GREMLIN Database
Q97YK2 - Antibiotic ABC transporter, ATP binding protein
UniProt: Q97YK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (233)
Sequences: 100712 (59383)
Seq/√Len: 3890.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E197_R3.5351.00
15_I18_D3.0621.00
30_V199_F2.9981.00
3_V23_E2.9251.00
74_E147_S2.8711.00
120_Y123_N2.8181.00
197_R209_S2.7751.00
31_S195_S2.7601.00
6_N19_N2.7421.00
5_S57_E2.7251.00
10_K15_I2.6701.00
57_E64_N2.6501.00
25_K28_E2.4961.00
3_V59_Q2.4771.00
8_V15_I2.3521.00
8_V55_R2.3481.00
211_T214_D2.3251.00
210_G214_D2.3101.00
9_K46_I2.1741.00
18_D205_K2.1561.00
5_S59_Q2.1551.00
199_F209_S2.1491.00
61_L147_S2.1181.00
199_F206_I2.0581.00
8_V19_N2.0181.00
107_E145_N1.9681.00
109_N121_A1.9501.00
4_V7_I1.9261.00
110_R114_F1.9241.00
114_F177_D1.9031.00
91_K95_E1.8331.00
91_K121_A1.8031.00
26_K147_S1.7921.00
91_K105_K1.7381.00
105_K109_N1.7151.00
90_G128_Y1.6991.00
145_N179_V1.6651.00
44_I184_T1.6591.00
95_E108_V1.6381.00
107_E110_R1.6361.00
171_N193_K1.6001.00
44_I150_I1.5951.00
11_Y16_A1.5861.00
113_E118_E1.5581.00
123_N127_K1.5521.00
11_Y42_T1.5461.00
22_L199_F1.5251.00
91_K122_N1.5251.00
192_K213_E1.5051.00
210_G215_M1.4421.00
61_L74_E1.4401.00
9_K51_M1.4401.00
9_K54_D1.4341.00
6_N21_S1.4201.00
8_V18_D1.4161.00
94_L112_L1.4151.00
95_E105_K1.3991.00
185_S191_V1.3851.00
59_Q64_N1.3591.00
4_V22_L1.3541.00
28_E196_D1.3531.00
30_V209_S1.3471.00
112_L121_A1.3351.00
64_N67_K1.3351.00
24_V30_V1.3321.00
202_Y207_V1.3201.00
10_K54_D1.3181.00
114_F172_K1.3161.00
91_K109_N1.3151.00
91_K108_V1.3061.00
7_I53_P1.2971.00
25_K197_R1.2961.00
89_T92_Q1.2821.00
20_V43_L1.2741.00
22_L43_L1.2641.00
219_F223_Q1.2611.00
221_G224_V1.2491.00
29_F174_K1.2361.00
109_N113_E1.2261.00
4_V47_L1.2201.00
111_V143_L1.2061.00
214_D218_E1.2051.00
145_N177_D1.2021.00
63_E68_S1.1981.00
30_V197_R1.1941.00
31_S191_V1.1831.00
106_S110_R1.1781.00
151_M181_I1.1731.00
111_V115_V1.1651.00
208_F218_E1.1501.00
88_L92_Q1.1491.00
207_V221_G1.1261.00
5_S23_E1.1211.00
49_T52_K1.1211.00
174_K181_I1.1201.00
107_E111_V1.1111.00
111_V139_A1.1051.00
48_L77_Y1.1031.00
116_E165_K1.0981.00
32_L43_L1.0891.00
46_I53_P1.0871.00
164_L168_E1.0771.00
93_V140_E1.0661.00
223_Q227_E1.0611.00
26_K61_L1.0591.00
87_F92_Q1.0461.00
45_R51_M1.0451.00
89_T122_N1.0421.00
167_R190_D1.0401.00
169_L172_K1.0271.00
222_I225_V1.0231.00
29_F181_I1.0231.00
29_F183_M1.0201.00
4_V43_L1.0191.00
29_F195_S1.0181.00
213_E217_K1.0161.00
212_V222_I1.0001.00
118_E121_A0.9971.00
17_L46_I0.9951.00
163_S187_E0.9941.00
94_L143_L0.9831.00
171_N174_K0.9751.00
80_E130_K0.9741.00
92_Q95_E0.9721.00
120_Y128_Y0.9711.00
110_R113_E0.9701.00
5_S21_S0.9661.00
76_G146_P0.9611.00
112_L117_M0.9581.00
43_L201_I0.9571.00
163_S190_D0.9481.00
198_I212_V0.9471.00
32_L182_L0.9471.00
214_D217_K0.9311.00
105_K108_V0.9311.00
101_R144_G0.9281.00
6_N55_R0.9251.00
76_G141_A0.9241.00
158_I166_T0.9241.00
70_R73_K0.9221.00
47_L182_L0.9191.00
98_A107_E0.9171.00
115_V139_A0.9081.00
151_M170_L0.9071.00
98_A143_L0.9061.00
149_L179_V0.9051.00
208_F219_F0.9031.00
89_T124_P0.9001.00
222_I226_V0.8881.00
35_P202_Y0.8871.00
78_V151_M0.8741.00
63_E74_E0.8721.00
98_A102_G0.8701.00
90_G136_I0.8691.00
94_L108_V0.8611.00
32_L199_F0.8581.00
125_I136_I0.8521.00
171_N175_R0.8491.00
128_Y136_I0.8481.00
168_E171_N0.8471.00
26_K178_N0.8461.00
120_Y132_M0.8451.00
149_L181_I0.8381.00
167_R193_K0.8301.00
174_K196_D0.8281.00
51_M54_D0.8251.00
29_F171_N0.8251.00
208_F215_M0.8241.00
208_F220_L0.8241.00
2_I148_I0.8231.00
4_V58_V0.8171.00
106_S109_N0.8121.00
9_K42_T0.8111.00
95_E99_K0.8111.00
98_A103_V0.8041.00
153_E186_H0.8041.00
38_A201_I0.8021.00
24_V180_S0.8011.00
170_L181_I0.8011.00
78_V141_A0.8001.00
48_L150_I0.7991.00
84_Y133_V0.7981.00
53_P66_F0.7971.00
124_P127_K0.7941.00
147_S179_V0.7901.00
109_N118_E0.7871.00
105_K121_A0.7871.00
78_V138_I0.7861.00
225_V229_D0.7861.00
57_E66_F0.7841.00
104_D107_E0.7821.00
46_I51_M0.7821.00
10_K16_A0.7791.00
183_M195_S0.7741.00
87_F126_V0.7681.00
52_K66_F0.7681.00
10_K18_D0.7661.00
19_N55_R0.7631.00
17_L20_V0.7621.00
111_V114_F0.7621.00
64_N68_S0.7611.00
206_I209_S0.7611.00
212_V216_V0.7611.00
33_I191_V0.7571.00
88_L96_L0.7571.00
97_S140_E0.7551.00
88_L93_V0.7541.00
116_E172_K0.7531.00
19_N205_K0.7531.00
7_I46_I0.7521.00
192_K216_V0.7501.00
20_V206_I0.7491.00
165_K168_E0.7471.00
109_N112_L0.7391.00
202_Y226_V0.7361.00
24_V182_L0.7361.00
46_I58_V0.7351.00
17_L43_L0.7351.00
122_N125_I0.7301.00
30_V182_L0.7281.00
128_Y132_M0.7281.00
93_V125_I0.7261.00
150_I182_L0.7241.00
111_V142_L0.7221.00
83_N133_V0.7171.00
192_K212_V0.7161.00
110_R145_N0.7151.00
29_F194_L0.7141.00
89_T93_V0.7121.00
173_L179_V0.7081.00
70_R74_E0.7061.00
71_I75_V0.7041.00
25_K180_S0.7021.00
45_R50_L0.7021.00
76_G144_G0.6941.00
171_N194_L0.6921.00
221_G225_V0.6921.00
63_E70_R0.6911.00
224_V227_E0.6891.00
59_Q62_G0.6761.00
168_E172_K0.6751.00
2_I47_L0.6731.00
155_N166_T0.6681.00
33_I200_M0.6561.00
108_V111_V0.6551.00
224_V228_T0.6511.00
33_I188_L0.6441.00
82_P137_A0.6431.00
113_E119_N0.6431.00
202_Y221_G0.6411.00
10_K13_N0.6371.00
117_M120_Y0.6351.00
200_M215_M0.6321.00
23_E209_S0.6301.00
24_V148_I0.6291.00
219_F222_I0.6251.00
6_N9_K0.6241.00
168_E193_K0.6211.00
97_S144_G0.6201.00
15_I19_N0.6161.00
15_I55_R0.6141.00
188_L216_V0.6141.00
202_Y205_K0.6131.00
155_N190_D0.6101.00
61_L148_I0.6101.00
16_A42_T0.6101.00
148_I180_S0.6101.00
75_V148_I0.6081.00
226_V230_E0.6081.00
130_K135_R0.6081.00
2_I60_I0.6061.00
195_S198_I0.6051.00
101_R104_D0.6021.00
10_K55_R0.6011.00
48_L75_V0.5971.00
174_K177_D0.5961.00
162_F165_K0.5951.00
215_M224_V0.5941.00
197_R211_T0.5921.00
109_N119_N0.5881.00
46_I54_D0.5871.00
103_V107_E0.5851.00
69_K72_F0.5781.00
9_K17_L0.5771.00
115_V169_L0.5761.00
190_D194_L0.5751.00
226_V229_D0.5751.00
185_S190_D0.5741.00
172_K177_D0.5731.00
189_E193_K0.5731.00
85_P93_V0.5711.00
230_E233_K0.5701.00
60_I74_E0.5681.00
129_S132_M0.5661.00
49_T53_P0.5641.00
61_L65_P0.5641.00
81_I133_V0.5631.00
96_L100_I0.5611.00
47_L58_V0.5601.00
60_I148_I0.5581.00
86_P126_V0.5571.00
85_P88_L0.5571.00
41_T45_R0.5571.00
14_K203_K0.5561.00
109_N117_M0.5541.00
195_S212_V0.5521.00
49_T66_F0.5511.00
219_F224_V0.5501.00
60_I71_I0.5501.00
119_N125_I0.5491.00
28_E209_S0.5431.00
11_Y51_M0.5421.00
79_Q82_P0.5391.00
170_L183_M0.5381.00
214_D220_L0.5381.00
108_V112_L0.5371.00
208_F214_D0.5361.00
29_F196_D0.5341.00
3_V62_G0.5341.00
10_K14_K0.5331.00
69_K73_K0.5321.00
47_L150_I0.5311.00
191_V195_S0.5311.00
191_V198_I0.5291.00
219_F227_E0.5291.00
106_S113_E0.5281.00
36_N162_F0.5271.00
68_S71_I0.5271.00
218_E221_G0.5251.00
183_M194_L0.5221.00
112_L115_V0.5221.00
207_V222_I0.5201.00
84_Y125_I0.5201.00
208_F223_Q0.5201.00
216_V219_F0.5201.00
36_N153_E0.5191.00
9_K12_G0.5181.00
63_E71_I0.5171.00
200_M219_F0.5161.00
187_E190_D0.5121.00
65_P68_S0.5111.00
138_I166_T0.5111.00
57_E67_K0.5071.00
223_Q226_V0.5051.00
62_G65_P0.5041.00
82_P133_V0.5021.00
58_V65_P0.5021.00
86_P133_V0.5011.00
135_R162_F0.5011.00
174_K179_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.8956 100 0.133 Contact Map
3tuiC 2 1 100 0.169 Contact Map
3d31A 2 0.9966 100 0.183 Contact Map
2it1A 1 0.9966 100 0.189 Contact Map
1v43A 2 0.9596 100 0.189 Contact Map
4f4cA 1 0.7239 100 0.189 Contact Map
2yyzA 1 0.9865 100 0.189 Contact Map
1z47A 2 1 100 0.19 Contact Map
4ry2A 2 0.7609 100 0.192 Contact Map
4rvcA 4 0.7879 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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