GREMLIN Database
Q97YK8 - Repressor in ring oxydation complex/ phenylacetic acid degradation pathway related protein (PaaX)
UniProt: Q97YK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (254)
Sequences: 1163 (815)
Seq/√Len: 51.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_S258_E4.8591.00
181_E237_I4.4741.00
184_Y241_A3.9891.00
110_R114_R3.5361.00
13_D210_R3.4111.00
104_E107_R3.1531.00
176_N179_E3.1501.00
232_L238_G3.1251.00
21_T57_E3.0041.00
55_V67_K2.8961.00
45_L54_I2.8911.00
96_R158_I2.7541.00
95_W133_P2.7321.00
232_L236_W2.6331.00
32_K38_E2.5451.00
23_S63_K2.4261.00
192_S240_K2.3801.00
97_I161_A2.3361.00
24_S45_L2.2431.00
97_I129_T2.2311.00
166_Q169_H2.2251.00
91_W230_D2.2201.00
25_K63_K2.1411.00
23_S26_S2.0691.00
181_E185_K2.0201.00
7_F41_I2.0141.00
6_L36_F1.9931.00
94_K162_D1.9861.00
243_D247_K1.9811.00
194_M209_T1.9571.00
30_I207_F1.9290.99
100_Y128_S1.8940.99
99_V129_T1.8370.99
110_R113_L1.8060.99
13_D249_R1.7830.99
215_H218_R1.7750.99
106_N109_V1.7620.99
4_Q231_L1.7540.99
98_V158_I1.7410.99
145_N153_S1.7190.99
184_Y224_D1.7180.99
49_K54_I1.6920.99
18_A261_Y1.6890.99
255_K258_E1.6860.98
239_Y243_D1.6730.98
28_I120_L1.6590.98
75_R221_L1.6280.98
116_E147_L1.6140.98
91_W94_K1.5820.98
183_A223_I1.5810.98
8_F48_M1.5390.97
157_D173_R1.5090.97
185_K240_K1.4940.97
102_I149_N1.4720.96
208_V212_E1.4630.96
198_V201_M1.4630.96
104_E111_D1.4370.96
96_R122_F1.4230.96
103_P107_R1.4160.96
224_D232_L1.4100.95
91_W231_L1.3960.95
207_F259_F1.3860.95
21_T67_K1.3770.95
182_Q186_S1.3680.95
73_L77_L1.3570.94
140_L183_A1.3470.94
76_L79_G1.3340.94
140_L144_I1.3000.93
53_L215_H1.3000.93
133_P236_W1.2840.92
31_L242_Y1.2810.92
177_L233_P1.2760.92
192_S195_L1.2680.92
172_E234_Q1.2660.92
185_K235_N1.2270.91
214_V245_F1.2240.91
45_L56_S1.2150.90
90_R230_D1.2140.90
115_R161_A1.2070.90
162_D203_S1.2060.90
97_I131_I1.2040.90
183_A230_D1.2000.90
107_R245_F1.1940.89
100_Y103_P1.1890.89
229_E239_Y1.1860.89
110_R123_G1.1620.88
67_K129_T1.1610.88
7_F175_W1.1540.88
53_L75_R1.1540.88
185_K237_I1.1490.88
24_S62_K1.1440.87
140_L149_N1.1400.87
19_G105_N1.1400.87
13_D64_I1.1270.87
202_K205_E1.1150.86
11_Y157_D1.1120.86
113_L156_V1.1110.86
82_R121_G1.1070.86
175_W224_D1.0860.84
31_L41_I1.0830.84
210_R257_N1.0710.84
178_V188_L1.0560.83
253_T256_A1.0510.82
20_G41_I1.0510.82
98_V156_V1.0460.82
25_K65_R1.0310.81
179_E182_Q1.0260.81
144_I156_V1.0260.81
117_L122_F1.0250.81
107_R131_I1.0230.81
182_Q202_K1.0140.80
100_Y104_E1.0020.79
3_I53_L1.0000.79
34_F208_V0.9950.79
11_Y41_I0.9950.79
162_D179_E0.9890.78
80_T83_V0.9780.78
196_K206_A0.9710.77
239_Y247_K0.9680.77
36_F41_I0.9670.77
254_P258_E0.9660.77
214_V222_N0.9650.77
190_E216_E0.9640.77
49_K174_C0.9620.76
153_S240_K0.9590.76
10_L211_I0.9570.76
125_L174_C0.9560.76
3_I43_A0.9540.76
122_F140_L0.9510.76
192_S244_L0.9490.75
138_D182_Q0.9460.75
33_E204_N0.9430.75
195_L247_K0.9410.75
185_K188_L0.9360.74
257_N261_Y0.9350.74
110_R130_W0.9340.74
218_R222_N0.9330.74
95_W236_W0.9240.73
168_N171_V0.9200.73
13_D43_A0.9160.73
244_L248_L0.9160.73
182_Q185_K0.9140.73
79_G215_H0.9100.72
115_R199_N0.9080.72
122_F132_S0.9030.72
178_V182_Q0.9030.72
247_K251_E0.9000.71
28_I211_I0.8950.71
88_R138_D0.8950.71
182_Q200_S0.8930.71
39_G46_H0.8860.70
45_L181_E0.8790.70
218_R245_F0.8770.69
177_L238_G0.8740.69
230_D243_D0.8740.69
161_A165_D0.8740.69
53_L222_N0.8730.69
214_V249_R0.8730.69
199_N247_K0.8720.69
25_K117_L0.8720.69
201_M206_A0.8680.69
99_V126_A0.8680.69
84_Y218_R0.8660.68
142_K178_V0.8650.68
186_S200_S0.8590.68
76_L130_W0.8520.67
78_E128_S0.8500.67
97_I144_I0.8500.67
9_T215_H0.8470.67
11_Y20_G0.8460.67
248_L252_L0.8450.67
243_D254_P0.8440.66
8_F11_Y0.8430.66
132_S135_P0.8370.66
154_V178_V0.8370.66
222_N238_G0.8360.66
182_Q254_P0.8310.65
104_E110_R0.8270.65
172_E216_E0.8260.65
168_N247_K0.8220.64
133_P224_D0.8190.64
193_P206_A0.8160.64
240_K244_L0.8060.63
210_R214_V0.8000.62
24_S66_Y0.8000.62
132_S136_I0.7990.62
204_N208_V0.7990.62
27_L61_D0.7980.62
214_V218_R0.7960.62
5_S170_L0.7950.62
70_E192_S0.7920.62
21_T65_R0.7840.61
44_G218_R0.7840.61
26_S29_I0.7800.60
186_S190_E0.7780.60
43_A249_R0.7770.60
104_E114_R0.7760.60
66_Y206_A0.7720.60
70_E202_K0.7720.60
100_Y114_R0.7640.59
201_M255_K0.7610.58
122_F136_I0.7570.58
79_G249_R0.7550.58
23_S191_W0.7550.58
78_E167_P0.7520.58
142_K162_D0.7480.57
105_N138_D0.7450.57
173_R194_M0.7440.57
103_P106_N0.7420.57
102_I109_V0.7420.57
16_K27_L0.7400.56
33_E259_F0.7380.56
153_S156_V0.7330.56
57_E67_K0.7330.56
112_R169_H0.7290.55
29_I33_E0.7250.55
70_E258_E0.7240.55
10_L261_Y0.7200.54
37_S125_L0.7200.54
43_A79_G0.7180.54
100_Y111_D0.7170.54
13_D91_W0.7160.54
185_K189_E0.7130.54
72_G260_F0.7120.53
186_S216_E0.7110.53
92_D119_W0.7090.53
5_S84_Y0.7040.53
114_R232_L0.7030.53
233_P236_W0.6980.52
222_N245_F0.6980.52
200_S203_S0.6970.52
69_S72_G0.6970.52
210_R249_R0.6960.52
240_K254_P0.6950.52
75_R79_G0.6910.51
217_Y241_A0.6910.51
55_V202_K0.6910.51
195_L199_N0.6900.51
100_Y115_R0.6890.51
109_V200_S0.6860.51
46_H252_L0.6860.51
95_W117_L0.6850.51
101_N159_F0.6820.50
138_D189_E0.6820.50
35_G116_E0.6810.50
102_I107_R0.6810.50
70_E74_L0.6780.50
251_E255_K0.6780.50
177_L212_E0.6780.50
133_P175_W0.6740.50
40_A82_R0.6740.50
102_I115_R0.6690.49
204_N259_F0.6670.49
4_Q10_L0.6660.49
5_S22_I0.6620.48
14_Y245_F0.6620.48
31_L226_D0.6590.48
121_G175_W0.6570.48
186_S243_D0.6550.48
83_V97_I0.6550.48
172_E176_N0.6540.47
159_F167_P0.6520.47
83_V123_G0.6460.47
176_N187_F0.6440.46
121_G184_Y0.6430.46
187_F241_A0.6420.46
98_V106_N0.6410.46
189_E250_E0.6410.46
98_V124_M0.6400.46
209_T230_D0.6390.46
188_L240_K0.6350.45
64_I222_N0.6310.45
46_H120_L0.6300.45
149_N186_S0.6260.45
83_V218_R0.6250.44
131_I149_N0.6230.44
29_I182_Q0.6230.44
103_P123_G0.6210.44
72_G116_E0.6190.44
180_V237_I0.6170.44
179_E183_A0.6170.44
61_D93_G0.6160.44
191_W207_F0.6150.43
19_G38_E0.6140.43
107_R121_G0.6130.43
66_Y252_L0.6130.43
89_R182_Q0.6100.43
144_I234_Q0.6090.43
114_R119_W0.6070.43
75_R78_E0.6060.43
11_Y31_L0.6050.42
11_Y15_I0.6050.42
57_E243_D0.6050.42
4_Q40_A0.6050.42
70_E138_D0.6040.42
93_G170_L0.6040.42
58_R61_D0.6030.42
248_L251_E0.6030.42
99_V231_L0.6010.42
217_Y249_R0.6010.42
81_R85_E0.6000.42
10_L207_F0.5970.42
11_Y24_S0.5970.42
13_D214_V0.5960.42
100_Y215_H0.5960.42
165_D234_Q0.5930.41
161_A196_K0.5910.41
128_S181_E0.5910.41
117_L187_F0.5900.41
45_L68_L0.5890.41
159_F163_Y0.5880.41
168_N172_E0.5880.41
180_V220_F0.5870.41
55_V258_E0.5860.41
162_D258_E0.5850.40
58_R62_K0.5850.40
52_G252_L0.5840.40
88_R211_I0.5830.40
215_H222_N0.5830.40
173_R183_A0.5810.40
70_E230_D0.5800.40
131_I257_N0.5780.40
54_I243_D0.5750.39
48_M218_R0.5720.39
90_R145_N0.5710.39
187_F191_W0.5690.39
75_R116_E0.5680.39
142_K146_D0.5680.39
111_D114_R0.5680.39
84_Y238_G0.5670.39
43_A210_R0.5670.39
67_K239_Y0.5640.38
8_F231_L0.5630.38
169_H216_E0.5620.38
16_K80_T0.5610.38
79_G221_L0.5610.38
61_D92_D0.5600.38
192_S234_Q0.5600.38
22_I181_E0.5570.38
4_Q8_F0.5570.38
43_A214_V0.5570.38
3_I11_Y0.5540.37
3_I6_L0.5540.37
27_L58_R0.5520.37
27_L42_R0.5500.37
168_N189_E0.5490.37
28_I119_W0.5480.37
114_R123_G0.5470.37
140_L148_Y0.5460.37
45_L116_E0.5450.36
177_L232_L0.5440.36
123_G132_S0.5440.36
16_K84_Y0.5440.36
97_I198_V0.5440.36
32_K142_K0.5420.36
10_L21_T0.5390.36
193_P244_L0.5380.36
161_A178_V0.5370.36
30_I33_E0.5370.36
3_I37_S0.5370.36
108_E154_V0.5370.36
8_F215_H0.5340.35
179_E247_K0.5320.35
43_A64_I0.5320.35
34_F220_F0.5310.35
18_A215_H0.5310.35
247_K250_E0.5290.35
116_E201_M0.5290.35
172_E202_K0.5250.35
73_L117_L0.5250.35
109_V168_N0.5210.34
92_D230_D0.5190.34
188_L244_L0.5160.34
37_S40_A0.5140.34
74_L145_N0.5120.33
39_G43_A0.5110.33
211_I249_R0.5080.33
124_M189_E0.5030.33
40_A234_Q0.5020.32
131_I226_D0.5010.32
83_V217_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kfwX 4 0.8722 100 0.221 Contact Map
3l09A 4 0.8722 100 0.307 Contact Map
2co5A 2 0.3158 97.4 0.887 Contact Map
3f6vA 2 0.3271 97.1 0.893 Contact Map
4k2eA 2 0.2857 97 0.894 Contact Map
3cuoA 2 0.2857 97 0.894 Contact Map
1yg2A 2 0.6128 97 0.895 Contact Map
2qvoA 2 0.3008 96.9 0.896 Contact Map
1hsjA 2 0.3083 96.8 0.897 Contact Map
3l7wA 2 0.3534 96.6 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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