GREMLIN Database
Q97YJ3 - Uncharacterized protein
UniProt: Q97YJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (157)
Sequences: 137 (117)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L134_G4.9141.00
6_R31_P3.5230.96
155_H159_Y3.4940.96
63_C135_I3.1970.94
35_I47_L2.6900.86
36_T44_T2.4330.79
48_K60_I2.4240.79
140_K143_G2.3940.78
9_E48_K2.3680.77
22_K25_M2.2700.74
4_D13_D2.1380.70
19_K133_I2.0080.64
155_H160_D1.9070.60
138_A141_L1.7600.54
21_I50_A1.7450.53
44_T140_K1.7330.53
11_R49_V1.7260.52
40_R158_D1.7180.52
48_K159_Y1.6540.49
49_V133_I1.6290.48
29_N95_S1.6200.48
117_V127_N1.5870.46
21_I49_V1.5520.45
18_E22_K1.5280.44
79_F97_I1.5170.43
64_R154_A1.5020.43
154_A158_D1.4990.42
62_D154_A1.4990.42
82_A85_S1.4960.42
4_D31_P1.4700.41
51_L58_H1.4620.41
24_I50_A1.4570.41
123_F155_H1.4530.40
26_S135_I1.4460.40
79_F126_L1.4370.40
4_D8_K1.4360.40
40_R154_A1.4260.39
102_I133_I1.4130.39
61_I141_L1.3910.38
54_I125_H1.3870.38
79_F149_I1.3750.37
8_K51_L1.3670.37
22_K95_S1.3330.35
15_F41_I1.3320.35
17_R41_I1.3290.35
4_D53_E1.3260.35
98_R108_E1.3140.35
2_L8_K1.3050.34
38_V79_F1.2760.33
40_R62_D1.2620.33
67_R140_K1.2500.32
24_I35_I1.2430.32
62_D158_D1.2370.32
11_R18_E1.2190.31
44_T67_R1.2140.31
24_I157_Y1.1990.30
78_L81_N1.1980.30
95_S121_D1.1850.30
62_D155_H1.1680.29
80_S84_S1.1650.29
149_I157_Y1.1550.29
140_K145_L1.1330.28
44_T124_D1.1320.28
4_D58_H1.1250.27
34_L46_V1.1070.27
98_R115_E1.1060.27
28_I148_E1.1000.27
51_L154_A1.0940.26
81_N97_I1.0880.26
60_I71_S1.0870.26
123_F160_D1.0710.26
138_A158_D1.0650.25
49_V132_V1.0600.25
97_I125_H1.0600.25
61_I109_L1.0440.25
3_F7_P1.0420.25
6_R38_V1.0250.24
47_L53_E1.0150.24
32_L153_I1.0100.24
75_L108_E1.0000.23
59_V118_S0.9960.23
15_F53_E0.9890.23
124_D155_H0.9850.23
66_L112_K0.9840.23
35_I38_V0.9830.23
96_K125_H0.9740.22
123_F133_I0.9640.22
67_R145_L0.9630.22
53_E133_I0.9620.22
30_R126_L0.9570.22
38_V142_R0.9470.22
16_D38_V0.9450.22
140_K144_P0.9440.22
141_L158_D0.9410.21
48_K58_H0.9300.21
74_D87_L0.9270.21
83_F90_F0.9250.21
25_M54_I0.9250.21
41_I49_V0.9250.21
2_L36_T0.9210.21
79_F82_A0.9160.21
94_L149_I0.9160.21
117_V121_D0.9040.20
9_E60_I0.8980.20
44_T65_N0.8960.20
144_P148_E0.8890.20
143_G148_E0.8850.20
65_N138_A0.8810.20
103_L123_F0.8800.20
69_N112_K0.8770.20
68_P71_S0.8690.19
30_R44_T0.8670.19
102_I122_L0.8620.19
140_K151_E0.8580.19
156_A160_D0.8550.19
75_L156_A0.8520.19
19_K89_T0.8450.19
32_L51_L0.8380.19
99_G104_G0.8260.18
79_F99_G0.8230.18
11_R53_E0.8180.18
84_S140_K0.8140.18
38_V41_I0.8080.18
60_I159_Y0.8020.18
127_N141_L0.8020.18
31_P38_V0.7950.17
15_F150_K0.7940.17
28_I90_F0.7940.17
110_K129_K0.7930.17
90_F119_L0.7880.17
38_V82_A0.7870.17
29_N102_I0.7860.17
135_I151_E0.7850.17
5_E31_P0.7850.17
64_R155_H0.7770.17
7_P14_L0.7720.17
82_A123_F0.7720.17
14_L45_S0.7710.17
68_P133_I0.7690.17
16_D34_L0.7640.17
64_R158_D0.7570.17
33_I41_I0.7570.17
68_P159_Y0.7550.16
21_I142_R0.7520.16
14_L49_V0.7500.16
12_E52_N0.7490.16
59_V119_L0.7490.16
51_L142_R0.7480.16
67_R144_P0.7480.16
5_E75_L0.7400.16
35_I133_I0.7370.16
107_V111_W0.7330.16
68_P75_L0.7320.16
48_K133_I0.7270.16
8_K134_G0.7260.16
89_T129_K0.7210.16
65_N124_D0.7200.16
38_V44_T0.7120.15
11_R21_I0.7090.15
17_R85_S0.7040.15
69_N129_K0.7040.15
101_S107_V0.6970.15
44_T76_Y0.6950.15
55_K74_D0.6910.15
118_S127_N0.6880.15
68_P121_D0.6860.15
41_I66_L0.6790.15
19_K23_E0.6750.15
21_I135_I0.6740.15
51_L64_R0.6740.15
63_C138_A0.6660.14
66_L144_P0.6660.14
5_E30_R0.6630.14
12_E135_I0.6620.14
31_P111_W0.6610.14
8_K11_R0.6570.14
92_D95_S0.6520.14
155_H158_D0.6510.14
14_L33_I0.6510.14
92_D122_L0.6460.14
102_I149_I0.6430.14
67_R151_E0.6390.14
130_R149_I0.6390.14
11_R126_L0.6340.14
74_D107_V0.6300.14
52_N57_P0.6280.14
27_N82_A0.6200.13
1_M61_I0.6170.13
16_D154_A0.6160.13
17_R150_K0.6050.13
142_R154_A0.6020.13
118_S146_S0.6000.13
65_N79_F0.5980.13
18_E36_T0.5980.13
10_N110_K0.5960.13
51_L158_D0.5920.13
31_P148_E0.5840.13
85_S120_S0.5790.13
10_N79_F0.5770.13
47_L132_V0.5770.13
24_I118_S0.5710.12
112_K125_H0.5680.12
51_L134_G0.5620.12
47_L142_R0.5620.12
49_V53_E0.5610.12
40_R99_G0.5580.12
19_K103_L0.5570.12
38_V47_L0.5560.12
46_V132_V0.5550.12
10_N89_T0.5550.12
18_E124_D0.5510.12
24_I48_K0.5490.12
122_L131_I0.5480.12
76_Y80_S0.5410.12
106_S121_D0.5400.12
52_N120_S0.5400.12
25_M59_V0.5370.12
75_L115_E0.5340.12
23_E133_I0.5300.12
145_L150_K0.5290.12
46_V107_V0.5280.12
79_F83_F0.5270.12
69_N74_D0.5270.12
6_R157_Y0.5240.12
138_A145_L0.5240.12
5_E124_D0.5190.11
26_S102_I0.5180.11
16_D158_D0.5180.11
11_R25_M0.5130.11
16_D99_G0.5110.11
74_D90_F0.5110.11
54_I59_V0.5100.11
82_A99_G0.5070.11
77_S89_T0.5060.11
22_K33_I0.5030.11
10_N97_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.963 99.9 0.556 Contact Map
2qenA 1 0.9321 99.9 0.603 Contact Map
1w5sA 1 0.8519 99.5 0.739 Contact Map
2qbyA 1 0.8457 99.4 0.748 Contact Map
4xgcA 1 0.6667 99.4 0.75 Contact Map
1fnnA 1 0.8272 99.4 0.751 Contact Map
4xgcE 1 0.8395 99.3 0.763 Contact Map
2v1uA 1 0.8395 99.3 0.766 Contact Map
3te6A 1 0.821 99.1 0.783 Contact Map
2qbyB 1 0.8395 99.1 0.784 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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