GREMLIN Database
Q97YI3 - Acetyl-CoA synthetase (Acetate-CoA ligase) carboxy-end. (AcsA-2)
UniProt: Q97YI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (242)
Sequences: 68090 (46658)
Seq/√Len: 2999.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_H219_F3.1951.00
120_N123_A2.8831.00
86_E107_R2.8381.00
140_L148_W2.7961.00
103_E134_L2.6531.00
158_K163_R2.4471.00
248_K251_E2.4401.00
142_D148_W2.4191.00
140_L150_K2.4161.00
105_A134_L2.4081.00
104_I139_G2.3991.00
90_I105_A2.3101.00
197_K234_E2.2941.00
155_D249_R2.2801.00
181_E241_R2.2791.00
174_L182_V2.2331.00
123_A126_K2.0431.00
88_A96_E2.0431.00
173_I198_A2.0351.00
142_D146_Y2.0191.00
121_P125_A1.9901.00
91_D95_N1.9781.00
88_A105_A1.9751.00
101_V138_L1.9601.00
39_G43_E1.9351.00
175_Q223_R1.9311.00
168_E228_A1.9311.00
185_I199_F1.8841.00
200_I235_F1.8571.00
77_S148_W1.8101.00
170_E184_V1.7891.00
138_L153_G1.7521.00
141_M147_I1.7501.00
101_V150_K1.7301.00
251_E254_K1.7291.00
172_I223_R1.7151.00
174_L181_E1.7101.00
180_Q203_K1.7041.00
217_Q233_I1.6531.00
188_P194_N1.6471.00
219_F223_R1.5901.00
66_T106_V1.5811.00
80_K146_Y1.5521.00
101_V140_L1.5421.00
88_A132_W1.5371.00
59_C133_F1.5281.00
197_K232_E1.5251.00
242_T248_K1.5201.00
178_A206_Y1.5151.00
199_F236_V1.5141.00
202_L235_F1.5001.00
199_F252_L1.4911.00
201_V239_L1.4861.00
184_V198_A1.4761.00
178_A215_E1.4661.00
181_E201_V1.4621.00
167_E171_S1.4591.00
221_K229_Y1.4441.00
103_E153_G1.4261.00
89_V139_G1.4181.00
67_V87_I1.4171.00
74_K146_Y1.4121.00
69_N146_Y1.4051.00
139_G149_F1.4051.00
186_G194_N1.4041.00
122_E126_K1.3931.00
81_P87_I1.3871.00
195_V231_R1.3841.00
155_D167_E1.3751.00
74_K144_N1.3611.00
187_K197_K1.3601.00
172_I175_Q1.3591.00
157_I166_P1.3541.00
162_Y227_Y1.3431.00
127_K133_F1.3391.00
213_V217_Q1.3361.00
195_V232_E1.3331.00
114_F128_F1.3231.00
91_D97_V1.3061.00
129_R134_L1.3001.00
180_Q201_V1.2921.00
32_S37_V1.2891.00
160_S192_R1.2891.00
107_R132_W1.2881.00
156_V165_G1.2801.00
11_M191_L1.2721.00
221_K226_L1.2691.00
159_V164_L1.2651.00
213_V235_F1.2631.00
56_F65_V1.2631.00
38_G41_L1.2591.00
200_I233_I1.2591.00
123_A127_K1.2531.00
9_L30_V1.2401.00
29_A54_N1.2291.00
189_D195_V1.2261.00
69_N77_S1.2061.00
105_A132_W1.1951.00
225_A228_A1.1921.00
157_I196_I1.1901.00
219_F222_S1.1881.00
236_V255_R1.1781.00
251_E255_R1.1651.00
78_V149_F1.1641.00
85_H112_V1.1621.00
220_V229_Y1.1601.00
159_V231_R1.1561.00
214_E218_Q1.1551.00
45_A49_L1.1501.00
87_I106_V1.1491.00
218_Q222_S1.1481.00
10_R41_L1.1441.00
31_S56_F1.1381.00
77_S146_Y1.1371.00
170_E249_R1.1271.00
187_K232_E1.1131.00
40_D44_W1.1121.00
92_E153_G1.1051.00
43_E47_K1.1021.00
107_R130_G1.0951.00
124_T128_F1.0941.00
110_D113_L1.0821.00
217_Q221_K1.0731.00
9_L45_A1.0711.00
37_V42_I1.0631.00
155_D170_E1.0541.00
226_L229_Y1.0521.00
176_H216_I1.0391.00
14_K44_W1.0221.00
7_T35_E1.0141.00
183_A239_L0.9991.00
13_R44_W0.9981.00
27_L30_V0.9971.00
250_F254_K0.9951.00
236_V239_L0.9891.00
218_Q221_K0.9891.00
99_N143_Q0.9871.00
215_E218_Q0.9841.00
106_V135_M0.9831.00
29_A52_N0.9791.00
213_V233_I0.9751.00
183_A252_L0.9721.00
62_A113_L0.9701.00
198_A233_I0.9691.00
176_H215_E0.9671.00
44_W48_E0.9651.00
215_E219_F0.9611.00
62_A66_T0.9561.00
239_L247_L0.9471.00
88_A107_R0.9441.00
92_E103_E0.9371.00
87_I147_I0.9321.00
183_A247_L0.9311.00
10_R14_K0.9281.00
104_I149_F0.9241.00
201_V238_E0.9221.00
67_V147_I0.9211.00
94_G105_A0.9181.00
44_W47_K0.9161.00
10_R38_G0.9161.00
113_L133_F0.9081.00
62_A106_V0.9031.00
217_Q229_Y0.8971.00
232_E235_F0.8931.00
172_I220_V0.8921.00
97_V100_Q0.8891.00
220_V224_L0.8721.00
32_S53_V0.8641.00
120_N124_T0.8641.00
59_C62_A0.8621.00
74_K142_D0.8581.00
92_E95_N0.8541.00
9_L32_S0.8371.00
199_F253_R0.8331.00
209_S215_E0.8321.00
122_E125_A0.8311.00
183_A249_R0.8291.00
57_Y66_T0.8291.00
187_K195_V0.8241.00
91_D100_Q0.8201.00
171_S175_Q0.8181.00
89_V147_I0.8161.00
167_E170_E0.8161.00
202_L208_P0.8131.00
159_V192_R0.8121.00
89_V97_V0.7931.00
175_Q219_F0.7911.00
107_R131_H0.7881.00
105_A129_R0.7861.00
185_I253_R0.7861.00
202_L206_Y0.7851.00
101_V153_G0.7821.00
33_A65_V0.7811.00
59_C135_M0.7801.00
159_V196_I0.7721.00
91_D94_G0.7711.00
82_T85_H0.7691.00
205_G208_P0.7671.00
41_L44_W0.7661.00
240_P252_L0.7631.00
87_I104_I0.7611.00
138_L151_G0.7611.00
173_I220_V0.7581.00
213_V232_E0.7581.00
114_F127_K0.7571.00
10_R44_W0.7531.00
172_I224_L0.7491.00
134_L153_G0.7491.00
42_I55_E0.7481.00
188_P193_G0.7481.00
30_V45_A0.7461.00
139_G147_I0.7451.00
70_S73_R0.7421.00
157_I186_G0.7381.00
159_V186_G0.7371.00
216_I233_I0.7351.00
37_V53_V0.7321.00
189_D192_R0.7301.00
99_N140_L0.7291.00
42_I46_M0.7271.00
11_M14_K0.7261.00
171_S174_L0.7211.00
86_E132_W0.7151.00
33_A56_F0.7141.00
17_S44_W0.7101.00
121_P124_T0.7101.00
65_V68_N0.7081.00
90_I96_E0.7031.00
180_Q202_L0.7021.00
56_F68_N0.7001.00
46_M52_N0.7001.00
214_E217_Q0.6991.00
173_I182_V0.6981.00
40_D43_E0.6961.00
176_H179_V0.6911.00
172_I219_F0.6861.00
21_R24_D0.6851.00
87_I139_G0.6841.00
234_E255_R0.6841.00
89_V102_G0.6791.00
181_E239_L0.6781.00
78_V139_G0.6711.00
194_N253_R0.6681.00
45_A53_V0.6681.00
21_R48_E0.6671.00
32_S55_E0.6671.00
96_E105_A0.6661.00
66_T85_H0.6661.00
128_F134_L0.6661.00
120_N126_K0.6661.00
188_P192_R0.6641.00
166_P249_R0.6621.00
250_F253_R0.6591.00
55_E76_G0.6581.00
224_L228_A0.6551.00
217_Q220_V0.6521.00
32_S45_A0.6511.00
30_V51_P0.6511.00
159_V195_V0.6501.00
199_F234_E0.6471.00
127_K154_D0.6471.00
17_S22_D0.6411.00
124_T127_K0.6391.00
59_C64_L0.6371.00
200_I213_V0.6361.00
62_A133_F0.6351.00
37_V55_E0.6341.00
179_V182_V0.6341.00
180_Q204_D0.6331.00
151_G167_E0.6321.00
206_Y209_S0.6291.00
63_N66_T0.6271.00
188_P191_L0.6261.00
43_E46_M0.6251.00
89_V104_I0.6211.00
178_A202_L0.6211.00
151_G166_P0.6191.00
170_E198_A0.6181.00
16_V22_D0.6181.00
136_G154_D0.6151.00
187_K199_F0.6131.00
36_A149_F0.6131.00
203_K206_Y0.6121.00
178_A203_K0.6111.00
189_D193_G0.6091.00
7_T11_M0.6091.00
90_I134_L0.6071.00
170_E174_L0.6061.00
43_E75_I0.6061.00
155_D166_P0.6051.00
156_V163_R0.6041.00
17_S48_E0.6041.00
104_I147_I0.6021.00
42_I76_G0.6011.00
7_T10_R0.6001.00
89_V141_M0.5971.00
10_R40_D0.5951.00
33_A64_L0.5951.00
59_C63_N0.5921.00
86_E130_G0.5921.00
240_P255_R0.5901.00
179_V200_I0.5881.00
16_V48_E0.5871.00
67_V78_V0.5841.00
152_R246_K0.5841.00
55_E78_V0.5841.00
187_K254_K0.5801.00
85_H110_D0.5791.00
208_P213_V0.5701.00
62_A65_V0.5691.00
244_T248_K0.5671.00
56_F64_L0.5661.00
116_G121_P0.5641.00
8_A11_M0.5631.00
100_Q140_L0.5561.00
38_G174_L0.5531.00
32_S56_F0.5531.00
199_F255_R0.5511.00
166_P184_V0.5501.00
200_I216_I0.5501.00
65_V82_T0.5461.00
8_A65_V0.5461.00
107_R110_D0.5441.00
81_P85_H0.5441.00
100_Q141_M0.5431.00
96_E141_M0.5421.00
33_A63_N0.5401.00
103_E138_L0.5401.00
39_G76_G0.5371.00
90_I132_W0.5361.00
77_S142_D0.5351.00
182_V220_V0.5341.00
54_N68_N0.5341.00
169_I196_I0.5331.00
143_Q148_W0.5321.00
154_D194_N0.5301.00
173_I216_I0.5231.00
139_G150_K0.5221.00
47_K50_S0.5221.00
46_M50_S0.5201.00
158_K164_L0.5191.00
178_A219_F0.5181.00
66_T87_I0.5181.00
66_T112_V0.5171.00
81_P141_M0.5161.00
88_A141_M0.5161.00
205_G209_S0.5161.00
75_I148_W0.5161.00
11_M15_E0.5151.00
76_G148_W0.5151.00
159_V194_N0.5151.00
185_I249_R0.5151.00
59_C66_T0.5121.00
221_K230_P0.5101.00
64_L68_N0.5101.00
42_I53_V0.5091.00
158_K165_G0.5081.00
46_M73_R0.5081.00
204_D207_S0.5061.00
37_V41_L0.5041.00
128_F131_H0.5021.00
129_R132_W0.5021.00
90_I94_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3etcA 2 0.9154 100 0.086 Contact Map
3tsyA 2 0.5808 100 0.122 Contact Map
1pg4A 1 0.9962 100 0.123 Contact Map
3c5eA 1 0.9769 100 0.128 Contact Map
4wd1A 1 0.9731 100 0.133 Contact Map
1mdbA 1 0.9692 100 0.138 Contact Map
3ni2A 1 0.9538 100 0.138 Contact Map
1v25A 2 0.8654 100 0.141 Contact Map
1ry2A 1 0.9692 100 0.141 Contact Map
3g7sA 2 0.8308 100 0.142 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.