GREMLIN Database
Q97YJ5 - Restriction endonuclease related protein
UniProt: Q97YJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 559 (419)
Sequences: 387 (319)
Seq/√Len: 15.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
356_A361_A4.9741.00
271_L425_A3.1230.99
288_V299_Y3.0930.98
190_N193_Y2.8990.98
281_T446_F2.8640.97
281_T351_D2.8470.97
157_K161_L2.7260.97
165_I168_N2.5660.95
335_Y361_A2.5370.95
351_D446_F2.4150.93
281_T442_L2.3810.93
243_N246_I2.3360.92
303_T367_T2.3100.91
304_A353_L2.2990.91
431_D445_R2.2800.91
154_F161_L2.2710.91
201_V208_I2.1890.89
460_L463_F2.1860.89
369_F417_P2.0970.87
168_N171_D2.0900.87
208_I218_T2.0710.86
112_L116_L2.0510.86
305_N364_E2.0380.85
236_E471_S2.0330.85
257_S451_F2.0190.85
369_F478_V2.0180.85
194_T197_N2.0180.85
304_A359_D2.0050.84
349_V363_G1.9890.84
263_K317_E1.9820.83
434_N439_G1.9700.83
157_K160_W1.9590.83
367_T440_D1.9210.81
223_S226_R1.9020.81
73_I77_L1.8900.80
63_W69_N1.8720.80
304_A439_G1.8700.80
150_W154_F1.8660.79
359_D436_F1.8540.79
429_L439_G1.8430.79
313_L478_V1.8400.78
350_I363_G1.8300.78
304_A361_A1.7990.77
356_A364_E1.7940.77
253_I356_A1.7930.77
316_G359_D1.7750.76
355_R427_I1.7660.75
275_P355_R1.7500.75
276_P431_D1.7490.75
359_D364_E1.7350.74
304_A355_R1.7210.74
151_I162_H1.7130.73
150_W161_L1.7030.73
110_K117_R1.7030.73
369_F451_F1.6960.72
311_R370_S1.6820.72
276_P355_R1.6800.72
28_Y36_P1.6780.72
215_I221_F1.6660.71
304_A363_G1.6650.71
276_P353_L1.6560.71
215_I220_E1.6460.70
211_K218_T1.6310.69
274_G280_K1.6170.69
151_I155_R1.6120.68
164_S176_V1.6090.68
368_I430_V1.6060.68
156_I164_S1.6020.68
359_D443_A1.5990.68
305_N359_D1.5990.68
265_L424_I1.5990.68
304_A443_A1.5990.68
350_I353_L1.5810.67
164_S173_N1.5760.67
213_E220_E1.5520.65
286_R356_A1.5500.65
189_S193_Y1.5320.64
452_D457_T1.5320.64
310_R361_A1.5290.64
435_L440_D1.5260.64
310_R359_D1.5200.64
273_A436_F1.5190.64
304_A350_I1.5150.63
463_F467_Y1.5120.63
279_G352_E1.5090.63
303_T334_A1.5080.63
313_L436_F1.5010.63
442_L451_F1.4940.62
309_F315_G1.4930.62
108_N115_L1.4920.62
191_Q208_I1.4860.62
351_D442_L1.4850.62
317_E348_V1.4830.62
279_G428_N1.4760.61
352_E428_N1.4750.61
24_T27_D1.4750.61
273_A478_V1.4680.61
202_K208_I1.4610.61
272_L434_N1.4470.60
161_L165_I1.4440.60
305_N310_R1.4420.59
430_V433_R1.4410.59
251_F347_Y1.4390.59
363_G445_R1.4350.59
276_P304_A1.4290.59
363_G444_R1.4230.58
355_R361_A1.4230.58
104_I107_K1.4120.58
203_A206_Q1.4100.58
308_W361_A1.4030.57
55_Y59_G1.3910.57
420_R472_E1.3860.56
306_S356_A1.3860.56
58_L63_W1.3850.56
264_A479_K1.3850.56
214_E219_L1.3660.55
442_L446_F1.3620.55
276_P363_G1.3620.55
153_R157_K1.3540.55
433_R443_A1.3530.54
30_E41_G1.3490.54
263_K288_V1.3360.54
360_K435_L1.3310.53
147_D150_W1.3210.53
281_T287_T1.3200.53
278_T496_V1.3170.52
211_K216_R1.3120.52
305_N356_A1.3090.52
18_S22_A1.3000.51
205_Q208_I1.3000.51
316_G364_E1.2990.51
275_P366_M1.2980.51
364_E443_A1.2930.51
250_G286_R1.2830.50
258_V475_K1.2830.50
251_F454_P1.2750.50
189_S194_T1.2660.50
165_I173_N1.2660.50
440_D454_P1.2630.49
185_V210_S1.2600.49
356_A359_D1.2590.49
276_P436_F1.2500.49
477_K490_N1.2360.48
258_V261_I1.2350.48
168_N176_V1.2340.48
243_N285_I1.2320.48
484_Y488_N1.2310.48
316_G350_I1.2250.47
186_N208_I1.2250.47
117_R120_E1.2140.47
313_L357_D1.2130.46
308_W313_L1.2120.46
277_G280_K1.2120.46
274_G277_G1.2120.46
276_P445_R1.2100.46
331_F442_L1.2070.46
59_G62_L1.2040.46
366_M370_S1.2000.46
162_H177_G1.1960.46
25_F32_G1.1950.45
276_P303_T1.1930.45
305_N444_R1.1910.45
125_G138_R1.1910.45
363_G431_D1.1890.45
303_T366_M1.1870.45
277_G354_N1.1810.45
305_N313_L1.1810.45
353_L427_I1.1790.45
269_N369_F1.1780.45
58_L61_T1.1760.44
146_G157_K1.1750.44
353_L363_G1.1720.44
49_S53_S1.1710.44
48_E57_E1.1680.44
433_R442_L1.1680.44
282_S301_V1.1640.44
38_F42_E1.1590.43
303_T440_D1.1580.43
301_V351_D1.1520.43
101_K105_E1.1500.43
108_N114_A1.1470.43
415_N448_I1.1450.43
288_V347_Y1.1450.43
434_N443_A1.1430.43
308_W317_E1.1410.42
429_L434_N1.1360.42
196_D203_A1.1350.42
81_D89_K1.1330.42
155_R164_S1.1290.42
58_L62_L1.1270.42
306_S359_D1.1230.41
196_D221_F1.1150.41
270_V347_Y1.1100.41
278_T426_T1.1080.41
71_S77_L1.1040.40
193_Y197_N1.1030.40
429_L447_V1.1010.40
17_D42_E1.0990.40
287_T435_L1.0960.40
431_D444_R1.0930.40
276_P444_R1.0890.40
355_R363_G1.0860.39
284_A349_V1.0840.39
162_H168_N1.0830.39
193_Y212_K1.0820.39
357_D418_L1.0680.38
84_Y88_D1.0650.38
274_G352_E1.0630.38
280_K352_E1.0630.38
303_T361_A1.0610.38
275_P442_L1.0600.38
190_N201_V1.0540.38
436_F478_V1.0530.38
205_Q213_E1.0510.37
38_F43_K1.0470.37
274_G279_G1.0430.37
349_V353_L1.0350.37
302_A445_R1.0340.37
251_F435_L1.0330.37
282_S442_L1.0320.36
305_N361_A1.0290.36
213_E217_S1.0270.36
274_G428_N1.0240.36
25_F39_F1.0240.36
280_K428_N1.0240.36
251_F426_T1.0210.36
284_A334_A1.0190.36
107_K116_L1.0160.36
355_R444_R1.0150.36
306_S439_G1.0130.35
34_F42_E1.0110.35
313_L365_L1.0080.35
431_D435_L1.0080.35
32_G43_K1.0070.35
304_A445_R1.0030.35
271_L444_R0.9990.35
285_I299_Y0.9990.35
208_I222_Y0.9960.35
29_I32_G0.9950.35
194_T214_E0.9930.34
309_F447_V0.9910.34
77_L81_D0.9900.34
162_H176_V0.9900.34
263_K348_V0.9870.34
316_G444_R0.9850.34
437_Y482_V0.9850.34
269_N304_A0.9840.34
314_I357_D0.9840.34
147_D152_V0.9780.34
425_A429_L0.9770.34
65_A68_E0.9760.34
442_L496_V0.9740.33
200_A218_T0.9740.33
310_R313_L0.9700.33
305_N308_W0.9690.33
287_T347_Y0.9670.33
282_S304_A0.9670.33
194_T200_A0.9660.33
275_P302_A0.9660.33
492_K496_V0.9510.32
115_L119_K0.9490.32
269_N424_I0.9480.32
108_N112_L0.9470.32
38_F45_H0.9450.32
203_A208_I0.9440.32
359_D366_M0.9430.32
197_N208_I0.9370.32
264_A475_K0.9340.31
261_I287_T0.9330.31
274_G354_N0.9320.31
280_K354_N0.9320.31
25_F28_Y0.9320.31
304_A313_L0.9270.31
363_G435_L0.9270.31
58_L69_N0.9260.31
19_Q28_Y0.9200.31
227_F491_E0.9160.31
273_A440_D0.9150.31
306_S367_T0.9140.30
269_N422_R0.9120.30
188_Q208_I0.9110.30
282_S447_V0.9110.30
212_K215_I0.9100.30
425_A434_N0.9060.30
29_I50_I0.9050.30
304_A427_I0.9050.30
255_Q260_I0.9020.30
304_A435_L0.9000.30
204_F218_T0.8980.30
53_S56_G0.8930.29
304_A310_R0.8910.29
56_G66_S0.8880.29
196_D208_I0.8870.29
205_Q218_T0.8870.29
18_S24_T0.8830.29
439_G443_A0.8820.29
304_A349_V0.8810.29
275_P495_K0.8780.29
273_A308_W0.8780.29
18_S21_S0.8760.29
429_L440_D0.8730.29
150_W157_K0.8730.29
370_S486_R0.8680.28
477_K484_Y0.8670.28
436_F442_L0.8660.28
17_D30_E0.8650.28
427_I433_R0.8650.28
22_A25_F0.8640.28
146_G156_I0.8540.28
255_Q333_E0.8510.28
434_N441_A0.8490.27
353_L429_L0.8460.27
36_P40_I0.8450.27
313_L359_D0.8440.27
438_V494_D0.8440.27
331_F486_R0.8430.27
190_N214_E0.8430.27
25_F50_I0.8420.27
158_I166_R0.8380.27
276_P350_I0.8360.27
152_V178_E0.8320.27
265_L270_V0.8270.26
261_I270_V0.8260.26
299_Y486_R0.8250.26
34_F40_I0.8250.26
264_A440_D0.8240.26
441_A444_R0.8230.26
351_D478_V0.8230.26
301_V447_V0.8210.26
359_D363_G0.8210.26
163_E173_N0.8180.26
316_G332_I0.8180.26
430_V437_Y0.8180.26
35_V52_Y0.8170.26
299_Y306_S0.8160.26
355_R442_L0.8150.26
145_E177_G0.8150.26
303_T447_V0.8120.26
160_W164_S0.8120.26
359_D374_P0.8120.26
252_Y347_Y0.8110.26
60_Y63_W0.8070.26
35_V38_F0.8070.26
443_A489_L0.8060.26
287_T479_K0.8060.26
488_N494_D0.8050.25
201_V205_Q0.8050.25
275_P435_L0.8030.25
18_S29_I0.8030.25
283_L286_R0.7990.25
310_R443_A0.7970.25
162_H170_N0.7960.25
18_S23_Q0.7960.25
213_E218_T0.7960.25
274_G426_T0.7940.25
280_K426_T0.7940.25
451_F454_P0.7900.25
148_K154_F0.7880.25
25_F29_I0.7870.25
275_P494_D0.7860.25
240_C345_N0.7860.25
157_K173_N0.7850.25
253_I286_R0.7840.25
178_E195_E0.7820.24
213_E216_R0.7800.24
257_S260_I0.7800.24
304_A357_D0.7770.24
303_T353_L0.7760.24
30_E42_E0.7760.24
269_N363_G0.7750.24
305_N453_Y0.7750.24
271_L305_N0.7700.24
245_Q345_N0.7690.24
299_Y348_V0.7670.24
27_D41_G0.7640.24
299_Y457_T0.7640.24
38_F56_G0.7640.24
153_R164_S0.7640.24
261_I449_I0.7610.24
440_D447_V0.7600.24
173_N177_G0.7600.24
316_G367_T0.7590.24
282_S430_V0.7570.23
303_T363_G0.7560.23
19_Q23_Q0.7540.23
39_F44_S0.7510.23
276_P349_V0.7500.23
102_N110_K0.7480.23
282_S454_P0.7480.23
304_A316_G0.7480.23
459_D463_F0.7470.23
364_E444_R0.7460.23
366_M447_V0.7450.23
64_G72_N0.7430.23
282_S303_T0.7420.23
356_A444_R0.7410.23
463_F466_T0.7400.23
305_N366_M0.7390.23
349_V445_R0.7390.23
304_A434_N0.7350.23
304_A368_I0.7330.22
276_P435_L0.7260.22
353_L445_R0.7250.22
285_I474_F0.7250.22
172_S176_V0.7250.22
107_K114_A0.7230.22
304_A308_W0.7210.22
300_E307_L0.7210.22
305_N439_G0.7200.22
18_S31_K0.7190.22
311_R359_D0.7190.22
352_E355_R0.7190.22
276_P441_A0.7180.22
366_M482_V0.7150.22
316_G363_G0.7130.22
315_G443_A0.7130.22
269_N445_R0.7120.22
348_V481_L0.7110.22
303_T355_R0.7110.22
309_F372_P0.7110.22
308_W359_D0.7090.22
433_R437_Y0.7080.21
276_P433_R0.7040.21
364_E437_Y0.7040.21
368_I440_D0.7030.21
464_L468_A0.7030.21
271_L439_G0.6990.21
108_N118_T0.6990.21
23_Q49_S0.6980.21
305_N433_R0.6970.21
457_T491_E0.6940.21
304_A444_R0.6940.21
308_W356_A0.6930.21
356_A439_G0.6900.21
212_K216_R0.6900.21
351_D354_N0.6880.21
345_N438_V0.6880.21
357_D436_F0.6870.21
315_G412_S0.6870.21
361_A368_I0.6860.21
313_L373_Y0.6860.21
213_E219_L0.6860.21
335_Y442_L0.6840.21
311_R453_Y0.6820.20
269_N355_R0.6800.20
152_V171_D0.6800.20
360_K442_L0.6770.20
347_Y426_T0.6750.20
127_G133_T0.6740.20
279_G351_D0.6720.20
254_P257_S0.6720.20
53_S58_L0.6700.20
102_N106_I0.6690.20
46_W50_I0.6660.20
42_E53_S0.6640.20
162_H165_I0.6620.20
169_Y174_K0.6620.20
43_K46_W0.6620.20
349_V355_R0.6620.20
203_A220_E0.6590.20
306_S448_I0.6550.20
282_S368_I0.6550.20
310_R355_R0.6550.20
205_Q214_E0.6540.19
163_E168_N0.6530.19
269_N316_G0.6530.19
304_A356_A0.6520.19
317_E366_M0.6500.19
152_V162_H0.6500.19
488_N496_V0.6480.19
281_T301_V0.6480.19
288_V298_C0.6470.19
278_T455_K0.6470.19
191_Q196_D0.6470.19
277_G352_E0.6450.19
203_A221_F0.6450.19
359_D439_G0.6440.19
457_T486_R0.6410.19
286_R289_R0.6400.19
316_G355_R0.6380.19
362_F441_A0.6370.19
474_F487_V0.6370.19
435_L445_R0.6360.19
284_A290_A0.6330.19
169_Y176_V0.6330.19
268_T284_A0.6320.19
480_D483_K0.6320.19
26_L32_G0.6310.19
147_D159_F0.6310.19
308_W335_Y0.6290.19
169_Y175_W0.6290.19
364_E453_Y0.6280.19
278_T492_K0.6260.18
317_E440_D0.6250.18
62_L65_A0.6230.18
243_N345_N0.6210.18
276_P429_L0.6210.18
356_A452_D0.6210.18
112_L115_L0.6200.18
251_F447_V0.6200.18
268_T288_V0.6200.18
164_S169_Y0.6200.18
347_Y435_L0.6190.18
351_D370_S0.6190.18
228_S488_N0.6180.18
364_E433_R0.6180.18
367_T443_A0.6170.18
351_D428_N0.6170.18
197_N210_S0.6170.18
460_L465_K0.6150.18
103_K117_R0.6150.18
188_Q197_N0.6140.18
30_E36_P0.6120.18
271_L356_A0.6110.18
160_W175_W0.6090.18
171_D175_W0.6090.18
240_C260_I0.6080.18
84_Y89_K0.6050.18
188_Q192_C0.6050.18
22_A29_I0.6030.18
214_E222_Y0.6030.18
254_P465_K0.6000.18
50_I65_A0.5990.18
353_L435_L0.5980.18
331_F417_P0.5980.18
37_C45_H0.5970.18
313_L369_F0.5960.17
17_D23_Q0.5940.17
353_L359_D0.5930.17
216_R222_Y0.5930.17
148_K159_F0.5900.17
424_I444_R0.5880.17
197_N207_F0.5880.17
356_A368_I0.5870.17
304_A366_M0.5860.17
301_V439_G0.5830.17
301_V434_N0.5820.17
460_L467_Y0.5820.17
277_G428_N0.5820.17
272_L425_A0.5820.17
429_L441_A0.5820.17
157_K163_E0.5800.17
289_R488_N0.5790.17
186_N189_S0.5780.17
415_N489_L0.5760.17
299_Y349_V0.5750.17
17_D44_S0.5720.17
269_N306_S0.5710.17
309_F368_I0.5700.17
253_I273_A0.5690.17
349_V431_D0.5680.17
415_N443_A0.5670.17
31_K39_F0.5640.16
269_N368_I0.5630.16
95_K98_T0.5630.16
300_E337_N0.5620.16
52_Y59_G0.5610.16
315_G367_T0.5550.16
349_V438_V0.5540.16
275_P437_Y0.5530.16
278_T482_V0.5520.16
252_Y494_D0.5520.16
273_A332_I0.5520.16
307_L311_R0.5500.16
365_L443_A0.5500.16
375_S416_E0.5500.16
353_L439_G0.5500.16
157_K164_S0.5500.16
355_R433_R0.5500.16
367_T433_R0.5500.16
208_I221_F0.5490.16
30_E35_V0.5490.16
305_N368_I0.5480.16
26_L31_K0.5470.16
316_G443_A0.5470.16
356_A496_V0.5470.16
422_R491_E0.5430.16
282_S292_T0.5410.16
151_I154_F0.5410.16
130_T137_M0.5410.16
433_R440_D0.5410.16
303_T431_D0.5400.16
160_W171_D0.5400.16
23_Q26_L0.5390.16
361_A443_A0.5350.16
254_P260_I0.5340.16
308_W443_A0.5340.16
289_R496_V0.5290.15
207_F221_F0.5280.15
269_N353_L0.5270.15
190_N205_Q0.5250.15
365_L373_Y0.5230.15
22_A40_I0.5220.15
263_K299_Y0.5210.15
47_V51_K0.5200.15
211_K220_E0.5180.15
211_K214_E0.5180.15
206_Q209_L0.5180.15
110_K113_V0.5170.15
350_I444_R0.5170.15
102_N105_E0.5160.15
301_V333_E0.5160.15
170_N173_N0.5150.15
270_V287_T0.5150.15
21_S27_D0.5140.15
356_A366_M0.5140.15
415_N418_L0.5130.15
315_G426_T0.5130.15
17_D22_A0.5130.15
58_L66_S0.5130.15
164_S193_Y0.5130.15
301_V366_M0.5120.15
304_A436_F0.5110.15
283_L368_I0.5110.15
276_P366_M0.5110.15
240_C257_S0.5090.15
355_R436_F0.5080.15
190_N194_T0.5070.15
162_H173_N0.5070.15
345_N474_F0.5070.15
435_L439_G0.5070.15
442_L450_Y0.5060.15
334_A447_V0.5040.15
241_N265_L0.5030.15
308_W436_F0.5020.15
23_Q42_E0.5010.15
464_L467_Y0.5010.15
52_Y63_W0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkgA 2 0.8909 100 0.649 Contact Map
4akgA 2 0.9016 100 0.665 Contact Map
4rh7A 1 0.8855 99.9 0.818 Contact Map
2r44A 1 0.5045 99.8 0.852 Contact Map
3nbxX 1 0.4705 99.5 0.876 Contact Map
1ofhA 3 0.4705 99.5 0.878 Contact Map
1g8pA 1 0.4597 99.5 0.878 Contact Map
4qhsA 3 0.4097 99.5 0.879 Contact Map
1jbkA 1 0.322 99.5 0.879 Contact Map
3hwsA 3 0.4651 99.5 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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