GREMLIN Database
Q97YI6 - First ORF in transposon ISC1904
UniProt: Q97YI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (182)
Sequences: 478 (336)
Seq/√Len: 24.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.2281.00
60_A78_L4.1751.00
82_V119_V3.7081.00
117_R144_E3.5141.00
7_A11_L2.7740.99
103_F126_L2.6710.99
58_L148_I2.6590.99
110_I138_C2.6120.99
13_I21_Y2.3690.98
17_T21_Y2.3300.98
91_D102_G2.3090.98
135_E139_K2.2560.97
85_Y146_V2.1830.97
16_A19_R2.1400.96
106_L115_V2.1370.96
18_L39_F2.0530.96
5_K9_Q2.0300.95
22_V37_W1.9880.95
55_K109_M1.9720.94
98_M132_E1.9620.94
96_L129_F1.9180.94
111_L141_H1.9070.93
75_V90_T1.8370.92
77_Y121_A1.8280.92
58_L88_V1.8120.91
58_L78_L1.7470.90
131_F145_I1.7390.90
22_V29_P1.6890.88
3_R34_S1.6800.88
119_V132_E1.6560.87
138_C143_C1.6500.87
110_I115_V1.6490.87
87_Q109_M1.6350.86
131_F147_V1.6200.86
89_I102_G1.6070.85
110_I118_V1.5720.84
127_V131_F1.5120.82
98_M167_S1.5030.81
4_S19_R1.4980.81
166_L177_S1.4950.81
109_M114_E1.4900.81
75_V88_V1.4840.81
110_I120_I1.4700.80
12_G142_G1.4690.80
155_E159_E1.4630.80
40_R43_D1.4550.79
119_V146_V1.4550.79
72_A76_K1.4360.78
138_C172_L1.3980.76
16_A24_K1.3540.74
70_D73_N1.3460.73
26_Y33_Q1.3390.73
122_Y159_E1.3320.73
96_L130_G1.3260.72
4_S18_L1.3060.71
7_A44_V1.2810.70
166_L170_G1.2550.68
167_S170_G1.2530.68
27_I30_V1.2480.68
7_A27_I1.2400.67
15_Y19_R1.2340.67
17_T20_E1.2310.67
31_I37_W1.2090.65
170_G175_M1.1930.64
121_A178_H1.1870.64
22_V27_I1.1870.64
8_C15_Y1.1750.63
56_V144_E1.1550.61
62_V67_Q1.1510.61
64_S67_Q1.1470.61
131_F134_L1.1420.61
91_D167_S1.1390.60
22_V39_F1.1370.60
67_Q70_D1.1350.60
57_I75_V1.1340.60
91_D121_A1.1320.60
8_C13_I1.1220.59
89_I118_V1.1120.58
20_E23_K1.1070.58
58_L82_V1.1060.58
78_L148_I1.0890.57
95_G126_L1.0710.56
117_R146_V1.0620.55
159_E170_G1.0600.55
89_I106_L1.0450.54
76_K79_E1.0450.54
14_S20_E1.0410.53
3_R38_R1.0390.53
173_H176_R1.0330.53
62_V71_L1.0230.52
72_A75_V1.0020.51
56_V119_V0.9940.50
14_S172_L0.9890.50
27_I134_L0.9800.49
8_C171_K0.9790.49
138_C169_S0.9750.49
75_V107_L0.9690.48
170_G177_S0.9620.48
8_C18_L0.9580.47
28_K43_D0.9540.47
129_F160_D0.9540.47
4_S29_P0.9480.47
148_I154_E0.9470.47
171_K175_M0.9470.47
98_M127_V0.9460.47
127_V134_L0.9390.46
156_E168_F0.9350.46
19_R39_F0.9150.44
161_L165_L0.9140.44
57_I89_I0.9060.44
164_I174_G0.9050.44
22_V31_I0.9020.43
77_Y149_N0.8970.43
13_I20_E0.8950.43
108_R140_A0.8950.43
139_K171_K0.8940.43
157_L166_L0.8900.43
7_A38_R0.8890.42
181_E185_K0.8850.42
19_R22_V0.8830.42
11_L18_L0.8820.42
95_G103_F0.8700.41
4_S15_Y0.8610.41
158_V161_L0.8570.40
7_A18_L0.8550.40
134_L138_C0.8470.40
26_Y34_S0.8450.39
166_L178_H0.8440.39
56_V93_G0.8420.39
85_Y148_I0.8410.39
4_S7_A0.8240.38
30_V38_R0.8170.37
110_I143_C0.8170.37
157_L160_D0.8110.37
63_S67_Q0.8110.37
81_Q146_V0.8080.37
27_I43_D0.8070.37
43_D46_R0.8060.37
54_R143_C0.7950.36
18_L22_V0.7930.36
118_V183_V0.7840.35
48_M108_R0.7780.35
67_Q73_N0.7730.35
93_G163_S0.7680.34
19_R31_I0.7600.34
81_Q85_Y0.7560.33
19_R36_K0.7510.33
42_E73_N0.7460.33
78_L143_C0.7440.33
121_A166_L0.7400.32
177_S183_V0.7370.32
3_R33_Q0.7360.32
73_N162_V0.7350.32
118_V145_I0.7310.32
50_I116_S0.7250.31
39_F43_D0.7230.31
55_K87_Q0.7200.31
54_R142_G0.7190.31
6_E43_D0.7140.31
100_R127_V0.7130.31
9_Q68_K0.7090.30
63_S128_R0.7090.30
10_R90_T0.7080.30
30_V43_D0.7010.30
56_V116_S0.6940.30
89_I109_M0.6940.30
6_E157_L0.6920.29
119_V134_L0.6880.29
160_D174_G0.6840.29
85_Y121_A0.6820.29
103_F127_V0.6820.29
5_K34_S0.6790.29
97_N141_H0.6760.28
155_E158_V0.6760.28
44_V118_V0.6720.28
13_I31_I0.6710.28
48_M51_I0.6680.28
68_K179_K0.6640.28
120_I147_V0.6640.28
33_Q113_N0.6610.28
157_L168_F0.6610.28
19_R37_W0.6610.28
92_I145_I0.6560.27
96_L133_I0.6560.27
91_D145_I0.6560.27
57_I106_L0.6520.27
160_D164_I0.6500.27
77_Y178_H0.6470.27
14_S22_V0.6440.27
77_Y163_S0.6430.27
64_S73_N0.6400.26
149_N153_K0.6380.26
54_R112_N0.6360.26
123_P165_L0.6320.26
70_D121_A0.6310.26
129_F164_I0.6280.26
107_L146_V0.6270.26
147_V165_L0.6250.26
92_I100_R0.6200.25
6_E146_V0.6200.25
119_V136_E0.6160.25
177_S180_Y0.6130.25
81_Q149_N0.6120.25
161_L164_I0.6070.25
84_E119_V0.6040.24
92_I101_K0.6040.24
161_L174_G0.6030.24
55_K116_S0.6000.24
29_P39_F0.5990.24
129_F174_G0.5990.24
77_Y91_D0.5960.24
107_L111_L0.5940.24
64_S174_G0.5910.24
137_V140_A0.5900.24
91_D98_M0.5890.24
118_V147_V0.5890.24
103_F167_S0.5880.24
35_G90_T0.5830.23
169_S175_M0.5810.23
23_K101_K0.5790.23
8_C12_G0.5760.23
6_E57_I0.5740.23
101_K165_L0.5730.23
81_Q148_I0.5690.23
82_V85_Y0.5690.23
36_K39_F0.5660.22
69_D164_I0.5660.22
8_C103_F0.5650.22
130_G169_S0.5650.22
93_G144_E0.5630.22
34_S113_N0.5590.22
73_N76_K0.5580.22
57_I115_V0.5580.22
110_I147_V0.5570.22
12_G129_F0.5530.22
91_D111_L0.5520.22
5_K19_R0.5520.22
142_G161_L0.5510.22
66_T121_A0.5480.22
134_L157_L0.5460.21
56_V87_Q0.5430.21
23_K31_I0.5420.21
104_L136_E0.5410.21
120_I145_I0.5390.21
32_L36_K0.5380.21
31_I36_K0.5370.21
124_D128_R0.5370.21
57_I150_Q0.5340.21
22_V34_S0.5320.21
103_F116_S0.5300.21
130_G146_V0.5290.21
45_E48_M0.5290.21
161_L168_F0.5280.21
15_Y37_W0.5260.21
99_K141_H0.5250.20
6_E32_L0.5210.20
28_K35_G0.5180.20
153_K175_M0.5140.20
13_I38_R0.5090.20
5_K8_C0.5090.20
63_S129_F0.5080.20
29_P43_D0.5080.20
22_V32_L0.5080.20
76_K80_E0.5080.20
118_V126_L0.5070.20
44_V85_Y0.5070.20
66_T122_Y0.5060.20
178_H184_K0.5050.20
31_I40_R0.5040.20
115_V143_C0.5020.19
110_I145_I0.5020.19
32_L41_E0.5010.19
135_E145_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7188 100 0.65 Contact Map
3lhkA 2 0.7292 100 0.652 Contact Map
3g13A 2 0.7292 99.8 0.731 Contact Map
3bvpA 4 0.625 99.8 0.74 Contact Map
3guvA 2 0.6875 99.8 0.74 Contact Map
4bqqA 2 0.6979 99.8 0.741 Contact Map
2mhcA 1 0.5625 99.8 0.742 Contact Map
2gm5A 4 0.6302 99.8 0.751 Contact Map
1gdtA 2 0.6875 99.7 0.757 Contact Map
3pkzA 4 0.5833 99.7 0.761 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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