GREMLIN Database
THIC1 - Phosphomethylpyrimidine synthase 1
UniProt: Q97YJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (417)
Sequences: 1088 (401)
Seq/√Len: 19.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
381_D394_Y3.7711.00
103_D150_K3.7631.00
61_T359_K3.3371.00
54_P59_L3.2501.00
251_V255_L3.2391.00
382_N385_S3.2121.00
33_R39_I3.1190.99
251_V263_V3.0790.99
145_L209_Y3.0140.99
343_E392_R2.9550.99
180_I417_M2.9470.99
275_A279_K2.9330.99
83_V93_L2.9070.99
297_P354_A2.8980.99
19_I54_P2.7850.99
34_I41_L2.6800.98
180_I231_A2.6650.98
214_F221_I2.6540.98
14_D17_K2.6420.98
28_E31_R2.5430.97
25_I30_V2.5230.97
145_L210_L2.5160.97
148_V203_Y2.4940.97
152_L219_A2.4750.97
212_E257_E2.4190.97
149_E153_K2.3860.96
12_I31_R2.3750.96
107_R154_D2.3410.96
5_E215_K2.3040.95
103_D124_Q2.2750.95
30_V39_I2.2590.95
313_A324_L2.2500.95
75_N78_M2.2200.94
182_I191_A2.2190.94
370_E382_N2.2070.94
300_V367_W2.2000.94
19_I41_L2.1820.94
13_T16_M2.1550.93
278_V319_A2.1310.93
65_I345_A2.1100.93
353_H368_D2.0990.92
38_K57_K2.0940.92
349_R367_W2.0850.92
271_L314_A2.0730.92
22_L51_K2.0730.92
29_K33_R2.0270.91
252_K286_G2.0160.91
27_V31_R2.0100.91
149_E216_E2.0020.90
17_K21_K1.9930.90
215_K257_E1.9690.90
119_T156_V1.9640.90
208_G253_S1.9540.89
101_D104_D1.9300.89
38_K287_G1.9290.89
81_E84_K1.9270.89
302_A308_A1.9260.89
148_V210_L1.9180.88
236_H277_D1.9130.88
81_E338_V1.8680.87
124_Q128_E1.8620.87
271_L315_I1.8290.86
161_I221_I1.8250.86
179_I369_D1.8130.85
30_V33_R1.8110.85
215_K258_G1.7560.83
365_R369_D1.7550.83
255_L286_G1.7520.83
152_L159_M1.7470.83
3_I16_M1.7320.83
33_R38_K1.7260.82
39_I59_L1.7220.82
87_N114_E1.6770.80
179_I233_G1.6310.78
17_K27_V1.6250.78
211_L221_I1.6160.78
272_N360_L1.6090.78
326_Y341_V1.6060.77
5_E258_G1.6050.77
273_E283_K1.5810.76
309_S327_L1.5690.76
373_Y377_K1.5570.75
199_S205_K1.5540.75
167_K198_N1.5530.75
4_I40_I1.5470.75
204_R249_R1.5430.74
395_Q399_Q1.5410.74
263_V281_M1.5050.73
40_I220_V1.5040.72
161_I210_L1.4920.72
213_M219_A1.4830.71
61_T361_G1.4820.71
281_M290_Y1.4760.71
277_D290_Y1.4670.71
370_E386_R1.4660.70
12_I27_V1.4660.70
236_H290_Y1.4600.70
223_L247_T1.4590.70
179_I231_A1.4500.70
141_E206_H1.4500.70
43_R50_K1.4460.69
65_I86_A1.4440.69
41_L54_P1.4390.69
281_M285_T1.4340.69
342_E346_I1.4320.69
3_I13_T1.4320.69
374_Y382_N1.4250.68
244_L290_Y1.4220.68
66_N160_T1.4120.68
32_N36_E1.3960.67
83_V113_S1.3900.66
92_T116_P1.3750.65
382_N386_R1.3750.65
67_I83_V1.3720.65
379_E382_N1.3650.65
84_K112_A1.3520.64
110_I151_H1.3510.64
9_S258_G1.3400.63
206_H209_Y1.3390.63
141_E205_K1.3390.63
169_L246_E1.3380.63
313_A348_Y1.3230.62
42_I55_I1.3150.62
30_V34_I1.3100.62
246_E249_R1.3080.61
342_E392_R1.3010.61
232_T357_V1.2920.60
4_I255_L1.2920.60
65_I93_L1.2880.60
80_L83_V1.2870.60
6_E11_Q1.2820.60
88_R391_Q1.2790.60
168_E200_E1.2750.59
372_S417_M1.2740.59
158_F323_L1.2660.59
58_G322_D1.2570.58
16_M30_V1.2550.58
339_K343_E1.2540.58
255_L263_V1.2480.58
151_H159_M1.2470.58
211_L259_V1.2440.57
149_E209_Y1.2410.57
231_A372_S1.2400.57
207_W223_L1.2370.57
363_R366_K1.2350.57
236_H241_V1.2310.57
298_I301_G1.2300.57
317_S355_G1.2290.57
282_K322_D1.2250.56
86_A345_A1.2230.56
103_D154_D1.2140.56
57_K287_G1.2010.55
275_A319_A1.2010.55
369_D373_Y1.1990.55
64_N70_S1.1950.54
40_I262_M1.1920.54
272_N365_R1.1920.54
29_K39_I1.1830.54
241_V280_L1.1820.54
211_L257_E1.1810.53
7_A13_T1.1640.52
102_L105_I1.1550.52
100_G105_I1.1530.52
324_L348_Y1.1440.51
142_D145_L1.1440.51
318_A359_K1.1420.51
255_L288_V1.1380.51
144_L148_V1.1380.51
4_I251_V1.1350.51
235_A273_E1.1330.50
3_I218_D1.1330.50
307_I347_A1.1230.50
19_I34_I1.1220.50
167_K194_M1.1210.50
87_N113_S1.1140.49
63_V345_A1.1130.49
25_I29_K1.1130.49
221_I263_V1.1110.49
113_S117_V1.1080.49
292_V316_S1.1030.48
225_D229_P1.1000.48
46_K217_Y1.0970.48
209_Y216_E1.0910.48
120_V293_L1.0850.47
180_I372_S1.0770.47
106_R154_D1.0710.46
253_S257_E1.0700.46
85_V89_W1.0680.46
392_R395_Q1.0630.46
148_V159_M1.0620.46
400_F409_T1.0600.46
18_E51_K1.0570.46
141_E145_L1.0560.45
16_M31_R1.0550.45
300_V353_H1.0530.45
278_V321_A1.0520.45
274_I315_I1.0510.45
418_M422_D1.0490.45
245_L284_L1.0480.45
170_A194_M1.0440.45
64_N120_V1.0430.45
64_N264_E1.0420.45
280_L290_Y1.0410.44
188_D416_P1.0390.44
109_I117_V1.0370.44
381_D385_S1.0350.44
309_S348_Y1.0220.43
300_V368_D1.0180.43
60_T349_R1.0180.43
55_I116_P1.0170.43
134_S138_Y1.0110.43
89_W345_A1.0090.42
151_H154_D1.0070.42
47_Y52_L1.0050.42
406_K421_M0.9960.42
238_E252_K0.9940.42
370_E373_Y0.9940.42
16_M41_L0.9870.41
224_G264_E0.9860.41
120_V264_E0.9840.41
53_V91_D0.9790.41
264_E293_L0.9750.40
251_V286_G0.9740.40
285_T290_Y0.9740.40
63_V117_V0.9730.40
61_T356_D0.9720.40
164_G223_L0.9710.40
315_I319_A0.9680.40
67_I93_L0.9600.39
211_L214_F0.9600.39
243_E295_P0.9590.39
117_V272_N0.9550.39
34_I54_P0.9540.39
64_N293_L0.9530.39
91_D349_R0.9490.39
346_I349_R0.9460.39
168_E242_G0.9460.39
406_K418_M0.9450.39
270_P273_E0.9430.38
34_I40_I0.9370.38
30_V59_L0.9340.38
164_G247_T0.9320.38
323_L348_Y0.9310.38
142_D209_Y0.9290.38
146_S150_K0.9280.37
391_Q395_Q0.9230.37
70_S224_G0.9170.37
61_T318_A0.9150.37
202_P316_S0.9150.37
296_L309_S0.9140.37
87_N115_L0.9140.37
108_E111_R0.9110.36
245_L280_L0.9100.36
392_R396_V0.9090.36
146_S149_E0.9050.36
185_R293_L0.9040.36
334_G400_F0.9010.36
254_A261_V0.9010.36
224_G293_L0.8930.35
58_G282_K0.8890.35
337_T399_Q0.8890.35
251_V354_A0.8880.35
89_W342_E0.8860.35
160_T291_Y0.8780.35
39_I58_G0.8770.34
53_V116_P0.8760.34
18_E21_K0.8720.34
65_I83_V0.8710.34
271_L274_I0.8690.34
387_L390_P0.8650.34
4_I258_G0.8650.34
298_I368_D0.8630.34
301_G350_I0.8630.34
247_T263_V0.8620.34
64_N224_G0.8600.33
7_A35_S0.8600.33
384_I393_A0.8590.33
179_I373_Y0.8580.33
70_S264_E0.8580.33
84_K88_R0.8570.33
161_I203_Y0.8540.33
16_M35_S0.8510.33
380_W410_M0.8510.33
80_L113_S0.8480.33
176_S238_E0.8420.32
148_V161_I0.8410.32
144_L203_Y0.8410.32
48_P111_R0.8400.32
160_T293_L0.8390.32
139_F197_N0.8350.32
142_D198_N0.8340.32
244_L281_M0.8330.32
236_H273_E0.8330.32
152_L213_M0.8320.32
7_A16_M0.8300.32
161_I166_T0.8280.32
165_I226_A0.8280.32
40_I255_L0.8260.32
191_A420_A0.8250.32
346_I350_I0.8240.31
33_R58_G0.8220.31
141_E209_Y0.8190.31
120_V291_Y0.8160.31
70_S293_L0.8150.31
163_A221_I0.8130.31
179_I372_S0.8110.31
244_L277_D0.8080.31
144_L147_T0.8050.30
397_Y406_K0.8050.30
160_T235_A0.8040.30
163_A273_E0.8040.30
109_I355_G0.8030.30
70_S120_V0.8010.30
181_P189_M0.7990.30
409_T424_V0.7950.30
159_M214_F0.7920.30
120_V224_G0.7920.30
244_L280_L0.7880.29
397_Y407_A0.7810.29
334_G396_V0.7780.29
12_I28_E0.7750.29
95_D229_P0.7730.29
388_I391_Q0.7730.29
66_N224_G0.7720.29
276_W279_K0.7720.29
143_E151_H0.7720.29
36_E287_G0.7720.29
39_I54_P0.7710.29
204_R207_W0.7700.29
277_D291_Y0.7670.28
317_S361_G0.7620.28
231_A355_G0.7590.28
66_N182_I0.7580.28
133_K138_Y0.7580.28
176_S286_G0.7570.28
139_F143_E0.7560.28
367_W388_I0.7540.28
8_R258_G0.7500.28
80_L84_K0.7490.27
67_I136_G0.7450.27
91_D188_D0.7410.27
240_Q292_V0.7400.27
95_D225_D0.7400.27
145_L149_E0.7380.27
135_G138_Y0.7360.27
22_L53_V0.7360.27
165_I169_L0.7360.27
188_D419_W0.7350.27
308_A327_L0.7280.26
69_T98_T0.7270.26
272_N279_K0.7240.26
313_A371_V0.7220.26
343_E347_A0.7220.26
185_R264_E0.7210.26
165_I209_Y0.7180.26
170_A383_M0.7150.26
232_T372_S0.7140.26
64_N69_T0.7130.26
174_L195_I0.7120.26
161_I214_F0.7100.26
160_T225_D0.7090.25
212_E215_K0.7090.25
90_G341_V0.7090.25
26_P29_K0.7040.25
396_V400_F0.7040.25
388_I393_A0.7020.25
76_L104_D0.6960.25
219_A385_S0.6940.25
53_V92_T0.6910.25
92_T323_L0.6890.24
180_I190_I0.6880.24
315_I318_A0.6870.24
367_W372_S0.6850.24
47_Y50_K0.6840.24
163_A250_L0.6830.24
160_T182_I0.6830.24
85_V338_V0.6820.24
55_I394_Y0.6810.24
334_G383_M0.6790.24
101_D128_E0.6790.24
120_V185_R0.6740.24
12_I16_M0.6710.24
378_L407_A0.6710.24
119_T227_L0.6710.24
107_R338_V0.6680.24
31_R35_S0.6680.24
241_V244_L0.6660.23
160_T185_R0.6640.23
7_A10_G0.6640.23
85_V88_R0.6610.23
94_M293_L0.6610.23
79_E82_K0.6600.23
214_F259_V0.6590.23
32_N216_E0.6570.23
151_H181_P0.6560.23
238_E245_L0.6530.23
144_L202_P0.6530.23
159_M166_T0.6520.23
338_V345_A0.6520.23
242_G371_V0.6520.23
42_I220_V0.6510.23
114_E157_A0.6500.23
276_W283_K0.6480.23
142_D210_L0.6480.23
273_E276_W0.6470.23
95_D119_T0.6440.22
119_T147_T0.6430.22
337_T401_G0.6430.22
358_V386_R0.6420.22
397_Y400_F0.6410.22
209_Y212_E0.6390.22
36_E57_K0.6370.22
248_A285_T0.6370.22
207_W278_V0.6360.22
159_M219_A0.6360.22
24_G27_V0.6360.22
94_M118_G0.6350.22
248_A288_V0.6350.22
165_I227_L0.6350.22
44_N157_A0.6340.22
240_Q244_L0.6330.22
157_A220_V0.6330.22
191_A424_V0.6330.22
378_L417_M0.6320.22
90_G409_T0.6290.22
164_G210_L0.6290.22
13_T41_L0.6260.22
63_V258_G0.6260.22
137_A196_H0.6260.22
42_I53_V0.6230.21
311_I314_A0.6230.21
238_E249_R0.6220.21
34_I263_V0.6210.21
208_G257_E0.6200.21
405_V409_T0.6200.21
214_F219_A0.6200.21
110_I117_V0.6190.21
247_T288_V0.6180.21
88_R349_R0.6180.21
269_V280_L0.6170.21
154_D217_Y0.6170.21
235_A291_Y0.6160.21
145_L206_H0.6160.21
205_K209_Y0.6160.21
113_S188_D0.6150.21
207_W247_T0.6150.21
150_K154_D0.6120.21
59_L317_S0.6110.21
33_R57_K0.6090.21
190_I210_L0.6090.21
163_A292_V0.6090.21
315_I346_I0.6080.21
189_M372_S0.6080.21
185_R291_Y0.6060.21
394_Y398_T0.6050.21
2_A218_D0.6050.21
92_T158_F0.6030.21
66_N70_S0.6030.21
252_K302_A0.6030.21
77_Q108_E0.6030.21
15_E18_E0.6020.21
182_I224_G0.6010.21
164_G226_A0.6010.21
69_T102_L0.6000.21
350_I388_I0.6000.21
207_W221_I0.5990.20
264_E291_Y0.5990.20
99_G189_M0.5990.20
309_S406_K0.5980.20
251_V355_G0.5980.20
366_K370_E0.5970.20
24_G362_R0.5960.20
339_K342_E0.5950.20
125_V318_A0.5950.20
242_G246_E0.5930.20
93_L115_L0.5930.20
137_A192_G0.5920.20
236_H280_L0.5910.20
95_D292_V0.5900.20
371_V383_M0.5900.20
107_R111_R0.5900.20
367_W386_R0.5890.20
202_P292_V0.5880.20
87_N112_A0.5870.20
231_A383_M0.5850.20
226_A288_V0.5840.20
26_P32_N0.5840.20
5_E9_S0.5840.20
64_N185_R0.5820.20
17_K300_V0.5820.20
271_L319_A0.5810.20
142_D153_K0.5810.20
118_G293_L0.5810.20
2_A5_E0.5800.20
126_F189_M0.5800.20
408_C411_C0.5800.20
302_A333_L0.5790.20
98_T224_G0.5780.20
4_I8_R0.5780.20
174_L238_E0.5770.20
397_Y409_T0.5760.20
14_D31_R0.5750.19
229_P316_S0.5750.19
118_G266_P0.5750.19
77_Q81_E0.5740.19
98_T226_A0.5740.19
182_I189_M0.5730.19
124_Q383_M0.5720.19
98_T419_W0.5710.19
60_T314_A0.5710.19
355_G360_L0.5700.19
207_W254_A0.5670.19
278_V292_V0.5670.19
145_L262_M0.5670.19
193_W197_N0.5660.19
377_K421_M0.5660.19
145_L226_A0.5660.19
124_Q147_T0.5660.19
3_I7_A0.5650.19
156_V232_T0.5650.19
173_A238_E0.5640.19
55_I110_I0.5640.19
166_T407_A0.5630.19
120_V160_T0.5620.19
411_C415_C0.5620.19
259_V284_L0.5620.19
408_C415_C0.5620.19
95_D156_V0.5610.19
110_I313_A0.5590.19
217_Y357_V0.5590.19
302_A371_V0.5580.19
166_T239_F0.5580.19
80_L112_A0.5570.19
160_T229_P0.5570.19
99_G124_Q0.5570.19
314_A318_A0.5570.19
64_N291_Y0.5560.19
7_A31_R0.5560.19
103_D107_R0.5560.19
9_S256_K0.5550.19
148_V163_A0.5550.19
6_E9_S0.5540.19
159_M210_L0.5540.19
137_A189_M0.5530.19
198_N349_R0.5530.19
273_E277_D0.5530.19
300_V349_R0.5520.19
371_V387_L0.5510.19
164_G277_D0.5500.18
71_D337_T0.5500.18
195_I337_T0.5490.18
137_A181_P0.5480.18
93_L367_W0.5480.18
108_E112_A0.5460.18
55_I122_V0.5460.18
235_A270_P0.5460.18
141_E199_S0.5460.18
84_K221_I0.5440.18
69_T335_L0.5440.18
145_L159_M0.5430.18
95_D313_A0.5430.18
271_L360_L0.5430.18
4_I34_I0.5420.18
251_V281_M0.5420.18
251_V261_V0.5420.18
77_Q111_R0.5420.18
247_T295_P0.5380.18
66_N120_V0.5380.18
124_Q181_P0.5370.18
313_A323_L0.5370.18
266_P293_L0.5350.18
346_I392_R0.5350.18
11_Q359_K0.5340.18
31_R399_Q0.5340.18
158_F348_Y0.5330.18
57_K61_T0.5330.18
403_P407_A0.5320.18
110_I314_A0.5320.18
163_A207_W0.5320.18
160_T224_G0.5310.18
245_L282_K0.5300.18
65_I89_W0.5290.18
102_L124_Q0.5290.18
396_V399_Q0.5280.18
240_Q326_Y0.5260.18
64_N335_L0.5260.18
98_T185_R0.5260.18
202_P379_E0.5250.18
164_G380_W0.5250.18
231_A354_A0.5250.18
181_P191_A0.5240.18
157_A297_P0.5240.18
99_G102_L0.5210.17
168_E262_M0.5190.17
414_Y419_W0.5170.17
85_V345_A0.5170.17
12_I84_K0.5160.17
378_L420_A0.5160.17
244_L327_L0.5140.17
174_L400_F0.5140.17
313_A355_G0.5140.17
374_Y386_R0.5130.17
18_E22_L0.5130.17
44_N47_Y0.5100.17
210_L221_I0.5100.17
120_V335_L0.5100.17
399_Q416_P0.5090.17
318_A358_V0.5080.17
77_Q84_K0.5060.17
124_Q132_K0.5060.17
316_S379_E0.5060.17
95_D353_H0.5050.17
247_T360_L0.5050.17
390_P393_A0.5040.17
75_N409_T0.5040.17
126_F137_A0.5040.17
246_E253_S0.5030.17
196_H263_V0.5030.17
304_Y307_I0.5030.17
227_L243_E0.5030.17
105_I109_I0.5010.17
167_K390_P0.5010.17
94_M160_T0.5010.17
347_A350_I0.5010.17
74_V78_M0.5000.17
271_L318_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s28A 2 0.9838 100 0.041 Contact Map
3epoA 2 0.8984 100 0.041 Contact Map
2h9aB 1 0.5566 93.9 0.973 Contact Map
1eyeA 2 0.4896 93.8 0.973 Contact Map
1aj0A 1 0.5635 92.6 0.974 Contact Map
2dqwA 2 0.5035 92 0.974 Contact Map
2y5sA 2 0.5358 91.7 0.974 Contact Map
4djdD 1 0.5612 91.3 0.975 Contact Map
2czdA 2 0.4596 90.8 0.975 Contact Map
4muzA 2 0.4642 89.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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