THIC1 - SULSO - GREMLIN Contacts

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THIC1 - Phosphomethylpyrimidine synthase 1

UniProt:	Q97YJ8	Sequences: MAIIEEARSGQITDEMKEISKLEGIPVEKVRNRISECKIILIRNAKYPSKKLVPIGKGLTTKVNINIGTSDEVVNLQMELEKVKVANRWGDTLMDLSTGGDLDDIRREIIRASELPVGTVPVYQVFIESFKKKSGGAYFTEDELLSTVEKHLKDGVAFMTIHAGITKELAIRALKSNRIIPIVSRGGDMIAGWMIHNNSENPYRKHWGYLLEMFKEYDAVISLGDALRPGATGDAHDEFQVGELLETARLVKSALKEGVQVMVEGPGHVPLNEIAWDVKLMKKLTGGVPYYVLGPLPIDVGAPYDHIASAIGAAISSAAGADLLCYLTPAEHLGLPTVKQVEEGAIAYRIAAHAGDVVKLGRRVRKWDDEVSYYRGKLEWDNMISRLIDPQRAYQVYTQFGIPKVKACTMCGGYCPMMWAMDQVRKIGSSSSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	433 (417)
Sequences:	1088 (401)
Seq/√Len:	19.6

ECOLI - THIC
BACSU - THIC
HALSA - THIC
SULSO - THIC1 THIC2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
381_D	394_Y	3.771	1.00
103_D	150_K	3.763	1.00
61_T	359_K	3.337	1.00
54_P	59_L	3.250	1.00
251_V	255_L	3.239	1.00
382_N	385_S	3.212	1.00
33_R	39_I	3.119	0.99
251_V	263_V	3.079	0.99
145_L	209_Y	3.014	0.99
343_E	392_R	2.955	0.99
180_I	417_M	2.947	0.99
275_A	279_K	2.933	0.99
83_V	93_L	2.907	0.99
297_P	354_A	2.898	0.99
19_I	54_P	2.785	0.99
34_I	41_L	2.680	0.98
180_I	231_A	2.665	0.98
214_F	221_I	2.654	0.98
14_D	17_K	2.642	0.98
28_E	31_R	2.543	0.97
25_I	30_V	2.523	0.97
145_L	210_L	2.516	0.97
148_V	203_Y	2.494	0.97
152_L	219_A	2.475	0.97
212_E	257_E	2.419	0.97
149_E	153_K	2.386	0.96
12_I	31_R	2.375	0.96
107_R	154_D	2.341	0.96
5_E	215_K	2.304	0.95
103_D	124_Q	2.275	0.95
30_V	39_I	2.259	0.95
313_A	324_L	2.250	0.95
75_N	78_M	2.220	0.94
182_I	191_A	2.219	0.94
370_E	382_N	2.207	0.94
300_V	367_W	2.200	0.94
19_I	41_L	2.182	0.94
13_T	16_M	2.155	0.93
278_V	319_A	2.131	0.93
65_I	345_A	2.110	0.93
353_H	368_D	2.099	0.92
38_K	57_K	2.094	0.92
349_R	367_W	2.085	0.92
271_L	314_A	2.073	0.92
22_L	51_K	2.073	0.92
29_K	33_R	2.027	0.91
252_K	286_G	2.016	0.91
27_V	31_R	2.010	0.91
149_E	216_E	2.002	0.90
17_K	21_K	1.993	0.90
215_K	257_E	1.969	0.90
119_T	156_V	1.964	0.90
208_G	253_S	1.954	0.89
101_D	104_D	1.930	0.89
38_K	287_G	1.929	0.89
81_E	84_K	1.927	0.89
302_A	308_A	1.926	0.89
148_V	210_L	1.918	0.88
236_H	277_D	1.913	0.88
81_E	338_V	1.868	0.87
124_Q	128_E	1.862	0.87
271_L	315_I	1.829	0.86
161_I	221_I	1.825	0.86
179_I	369_D	1.813	0.85
30_V	33_R	1.811	0.85
215_K	258_G	1.756	0.83
365_R	369_D	1.755	0.83
255_L	286_G	1.752	0.83
152_L	159_M	1.747	0.83
3_I	16_M	1.732	0.83
33_R	38_K	1.726	0.82
39_I	59_L	1.722	0.82
87_N	114_E	1.677	0.80
179_I	233_G	1.631	0.78
17_K	27_V	1.625	0.78
211_L	221_I	1.616	0.78
272_N	360_L	1.609	0.78
326_Y	341_V	1.606	0.77
5_E	258_G	1.605	0.77
273_E	283_K	1.581	0.76
309_S	327_L	1.569	0.76
373_Y	377_K	1.557	0.75
199_S	205_K	1.554	0.75
167_K	198_N	1.553	0.75
4_I	40_I	1.547	0.75
204_R	249_R	1.543	0.74
395_Q	399_Q	1.541	0.74
263_V	281_M	1.505	0.73
40_I	220_V	1.504	0.72
161_I	210_L	1.492	0.72
213_M	219_A	1.483	0.71
61_T	361_G	1.482	0.71
281_M	290_Y	1.476	0.71
277_D	290_Y	1.467	0.71
370_E	386_R	1.466	0.70
12_I	27_V	1.466	0.70
236_H	290_Y	1.460	0.70
223_L	247_T	1.459	0.70
179_I	231_A	1.450	0.70
141_E	206_H	1.450	0.70
43_R	50_K	1.446	0.69
65_I	86_A	1.444	0.69
41_L	54_P	1.439	0.69
281_M	285_T	1.434	0.69
342_E	346_I	1.432	0.69
3_I	13_T	1.432	0.69
374_Y	382_N	1.425	0.68
244_L	290_Y	1.422	0.68
66_N	160_T	1.412	0.68
32_N	36_E	1.396	0.67
83_V	113_S	1.390	0.66
92_T	116_P	1.375	0.65
382_N	386_R	1.375	0.65
67_I	83_V	1.372	0.65
379_E	382_N	1.365	0.65
84_K	112_A	1.352	0.64
110_I	151_H	1.351	0.64
9_S	258_G	1.340	0.63
206_H	209_Y	1.339	0.63
141_E	205_K	1.339	0.63
169_L	246_E	1.338	0.63
313_A	348_Y	1.323	0.62
42_I	55_I	1.315	0.62
30_V	34_I	1.310	0.62
246_E	249_R	1.308	0.61
342_E	392_R	1.301	0.61
232_T	357_V	1.292	0.60
4_I	255_L	1.292	0.60
65_I	93_L	1.288	0.60
80_L	83_V	1.287	0.60
6_E	11_Q	1.282	0.60
88_R	391_Q	1.279	0.60
168_E	200_E	1.275	0.59
372_S	417_M	1.274	0.59
158_F	323_L	1.266	0.59
58_G	322_D	1.257	0.58
16_M	30_V	1.255	0.58
339_K	343_E	1.254	0.58
255_L	263_V	1.248	0.58
151_H	159_M	1.247	0.58
211_L	259_V	1.244	0.57
149_E	209_Y	1.241	0.57
231_A	372_S	1.240	0.57
207_W	223_L	1.237	0.57
363_R	366_K	1.235	0.57
236_H	241_V	1.231	0.57
298_I	301_G	1.230	0.57
317_S	355_G	1.229	0.57
282_K	322_D	1.225	0.56
86_A	345_A	1.223	0.56
103_D	154_D	1.214	0.56
57_K	287_G	1.201	0.55
275_A	319_A	1.201	0.55
369_D	373_Y	1.199	0.55
64_N	70_S	1.195	0.54
40_I	262_M	1.192	0.54
272_N	365_R	1.192	0.54
29_K	39_I	1.183	0.54
241_V	280_L	1.182	0.54
211_L	257_E	1.181	0.53
7_A	13_T	1.164	0.52
102_L	105_I	1.155	0.52
100_G	105_I	1.153	0.52
324_L	348_Y	1.144	0.51
142_D	145_L	1.144	0.51
318_A	359_K	1.142	0.51
255_L	288_V	1.138	0.51
144_L	148_V	1.138	0.51
4_I	251_V	1.135	0.51
235_A	273_E	1.133	0.50
3_I	218_D	1.133	0.50
307_I	347_A	1.123	0.50
19_I	34_I	1.122	0.50
167_K	194_M	1.121	0.50
87_N	113_S	1.114	0.49
63_V	345_A	1.113	0.49
25_I	29_K	1.113	0.49
221_I	263_V	1.111	0.49
113_S	117_V	1.108	0.49
292_V	316_S	1.103	0.48
225_D	229_P	1.100	0.48
46_K	217_Y	1.097	0.48
209_Y	216_E	1.091	0.48
120_V	293_L	1.085	0.47
180_I	372_S	1.077	0.47
106_R	154_D	1.071	0.46
253_S	257_E	1.070	0.46
85_V	89_W	1.068	0.46
392_R	395_Q	1.063	0.46
148_V	159_M	1.062	0.46
400_F	409_T	1.060	0.46
18_E	51_K	1.057	0.46
141_E	145_L	1.056	0.45
16_M	31_R	1.055	0.45
300_V	353_H	1.053	0.45
278_V	321_A	1.052	0.45
274_I	315_I	1.051	0.45
418_M	422_D	1.049	0.45
245_L	284_L	1.048	0.45
170_A	194_M	1.044	0.45
64_N	120_V	1.043	0.45
64_N	264_E	1.042	0.45
280_L	290_Y	1.041	0.44
188_D	416_P	1.039	0.44
109_I	117_V	1.037	0.44
381_D	385_S	1.035	0.44
309_S	348_Y	1.022	0.43
300_V	368_D	1.018	0.43
60_T	349_R	1.018	0.43
55_I	116_P	1.017	0.43
134_S	138_Y	1.011	0.43
89_W	345_A	1.009	0.42
151_H	154_D	1.007	0.42
47_Y	52_L	1.005	0.42
406_K	421_M	0.996	0.42
238_E	252_K	0.994	0.42
370_E	373_Y	0.994	0.42
16_M	41_L	0.987	0.41
224_G	264_E	0.986	0.41
120_V	264_E	0.984	0.41
53_V	91_D	0.979	0.41
264_E	293_L	0.975	0.40
251_V	286_G	0.974	0.40
285_T	290_Y	0.974	0.40
63_V	117_V	0.973	0.40
61_T	356_D	0.972	0.40
164_G	223_L	0.971	0.40
315_I	319_A	0.968	0.40
67_I	93_L	0.960	0.39
211_L	214_F	0.960	0.39
243_E	295_P	0.959	0.39
117_V	272_N	0.955	0.39
34_I	54_P	0.954	0.39
64_N	293_L	0.953	0.39
91_D	349_R	0.949	0.39
346_I	349_R	0.946	0.39
168_E	242_G	0.946	0.39
406_K	418_M	0.945	0.39
270_P	273_E	0.943	0.38
34_I	40_I	0.937	0.38
30_V	59_L	0.934	0.38
164_G	247_T	0.932	0.38
323_L	348_Y	0.931	0.38
142_D	209_Y	0.929	0.38
146_S	150_K	0.928	0.37
391_Q	395_Q	0.923	0.37
70_S	224_G	0.917	0.37
61_T	318_A	0.915	0.37
202_P	316_S	0.915	0.37
296_L	309_S	0.914	0.37
87_N	115_L	0.914	0.37
108_E	111_R	0.911	0.36
245_L	280_L	0.910	0.36
392_R	396_V	0.909	0.36
146_S	149_E	0.905	0.36
185_R	293_L	0.904	0.36
334_G	400_F	0.901	0.36
254_A	261_V	0.901	0.36
224_G	293_L	0.893	0.35
58_G	282_K	0.889	0.35
337_T	399_Q	0.889	0.35
251_V	354_A	0.888	0.35
89_W	342_E	0.886	0.35
160_T	291_Y	0.878	0.35
39_I	58_G	0.877	0.34
53_V	116_P	0.876	0.34
18_E	21_K	0.872	0.34
65_I	83_V	0.871	0.34
271_L	274_I	0.869	0.34
387_L	390_P	0.865	0.34
4_I	258_G	0.865	0.34
298_I	368_D	0.863	0.34
301_G	350_I	0.863	0.34
247_T	263_V	0.862	0.34
64_N	224_G	0.860	0.33
7_A	35_S	0.860	0.33
384_I	393_A	0.859	0.33
179_I	373_Y	0.858	0.33
70_S	264_E	0.858	0.33
84_K	88_R	0.857	0.33
161_I	203_Y	0.854	0.33
16_M	35_S	0.851	0.33
380_W	410_M	0.851	0.33
80_L	113_S	0.848	0.33
176_S	238_E	0.842	0.32
148_V	161_I	0.841	0.32
144_L	203_Y	0.841	0.32
48_P	111_R	0.840	0.32
160_T	293_L	0.839	0.32
139_F	197_N	0.835	0.32
142_D	198_N	0.834	0.32
244_L	281_M	0.833	0.32
236_H	273_E	0.833	0.32
152_L	213_M	0.832	0.32
7_A	16_M	0.830	0.32
161_I	166_T	0.828	0.32
165_I	226_A	0.828	0.32
40_I	255_L	0.826	0.32
191_A	420_A	0.825	0.32
346_I	350_I	0.824	0.31
33_R	58_G	0.822	0.31
141_E	209_Y	0.819	0.31
120_V	291_Y	0.816	0.31
70_S	293_L	0.815	0.31
163_A	221_I	0.813	0.31
179_I	372_S	0.811	0.31
244_L	277_D	0.808	0.31
144_L	147_T	0.805	0.30
397_Y	406_K	0.805	0.30
160_T	235_A	0.804	0.30
163_A	273_E	0.804	0.30
109_I	355_G	0.803	0.30
70_S	120_V	0.801	0.30
181_P	189_M	0.799	0.30
409_T	424_V	0.795	0.30
159_M	214_F	0.792	0.30
120_V	224_G	0.792	0.30
244_L	280_L	0.788	0.29
397_Y	407_A	0.781	0.29
334_G	396_V	0.778	0.29
12_I	28_E	0.775	0.29
95_D	229_P	0.773	0.29
388_I	391_Q	0.773	0.29
66_N	224_G	0.772	0.29
276_W	279_K	0.772	0.29
143_E	151_H	0.772	0.29
36_E	287_G	0.772	0.29
39_I	54_P	0.771	0.29
204_R	207_W	0.770	0.29
277_D	291_Y	0.767	0.28
317_S	361_G	0.762	0.28
231_A	355_G	0.759	0.28
66_N	182_I	0.758	0.28
133_K	138_Y	0.758	0.28
176_S	286_G	0.757	0.28
139_F	143_E	0.756	0.28
367_W	388_I	0.754	0.28
8_R	258_G	0.750	0.28
80_L	84_K	0.749	0.27
67_I	136_G	0.745	0.27
91_D	188_D	0.741	0.27
240_Q	292_V	0.740	0.27
95_D	225_D	0.740	0.27
145_L	149_E	0.738	0.27
135_G	138_Y	0.736	0.27
22_L	53_V	0.736	0.27
165_I	169_L	0.736	0.27
188_D	419_W	0.735	0.27
308_A	327_L	0.728	0.26
69_T	98_T	0.727	0.26
272_N	279_K	0.724	0.26
313_A	371_V	0.722	0.26
343_E	347_A	0.722	0.26
185_R	264_E	0.721	0.26
165_I	209_Y	0.718	0.26
170_A	383_M	0.715	0.26
232_T	372_S	0.714	0.26
64_N	69_T	0.713	0.26
174_L	195_I	0.712	0.26
161_I	214_F	0.710	0.26
160_T	225_D	0.709	0.25
212_E	215_K	0.709	0.25
90_G	341_V	0.709	0.25
26_P	29_K	0.704	0.25
396_V	400_F	0.704	0.25
388_I	393_A	0.702	0.25
76_L	104_D	0.696	0.25
219_A	385_S	0.694	0.25
53_V	92_T	0.691	0.25
92_T	323_L	0.689	0.24
180_I	190_I	0.688	0.24
315_I	318_A	0.687	0.24
367_W	372_S	0.685	0.24
47_Y	50_K	0.684	0.24
163_A	250_L	0.683	0.24
160_T	182_I	0.683	0.24
85_V	338_V	0.682	0.24
55_I	394_Y	0.681	0.24
334_G	383_M	0.679	0.24
101_D	128_E	0.679	0.24
120_V	185_R	0.674	0.24
12_I	16_M	0.671	0.24
378_L	407_A	0.671	0.24
119_T	227_L	0.671	0.24
107_R	338_V	0.668	0.24
31_R	35_S	0.668	0.24
241_V	244_L	0.666	0.23
160_T	185_R	0.664	0.23
7_A	10_G	0.664	0.23
85_V	88_R	0.661	0.23
94_M	293_L	0.661	0.23
79_E	82_K	0.660	0.23
214_F	259_V	0.659	0.23
32_N	216_E	0.657	0.23
151_H	181_P	0.656	0.23
238_E	245_L	0.653	0.23
144_L	202_P	0.653	0.23
159_M	166_T	0.652	0.23
338_V	345_A	0.652	0.23
242_G	371_V	0.652	0.23
42_I	220_V	0.651	0.23
114_E	157_A	0.650	0.23
276_W	283_K	0.648	0.23
142_D	210_L	0.648	0.23
273_E	276_W	0.647	0.23
95_D	119_T	0.644	0.22
119_T	147_T	0.643	0.22
337_T	401_G	0.643	0.22
358_V	386_R	0.642	0.22
397_Y	400_F	0.641	0.22
209_Y	212_E	0.639	0.22
36_E	57_K	0.637	0.22
248_A	285_T	0.637	0.22
207_W	278_V	0.636	0.22
159_M	219_A	0.636	0.22
24_G	27_V	0.636	0.22
94_M	118_G	0.635	0.22
248_A	288_V	0.635	0.22
165_I	227_L	0.635	0.22
44_N	157_A	0.634	0.22
240_Q	244_L	0.633	0.22
157_A	220_V	0.633	0.22
191_A	424_V	0.633	0.22
378_L	417_M	0.632	0.22
90_G	409_T	0.629	0.22
164_G	210_L	0.629	0.22
13_T	41_L	0.626	0.22
63_V	258_G	0.626	0.22
137_A	196_H	0.626	0.22
42_I	53_V	0.623	0.21
311_I	314_A	0.623	0.21
238_E	249_R	0.622	0.21
34_I	263_V	0.621	0.21
208_G	257_E	0.620	0.21
405_V	409_T	0.620	0.21
214_F	219_A	0.620	0.21
110_I	117_V	0.619	0.21
247_T	288_V	0.618	0.21
88_R	349_R	0.618	0.21
269_V	280_L	0.617	0.21
154_D	217_Y	0.617	0.21
235_A	291_Y	0.616	0.21
145_L	206_H	0.616	0.21
205_K	209_Y	0.616	0.21
113_S	188_D	0.615	0.21
207_W	247_T	0.615	0.21
150_K	154_D	0.612	0.21
59_L	317_S	0.611	0.21
33_R	57_K	0.609	0.21
190_I	210_L	0.609	0.21
163_A	292_V	0.609	0.21
315_I	346_I	0.608	0.21
189_M	372_S	0.608	0.21
185_R	291_Y	0.606	0.21
394_Y	398_T	0.605	0.21
2_A	218_D	0.605	0.21
92_T	158_F	0.603	0.21
66_N	70_S	0.603	0.21
252_K	302_A	0.603	0.21
77_Q	108_E	0.603	0.21
15_E	18_E	0.602	0.21
182_I	224_G	0.601	0.21
164_G	226_A	0.601	0.21
69_T	102_L	0.600	0.21
350_I	388_I	0.600	0.21
207_W	221_I	0.599	0.20
264_E	291_Y	0.599	0.20
99_G	189_M	0.599	0.20
309_S	406_K	0.598	0.20
251_V	355_G	0.598	0.20
366_K	370_E	0.597	0.20
24_G	362_R	0.596	0.20
339_K	342_E	0.595	0.20
125_V	318_A	0.595	0.20
242_G	246_E	0.593	0.20
93_L	115_L	0.593	0.20
137_A	192_G	0.592	0.20
236_H	280_L	0.591	0.20
95_D	292_V	0.590	0.20
371_V	383_M	0.590	0.20
107_R	111_R	0.590	0.20
367_W	386_R	0.589	0.20
202_P	292_V	0.588	0.20
87_N	112_A	0.587	0.20
231_A	383_M	0.585	0.20
226_A	288_V	0.584	0.20
26_P	32_N	0.584	0.20
5_E	9_S	0.584	0.20
64_N	185_R	0.582	0.20
17_K	300_V	0.582	0.20
271_L	319_A	0.581	0.20
142_D	153_K	0.581	0.20
118_G	293_L	0.581	0.20
2_A	5_E	0.580	0.20
126_F	189_M	0.580	0.20
408_C	411_C	0.580	0.20
302_A	333_L	0.579	0.20
98_T	224_G	0.578	0.20
4_I	8_R	0.578	0.20
174_L	238_E	0.577	0.20
397_Y	409_T	0.576	0.20
14_D	31_R	0.575	0.19
229_P	316_S	0.575	0.19
118_G	266_P	0.575	0.19
77_Q	81_E	0.574	0.19
98_T	226_A	0.574	0.19
182_I	189_M	0.573	0.19
124_Q	383_M	0.572	0.19
98_T	419_W	0.571	0.19
60_T	314_A	0.571	0.19
355_G	360_L	0.570	0.19
207_W	254_A	0.567	0.19
278_V	292_V	0.567	0.19
145_L	262_M	0.567	0.19
193_W	197_N	0.566	0.19
377_K	421_M	0.566	0.19
145_L	226_A	0.566	0.19
124_Q	147_T	0.566	0.19
3_I	7_A	0.565	0.19
156_V	232_T	0.565	0.19
173_A	238_E	0.564	0.19
55_I	110_I	0.564	0.19
166_T	407_A	0.563	0.19
120_V	160_T	0.562	0.19
411_C	415_C	0.562	0.19
259_V	284_L	0.562	0.19
408_C	415_C	0.562	0.19
95_D	156_V	0.561	0.19
110_I	313_A	0.559	0.19
217_Y	357_V	0.559	0.19
302_A	371_V	0.558	0.19
166_T	239_F	0.558	0.19
80_L	112_A	0.557	0.19
160_T	229_P	0.557	0.19
99_G	124_Q	0.557	0.19
314_A	318_A	0.557	0.19
64_N	291_Y	0.556	0.19
7_A	31_R	0.556	0.19
103_D	107_R	0.556	0.19
9_S	256_K	0.555	0.19
148_V	163_A	0.555	0.19
6_E	9_S	0.554	0.19
159_M	210_L	0.554	0.19
137_A	189_M	0.553	0.19
198_N	349_R	0.553	0.19
273_E	277_D	0.553	0.19
300_V	349_R	0.552	0.19
371_V	387_L	0.551	0.19
164_G	277_D	0.550	0.18
71_D	337_T	0.550	0.18
195_I	337_T	0.549	0.18
137_A	181_P	0.548	0.18
93_L	367_W	0.548	0.18
108_E	112_A	0.546	0.18
55_I	122_V	0.546	0.18
235_A	270_P	0.546	0.18
141_E	199_S	0.546	0.18
84_K	221_I	0.544	0.18
69_T	335_L	0.544	0.18
145_L	159_M	0.543	0.18
95_D	313_A	0.543	0.18
271_L	360_L	0.543	0.18
4_I	34_I	0.542	0.18
251_V	281_M	0.542	0.18
251_V	261_V	0.542	0.18
77_Q	111_R	0.542	0.18
247_T	295_P	0.538	0.18
66_N	120_V	0.538	0.18
124_Q	181_P	0.537	0.18
313_A	323_L	0.537	0.18
266_P	293_L	0.535	0.18
346_I	392_R	0.535	0.18
11_Q	359_K	0.534	0.18
31_R	399_Q	0.534	0.18
158_F	348_Y	0.533	0.18
57_K	61_T	0.533	0.18
403_P	407_A	0.532	0.18
110_I	314_A	0.532	0.18
163_A	207_W	0.532	0.18
160_T	224_G	0.531	0.18
245_L	282_K	0.530	0.18
65_I	89_W	0.529	0.18
102_L	124_Q	0.529	0.18
396_V	399_Q	0.528	0.18
240_Q	326_Y	0.526	0.18
64_N	335_L	0.526	0.18
98_T	185_R	0.526	0.18
202_P	379_E	0.525	0.18
164_G	380_W	0.525	0.18
231_A	354_A	0.525	0.18
181_P	191_A	0.524	0.18
157_A	297_P	0.524	0.18
99_G	102_L	0.521	0.17
168_E	262_M	0.519	0.17
414_Y	419_W	0.517	0.17
85_V	345_A	0.517	0.17
12_I	84_K	0.516	0.17
378_L	420_A	0.516	0.17
244_L	327_L	0.514	0.17
174_L	400_F	0.514	0.17
313_A	355_G	0.514	0.17
374_Y	386_R	0.513	0.17
18_E	22_L	0.513	0.17
44_N	47_Y	0.510	0.17
210_L	221_I	0.510	0.17
120_V	335_L	0.510	0.17
399_Q	416_P	0.509	0.17
318_A	358_V	0.508	0.17
77_Q	84_K	0.506	0.17
124_Q	132_K	0.506	0.17
316_S	379_E	0.506	0.17
95_D	353_H	0.505	0.17
247_T	360_L	0.505	0.17
390_P	393_A	0.504	0.17
75_N	409_T	0.504	0.17
126_F	137_A	0.504	0.17
246_E	253_S	0.503	0.17
196_H	263_V	0.503	0.17
304_Y	307_I	0.503	0.17
227_L	243_E	0.503	0.17
105_I	109_I	0.501	0.17
167_K	390_P	0.501	0.17
94_M	160_T	0.501	0.17
347_A	350_I	0.501	0.17
74_V	78_M	0.500	0.17
271_L	318_A	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4s28A	2	0.9838	100	0.041	Contact Map
3epoA	2	0.8984	100	0.041	Contact Map
2h9aB	1	0.5566	93.9	0.973	Contact Map
1eyeA	2	0.4896	93.8	0.973	Contact Map
1aj0A	1	0.5635	92.6	0.974	Contact Map
2dqwA	2	0.5035	92	0.974	Contact Map
2y5sA	2	0.5358	91.7	0.974	Contact Map
4djdD	1	0.5612	91.3	0.975	Contact Map
2czdA	2	0.4596	90.8	0.975	Contact Map
4muzA	2	0.4642	89.8	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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