Q97YK6 - SULSO - GREMLIN Contacts

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Q97YK6 - Second ORF in transposon ISC1316

UniProt:	Q97YK6	Sequences: MITSSRPFHLLGKVVAIDVGIEKLVTTSDGQYFPNLKPFERALTKVRELHRSLSRKRFLSHNWFKAKVKLARVYEHVKNLRKDIYMKLGKYFAEYYDIVVMEDISVKKLVGKSLKVRRRLHDVGFYEFRTILEYQLIKYGKKFQWCFTNFTQNDTISMEEKNIRAELEKSAYFNTRSKKFSYLLKKLTENEFIYKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	196 (185)
Sequences:	4324 (2613)
Seq/√Len:	192.1

ECOLI - INSQ
HALSA - Q9HSD4 Q9HSY4 Q9HHG8 Q9HSW7 Q9HHU6 Q9HSW9 Q9HM87 Q9HHJ9 Q9HSZ6 Q9HHX8
SULSO - Q97YK6 Q97XA4 Q97XQ8 Q97V53 Q97YF7 Q97V47 Q97Y44 Q97YI2 Q97V25 Q97XP1 Q7LX59 Q97U09 Q97YW4 Q97YI5 Q97Z61 Q97UQ8 Q97U68 Q97XQ0 Q97XB6 Q97YU1 Q97Y48 Q97U51 Q97YW9 Q97Y67 Q97WY6 Q97X39 Q97WZ3 Q7LXH2 Q7LXD9 Q7LXH6 Q97YH4 Q97XN2 Y2105 Q7LX74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_D	87_K	4.602	1.00
105_S	108_K	3.590	1.00
156_I	188_T	3.351	1.00
136_L	143_F	3.111	1.00
129_R	145_W	2.932	1.00
127_E	131_I	2.742	1.00
101_M	132_L	2.487	1.00
110_V	121_H	2.434	1.00
168_E	171_A	2.422	1.00
24_L	128_F	2.406	1.00
90_K	94_E	2.377	1.00
146_C	193_I	2.282	1.00
150_F	153_N	2.087	1.00
155_T	158_M	2.060	1.00
43_L	118_R	2.043	1.00
127_E	130_T	2.018	1.00
93_A	136_L	2.013	1.00
133_E	145_W	1.999	1.00
86_M	134_Y	1.957	1.00
42_A	80_L	1.920	1.00
49_L	66_A	1.905	1.00
89_G	131_I	1.884	1.00
175_T	182_Y	1.872	1.00
114_L	117_R	1.846	1.00
86_M	131_I	1.845	1.00
85_Y	131_I	1.811	1.00
151_T	193_I	1.778	1.00
85_Y	127_E	1.774	1.00
82_K	127_E	1.762	1.00
97_D	141_K	1.760	1.00
101_M	143_F	1.727	1.00
99_V	136_L	1.633	1.00
86_M	135_Q	1.623	1.00
24_L	84_I	1.618	1.00
53_L	67_K	1.583	1.00
174_N	183_L	1.567	1.00
86_M	89_G	1.567	1.00
75_E	79_N	1.533	1.00
17_I	25_V	1.532	1.00
52_S	56_K	1.528	1.00
101_M	145_W	1.518	1.00
176_R	179_K	1.492	1.00
113_S	117_R	1.488	1.00
56_K	66_A	1.481	1.00
128_F	132_L	1.477	1.00
27_T	31_Q	1.464	1.00
101_M	129_R	1.431	1.00
66_A	70_L	1.428	1.00
172_Y	185_K	1.424	1.00
14_V	194_Y	1.399	1.00
174_N	181_S	1.389	1.00
64_F	67_K	1.377	1.00
102_E	148_T	1.372	1.00
103_D	145_W	1.372	1.00
120_L	125_F	1.371	1.00
23_K	26_T	1.340	1.00
59_L	63_W	1.335	1.00
133_E	137_I	1.301	1.00
26_T	187_L	1.273	1.00
151_T	155_T	1.272	1.00
153_N	156_I	1.269	1.00
61_H	64_F	1.266	1.00
14_V	98_I	1.265	1.00
191_E	195_K	1.251	1.00
49_L	73_V	1.250	1.00
161_K	177_S	1.243	1.00
164_R	167_L	1.232	1.00
19_V	129_R	1.195	1.00
91_Y	95_Y	1.194	1.00
154_D	167_L	1.161	1.00
163_I	167_L	1.150	1.00
42_A	77_V	1.143	1.00
105_S	148_T	1.134	1.00
89_G	134_Y	1.127	1.00
93_A	139_Y	1.126	1.00
26_T	32_Y	1.125	1.00
169_K	172_Y	1.121	1.00
45_K	49_L	1.104	1.00
173_F	182_Y	1.104	1.00
89_G	128_F	1.101	1.00
93_A	141_K	1.098	1.00
85_Y	128_F	1.098	1.00
167_L	171_A	1.084	1.00
46_V	74_Y	1.074	1.00
82_K	131_I	1.057	1.00
50_H	54_S	1.049	1.00
49_L	52_S	1.042	1.00
133_E	143_F	1.035	1.00
15_V	96_Y	1.025	1.00
53_L	66_A	1.014	1.00
90_K	139_Y	1.012	1.00
89_G	135_Q	0.999	1.00
131_I	134_Y	0.996	1.00
19_V	125_F	0.995	1.00
17_I	27_T	0.985	0.99
135_Q	138_K	0.982	0.99
157_S	181_S	0.979	0.99
38_P	80_L	0.973	0.99
187_L	191_E	0.973	0.99
151_T	156_I	0.962	0.99
85_Y	89_G	0.961	0.99
169_K	185_K	0.957	0.99
164_R	177_S	0.936	0.99
158_M	179_K	0.934	0.99
92_F	99_V	0.930	0.99
161_K	178_K	0.930	0.99
94_E	139_Y	0.922	0.99
13_K	97_D	0.917	0.99
46_V	70_L	0.910	0.99
154_D	163_I	0.905	0.99
78_K	82_K	0.903	0.99
168_E	172_Y	0.899	0.99
53_L	70_L	0.898	0.99
15_V	28_S	0.895	0.99
23_K	32_Y	0.890	0.99
62_N	65_K	0.889	0.99
63_W	67_K	0.884	0.99
100_V	144_Q	0.881	0.99
11_L	97_D	0.881	0.99
136_L	141_K	0.869	0.99
100_V	193_I	0.869	0.99
183_L	187_L	0.849	0.98
130_T	133_E	0.848	0.98
158_M	181_S	0.848	0.98
155_T	163_I	0.847	0.98
93_A	99_V	0.847	0.98
158_M	176_R	0.844	0.98
153_N	167_L	0.841	0.98
67_K	71_A	0.840	0.98
15_V	27_T	0.839	0.98
14_V	100_V	0.838	0.98
110_V	113_S	0.836	0.98
103_D	148_T	0.835	0.98
187_L	190_N	0.828	0.98
32_Y	184_L	0.823	0.98
21_I	123_V	0.822	0.98
46_V	54_S	0.820	0.98
148_T	151_T	0.819	0.98
46_V	77_V	0.814	0.98
126_Y	130_T	0.813	0.98
183_L	191_E	0.802	0.98
49_L	70_L	0.799	0.98
56_K	62_N	0.795	0.98
85_Y	124_G	0.793	0.98
167_L	174_N	0.789	0.97
69_K	72_R	0.788	0.97
188_T	192_F	0.788	0.97
103_D	129_R	0.786	0.97
134_Y	138_K	0.772	0.97
47_R	51_R	0.765	0.97
21_I	119_R	0.763	0.97
173_F	183_L	0.763	0.97
47_R	50_H	0.756	0.97
50_H	74_Y	0.756	0.97
82_K	86_M	0.754	0.97
79_N	83_D	0.753	0.97
151_T	154_D	0.751	0.97
191_E	194_Y	0.750	0.97
89_G	132_L	0.749	0.96
163_I	166_E	0.747	0.96
48_E	52_S	0.745	0.96
106_V	126_Y	0.740	0.96
35_N	38_P	0.739	0.96
168_E	185_K	0.737	0.96
29_D	96_Y	0.731	0.96
50_H	70_L	0.728	0.96
151_T	158_M	0.726	0.96
77_V	122_D	0.720	0.96
8_F	11_L	0.717	0.96
171_A	185_K	0.717	0.96
8_F	141_K	0.715	0.95
88_L	91_Y	0.713	0.95
16_A	194_Y	0.703	0.95
81_R	122_D	0.703	0.95
98_I	144_Q	0.698	0.95
79_N	82_K	0.693	0.95
94_E	98_I	0.679	0.94
154_D	192_F	0.678	0.94
35_N	123_V	0.677	0.94
32_Y	187_L	0.677	0.94
164_R	168_E	0.674	0.94
39_F	42_A	0.673	0.94
76_H	80_L	0.673	0.94
84_I	88_L	0.670	0.94
27_T	30_G	0.666	0.93
129_R	133_E	0.664	0.93
172_Y	184_L	0.662	0.93
164_R	174_N	0.661	0.93
52_S	55_R	0.658	0.93
113_S	116_V	0.657	0.93
110_V	117_R	0.655	0.93
31_Q	91_Y	0.650	0.93
116_V	119_R	0.645	0.92
113_S	121_H	0.640	0.92
153_N	158_M	0.639	0.92
156_I	183_L	0.638	0.92
42_A	76_H	0.634	0.92
20_G	26_T	0.634	0.92
164_R	171_A	0.634	0.92
100_V	194_Y	0.632	0.91
165_A	168_E	0.631	0.91
25_V	88_L	0.630	0.91
28_S	190_N	0.629	0.91
52_S	69_K	0.628	0.91
106_V	125_F	0.628	0.91
98_I	142_K	0.621	0.91
45_K	73_V	0.617	0.91
42_A	73_V	0.610	0.90
114_L	121_H	0.610	0.90
53_L	63_W	0.609	0.90
38_P	42_A	0.608	0.90
22_E	26_T	0.608	0.90
24_L	89_G	0.606	0.90
74_Y	81_R	0.602	0.89
171_A	174_N	0.601	0.89
10_L	13_K	0.600	0.89
28_S	187_L	0.599	0.89
23_K	34_P	0.598	0.89
189_E	192_F	0.597	0.89
73_V	77_V	0.594	0.89
112_K	115_K	0.590	0.88
39_F	43_L	0.589	0.88
46_V	50_H	0.588	0.88
57_R	60_S	0.585	0.88
150_F	155_T	0.584	0.88
102_E	152_Q	0.583	0.88
155_T	179_K	0.580	0.88
88_L	128_F	0.580	0.88
16_A	100_V	0.579	0.88
108_K	120_L	0.577	0.87
169_K	184_L	0.575	0.87
32_Y	35_N	0.570	0.87
56_K	63_W	0.568	0.87
161_K	164_R	0.563	0.86
116_V	120_L	0.561	0.86
47_R	55_R	0.557	0.85
42_A	46_V	0.557	0.85
156_I	191_E	0.553	0.85
156_I	181_S	0.549	0.85
60_S	63_W	0.548	0.85
50_H	53_L	0.547	0.84
54_S	70_L	0.544	0.84
51_R	54_S	0.541	0.84
131_I	135_Q	0.538	0.83
155_T	176_R	0.538	0.83
49_L	69_K	0.536	0.83
90_K	131_I	0.534	0.83
56_K	60_S	0.534	0.83
104_I	148_T	0.532	0.83
90_K	135_Q	0.532	0.83
39_F	118_R	0.532	0.83
24_L	123_V	0.529	0.82
23_K	184_L	0.528	0.82
17_I	92_F	0.528	0.82
156_I	189_E	0.525	0.82
40_E	43_L	0.524	0.82
68_V	72_R	0.522	0.82
52_S	66_A	0.518	0.81
161_K	174_N	0.516	0.81
41_R	44_T	0.516	0.81
175_T	181_S	0.515	0.81
181_S	191_E	0.514	0.81
106_V	120_L	0.513	0.81
40_E	119_R	0.513	0.81
63_W	66_A	0.511	0.80
115_K	119_R	0.510	0.80
86_M	90_K	0.509	0.80
181_S	188_T	0.508	0.80
157_S	191_E	0.508	0.80
53_L	56_K	0.505	0.79
64_F	68_V	0.504	0.79
157_S	183_L	0.504	0.79
21_I	110_V	0.504	0.79
147_F	150_F	0.502	0.79
163_I	168_E	0.502	0.79
170_S	173_F	0.501	0.79
33_F	88_L	0.500	0.79
12_G	97_D	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vhxA	2	0.6735	90.1	0.903	Contact Map
1nu0A	1	0.6327	87.2	0.908	Contact Map
1iv0A	1	0.4949	87	0.909	Contact Map
1ffkW	1	0.3214	83.5	0.913	Contact Map
4c2mI	1	0.25	82.3	0.914	Contact Map
1qypA	1	0.2347	74.4	0.92	Contact Map
1vq8Z	1	0.3265	73.5	0.92	Contact Map
2k4xA	1	0.2806	70	0.922	Contact Map
3j20Y	1	0.2551	68.3	0.923	Contact Map
4aybP	1	0.2143	68.3	0.923	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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