GREMLIN Database
ILVC2 - Putative ketol-acid reductoisomerase 2
UniProt: Q97YJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (317)
Sequences: 1919 (667)
Seq/√Len: 37.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_I39_L4.6801.00
96_Q101_F4.1971.00
148_V173_A3.8801.00
206_I241_I3.2001.00
17_T40_N3.0441.00
97_G121_S2.9511.00
250_M261_T2.9061.00
150_L161_W2.8461.00
102_V125_I2.8161.00
78_I86_V2.8001.00
30_Q106_A2.7701.00
174_I178_I2.7001.00
202_L234_L2.5921.00
206_I234_L2.5921.00
308_E312_Q2.5851.00
119_P122_V2.5501.00
258_Q307_W2.5231.00
186_E220_S2.4421.00
139_L142_Q2.4261.00
88_E92_A2.3731.00
52_E55_K2.3641.00
275_I278_N2.3351.00
85_E89_K2.3281.00
81_E255_T2.2850.99
138_D243_E2.2200.99
244_E248_N2.1770.99
264_R279_E2.1620.99
8_A174_I2.1350.99
272_V275_I2.1050.99
35_R59_F2.0700.99
267_K282_Y2.0410.99
104_D125_I2.0240.99
76_L91_I1.9820.99
85_E297_Q1.9790.98
34_M170_G1.9440.98
47_K63_E1.9360.98
102_V163_Y1.9300.98
207_K310_A1.9290.98
51_Y55_K1.9070.98
13_L166_A1.9000.98
102_V123_D1.8860.98
169_K174_I1.8760.98
45_N48_D1.8520.98
264_R282_Y1.7990.97
264_R291_E1.7960.97
298_A301_P1.7770.97
43_V59_F1.7670.97
64_I90_K1.7660.97
11_D14_K1.7520.97
65_D90_K1.7470.97
155_D162_D1.7350.96
23_Y57_E1.7320.96
271_V274_R1.7300.96
123_D160_A1.6730.96
161_W181_I1.6540.95
75_L106_A1.6500.95
206_I231_S1.6370.95
220_S223_A1.6290.95
19_G67_A1.6270.95
5_V174_I1.5930.94
62_Y70_R1.5750.94
21_I76_L1.5660.94
135_G138_D1.5640.94
74_A101_F1.5610.94
109_Y289_A1.5540.94
131_M173_A1.5460.93
296_Q300_Y1.5450.93
30_Q75_L1.5220.93
51_Y63_E1.5190.93
121_S156_A1.5180.93
123_D159_K1.5090.93
42_I70_R1.5070.92
317_K321_E1.5010.92
55_K60_E1.4980.92
21_I44_G1.4890.92
60_E70_R1.4630.91
203_F261_T1.4590.91
42_I62_Y1.4560.91
291_E302_V1.4560.91
139_L144_K1.4540.91
75_L104_D1.4530.91
202_L206_I1.4420.91
203_F246_I1.4270.90
294_L297_Q1.4180.90
17_T42_I1.4020.89
281_K285_D1.4010.89
255_T300_Y1.3920.89
47_K51_Y1.3920.89
267_K275_I1.3910.89
294_L298_A1.3620.88
68_V101_F1.3570.88
292_W295_E1.3530.88
263_T291_E1.3510.88
17_T70_R1.3360.87
264_R268_Y1.3350.87
68_V94_V1.3290.87
262_L307_W1.3260.87
263_T282_Y1.3220.86
206_I315_M1.3130.86
278_N282_Y1.3040.86
134_E252_H1.3040.86
69_R94_V1.3020.86
204_G273_R1.3010.86
258_Q262_L1.3010.86
305_R309_L1.2900.85
231_S241_I1.2840.85
216_E273_R1.2790.85
203_F250_M1.2720.84
83_M110_N1.2630.84
292_W300_Y1.2590.84
211_D273_R1.2590.84
204_G207_K1.2550.83
52_E56_K1.2530.83
216_E277_E1.2460.83
136_I146_Y1.2450.83
204_G208_A1.2400.83
303_F307_W1.2340.82
112_A185_E1.2320.82
48_D59_F1.2220.82
268_Y272_V1.2190.82
32_T59_F1.2160.81
210_Y314_E1.2050.81
68_V74_A1.2010.81
231_S315_M1.1980.80
290_K294_L1.1940.80
292_W296_Q1.1850.80
8_A178_I1.1840.80
123_D156_A1.1830.80
115_L293_S1.1800.79
125_I160_A1.1750.79
37_N140_H1.1680.79
18_I170_G1.1610.78
40_N60_E1.1600.78
63_E66_E1.1600.78
262_L306_L1.1550.78
46_V49_K1.1510.78
102_V157_S1.1490.77
101_F122_V1.1470.77
293_S298_A1.1250.76
211_D313_S1.1200.76
21_I78_I1.1190.76
287_S291_E1.1180.76
256_T288_F1.1060.75
208_A212_I1.0850.73
243_E248_N1.0800.73
28_R252_H1.0790.73
110_N116_I1.0760.73
123_D157_S1.0730.72
197_T209_C1.0680.72
84_K88_E1.0660.72
268_Y279_E1.0660.72
282_Y287_S1.0510.71
159_K162_D1.0510.71
95_L122_V1.0480.71
253_H261_T1.0400.70
64_I68_V1.0400.70
275_I282_Y1.0380.70
8_A169_K1.0360.70
10_L169_K1.0250.69
121_S154_Q1.0230.69
65_D94_V1.0200.69
186_E223_A1.0190.68
9_N12_P1.0170.68
45_N50_Y1.0140.68
109_Y115_L1.0130.68
294_L305_R1.0100.68
94_V101_F1.0080.68
306_L310_A1.0060.67
202_L241_I1.0040.67
48_D51_Y0.9870.66
308_E311_T0.9830.66
270_D274_R0.9800.65
101_F119_P0.9790.65
198_W209_C0.9750.65
270_D273_R0.9720.65
156_A160_A0.9710.65
131_M146_Y0.9650.64
104_D167_I0.9620.64
40_N70_R0.9530.63
300_Y304_Y0.9510.63
28_R134_E0.9400.62
12_P166_A0.9340.62
59_F62_Y0.9330.62
324_K327_G0.9310.61
5_V169_K0.9270.61
305_R308_E0.9240.61
63_E68_V0.9210.61
50_Y61_V0.9180.60
102_V160_A0.9140.60
118_P121_S0.9070.59
74_A119_P0.9070.59
247_F311_T0.9040.59
20_V167_I0.9020.59
268_Y275_I0.8940.58
197_T268_Y0.8840.57
248_N251_V0.8830.57
35_R48_D0.8760.57
292_W303_F0.8760.57
53_L57_E0.8730.56
21_I64_I0.8710.56
263_T306_L0.8650.56
95_L119_P0.8620.55
274_R277_E0.8620.55
279_E282_Y0.8620.55
42_I74_A0.8590.55
144_K328_R0.8550.55
9_N162_D0.8530.55
161_W165_K0.8490.54
20_V34_M0.8470.54
32_T57_E0.8450.54
204_G266_F0.8440.54
131_M148_V0.8420.54
255_T292_W0.8360.53
21_I68_V0.8320.53
300_Y303_F0.8310.53
72_D101_F0.8300.53
250_M310_A0.8270.52
20_V31_A0.8260.52
302_V306_L0.8250.52
144_K329_K0.8220.52
114_G117_R0.8220.52
212_I273_R0.8210.52
127_V168_A0.8200.52
231_S246_I0.8190.52
84_K297_Q0.8190.52
46_V51_Y0.8180.52
135_G242_A0.8080.51
264_R275_I0.8070.51
326_L329_K0.8020.50
83_M116_I0.7980.50
87_Y103_L0.7980.50
45_N61_V0.7970.50
322_L326_L0.7960.50
39_L170_G0.7960.50
19_G42_I0.7930.49
271_V275_I0.7910.49
73_V125_I0.7770.48
101_F121_S0.7760.48
109_Y188_A0.7730.48
294_L309_L0.7730.48
247_F316_A0.7670.47
206_I238_A0.7660.47
111_V126_M0.7580.46
62_Y66_E0.7580.46
139_L242_A0.7550.46
204_G250_M0.7550.46
115_L296_Q0.7520.46
302_V305_R0.7520.46
97_G101_F0.7510.46
53_L56_K0.7510.46
44_G50_Y0.7510.46
83_M105_F0.7480.45
138_D141_K0.7440.45
294_L302_V0.7410.45
97_G156_A0.7390.45
148_V171_I0.7390.45
169_K178_I0.7380.44
125_I150_L0.7340.44
115_L294_L0.7330.44
282_Y285_D0.7330.44
82_V86_V0.7320.44
241_I246_I0.7300.44
13_L170_G0.7300.44
72_D96_Q0.7270.44
282_Y291_E0.7220.43
12_P163_Y0.7210.43
311_T314_E0.7200.43
294_L308_E0.7190.43
15_G166_A0.7190.43
131_M138_D0.7140.42
139_L327_G0.7110.42
163_Y166_A0.7090.42
246_I310_A0.7080.42
278_N281_K0.7060.42
41_V44_G0.7030.41
144_K242_A0.7020.41
50_Y53_L0.7020.41
76_L86_V0.7010.41
25_N134_E0.6980.41
32_T50_Y0.6970.41
278_N287_S0.6930.41
54_A59_F0.6920.40
217_Y280_A0.6920.40
34_M167_I0.6920.40
109_Y293_S0.6890.40
201_I205_A0.6880.40
317_K320_K0.6850.40
150_L164_A0.6840.40
126_M148_V0.6810.40
35_R57_E0.6790.39
134_E251_V0.6730.39
21_I91_I0.6720.39
259_Y291_E0.6700.39
84_K293_S0.6700.39
287_S290_K0.6690.39
113_F188_A0.6680.38
48_D57_E0.6660.38
269_Y272_V0.6650.38
259_Y328_R0.6610.38
69_R96_Q0.6610.38
149_L181_I0.6610.38
51_Y61_V0.6580.38
28_R57_E0.6570.38
124_T154_Q0.6560.37
10_L39_L0.6560.37
303_F306_L0.6550.37
73_V166_A0.6550.37
161_W164_A0.6530.37
204_G261_T0.6490.37
45_N51_Y0.6440.36
247_F320_K0.6430.36
114_G299_G0.6400.36
144_K327_G0.6380.36
81_E329_K0.6360.36
81_E258_Q0.6340.36
81_E253_H0.6340.36
279_E291_E0.6320.35
138_D248_N0.6310.35
104_D163_Y0.6310.35
78_I82_V0.6310.35
262_L291_E0.6290.35
197_T234_L0.6290.35
66_E70_R0.6270.35
131_M135_G0.6250.35
131_M175_P0.6250.35
54_A61_V0.6240.35
46_V82_V0.6210.35
50_Y54_A0.6200.35
112_A153_K0.6180.34
16_K163_Y0.6180.34
155_D158_G0.6180.34
291_E294_L0.6170.34
197_T279_E0.6160.34
75_L167_I0.6140.34
97_G122_V0.6110.34
168_A178_I0.6110.34
148_V178_I0.6090.34
263_T275_I0.6090.34
74_A122_V0.6080.34
307_W311_T0.6080.34
290_K302_V0.6050.33
309_L312_Q0.6030.33
19_G74_A0.6010.33
319_E323_Y0.6010.33
228_F231_S0.6010.33
193_M280_A0.6000.33
30_Q104_D0.6000.33
114_G153_K0.6000.33
115_L297_Q0.5990.33
46_V64_I0.5980.33
19_G44_G0.5970.33
163_Y290_K0.5970.33
264_R278_N0.5970.33
96_Q122_V0.5950.33
204_G283_I0.5920.32
28_R32_T0.5910.32
70_R166_A0.5900.32
125_I164_A0.5890.32
135_G139_L0.5870.32
117_R304_Y0.5860.32
49_K52_E0.5860.32
188_A289_A0.5850.32
250_M253_H0.5850.32
150_L223_A0.5850.32
189_L284_W0.5850.32
291_E306_L0.5840.32
44_G48_D0.5830.32
321_E324_K0.5820.32
217_Y284_W0.5820.32
102_V159_K0.5810.31
307_W310_A0.5780.31
92_A119_P0.5770.31
32_T36_E0.5760.31
139_L173_A0.5740.31
19_G71_S0.5730.31
66_E69_R0.5720.31
125_I163_Y0.5710.31
234_L241_I0.5710.31
123_D163_Y0.5700.31
204_G211_D0.5700.31
13_L70_R0.5700.31
138_D142_Q0.5700.31
194_S199_V0.5700.31
6_L169_K0.5690.31
312_Q317_K0.5670.30
5_V10_L0.5660.30
287_S302_V0.5610.30
294_L301_P0.5610.30
35_R47_K0.5610.30
135_G329_K0.5600.30
259_Y264_R0.5570.30
68_V76_L0.5560.30
246_I315_M0.5560.30
64_I78_I0.5550.30
270_D277_E0.5530.29
189_L219_V0.5520.29
97_G119_P0.5510.29
141_K144_K0.5500.29
20_V106_A0.5500.29
263_T279_E0.5490.29
35_R62_Y0.5470.29
273_R277_E0.5460.29
255_T307_W0.5460.29
173_A328_R0.5460.29
136_I173_A0.5450.29
320_K324_K0.5450.29
31_A293_S0.5450.29
207_K246_I0.5440.29
135_G326_L0.5440.29
264_R267_K0.5430.29
116_I256_T0.5430.29
235_A239_R0.5420.29
28_R251_V0.5420.29
70_R101_F0.5400.28
301_P304_Y0.5390.28
78_I81_E0.5380.28
185_E223_A0.5380.28
263_T268_Y0.5370.28
210_Y220_S0.5370.28
306_L309_L0.5340.28
106_A234_L0.5320.28
211_D266_F0.5320.28
113_F285_D0.5300.28
264_R306_L0.5300.28
267_K278_N0.5290.28
174_I329_K0.5280.28
5_V36_E0.5280.28
8_A12_P0.5270.27
127_V144_K0.5270.27
44_G74_A0.5260.27
32_T35_R0.5240.27
14_K120_K0.5230.27
43_V62_Y0.5220.27
263_T278_N0.5200.27
279_E287_S0.5190.27
204_G268_Y0.5190.27
32_T53_L0.5160.27
6_L14_K0.5150.27
68_V91_I0.5150.27
68_V71_S0.5140.27
208_A274_R0.5140.27
63_E90_K0.5140.27
253_H257_S0.5140.27
231_S234_L0.5130.26
114_G304_Y0.5130.26
65_D93_P0.5120.26
62_Y67_A0.5120.26
35_R60_E0.5110.26
115_L299_G0.5100.26
11_D52_E0.5090.26
42_I71_S0.5090.26
255_T303_F0.5080.26
113_F305_R0.5070.26
303_F310_A0.5070.26
317_K324_K0.5070.26
165_K178_I0.5070.26
177_G226_L0.5060.26
39_L166_A0.5060.26
113_F256_T0.5060.26
76_L83_M0.5050.26
16_K72_D0.5050.26
314_E318_A0.5050.26
148_V174_I0.5050.26
159_K163_Y0.5040.26
173_A234_L0.5040.26
126_M151_G0.5040.26
255_T258_Q0.5040.26
247_F251_V0.5030.26
234_L253_H0.5030.26
144_K176_G0.5030.26
261_T310_A0.5010.26
28_R31_A0.5010.26
125_I327_G0.5010.26
36_E141_K0.5010.26
148_V223_A0.5010.26
117_R120_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulkA 3 0.964 100 0.5 Contact Map
4xdzA 2 0.973 100 0.53 Contact Map
4xdyA 2 0.967 100 0.532 Contact Map
4tskA 3 0.979 100 0.55 Contact Map
3fr7A 2 0.961 100 0.58 Contact Map
1np3A 4 0.97 100 0.609 Contact Map
4kqwA 2 0.97 100 0.621 Contact Map
4yt2A 2 0.9039 99.9 0.842 Contact Map
3ggoA 2 0.7898 99.6 0.879 Contact Map
3c24A 2 0.7808 99.4 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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