GREMLIN Database
Q97YJ2 - Uncharacterized protein
UniProt: Q97YJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (172)
Sequences: 167 (153)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_A76_Y3.8310.99
118_V152_I3.5510.98
30_F66_P3.5200.98
101_I119_L3.4920.98
41_K44_E3.3300.97
32_K60_A3.2500.97
54_V72_A3.1490.96
122_I162_I3.0450.96
54_V76_Y2.7690.93
36_R55_I2.6690.91
96_E100_L2.6470.91
6_D158_K2.5420.89
31_D34_K2.4730.88
35_S63_D2.4530.87
72_A82_L2.3860.86
18_Y149_L2.2060.81
85_V100_L2.1510.79
91_N153_L2.0970.77
89_A100_L1.9410.71
89_A96_E1.9250.71
157_K164_E1.8890.69
59_I63_D1.8650.68
119_L168_F1.8580.68
46_L77_F1.8170.66
40_R44_E1.7300.62
133_L137_Q1.6900.60
40_R52_E1.6480.58
20_R67_G1.5890.55
25_I52_E1.5800.55
137_Q140_E1.5730.54
157_K162_I1.5650.54
168_F173_Y1.5400.53
168_F177_S1.5230.52
108_S112_A1.5080.51
132_I176_A1.4480.48
161_I173_Y1.4370.48
30_F35_S1.4100.46
38_F56_Q1.3400.43
173_Y177_S1.3370.43
108_S111_V1.3040.41
9_G12_D1.2970.41
40_R81_D1.2900.41
57_D84_R1.2790.40
17_L129_W1.2780.40
53_N84_R1.2550.39
118_V149_L1.2480.39
48_L61_M1.2480.39
37_Q41_K1.2460.38
132_I165_N1.2410.38
127_N160_S1.2390.38
13_P66_P1.2330.38
37_Q165_N1.2300.38
7_F17_L1.2130.37
118_V164_E1.2090.37
36_R56_Q1.2070.37
76_Y82_L1.2040.36
51_E158_K1.2030.36
18_Y80_R1.1870.36
27_L30_F1.1860.36
114_R152_I1.1560.34
155_T162_I1.1520.34
4_L7_F1.1450.34
58_I72_A1.1100.32
57_D60_A1.0950.32
162_I169_L1.0940.32
54_V82_L1.0870.31
70_T74_N1.0840.31
68_W129_W1.0820.31
62_V125_G1.0750.31
149_L157_K1.0370.29
154_N158_K1.0300.29
51_E154_N1.0270.29
100_L146_T1.0220.29
29_R169_L1.0210.29
140_E176_A1.0150.28
3_L149_L1.0090.28
70_T103_V1.0080.28
27_L66_P1.0020.28
136_V141_G1.0000.28
34_K37_Q0.9960.28
31_D91_N0.9890.27
1_M57_D0.9880.27
19_G38_F0.9880.27
2_G18_Y0.9840.27
48_L77_F0.9810.27
89_A165_N0.9710.27
108_S140_E0.9660.26
37_Q45_E0.9650.26
37_Q87_D0.9640.26
50_V155_T0.9520.26
29_R161_I0.9520.26
45_E129_W0.9520.26
2_G171_P0.9450.26
4_L160_S0.9400.25
133_L146_T0.9400.25
51_E147_S0.9400.25
62_V161_I0.9350.25
70_T89_A0.9330.25
28_E41_K0.9270.25
101_I158_K0.9220.25
83_K86_K0.9200.25
43_F50_V0.9130.24
130_S176_A0.9130.24
37_Q163_D0.9120.24
30_F64_G0.9000.24
92_V95_N0.8880.23
95_N133_L0.8860.23
18_Y151_N0.8790.23
41_K45_E0.8720.23
130_S162_I0.8590.22
93_A100_L0.8540.22
19_G69_L0.8540.22
62_V173_Y0.8430.22
52_E60_A0.8380.22
44_E49_K0.8370.22
27_L85_V0.8300.21
32_K36_R0.8300.21
60_A145_S0.8260.21
84_R117_T0.8250.21
14_G60_A0.8200.21
129_W133_L0.8170.21
81_D89_A0.8170.21
76_Y81_D0.8160.21
47_S53_N0.8130.21
51_E87_D0.8110.21
7_F155_T0.8100.21
57_D61_M0.8090.21
97_I173_Y0.8080.21
63_D66_P0.8060.21
31_D36_R0.8040.21
121_C135_C0.8000.21
25_I28_E0.7960.20
82_L85_V0.7950.20
35_S125_G0.7900.20
78_N116_R0.7880.20
25_I128_S0.7850.20
8_L33_E0.7690.20
56_Q153_L0.7670.19
75_Q78_N0.7640.19
70_T146_T0.7630.19
48_L137_Q0.7600.19
19_G68_W0.7560.19
83_K165_N0.7540.19
90_I96_E0.7450.19
85_V162_I0.7450.19
48_L142_S0.7390.19
41_K154_N0.7380.19
5_H159_L0.7380.19
57_D86_K0.7330.18
79_N175_E0.7230.18
90_I93_A0.7230.18
71_L92_V0.7210.18
81_D87_D0.7200.18
51_E91_N0.7190.18
71_L174_K0.7180.18
10_V120_R0.7180.18
150_S162_I0.7150.18
114_R129_W0.7150.18
29_R138_N0.7130.18
157_K169_L0.7060.18
14_G81_D0.7050.18
18_Y163_D0.7040.18
36_R113_K0.6930.17
97_I172_V0.6920.17
85_V89_A0.6900.17
50_V103_V0.6900.17
41_K139_E0.6890.17
145_S168_F0.6860.17
57_D83_K0.6840.17
92_V112_A0.6820.17
19_G129_W0.6770.17
46_L58_I0.6760.17
133_L164_E0.6750.17
9_G14_G0.6740.17
44_E51_E0.6720.17
135_C139_E0.6710.17
3_L89_A0.6700.17
20_R115_Y0.6660.17
97_I165_N0.6660.17
37_Q61_M0.6640.16
120_R124_K0.6630.16
78_N113_K0.6630.16
15_S29_R0.6550.16
25_I87_D0.6470.16
6_D121_C0.6380.16
99_S128_S0.6370.16
50_V61_M0.6360.16
113_K130_S0.6340.16
126_M131_K0.6340.16
44_E98_N0.6340.16
95_N98_N0.6300.16
22_Y155_T0.6260.15
25_I34_K0.6240.15
72_A85_V0.6240.15
36_R44_E0.6220.15
57_D82_L0.6210.15
51_E56_Q0.6160.15
5_H26_T0.6140.15
43_F170_D0.6130.15
8_L115_Y0.6130.15
30_F63_D0.6040.15
111_V159_L0.6020.15
174_K177_S0.6010.15
123_A151_N0.6000.15
19_G100_L0.5980.15
128_S155_T0.5970.15
36_R40_R0.5960.15
132_I144_I0.5960.15
91_N97_I0.5950.15
38_F64_G0.5940.15
67_G115_Y0.5910.15
19_G170_D0.5780.14
85_V96_E0.5770.14
2_G160_S0.5770.14
3_L72_A0.5770.14
58_I62_V0.5770.14
1_M120_R0.5760.14
10_V149_L0.5760.14
13_P45_E0.5730.14
76_Y79_N0.5730.14
14_G132_I0.5720.14
45_E141_G0.5650.14
7_F122_I0.5620.14
17_L45_E0.5610.14
57_D167_R0.5580.14
47_S60_A0.5580.14
89_A92_V0.5570.14
7_F10_V0.5550.14
15_S18_Y0.5550.14
51_E84_R0.5540.14
54_V85_V0.5530.14
26_T147_S0.5530.14
80_R169_L0.5520.14
3_L132_I0.5350.13
32_K56_Q0.5340.13
14_G79_N0.5330.13
21_Y141_G0.5330.13
83_K87_D0.5290.13
157_K163_D0.5240.13
40_R175_E0.5230.13
78_N162_I0.5210.13
120_R123_A0.5200.13
114_R144_I0.5190.13
82_L100_L0.5190.13
101_I140_E0.5180.13
15_S45_E0.5170.13
91_N95_N0.5160.13
90_I162_I0.5140.13
76_Y162_I0.5130.13
97_I161_I0.5120.13
39_L64_G0.5120.13
137_Q141_G0.5110.13
16_P114_R0.5080.13
60_A98_N0.5080.13
111_V148_V0.5080.13
39_L166_Y0.5040.13
10_V162_I0.5040.13
29_R155_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.9615 99.9 0.652 Contact Map
2qenA 1 0.956 99.9 0.667 Contact Map
1w5sA 1 0.9945 98.2 0.86 Contact Map
3pfiA 3 0.9176 97.7 0.876 Contact Map
1hqcA 1 0.9176 97.6 0.878 Contact Map
1fnnA 1 0.9725 97.3 0.884 Contact Map
4xgcA 1 0.8846 97.2 0.885 Contact Map
1z6tA 1 0.9615 96.9 0.89 Contact Map
2qbyA 1 0.9286 96.1 0.9 Contact Map
2qbyB 1 0.9451 96 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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