GREMLIN Database
Q97YI5 - Second ORF in transposon ISC1904
UniProt: Q97YI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (346)
Sequences: 4384 (2779)
Seq/√Len: 149.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_D267_K5.3981.00
287_N290_S4.4001.00
339_P366_N4.1471.00
319_A326_V3.6701.00
282_A375_M3.0841.00
205_L311_I3.0761.00
312_H328_E3.0051.00
283_V315_L2.8961.00
346_R349_G2.8891.00
310_S314_V2.8051.00
19_F321_L2.7691.00
270_N274_D2.7291.00
310_S313_R2.4301.00
337_S344_V2.4251.00
172_P181_L2.4181.00
336_R345_S2.4081.00
316_K328_E2.3941.00
311_I315_L2.3731.00
333_F336_R2.3401.00
329_V371_I2.2681.00
273_L319_A2.2651.00
225_K301_R2.2501.00
292_F304_S2.2071.00
374_K377_G2.1341.00
281_F319_A2.1201.00
170_G186_K2.0821.00
266_H314_V2.0821.00
231_K246_G2.0751.00
283_V326_V2.0661.00
28_R31_S2.0571.00
266_H317_Y2.0561.00
334_T371_I2.0421.00
224_L260_R2.0181.00
296_N300_S1.9961.00
353_E360_K1.9821.00
54_K119_K1.9631.00
341_C357_C1.9601.00
246_G250_L1.9071.00
297_D300_S1.9021.00
205_L264_F1.8851.00
262_L310_S1.8831.00
36_K179_V1.8821.00
49_L96_I1.8681.00
316_K320_P1.8641.00
37_E86_H1.8531.00
269_V314_V1.8211.00
350_K363_R1.8071.00
345_S349_G1.7801.00
338_C341_C1.7701.00
354_C357_C1.7501.00
265_V314_V1.7491.00
266_H318_K1.7451.00
352_F361_L1.7451.00
51_S55_I1.7441.00
341_C354_C1.7301.00
50_W99_A1.7301.00
338_C357_C1.7261.00
340_R359_F1.7201.00
277_P324_S1.7171.00
241_K244_K1.7061.00
266_H269_V1.7031.00
244_K247_R1.6541.00
20_T182_P1.6241.00
283_V328_E1.6221.00
231_K234_K1.6091.00
265_V310_S1.6071.00
338_C354_C1.5601.00
35_I179_V1.5491.00
198_I206_D1.5461.00
44_K83_K1.5371.00
285_K328_E1.5121.00
67_L71_K1.4991.00
207_A365_L1.4981.00
33_E37_E1.4901.00
195_F372_Y1.4831.00
100_F104_K1.4771.00
143_I181_L1.4721.00
283_V312_H1.4571.00
269_V317_Y1.4401.00
343_F355_E1.4391.00
39_T179_V1.4381.00
68_P71_K1.4381.00
351_T360_K1.4371.00
352_F359_F1.4371.00
49_L99_A1.4301.00
235_V247_R1.3921.00
105_S117_I1.3911.00
144_T150_Y1.3821.00
316_K326_V1.3721.00
204_T207_A1.3701.00
32_K36_K1.3701.00
284_E331_P1.3531.00
269_V318_K1.3141.00
103_L119_K1.3111.00
255_H259_N1.3081.00
196_L208_Y1.3071.00
369_L373_L1.3011.00
208_Y212_K1.2941.00
347_K350_K1.2771.00
231_K253_Y1.2601.00
195_F280_F1.2521.00
110_A117_I1.2511.00
109_R117_I1.2451.00
90_H130_K1.2441.00
303_I308_W1.2401.00
104_K108_K1.2251.00
346_R350_K1.2191.00
216_I219_K1.2141.00
69_K72_E1.2021.00
42_L95_A1.1971.00
29_E32_K1.1951.00
228_M250_L1.1931.00
365_L369_L1.1891.00
54_K58_R1.1891.00
239_A243_T1.1861.00
224_L257_E1.1821.00
265_V311_I1.1771.00
273_L322_Y1.1721.00
90_H132_T1.1701.00
196_L276_Y1.1681.00
271_A275_L1.1661.00
94_K97_N1.1581.00
176_E255_H1.1551.00
287_N331_P1.1531.00
178_K255_H1.1531.00
339_P369_L1.1361.00
228_M254_S1.1341.00
339_P361_L1.1290.99
72_E75_K1.1230.99
197_A372_Y1.1220.99
78_R92_V1.1170.99
101_S105_S1.1160.99
200_S308_W1.1080.99
314_V317_Y1.1070.99
213_F362_D1.1070.99
269_V311_I1.1050.99
55_I59_K1.1010.99
98_D128_R1.0960.99
202_L306_T1.0950.99
361_L369_L1.0900.99
262_L314_V1.0800.99
155_W158_S1.0720.99
258_R262_L1.0680.99
270_N322_Y1.0640.99
227_S231_K1.0630.99
46_I95_A1.0600.99
212_K271_A1.0600.99
27_K35_I1.0570.99
137_V140_S1.0560.99
200_S312_H1.0550.99
347_K363_R1.0530.99
198_I208_Y1.0530.99
73_V77_L1.0480.99
65_I69_K1.0460.99
334_T374_K1.0450.99
27_K31_S1.0440.99
269_V315_L1.0430.99
88_A91_Y1.0380.99
105_S110_A1.0360.99
336_R344_V1.0340.99
329_V374_K1.0250.99
265_V269_V1.0240.99
138_G141_V1.0220.99
274_D322_Y1.0180.99
337_S374_K1.0170.99
288_K309_R1.0140.99
273_L281_F1.0140.99
21_Y185_Y1.0130.99
318_K321_L1.0120.99
282_A371_I1.0100.99
195_F376_C1.0090.99
232_R250_L1.0090.99
346_R363_R1.0030.99
127_V131_T1.0020.99
313_R316_K1.0020.99
70_K73_V0.9980.99
345_S352_F0.9950.99
280_F325_F0.9930.99
232_R236_Q0.9900.99
40_T43_Q0.9880.99
231_K250_L0.9880.99
235_V250_L0.9860.99
70_K74_Y0.9850.99
105_S109_R0.9840.99
54_K103_L0.9790.99
207_A213_F0.9780.99
234_K238_F0.9780.99
339_P359_F0.9770.99
285_K331_P0.9770.99
127_V130_K0.9750.99
361_L365_L0.9720.98
339_P367_A0.9650.98
94_K128_R0.9650.98
365_L368_S0.9510.98
50_W103_L0.9490.98
273_L324_S0.9480.98
56_Q60_N0.9420.98
350_K362_D0.9410.98
32_K179_V0.9400.98
329_V375_M0.9380.98
228_M257_E0.9360.98
243_T247_R0.9330.98
74_Y77_L0.9320.98
204_T215_T0.9230.98
44_K48_Y0.9210.98
296_N299_L0.9190.98
196_L209_D0.9180.98
46_I99_A0.9170.98
206_D268_F0.9110.98
192_P277_P0.9110.98
75_K78_R0.9100.98
90_H94_K0.9060.98
272_L281_F0.9050.98
109_R118_E0.8990.97
220_Q260_R0.8960.97
106_W120_P0.8950.97
75_K79_D0.8950.97
46_I102_I0.8940.97
24_K178_K0.8910.97
133_L146_R0.8900.97
71_K75_K0.8880.97
265_V307_V0.8870.97
98_D173_I0.8860.97
343_F356_R0.8850.97
331_P334_T0.8840.97
202_L302_K0.8830.97
106_W119_K0.8830.97
249_L252_K0.8830.97
231_K249_L0.8770.97
340_R369_L0.8760.97
52_L73_V0.8750.97
142_R150_Y0.8740.97
41_L83_K0.8740.97
280_F327_K0.8730.97
240_S243_T0.8710.97
333_F374_K0.8700.97
74_Y78_R0.8660.97
105_S108_K0.8660.97
288_K308_W0.8590.97
58_R61_G0.8560.97
133_L136_V0.8530.97
90_H131_T0.8490.96
351_T361_L0.8490.96
128_R171_E0.8480.96
292_F296_N0.8470.96
200_S206_D0.8470.96
195_F282_A0.8450.96
143_I172_P0.8430.96
76_P80_E0.8400.96
173_I182_P0.8360.96
367_A370_N0.8310.96
53_T100_F0.8300.96
253_Y257_E0.8290.96
93_D97_N0.8240.96
319_A324_S0.8240.96
69_K74_Y0.8200.96
339_P373_L0.8170.96
214_V264_F0.8170.96
270_N318_K0.8150.95
345_S363_R0.8130.95
48_Y52_L0.8120.95
229_E233_A0.8080.95
57_V61_G0.8080.95
343_F352_F0.8070.95
135_K144_T0.8050.95
153_F156_S0.7990.95
66_T69_K0.7980.95
349_G363_R0.7950.95
232_R254_S0.7940.95
369_L372_Y0.7920.95
84_I92_V0.7900.95
292_F300_S0.7880.95
196_L281_F0.7870.95
268_F271_A0.7870.95
145_V174_I0.7840.94
175_K178_K0.7820.94
135_K138_G0.7820.94
290_S331_P0.7810.94
68_P72_E0.7810.94
366_N370_N0.7790.94
333_F337_S0.7780.94
229_E232_R0.7730.94
256_R260_R0.7720.94
94_K98_D0.7720.94
337_S370_N0.7700.94
45_A95_A0.7670.94
194_N210_G0.7650.94
24_K180_Y0.7650.94
69_K73_V0.7640.94
220_Q224_L0.7610.94
69_K77_L0.7600.93
235_V246_G0.7590.93
264_F268_F0.7570.93
247_R251_R0.7550.93
327_K375_M0.7530.93
236_Q250_L0.7500.93
213_F365_L0.7490.93
53_T103_L0.7490.93
374_K378_F0.7440.93
285_K312_H0.7380.92
94_K130_K0.7380.92
352_F363_R0.7370.92
25_N181_L0.7360.92
191_T194_N0.7350.92
103_L106_W0.7340.92
57_V103_L0.7320.92
235_V243_T0.7280.92
23_I157_K0.7210.92
228_M232_R0.7200.92
201_N207_A0.7170.91
282_A372_Y0.7160.91
102_I120_P0.7160.91
272_L276_Y0.7140.91
199_D364_Q0.7140.91
41_L87_L0.7140.91
228_M236_Q0.7140.91
290_S303_I0.7130.91
38_Y42_L0.7100.91
34_L38_Y0.7090.91
153_F157_K0.7080.91
204_T213_F0.7080.91
297_D304_S0.7080.91
129_I145_V0.7080.91
203_Y207_A0.7070.91
90_H133_L0.7050.91
148_Y151_I0.7050.91
71_K96_I0.7050.91
96_I100_F0.7030.91
286_L331_P0.7020.90
29_E33_E0.7000.90
299_L303_I0.7000.90
87_L90_H0.7000.90
141_V145_V0.6950.90
224_L256_R0.6950.90
40_T44_K0.6940.90
230_V234_K0.6930.90
206_D311_I0.6920.90
48_Y77_L0.6900.90
229_E236_Q0.6880.90
41_L44_K0.6850.89
205_L306_T0.6840.89
90_H93_D0.6830.89
23_I181_L0.6830.89
65_I70_K0.6820.89
132_T135_K0.6820.89
222_Y301_R0.6810.89
205_L269_V0.6810.89
234_K237_S0.6780.89
35_I39_T0.6740.89
103_L107_R0.6740.89
309_R313_R0.6740.89
171_E184_R0.6730.89
168_E186_K0.6690.88
89_S130_K0.6660.88
174_I181_L0.6650.88
281_F315_L0.6640.88
234_K246_G0.6630.88
134_R169_L0.6630.88
37_E41_L0.6610.88
44_K81_L0.6610.88
282_A327_K0.6600.88
257_E305_R0.6590.88
189_W324_S0.6590.88
261_V305_R0.6580.87
141_V144_T0.6570.87
216_I306_T0.6530.87
238_F246_G0.6530.87
333_F344_V0.6480.87
99_A103_L0.6470.87
157_K160_F0.6470.87
68_P74_Y0.6460.86
73_V96_I0.6450.86
224_L228_M0.6430.86
349_G352_F0.6400.86
106_W109_R0.6340.85
52_L77_L0.6320.85
20_T184_R0.6320.85
67_L75_K0.6310.85
26_D154_S0.6310.85
75_K96_I0.6300.85
145_V148_Y0.6290.85
56_Q61_G0.6290.85
60_N64_K0.6280.85
189_W192_P0.6280.85
355_E363_R0.6260.85
262_L266_H0.6260.85
274_D280_F0.6260.85
144_T147_P0.6260.85
69_K75_K0.6250.85
38_Y88_A0.6250.85
221_L224_L0.6240.85
292_F297_D0.6230.84
371_I374_K0.6210.84
340_R361_L0.6200.84
137_V142_R0.6190.84
234_K249_L0.6180.84
51_S122_V0.6170.84
52_L55_I0.6150.84
53_T70_K0.6140.84
41_L84_I0.6130.83
149_E152_T0.6130.83
337_S342_G0.6110.83
243_T250_L0.6100.83
70_K93_D0.6100.83
92_V95_A0.6100.83
231_K235_V0.6090.83
127_V133_L0.6080.83
288_K303_I0.6080.83
315_L326_V0.6080.83
55_I58_R0.6070.83
22_S182_P0.6060.83
72_E77_L0.6050.83
317_Y321_L0.6050.83
67_L70_K0.6050.83
224_L253_Y0.6000.82
254_S261_V0.5990.82
67_L97_N0.5990.82
25_N153_F0.5990.82
361_L366_N0.5980.82
203_Y350_K0.5960.82
27_K32_K0.5950.82
276_Y281_F0.5950.82
244_K248_E0.5930.81
21_Y157_K0.5920.81
347_K362_D0.5920.81
312_H316_K0.5910.81
128_R131_T0.5870.81
74_Y96_I0.5870.81
108_K117_I0.5850.81
209_D365_L0.5840.80
126_Y130_K0.5830.80
128_R173_I0.5830.80
71_K74_Y0.5830.80
199_D335_S0.5820.80
126_Y129_I0.5820.80
205_L265_V0.5800.80
375_M379_P0.5800.80
194_N276_Y0.5800.80
330_N333_F0.5800.80
38_Y87_L0.5790.80
345_S350_K0.5790.80
130_K133_L0.5780.80
70_K77_L0.5780.80
337_S352_F0.5770.80
332_R336_R0.5770.80
347_K351_T0.5760.80
314_V318_K0.5760.80
89_S133_L0.5760.80
208_Y214_V0.5740.79
134_R172_P0.5730.79
37_E87_L0.5720.79
96_I99_A0.5710.79
87_L92_V0.5710.79
49_L73_V0.5690.79
233_A236_Q0.5680.79
376_C379_P0.5670.78
51_S54_K0.5670.78
38_Y129_I0.5670.78
153_F158_S0.5670.78
319_A322_Y0.5670.78
34_L37_E0.5670.78
222_Y302_K0.5650.78
30_E33_E0.5630.78
282_A374_K0.5620.78
91_Y129_I0.5620.78
309_R312_H0.5600.78
202_L293_V0.5600.78
288_K291_M0.5590.78
349_G355_E0.5590.78
95_A99_A0.5530.77
60_N63_Y0.5520.77
214_V271_A0.5510.77
91_Y127_V0.5510.77
259_N262_L0.5500.76
335_S345_S0.5450.76
37_E40_T0.5450.76
333_F352_F0.5440.76
214_V268_F0.5440.76
74_Y93_D0.5440.76
137_V144_T0.5420.75
197_A282_A0.5410.75
62_N65_I0.5410.75
267_K270_N0.5400.75
39_T42_L0.5400.75
218_L306_T0.5360.75
52_L56_Q0.5360.75
69_K76_P0.5360.75
180_Y255_H0.5360.75
373_L376_C0.5350.74
243_T246_G0.5350.74
268_F311_I0.5330.74
95_A98_D0.5320.74
203_Y346_R0.5310.74
178_K259_N0.5310.74
342_G370_N0.5300.74
194_N277_P0.5230.73
373_L378_F0.5220.73
64_K69_K0.5220.73
254_S258_R0.5200.72
65_I68_P0.5200.72
73_V76_P0.5190.72
129_I133_L0.5190.72
229_E297_D0.5170.72
296_N303_I0.5160.72
222_Y225_K0.5160.72
108_K111_I0.5150.72
221_L225_K0.5150.72
282_A376_C0.5140.71
225_K229_E0.5110.71
353_E359_F0.5090.71
39_T127_V0.5080.71
299_L302_K0.5080.71
25_N174_I0.5050.70
48_Y83_K0.5050.70
262_L307_V0.5050.70
185_Y274_D0.5040.70
345_S348_V0.5020.70
290_S293_V0.5010.70
229_E237_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3073 95.1 0.933 Contact Map
1vhxA 2 0.3239 94.5 0.936 Contact Map
1iv0A 1 0.2293 91.4 0.942 Contact Map
2k4xA 1 0.1253 84.4 0.949 Contact Map
1qypA 1 0.1017 84.3 0.949 Contact Map
4aybP 1 0.0946 83.3 0.949 Contact Map
3j20Y 1 0.1135 81.6 0.95 Contact Map
1ffkW 1 0.1655 77.3 0.952 Contact Map
1vd4A 1 0.1253 72.4 0.954 Contact Map
3j3w0 1 0.13 67.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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