GREMLIN Database
Q97YI8 - Isocitrate lyase (AceA/icl)
UniProt: Q97YI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (417)
Sequences: 745 (181)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_D328_K5.6931.00
56_K145_D5.4601.00
368_E375_R4.8561.00
64_E87_K4.8131.00
82_A148_L4.5970.99
272_G301_I4.5430.99
302_H307_G4.3440.99
30_N210_N3.8400.98
79_V128_A3.7430.97
130_I147_L3.7060.97
356_Y383_A3.4970.96
268_A284_F3.2690.94
384_Q391_V3.2690.94
204_A208_V3.2080.93
17_E21_D2.9660.90
188_E208_V2.7700.86
188_E204_A2.7190.85
26_G308_K2.6670.84
118_V171_L2.5680.81
139_E395_R2.5540.81
254_T260_E2.5030.80
102_L116_N2.4210.77
353_L357_H2.3520.75
389_T396_E2.3160.74
399_T425_A2.3040.73
52_L145_D2.3010.73
136_S144_I2.2930.73
325_D339_M2.2920.73
62_N309_M2.2900.73
102_L115_S2.2750.72
91_V121_L2.2250.71
261_I267_Y2.2010.70
210_N408_I2.1960.70
368_E371_P2.1750.69
328_K339_M2.1130.66
420_E425_A2.0900.66
59_N63_T2.0870.65
165_F405_V2.0420.64
118_V121_L2.0360.63
83_K396_E2.0320.63
26_G307_G2.0260.63
188_E207_R2.0150.63
414_A417_T2.0120.62
273_L301_I1.9950.62
205_F208_V1.9940.62
136_S142_H1.9910.62
154_A168_T1.9520.60
384_Q388_Y1.9520.60
288_K323_F1.9390.59
371_P374_V1.9240.59
206_I244_T1.9190.59
165_F169_K1.9120.58
164_A200_I1.9000.58
232_L268_A1.8960.58
60_L148_L1.8710.57
161_P207_R1.8640.56
161_P204_A1.8630.56
200_I208_V1.8300.55
70_F358_T1.8240.55
363_R367_N1.8230.55
51_K55_H1.8180.54
188_E396_E1.8180.54
161_P188_E1.8000.54
263_G267_Y1.7860.53
232_L293_E1.7510.51
266_E296_Q1.7440.51
204_A207_R1.7400.51
302_H308_K1.7240.50
18_W24_W1.7200.50
321_K326_D1.7170.50
79_V106_T1.7130.50
331_K335_E1.6910.49
46_E51_K1.6910.49
194_L425_A1.6670.48
69_T358_T1.6660.48
102_L120_N1.6510.47
373_Y388_Y1.6360.46
388_Y391_V1.6280.46
346_I374_V1.6200.46
292_E296_Q1.6020.45
205_F210_N1.5830.44
328_K331_K1.5560.43
205_F267_Y1.5340.42
165_F219_L1.5290.42
54_S295_R1.5140.41
237_L261_I1.5120.41
127_N164_A1.5000.41
335_E338_E1.4950.41
27_I307_G1.4840.40
232_L284_F1.4590.39
334_N338_E1.4520.39
83_K389_T1.4400.38
11_E14_L1.4400.38
210_N409_A1.4400.38
295_R299_E1.4340.38
374_V378_E1.4330.38
363_R386_E1.4310.38
145_D148_L1.4290.38
45_I412_G1.4170.37
60_L64_E1.4120.37
161_P208_V1.4020.37
35_D408_I1.3920.36
56_K146_Y1.3760.36
18_W22_P1.3690.35
244_T284_F1.3660.35
168_T179_V1.3640.35
205_F284_F1.3620.35
164_A208_V1.3590.35
244_T270_A1.3580.35
27_I308_K1.3530.35
73_L100_N1.3320.34
169_K219_L1.3250.34
208_V396_E1.3190.33
366_R374_V1.3150.33
364_A368_E1.3010.33
243_E246_N1.2900.32
136_S143_D1.2860.32
42_S130_I1.2850.32
12_K16_Y1.2650.31
252_K260_E1.2610.31
83_K146_Y1.2600.31
355_N390_A1.2600.31
168_T181_F1.2540.31
100_N121_L1.2520.31
47_Y219_L1.2490.31
247_Q270_A1.2460.31
233_N261_I1.2430.31
383_A396_E1.2410.31
116_N200_I1.2400.30
274_A362_A1.2290.30
173_E412_G1.2280.30
18_W21_D1.2210.30
38_K138_S1.2130.29
102_L121_L1.2090.29
16_Y33_P1.2040.29
161_P406_L1.2030.29
123_K173_E1.1930.29
202_I261_I1.1900.29
11_E15_E1.1900.29
368_E379_L1.1870.29
118_V122_V1.1780.28
118_V167_L1.1720.28
233_N263_G1.1680.28
116_N120_N1.1510.27
188_E406_L1.1470.27
173_E407_T1.1420.27
43_I147_L1.1400.27
235_K261_I1.1370.27
103_S170_A1.1370.27
400_D419_M1.1360.27
407_T412_G1.1360.27
273_L300_A1.1340.27
18_W33_P1.1100.26
106_T128_A1.1070.26
419_M425_A1.1040.26
33_P37_V1.1010.26
61_L309_M1.0970.26
127_N130_I1.0960.25
66_Y300_A1.0920.25
30_N408_I1.0920.25
51_K222_P1.0880.25
360_K386_E1.0840.25
136_S146_Y1.0830.25
18_W37_V1.0810.25
169_K378_E1.0780.25
406_L414_A1.0740.25
356_Y379_L1.0670.25
44_R47_Y1.0640.24
66_Y369_G1.0610.24
296_Q299_E1.0560.24
106_T219_L1.0550.24
219_L224_I1.0490.24
204_A396_E1.0480.24
284_F293_E1.0460.24
34_L383_A1.0420.24
200_I204_A1.0390.24
81_M106_T1.0370.24
304_H338_E1.0350.24
244_T282_L1.0320.23
351_W390_A1.0300.23
281_L309_M1.0290.23
206_I243_E1.0270.23
54_S223_T1.0270.23
27_I305_Y1.0260.23
16_Y34_L1.0230.23
268_A302_H1.0190.23
78_A84_A1.0170.23
268_A293_E1.0160.23
173_E219_L1.0150.23
134_Q173_E1.0050.23
83_K144_I1.0040.23
406_L410_S0.9990.22
146_Y391_V0.9980.22
235_K263_G0.9970.22
122_V171_L0.9950.22
123_K241_V0.9940.22
331_K337_G0.9930.22
50_A223_T0.9930.22
237_L249_L0.9930.22
291_L325_D0.9920.22
165_F218_V0.9900.22
69_T354_I0.9880.22
249_L254_T0.9880.22
363_R366_R0.9850.22
61_L369_G0.9840.22
43_I130_I0.9820.22
83_K188_E0.9810.22
46_E421_G0.9810.22
360_K379_L0.9800.22
404_L407_T0.9770.22
44_R220_G0.9670.21
421_G426_E0.9670.21
137_W266_E0.9670.21
60_L87_K0.9660.21
248_F275_Y0.9640.21
178_G389_T0.9590.21
87_K366_R0.9550.21
208_V406_L0.9470.21
261_I421_G0.9470.21
384_Q395_R0.9460.21
134_Q218_V0.9440.21
123_K127_N0.9440.21
232_L426_E0.9420.21
237_L322_K0.9360.21
59_N304_H0.9340.21
379_L391_V0.9340.21
202_I267_Y0.9330.21
392_S395_R0.9330.21
22_P33_P0.9270.20
356_Y396_E0.9230.20
389_T395_R0.9220.20
21_D24_W0.9180.20
82_A145_D0.9170.20
232_L287_S0.9130.20
225_L417_T0.9130.20
68_A337_G0.9060.20
205_F268_A0.9030.20
118_V154_A0.8990.20
16_Y259_Y0.8970.20
304_H307_G0.8950.19
205_F293_E0.8930.19
41_G351_W0.8910.19
146_Y244_T0.8880.19
249_L253_R0.8880.19
323_F357_H0.8780.19
40_R137_W0.8770.19
168_T171_L0.8720.19
56_K148_L0.8720.19
164_A211_A0.8710.19
122_V176_A0.8680.19
200_I205_F0.8670.19
11_E40_R0.8650.19
81_M121_L0.8650.19
412_G415_S0.8610.19
146_Y237_L0.8590.19
208_V416_T0.8580.18
66_Y337_G0.8580.18
43_I52_L0.8570.18
37_V137_W0.8560.18
127_N208_V0.8500.18
12_K15_E0.8490.18
235_K260_E0.8480.18
72_A116_N0.8470.18
421_G425_A0.8460.18
399_T416_T0.8460.18
188_E200_I0.8430.18
56_K143_D0.8410.18
65_P337_G0.8400.18
284_F346_I0.8380.18
121_L206_I0.8330.18
246_N259_Y0.8330.18
43_I49_L0.8320.18
91_V115_S0.8320.18
272_G346_I0.8300.18
417_T420_E0.8300.18
41_G137_W0.8290.18
173_E287_S0.8280.18
45_I181_F0.8270.18
356_Y360_K0.8250.18
293_E412_G0.8230.18
203_S263_G0.8220.18
303_T338_E0.8220.18
327_S338_E0.8160.17
207_R416_T0.8100.17
268_A412_G0.8090.17
106_T412_G0.8070.17
379_L384_Q0.8070.17
355_N395_R0.8060.17
407_T410_S0.8050.17
206_I246_N0.7990.17
383_A389_T0.7970.17
76_S104_N0.7950.17
129_L147_L0.7940.17
26_G302_H0.7940.17
124_R361_L0.7940.17
25_R32_K0.7880.17
27_I265_I0.7880.17
241_V379_L0.7850.17
62_N65_P0.7830.17
267_Y284_F0.7810.17
346_I356_Y0.7800.17
254_T376_L0.7790.17
406_L417_T0.7780.16
232_L341_Y0.7780.16
98_A290_D0.7770.16
243_E338_E0.7760.16
243_E282_L0.7740.16
259_Y331_K0.7720.16
17_E22_P0.7700.16
324_M329_I0.7690.16
263_G268_A0.7680.16
83_K204_A0.7680.16
247_Q274_A0.7670.16
56_K82_A0.7610.16
290_D346_I0.7610.16
396_E406_L0.7590.16
299_E339_M0.7590.16
164_A323_F0.7580.16
74_T121_L0.7570.16
200_I241_V0.7560.16
367_N385_A0.7550.16
351_W357_H0.7530.16
225_L259_Y0.7510.16
274_A383_A0.7500.16
207_R396_E0.7480.16
164_A404_L0.7440.16
107_Y111_S0.7430.16
127_N200_I0.7420.16
22_P37_V0.7410.16
45_I374_V0.7410.16
205_F272_G0.7380.16
208_V374_V0.7370.16
368_E385_A0.7340.15
44_R206_I0.7310.15
232_L259_Y0.7310.15
127_N173_E0.7310.15
17_E224_I0.7300.15
335_E339_M0.7300.15
346_I383_A0.7270.15
232_L301_I0.7270.15
134_Q343_F0.7250.15
292_E338_E0.7240.15
50_A54_S0.7230.15
237_L408_I0.7230.15
204_A392_S0.7220.15
188_E389_T0.7200.15
118_V261_I0.7160.15
235_K366_R0.7160.15
82_A89_I0.7160.15
136_S282_L0.7150.15
42_S60_L0.7150.15
326_D337_G0.7140.15
224_I338_E0.7130.15
49_L53_A0.7120.15
273_L304_H0.7110.15
273_L305_Y0.7110.15
65_P338_E0.7090.15
139_E372_A0.7090.15
293_E369_G0.7080.15
309_M417_T0.7050.15
203_S267_Y0.7040.15
61_L224_I0.7020.15
287_S293_E0.6980.15
55_H222_P0.6970.15
146_Y389_T0.6970.15
207_R409_A0.6970.15
232_L262_K0.6960.15
121_L171_L0.6930.15
325_D331_K0.6930.15
129_L282_L0.6910.15
292_E299_E0.6910.15
290_D399_T0.6910.15
76_S351_W0.6900.14
136_S147_L0.6890.14
15_E37_V0.6880.14
43_I51_K0.6870.14
29_R217_D0.6870.14
24_W208_V0.6860.14
194_L255_S0.6860.14
205_F374_V0.6860.14
139_E204_A0.6860.14
356_Y372_A0.6840.14
83_K395_R0.6840.14
138_S404_L0.6830.14
70_F357_H0.6820.14
33_P148_L0.6810.14
127_N232_L0.6800.14
188_E410_S0.6790.14
105_Q127_N0.6790.14
121_L326_D0.6760.14
343_F355_N0.6750.14
20_E24_W0.6750.14
116_N188_E0.6730.14
194_L399_T0.6730.14
384_Q392_S0.6720.14
32_K61_L0.6720.14
83_K260_E0.6710.14
177_A339_M0.6690.14
43_I259_Y0.6680.14
122_V164_A0.6660.14
366_R412_G0.6660.14
76_S355_N0.6660.14
100_N115_S0.6650.14
68_A369_G0.6630.14
326_D374_V0.6620.14
343_F347_T0.6610.14
218_V226_I0.6610.14
27_I302_H0.6600.14
200_I207_R0.6600.14
379_L383_A0.6600.14
351_W355_N0.6580.14
56_K270_A0.6580.14
110_L258_Y0.6570.14
42_S287_S0.6570.14
30_N205_F0.6560.14
188_E395_R0.6560.14
235_K293_E0.6540.14
120_N171_L0.6520.14
181_F205_F0.6510.14
299_E303_T0.6500.14
330_S334_N0.6500.14
295_R392_S0.6480.14
35_D360_K0.6470.14
247_Q295_R0.6460.14
32_K147_L0.6460.14
188_E416_T0.6450.14
30_N410_S0.6440.14
194_L420_E0.6430.14
28_K43_I0.6430.14
232_L267_Y0.6430.14
249_L259_Y0.6380.13
304_H367_N0.6370.13
181_F268_A0.6370.13
91_V353_L0.6360.13
261_I346_I0.6350.13
68_A81_M0.6350.13
72_A151_V0.6350.13
247_Q301_I0.6340.13
205_F301_I0.6330.13
373_Y391_V0.6330.13
363_R379_L0.6310.13
206_I210_N0.6280.13
383_A399_T0.6270.13
395_R406_L0.6270.13
323_F374_V0.6250.13
274_A279_A0.6250.13
203_S233_N0.6240.13
116_N151_V0.6190.13
99_D397_V0.6190.13
181_F223_T0.6170.13
269_I300_A0.6160.13
207_R406_L0.6160.13
59_N404_L0.6140.13
69_T400_D0.6130.13
20_E25_R0.6130.13
161_P425_A0.6130.13
211_A303_T0.6120.13
32_K44_R0.6100.13
30_N208_V0.6090.13
164_A181_F0.6090.13
52_L56_K0.6060.13
81_M333_M0.6060.13
140_G414_A0.6060.13
372_A384_Q0.6050.13
25_R28_K0.6040.13
204_A406_L0.6030.13
106_T136_S0.6030.13
65_P368_E0.6030.13
233_N267_Y0.6030.13
130_I337_G0.6030.13
406_L416_T0.6020.13
121_L168_T0.6020.13
65_P224_I0.6020.13
354_I390_A0.6010.13
247_Q300_A0.6000.13
38_K55_H0.6000.13
76_S357_H0.6000.13
96_V107_Y0.5990.13
246_N250_T0.5970.13
69_T336_L0.5970.13
404_L408_I0.5960.13
118_V176_A0.5960.13
243_E357_H0.5930.13
379_L388_Y0.5920.13
21_D37_V0.5870.12
121_L136_S0.5870.12
65_P296_Q0.5870.12
186_A396_E0.5860.12
194_L204_A0.5860.12
100_N165_F0.5840.12
50_A171_L0.5830.12
321_K329_I0.5830.12
219_L412_G0.5820.12
27_I414_A0.5810.12
243_E247_Q0.5800.12
115_S120_N0.5790.12
233_N292_E0.5780.12
21_D33_P0.5770.12
227_A336_L0.5760.12
208_V389_T0.5760.12
46_E425_A0.5750.12
96_V117_S0.5730.12
205_F232_L0.5720.12
154_A295_R0.5710.12
30_N407_T0.5690.12
287_S426_E0.5690.12
292_E421_G0.5690.12
354_I358_T0.5690.12
222_P282_L0.5670.12
51_K249_L0.5660.12
106_T378_E0.5660.12
38_K404_L0.5650.12
69_T372_A0.5640.12
282_L300_A0.5630.12
288_K303_T0.5630.12
331_K334_N0.5620.12
270_A329_I0.5620.12
164_A168_T0.5610.12
47_Y279_A0.5610.12
87_K282_L0.5580.12
232_L265_I0.5570.12
296_Q367_N0.5550.12
299_E334_N0.5540.12
20_E145_D0.5530.12
35_D144_I0.5530.12
128_A267_Y0.5530.12
111_S172_I0.5520.12
225_L262_K0.5520.12
106_T267_Y0.5520.12
204_A410_S0.5520.12
266_E300_A0.5520.12
66_Y91_V0.5510.12
140_G376_L0.5500.12
290_D383_A0.5490.12
73_L353_L0.5490.12
91_V226_I0.5490.12
269_I378_E0.5480.12
45_I293_E0.5470.12
286_T319_N0.5460.12
102_L170_A0.5460.12
118_V225_L0.5460.12
37_V44_R0.5450.12
127_N379_L0.5450.12
45_I363_R0.5440.12
25_R169_K0.5440.12
205_F244_T0.5440.12
83_K293_E0.5430.12
28_K44_R0.5430.12
255_S413_E0.5430.12
66_Y226_I0.5410.12
24_W171_L0.5400.12
147_L414_A0.5400.12
118_V265_I0.5390.12
87_K292_E0.5390.12
290_D293_E0.5390.12
96_V110_L0.5370.12
377_Q390_A0.5360.12
25_R225_L0.5350.11
366_R386_E0.5350.11
52_L59_N0.5350.11
207_R241_V0.5350.11
68_A334_N0.5320.11
173_E254_T0.5320.11
263_G266_E0.5310.11
371_P379_L0.5310.11
116_N194_L0.5310.11
106_T408_I0.5290.11
288_K392_S0.5290.11
346_I369_G0.5280.11
349_A352_H0.5270.11
348_L393_H0.5270.11
203_S261_I0.5260.11
312_Y316_P0.5260.11
313_N316_P0.5260.11
122_V268_A0.5260.11
220_G426_E0.5260.11
61_L65_P0.5260.11
371_P375_R0.5250.11
367_N406_L0.5250.11
405_V415_S0.5230.11
165_F397_V0.5230.11
326_D399_T0.5230.11
69_T76_S0.5220.11
262_K288_K0.5220.11
86_L355_N0.5220.11
326_D329_I0.5210.11
132_A389_T0.5200.11
244_T304_H0.5200.11
117_S215_A0.5190.11
127_N404_L0.5180.11
69_T353_L0.5170.11
303_T391_V0.5170.11
70_F76_S0.5160.11
299_E338_E0.5160.11
118_V279_A0.5150.11
171_L328_K0.5140.11
262_K408_I0.5140.11
244_T261_I0.5130.11
178_G375_R0.5130.11
70_F353_L0.5130.11
45_I173_E0.5120.11
12_K322_K0.5120.11
304_H308_K0.5110.11
177_A194_L0.5110.11
167_L171_L0.5110.11
130_I134_Q0.5110.11
204_A356_Y0.5090.11
154_A164_A0.5080.11
363_R385_A0.5080.11
206_I392_S0.5070.11
25_R37_V0.5070.11
181_F412_G0.5070.11
293_E410_S0.5060.11
135_I158_F0.5060.11
379_L392_S0.5050.11
129_L377_Q0.5050.11
173_E410_S0.5030.11
325_D335_E0.5030.11
178_G346_I0.5030.11
43_I47_Y0.5020.11
105_Q288_K0.5020.11
291_L367_N0.5010.11
207_R356_Y0.5000.11
208_V395_R0.5000.11
105_Q204_A0.5000.11
128_A328_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dquA 4 0.9199 100 0.255 Contact Map
3i4eA 4 0.9291 100 0.35 Contact Map
3lg3A 4 0.9359 100 0.352 Contact Map
3eolA 4 0.8238 100 0.354 Contact Map
1f8mA 4 0.9725 100 0.362 Contact Map
3lyeA 4 0.6316 100 0.776 Contact Map
3eooA 4 0.659 100 0.788 Contact Map
1zlpA 4 0.643 100 0.788 Contact Map
1xg4A 4 0.6499 100 0.789 Contact Map
3fa4A 5 0.6613 100 0.791 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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