GREMLIN Database
Q97YL2 - Enoyl CoA hydratase (PaaF-3)
UniProt: Q97YL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (248)
Sequences: 30211 (19959)
Seq/√Len: 1267.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_K174_T3.1541.00
188_K198_E3.0611.00
128_G186_L2.9451.00
132_E191_E2.9311.00
106_A123_C2.8021.00
198_E201_E2.7601.00
21_I200_L2.6291.00
48_R101_K2.5001.00
45_V96_R2.4931.00
12_K25_N2.3621.00
173_K205_Q2.3471.00
228_P231_N2.2441.00
15_V20_G2.2271.00
133_N192_P2.2201.00
179_E182_D2.1941.00
176_S179_E2.1741.00
167_Y173_K2.1361.00
129_A133_N2.1001.00
164_K183_L2.0431.00
15_V50_D2.0291.00
169_M217_A2.0151.00
21_I59_T1.9941.00
143_N209_G1.9791.00
13_I20_G1.9321.00
18_G54_K1.9041.00
107_S199_S1.8771.00
113_M137_G1.8521.00
41_D96_R1.8471.00
25_N61_A1.8381.00
251_E260_R1.8361.00
23_R61_A1.8251.00
107_S196_F1.8211.00
127_F190_V1.8081.00
254_R258_E1.7811.00
35_E39_E1.7811.00
167_Y187_D1.7511.00
20_G47_S1.7451.00
23_R59_T1.7401.00
166_I222_N1.7291.00
132_E178_K1.7191.00
200_L204_R1.7081.00
194_K197_E1.7001.00
56_L100_T1.6551.00
132_E192_P1.6481.00
179_E183_L1.6411.00
124_D218_K1.6341.00
46_E50_D1.6331.00
162_R166_I1.5771.00
194_K198_E1.5671.00
38_R89_F1.5601.00
20_G53_V1.5571.00
178_K182_D1.5521.00
10_Y39_E1.5421.00
127_F202_F1.5291.00
47_S56_L1.5051.00
167_Y188_K1.4941.00
128_G136_F1.4941.00
48_R96_R1.4811.00
126_R163_S1.4701.00
126_R159_L1.4651.00
64_R109_N1.4651.00
120_A126_R1.4481.00
10_Y33_N1.4461.00
166_I221_V1.4441.00
190_V198_E1.4381.00
17_D204_R1.4241.00
129_A192_P1.4181.00
22_I43_I1.4161.00
95_L230_Y1.4071.00
59_T109_N1.3991.00
13_I47_S1.3921.00
166_I170_I1.3781.00
181_Y189_L1.3761.00
16_E200_L1.3651.00
95_L99_S1.3601.00
109_N129_A1.3591.00
55_A203_A1.3561.00
109_N133_N1.3441.00
97_M104_I1.3421.00
108_I120_A1.3391.00
12_K61_A1.3331.00
16_E204_R1.3331.00
98_M155_F1.3251.00
164_K167_Y1.3201.00
216_F242_Q1.3121.00
44_I100_T1.3111.00
108_I112_C1.3101.00
79_S82_Y1.3091.00
173_K179_E1.3071.00
195_L199_S1.3031.00
117_L138_M1.2911.00
168_L175_L1.2691.00
41_D45_V1.2641.00
34_L74_E1.2631.00
16_E21_I1.2481.00
33_N36_M1.2271.00
137_G174_T1.2241.00
219_L223_E1.2101.00
65_F111_H1.2031.00
21_I196_F1.2021.00
141_V172_G1.1901.00
24_L36_M1.1901.00
111_H135_K1.1891.00
163_S187_D1.1871.00
41_D92_E1.1861.00
196_F199_S1.1831.00
249_A253_A1.1821.00
48_R100_T1.1781.00
164_K179_E1.1701.00
14_E23_R1.1631.00
15_V46_E1.1581.00
59_T196_F1.1431.00
227_L231_N1.1421.00
196_F200_L1.1371.00
29_A73_N1.1331.00
39_E43_I1.1251.00
177_P189_L1.1171.00
129_A195_L1.0871.00
175_L183_L1.0861.00
227_L235_L1.0851.00
67_S116_G1.0821.00
24_L67_S1.0791.00
209_G214_V1.0771.00
15_V52_N1.0771.00
223_E235_L1.0531.00
14_E21_I1.0501.00
99_S230_Y1.0491.00
56_L102_K1.0341.00
161_G164_K1.0341.00
26_R29_A1.0341.00
90_S150_E1.0331.00
203_A207_S1.0291.00
10_Y35_E1.0271.00
39_E42_N1.0191.00
42_N46_E1.0171.00
12_K23_R1.0111.00
34_L38_R1.0111.00
125_L202_F1.0001.00
197_E201_E0.9741.00
104_I123_C0.9731.00
160_V164_K0.9651.00
26_R71_D0.9591.00
118_E152_G0.9521.00
200_L203_A0.9421.00
181_Y186_L0.9401.00
212_L248_D0.9321.00
60_S63_P0.9311.00
57_I199_S0.9311.00
21_I57_I0.9301.00
101_K215_G0.9251.00
159_L163_S0.9171.00
43_I46_E0.9141.00
219_L239_M0.9111.00
141_V217_A0.9061.00
191_E194_K0.9041.00
59_T107_S0.9041.00
53_V102_K0.9001.00
211_S215_G0.9001.00
19_V55_A0.8931.00
56_L104_I0.8921.00
231_N234_A0.8911.00
117_L136_F0.8891.00
250_K254_R0.8881.00
178_K181_Y0.8861.00
154_Q232_A0.8851.00
109_N195_L0.8851.00
153_T236_E0.8841.00
129_A132_E0.8741.00
51_E102_K0.8721.00
135_K176_S0.8671.00
108_I136_F0.8631.00
147_I243_A0.8471.00
108_I126_R0.8431.00
216_F219_L0.8371.00
156_L160_V0.8261.00
216_F239_M0.8261.00
37_L93_V0.8241.00
125_L187_D0.8241.00
107_S195_L0.8191.00
235_L238_E0.8181.00
162_R225_M0.8181.00
201_E205_Q0.8151.00
84_G88_Q0.8141.00
132_E189_L0.8131.00
15_V53_V0.8131.00
45_V49_F0.8051.00
41_D89_F0.7971.00
208_R261_R0.7911.00
169_M221_V0.7881.00
129_A193_E0.7881.00
44_I97_M0.7881.00
45_V92_E0.7861.00
118_E140_E0.7831.00
113_M174_T0.7791.00
216_F243_A0.7771.00
34_L89_F0.7751.00
220_A239_M0.7711.00
181_Y188_K0.7691.00
160_V168_L0.7681.00
199_S203_A0.7681.00
48_R102_K0.7651.00
73_N257_F0.7651.00
168_L183_L0.7651.00
65_F109_N0.7631.00
22_I56_L0.7621.00
81_E85_L0.7611.00
10_Y36_M0.7601.00
143_N174_T0.7511.00
114_G139_P0.7511.00
38_R42_N0.7511.00
198_E202_F0.7501.00
47_S53_V0.7491.00
101_K219_L0.7451.00
197_E200_L0.7421.00
206_I214_V0.7391.00
41_D93_V0.7351.00
201_E204_R0.7281.00
50_D53_V0.7271.00
54_K211_S0.7271.00
26_R33_N0.7251.00
13_I43_I0.7251.00
11_F43_I0.7231.00
229_L233_F0.7221.00
205_Q209_G0.7221.00
188_K202_F0.7181.00
177_P186_L0.7161.00
247_E250_K0.7141.00
161_G165_A0.7111.00
223_E227_L0.7081.00
100_T104_I0.7071.00
58_I123_C0.7071.00
253_A257_F0.7071.00
13_I46_E0.7051.00
26_R31_A0.7041.00
94_M122_A0.7031.00
33_N74_E0.7021.00
180_A185_I0.7011.00
235_L239_M0.6981.00
121_L185_I0.6961.00
239_M242_Q0.6951.00
234_A238_E0.6941.00
167_Y171_T0.6941.00
210_P248_D0.6931.00
190_V195_L0.6911.00
154_Q157_A0.6841.00
32_H36_M0.6811.00
108_I134_I0.6771.00
15_V18_G0.6741.00
19_V57_I0.6731.00
204_R208_R0.6681.00
186_L189_L0.6651.00
100_T103_L0.6631.00
127_F188_K0.6621.00
80_P242_Q0.6611.00
47_S102_K0.6601.00
237_R241_N0.6541.00
57_I107_S0.6541.00
18_G52_N0.6531.00
88_Q92_E0.6531.00
140_E149_G0.6501.00
57_I200_L0.6471.00
109_N192_P0.6461.00
171_T202_F0.6451.00
84_G238_E0.6451.00
58_I104_I0.6441.00
140_E148_P0.6401.00
202_F205_Q0.6401.00
127_F199_S0.6371.00
113_M139_P0.6361.00
105_I203_A0.6361.00
148_P217_A0.6331.00
238_E242_Q0.6331.00
136_F186_L0.6311.00
127_F198_E0.6301.00
78_K82_Y0.6281.00
63_P109_N0.6251.00
164_K181_Y0.6251.00
220_A235_L0.6241.00
162_R222_N0.6231.00
140_E240_Q0.6201.00
88_Q237_R0.6191.00
137_G172_G0.6181.00
230_Y234_A0.6171.00
43_I47_S0.6141.00
35_E38_R0.6131.00
147_I220_A0.6111.00
50_D102_K0.6101.00
55_A105_I0.6031.00
40_L93_V0.6031.00
42_N45_V0.6001.00
76_K254_R0.5981.00
251_E258_E0.5971.00
118_E149_G0.5931.00
127_F195_L0.5921.00
36_M39_E0.5921.00
45_V48_R0.5911.00
162_R221_V0.5901.00
178_K189_L0.5881.00
128_G134_I0.5871.00
212_L246_S0.5781.00
170_I214_V0.5751.00
55_A207_S0.5711.00
106_A126_R0.5701.00
54_K207_S0.5691.00
111_H174_T0.5691.00
118_E151_G0.5671.00
217_A220_A0.5661.00
29_A71_D0.5651.00
13_I22_I0.5651.00
247_E251_E0.5641.00
44_I96_R0.5641.00
109_N134_I0.5601.00
251_E254_R0.5601.00
254_R257_F0.5591.00
141_V209_G0.5581.00
167_Y179_E0.5571.00
70_F75_I0.5571.00
19_V203_A0.5571.00
157_A160_V0.5541.00
252_G255_A0.5541.00
251_E255_A0.5531.00
146_L249_A0.5521.00
160_V165_A0.5521.00
177_P181_Y0.5511.00
147_I217_A0.5501.00
153_T232_A0.5501.00
248_D252_G0.5501.00
138_M169_M0.5491.00
19_V200_L0.5491.00
160_V183_L0.5481.00
84_G241_N0.5461.00
129_A134_I0.5451.00
175_L180_A0.5441.00
22_I58_I0.5441.00
176_S182_D0.5431.00
171_T206_I0.5381.00
159_L187_D0.5371.00
53_V56_L0.5371.00
157_A224_G0.5361.00
166_I218_K0.5351.00
120_A123_C0.5331.00
117_L185_I0.5321.00
154_Q158_R0.5311.00
194_K201_E0.5311.00
125_L206_I0.5301.00
22_I44_I0.5291.00
57_I196_F0.5281.00
164_K182_D0.5271.00
80_P84_G0.5261.00
118_E138_M0.5241.00
32_H115_G0.5191.00
133_N177_P0.5151.00
117_L121_L0.5141.00
92_E95_L0.5131.00
10_Y26_R0.5121.00
44_I104_I0.5101.00
212_L243_A0.5091.00
145_A210_P0.5091.00
118_E155_F0.5091.00
167_Y202_F0.5081.00
205_Q208_R0.5081.00
33_N71_D0.5071.00
31_A68_A0.5061.00
98_M229_L0.5061.00
23_R196_F0.5061.00
82_Y85_L0.5061.00
92_E96_R0.5041.00
173_K188_K0.5041.00
72_I144_L0.5041.00
115_G150_E0.5021.00
138_M152_G0.5011.00
114_G138_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ppyA 6 0.985 100 0.09 Contact Map
3kqfA 3 0.9625 100 0.101 Contact Map
4mi2A 3 0.9551 100 0.101 Contact Map
3peaA 3 0.9625 100 0.103 Contact Map
4lk5A 3 0.9363 100 0.105 Contact Map
1hzdA 5 0.9775 100 0.107 Contact Map
3hinA 5 0.9625 100 0.108 Contact Map
1nzyA 4 0.9625 100 0.108 Contact Map
3qreA 3 0.7303 100 0.109 Contact Map
4mouA 3 0.9513 100 0.11 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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