.89
84_K	87_I	0.668	0.89
128_L	205_V	0.665	0.88
102_F	109_V	0.662	0.88
214_D	223_Y	0.661	0.88
121_L	135_I	0.661	0.88
7_Y	244_G	0.660	0.88
170_Y	218_T	0.660	0.88
93_F	96_N	0.654	0.87
110_D	157_F	0.651	0.87
34_Q	229_K	0.650	0.87
9_S	13_Y	0.647	0.87
200_H	219_R	0.645	0.87
188_V	229_K	0.644	0.87
56_F	238_D	0.643	0.87
154_T	201_A	0.642	0.87
167_C	200_H	0.642	0.87
42_G	46_N	0.641	0.86
96_N	109_V	0.641	0.86
143_I	163_G	0.639	0.86
135_I	183_I	0.639	0.86
118_A	177_L	0.637	0.86
114_F	160_Y	0.637	0.86
53_V	59_I	0.635	0.86
99_F	102_F	0.633	0.86
202_W	241_P	0.632	0.86
189_M	241_P	0.631	0.86
150_T	167_C	0.631	0.86
134_T	138_F	0.630	0.85
144_I	170_Y	0.627	0.85
150_T	159_A	0.625	0.85
189_M	231_A	0.624	0.85
237_N	243_I	0.621	0.85
204_E	232_V	0.621	0.85
21_E	24_L	0.617	0.84
136_V	220_G	0.616	0.84
231_A	243_I	0.607	0.83
3_Y	82_L	0.607	0.83
13_Y	81_T	0.606	0.83
44_I	73_E	0.605	0.83
189_M	200_H	0.604	0.83
13_Y	20_N	0.601	0.83
7_Y	11_Y	0.590	0.82
19_S	69_H	0.589	0.81
194_D	219_R	0.586	0.81
247_V	253_W	0.585	0.81
154_T	159_A	0.580	0.80
99_F	103_L	0.578	0.80
159_A	168_Q	0.578	0.80
254_L	258_R	0.577	0.80
122_T	181_L	0.575	0.80
111_P	180_A	0.573	0.80
114_F	156_A	0.570	0.79
5_V	249_S	0.569	0.79
158_E	161_S	0.569	0.79
246_F	250_G	0.569	0.79
129_G	215_V	0.568	0.79
227_Y	244_G	0.568	0.79
199_T	219_R	0.563	0.79
89_T	92_E	0.560	0.78
71_R	163_G	0.560	0.78
173_I	187_Y	0.559	0.78
241_P	244_G	0.559	0.78
13_Y	244_G	0.558	0.78
203_V	215_V	0.558	0.78
11_Y	242_V	0.557	0.78
114_F	117_I	0.556	0.78
26_I	74_I	0.555	0.78
154_T	158_E	0.553	0.77
67_E	70_R	0.551	0.77
9_S	199_T	0.551	0.77
152_I	168_Q	0.549	0.77
9_S	17_V	0.549	0.77
172_H	238_D	0.549	0.77
17_V	72_L	0.549	0.77
7_Y	241_P	0.548	0.77
213_I	222_F	0.547	0.77
31_G	229_K	0.546	0.76
119_K	122_T	0.545	0.76
67_E	113_Q	0.543	0.76
95_Y	206_L	0.543	0.76
151_N	162_L	0.543	0.76
88_K	209_D	0.542	0.76
9_S	191_V	0.542	0.76
154_T	168_Q	0.542	0.76
43_T	49_K	0.538	0.75
92_E	209_D	0.538	0.75
104_L	234_R	0.537	0.75
116_K	141_K	0.537	0.75
133_E	215_V	0.536	0.75
16_D	46_N	0.532	0.75
29_Y	229_K	0.532	0.75
199_T	236_F	0.531	0.74
166_V	170_Y	0.528	0.74
172_H	175_L	0.528	0.74
57_G	207_T	0.527	0.74
166_V	199_T	0.527	0.74
126_K	131_V	0.526	0.74
168_Q	189_M	0.526	0.74
167_C	244_G	0.525	0.74
192_V	202_W	0.524	0.73
247_V	250_G	0.523	0.73
28_P	190_G	0.523	0.73
177_L	181_L	0.523	0.73
28_P	202_W	0.522	0.73
5_V	259_I	0.522	0.73
169_D	191_V	0.520	0.73
106_T	110_D	0.518	0.73
129_G	206_L	0.518	0.73
135_I	174_T	0.514	0.72
48_Y	66_Q	0.514	0.72
42_G	50_T	0.514	0.72
152_I	159_A	0.514	0.72
56_F	101_E	0.513	0.72
21_E	64_K	0.513	0.72
251_R	254_L	0.508	0.71
249_S	254_L	0.508	0.71
138_F	177_L	0.508	0.71
84_K	224_N	0.507	0.71
131_V	134_T	0.507	0.71
101_E	104_L	0.506	0.71
26_I	61_Y	0.506	0.71
54_D	57_G	0.504	0.71
58_N	202_W	0.502	0.70
152_I	160_Y	0.502	0.70
145_Y	201_A	0.502	0.70
107_R	111_P	0.501	0.70
39_H	45_P	0.501	0.70
24_L	74_I	0.501	0.70
246_F	253_W	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3isrA	3	0.9624	100	0.212	Contact Map
4xz7A	2	0.9474	100	0.494	Contact Map
4ktyA	1	0.8985	100	0.593	Contact Map
1g0dA	1	0.9436	100	0.594	Contact Map
2f4mA	2	0.6767	100	0.603	Contact Map
2q3zA	2	0.9624	100	0.603	Contact Map
3kd4A	3	0.906	100	0.606	Contact Map
1l9mA	2	0.9549	100	0.61	Contact Map
4fgqA	1	0.6015	99.9	0.639	Contact Map
1x3zA	1	0.8233	99.9	0.655	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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