GREMLIN Database
Q97YK6 - Second ORF in transposon ISC1316
UniProt: Q97YK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (185)
Sequences: 4324 (2613)
Seq/√Len: 192.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_D87_K4.6021.00
105_S108_K3.5901.00
156_I188_T3.3511.00
136_L143_F3.1111.00
129_R145_W2.9321.00
127_E131_I2.7421.00
101_M132_L2.4871.00
110_V121_H2.4341.00
168_E171_A2.4221.00
24_L128_F2.4061.00
90_K94_E2.3771.00
146_C193_I2.2821.00
150_F153_N2.0871.00
155_T158_M2.0601.00
43_L118_R2.0431.00
127_E130_T2.0181.00
93_A136_L2.0131.00
133_E145_W1.9991.00
86_M134_Y1.9571.00
42_A80_L1.9201.00
49_L66_A1.9051.00
89_G131_I1.8841.00
175_T182_Y1.8721.00
114_L117_R1.8461.00
86_M131_I1.8451.00
85_Y131_I1.8111.00
151_T193_I1.7781.00
85_Y127_E1.7741.00
82_K127_E1.7621.00
97_D141_K1.7601.00
101_M143_F1.7271.00
99_V136_L1.6331.00
86_M135_Q1.6231.00
24_L84_I1.6181.00
53_L67_K1.5831.00
174_N183_L1.5671.00
86_M89_G1.5671.00
75_E79_N1.5331.00
17_I25_V1.5321.00
52_S56_K1.5281.00
101_M145_W1.5181.00
176_R179_K1.4921.00
113_S117_R1.4881.00
56_K66_A1.4811.00
128_F132_L1.4771.00
27_T31_Q1.4641.00
101_M129_R1.4311.00
66_A70_L1.4281.00
172_Y185_K1.4241.00
14_V194_Y1.3991.00
174_N181_S1.3891.00
64_F67_K1.3771.00
102_E148_T1.3721.00
103_D145_W1.3721.00
120_L125_F1.3711.00
23_K26_T1.3401.00
59_L63_W1.3351.00
133_E137_I1.3011.00
26_T187_L1.2731.00
151_T155_T1.2721.00
153_N156_I1.2691.00
61_H64_F1.2661.00
14_V98_I1.2651.00
191_E195_K1.2511.00
49_L73_V1.2501.00
161_K177_S1.2431.00
164_R167_L1.2321.00
19_V129_R1.1951.00
91_Y95_Y1.1941.00
154_D167_L1.1611.00
163_I167_L1.1501.00
42_A77_V1.1431.00
105_S148_T1.1341.00
89_G134_Y1.1271.00
93_A139_Y1.1261.00
26_T32_Y1.1251.00
169_K172_Y1.1211.00
45_K49_L1.1041.00
173_F182_Y1.1041.00
89_G128_F1.1011.00
93_A141_K1.0981.00
85_Y128_F1.0981.00
167_L171_A1.0841.00
46_V74_Y1.0741.00
82_K131_I1.0571.00
50_H54_S1.0491.00
49_L52_S1.0421.00
133_E143_F1.0351.00
15_V96_Y1.0251.00
53_L66_A1.0141.00
90_K139_Y1.0121.00
89_G135_Q0.9991.00
131_I134_Y0.9961.00
19_V125_F0.9951.00
17_I27_T0.9850.99
135_Q138_K0.9820.99
157_S181_S0.9790.99
38_P80_L0.9730.99
187_L191_E0.9730.99
151_T156_I0.9620.99
85_Y89_G0.9610.99
169_K185_K0.9570.99
164_R177_S0.9360.99
158_M179_K0.9340.99
92_F99_V0.9300.99
161_K178_K0.9300.99
94_E139_Y0.9220.99
13_K97_D0.9170.99
46_V70_L0.9100.99
154_D163_I0.9050.99
78_K82_K0.9030.99
168_E172_Y0.8990.99
53_L70_L0.8980.99
15_V28_S0.8950.99
23_K32_Y0.8900.99
62_N65_K0.8890.99
63_W67_K0.8840.99
100_V144_Q0.8810.99
11_L97_D0.8810.99
136_L141_K0.8690.99
100_V193_I0.8690.99
183_L187_L0.8490.98
130_T133_E0.8480.98
158_M181_S0.8480.98
155_T163_I0.8470.98
93_A99_V0.8470.98
158_M176_R0.8440.98
153_N167_L0.8410.98
67_K71_A0.8400.98
15_V27_T0.8390.98
14_V100_V0.8380.98
110_V113_S0.8360.98
103_D148_T0.8350.98
187_L190_N0.8280.98
32_Y184_L0.8230.98
21_I123_V0.8220.98
46_V54_S0.8200.98
148_T151_T0.8190.98
46_V77_V0.8140.98
126_Y130_T0.8130.98
183_L191_E0.8020.98
49_L70_L0.7990.98
56_K62_N0.7950.98
85_Y124_G0.7930.98
167_L174_N0.7890.97
69_K72_R0.7880.97
188_T192_F0.7880.97
103_D129_R0.7860.97
134_Y138_K0.7720.97
47_R51_R0.7650.97
21_I119_R0.7630.97
173_F183_L0.7630.97
47_R50_H0.7560.97
50_H74_Y0.7560.97
82_K86_M0.7540.97
79_N83_D0.7530.97
151_T154_D0.7510.97
191_E194_Y0.7500.97
89_G132_L0.7490.96
163_I166_E0.7470.96
48_E52_S0.7450.96
106_V126_Y0.7400.96
35_N38_P0.7390.96
168_E185_K0.7370.96
29_D96_Y0.7310.96
50_H70_L0.7280.96
151_T158_M0.7260.96
77_V122_D0.7200.96
8_F11_L0.7170.96
171_A185_K0.7170.96
8_F141_K0.7150.95
88_L91_Y0.7130.95
16_A194_Y0.7030.95
81_R122_D0.7030.95
98_I144_Q0.6980.95
79_N82_K0.6930.95
94_E98_I0.6790.94
154_D192_F0.6780.94
35_N123_V0.6770.94
32_Y187_L0.6770.94
164_R168_E0.6740.94
39_F42_A0.6730.94
76_H80_L0.6730.94
84_I88_L0.6700.94
27_T30_G0.6660.93
129_R133_E0.6640.93
172_Y184_L0.6620.93
164_R174_N0.6610.93
52_S55_R0.6580.93
113_S116_V0.6570.93
110_V117_R0.6550.93
31_Q91_Y0.6500.93
116_V119_R0.6450.92
113_S121_H0.6400.92
153_N158_M0.6390.92
156_I183_L0.6380.92
42_A76_H0.6340.92
20_G26_T0.6340.92
164_R171_A0.6340.92
100_V194_Y0.6320.91
165_A168_E0.6310.91
25_V88_L0.6300.91
28_S190_N0.6290.91
52_S69_K0.6280.91
106_V125_F0.6280.91
98_I142_K0.6210.91
45_K73_V0.6170.91
42_A73_V0.6100.90
114_L121_H0.6100.90
53_L63_W0.6090.90
38_P42_A0.6080.90
22_E26_T0.6080.90
24_L89_G0.6060.90
74_Y81_R0.6020.89
171_A174_N0.6010.89
10_L13_K0.6000.89
28_S187_L0.5990.89
23_K34_P0.5980.89
189_E192_F0.5970.89
73_V77_V0.5940.89
112_K115_K0.5900.88
39_F43_L0.5890.88
46_V50_H0.5880.88
57_R60_S0.5850.88
150_F155_T0.5840.88
102_E152_Q0.5830.88
155_T179_K0.5800.88
88_L128_F0.5800.88
16_A100_V0.5790.88
108_K120_L0.5770.87
169_K184_L0.5750.87
32_Y35_N0.5700.87
56_K63_W0.5680.87
161_K164_R0.5630.86
116_V120_L0.5610.86
47_R55_R0.5570.85
42_A46_V0.5570.85
156_I191_E0.5530.85
156_I181_S0.5490.85
60_S63_W0.5480.85
50_H53_L0.5470.84
54_S70_L0.5440.84
51_R54_S0.5410.84
131_I135_Q0.5380.83
155_T176_R0.5380.83
49_L69_K0.5360.83
90_K131_I0.5340.83
56_K60_S0.5340.83
104_I148_T0.5320.83
90_K135_Q0.5320.83
39_F118_R0.5320.83
24_L123_V0.5290.82
23_K184_L0.5280.82
17_I92_F0.5280.82
156_I189_E0.5250.82
40_E43_L0.5240.82
68_V72_R0.5220.82
52_S66_A0.5180.81
161_K174_N0.5160.81
41_R44_T0.5160.81
175_T181_S0.5150.81
181_S191_E0.5140.81
106_V120_L0.5130.81
40_E119_R0.5130.81
63_W66_A0.5110.80
115_K119_R0.5100.80
86_M90_K0.5090.80
181_S188_T0.5080.80
157_S191_E0.5080.80
53_L56_K0.5050.79
64_F68_V0.5040.79
157_S183_L0.5040.79
21_I110_V0.5040.79
147_F150_F0.5020.79
163_I168_E0.5020.79
170_S173_F0.5010.79
33_F88_L0.5000.79
12_G97_D0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.6735 90.1 0.903 Contact Map
1nu0A 1 0.6327 87.2 0.908 Contact Map
1iv0A 1 0.4949 87 0.909 Contact Map
1ffkW 1 0.3214 83.5 0.913 Contact Map
4c2mI 1 0.25 82.3 0.914 Contact Map
1qypA 1 0.2347 74.4 0.92 Contact Map
1vq8Z 1 0.3265 73.5 0.92 Contact Map
2k4xA 1 0.2806 70 0.922 Contact Map
3j20Y 1 0.2551 68.3 0.923 Contact Map
4aybP 1 0.2143 68.3 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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