GREMLIN Database
Q97YI2 - Transposase ISC1316
UniProt: Q97YI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (354)
Sequences: 4589 (2967)
Seq/√Len: 157.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_D261_K5.3911.00
331_A361_N4.2391.00
279_H282_Q4.2251.00
311_L318_L3.5621.00
198_L303_L2.9401.00
274_V370_S2.9211.00
275_M307_L2.9031.00
304_R320_L2.8681.00
302_E306_V2.7151.00
264_K268_E2.7001.00
341_S344_D2.5851.00
284_V296_S2.4471.00
159_V171_I2.4191.00
302_E305_G2.3911.00
325_Y328_K2.3671.00
329_T336_V2.3401.00
217_L293_R2.3221.00
308_K320_L2.2931.00
303_L307_L2.2851.00
267_A311_L2.2051.00
369_G372_S2.1911.00
321_V366_I2.1841.00
348_V355_I2.1381.00
273_V311_L2.1111.00
260_M309_Y2.0911.00
223_L240_A2.0841.00
13_D16_T2.0721.00
260_M306_V2.0711.00
326_T366_I2.0451.00
333_C352_C2.0371.00
157_K176_D2.0271.00
330_C333_C1.9891.00
36_W40_Y1.9841.00
275_M318_L1.9821.00
328_K340_L1.9491.00
256_T302_E1.9441.00
216_A254_L1.9311.00
289_R292_R1.9191.00
345_R358_R1.9071.00
51_Q55_R1.8851.00
39_I97_F1.8821.00
263_G306_V1.8741.00
21_K163_L1.8651.00
349_C352_C1.8591.00
240_A244_L1.8441.00
198_L258_L1.8441.00
34_L80_A1.8401.00
333_C349_C1.8361.00
308_K312_E1.8301.00
52_T55_R1.8101.00
260_M263_G1.7941.00
330_C352_C1.7901.00
260_M310_Q1.7901.00
259_Y306_V1.7411.00
235_N238_F1.7381.00
332_R354_W1.7221.00
22_A70_Q1.7171.00
347_F356_A1.7011.00
271_D316_K1.6911.00
330_C349_C1.6841.00
35_R83_Y1.6821.00
21_K169_I1.6311.00
191_I199_L1.6291.00
9_R168_R1.6201.00
20_L169_I1.6131.00
238_F241_K1.6011.00
135_L171_I1.6011.00
275_M320_L1.5841.00
51_Q81_D1.5681.00
29_K67_E1.5511.00
226_E230_K1.5421.00
286_K292_R1.5301.00
230_K240_A1.5231.00
89_R95_A1.5141.00
259_Y302_E1.5071.00
74_Q113_Q1.5001.00
275_M304_R1.4911.00
340_L344_D1.4811.00
227_L241_K1.4751.00
82_R110_V1.4711.00
337_K340_L1.4711.00
263_G309_Y1.4571.00
18_R22_A1.4531.00
346_V355_I1.4521.00
347_F354_W1.4411.00
277_G320_L1.4401.00
337_K347_F1.4261.00
74_Q112_P1.4201.00
17_L21_K1.4121.00
263_G310_Q1.3911.00
276_E323_P1.3821.00
335_Y350_P1.3791.00
201_T205_E1.3781.00
188_V367_L1.3751.00
52_T56_Q1.3591.00
286_K289_R1.3591.00
200_V360_Y1.3551.00
197_K200_V1.3461.00
364_L368_R1.3361.00
189_V201_T1.3361.00
166_S249_E1.3341.00
342_L345_R1.3271.00
84_Y88_Q1.3221.00
24_L169_I1.3081.00
168_R249_E1.3031.00
219_K223_L1.3021.00
233_L237_W1.2831.00
249_E253_N1.2781.00
220_V244_L1.2751.00
34_L83_Y1.2731.00
51_Q80_A1.2701.00
5_G172_T1.2701.00
263_G303_L1.2651.00
223_L226_E1.2601.00
295_L300_F1.2541.00
55_R81_D1.2421.00
308_K318_L1.2321.00
220_V248_Y1.2311.00
39_I43_Q1.2141.00
331_A364_L1.2071.00
337_K350_P1.2051.00
188_V272_V1.1891.00
267_A314_Y1.1791.00
87_R97_F1.1721.00
265_W269_H1.1701.00
202_S206_Y1.1701.00
189_V270_Y1.1691.00
58_A80_A1.1691.00
216_A251_L1.1621.00
78_Q81_D1.1531.00
88_Q92_E1.1521.00
14_E17_L1.1521.00
328_K339_D1.1511.00
38_D54_L1.1481.00
223_L247_A1.1461.00
279_H323_P1.1441.00
27_A79_I1.1411.00
85_E89_R1.1411.00
227_L244_L1.1401.00
328_K336_V1.1271.00
342_L358_R1.1241.00
328_K338_N1.1231.00
259_Y303_L1.1231.00
286_K290_S1.1211.00
356_A364_L1.1191.00
12_T16_T1.1191.00
306_V309_Y1.1191.00
162_K172_T1.1111.00
193_V300_F1.1071.00
37_A57_L1.1061.00
55_R80_A1.1021.00
331_A356_A1.1021.00
321_V369_G1.1000.99
263_G307_L1.0980.99
264_K314_Y1.0900.99
310_Q313_K1.0900.99
78_Q112_P1.0890.99
137_L161_V1.0880.99
256_T306_V1.0870.99
195_V298_V1.0770.99
360_Y364_L1.0740.99
185_T271_D1.0710.99
40_Y44_R1.0630.99
191_I201_T1.0620.99
136_K142_T1.0550.99
62_R76_V1.0540.99
341_S358_R1.0450.99
190_A367_L1.0440.99
259_Y263_G1.0430.99
224_H228_S1.0410.99
31_Y79_I1.0210.99
72_Y75_V1.0200.99
341_S345_R1.0180.99
227_L240_A1.0150.99
284_V292_R1.0090.99
6_F175_V1.0020.99
326_T369_G1.0010.99
268_E314_Y1.0000.99
267_A316_K0.9980.99
56_Q59_L0.9950.99
329_T369_G0.9950.99
340_L347_F0.9930.99
267_A273_V0.9920.99
50_T53_E0.9870.99
356_A360_Y0.9810.99
337_K341_S0.9800.99
216_A220_V0.9680.99
331_A362_A0.9640.99
89_R94_L0.9580.99
193_V304_R0.9570.99
197_K208_P0.9570.99
35_R87_R0.9530.99
206_Y357_D0.9520.99
12_T20_L0.9510.99
220_V228_S0.9470.98
117_K136_K0.9390.98
266_F273_V0.9350.98
311_L316_K0.9320.98
29_K33_T0.9270.98
111_Y114_Y0.9270.98
188_V371_G0.9260.98
321_V370_S0.9250.98
82_R160_V0.9250.98
237_W241_K0.9240.98
31_Y86_A0.9210.98
25_K28_C0.9210.98
221_K224_H0.9180.98
344_D358_R0.9110.98
90_F97_F0.9050.98
346_V356_A0.9040.98
117_K120_H0.9010.98
223_L244_L0.9010.98
345_R357_D0.8980.98
224_H244_L0.8950.98
252_K256_T0.8950.98
116_W120_H0.8940.98
335_Y351_N0.8930.98
305_G308_K0.8920.98
74_Q78_Q0.8910.98
230_K236_N0.8910.98
147_V150_D0.8900.98
77_Q81_D0.8890.98
31_Y83_Y0.8880.98
89_R92_E0.8850.98
323_P326_T0.8850.98
224_H248_Y0.8850.98
344_D347_F0.8850.98
277_G323_P0.8820.98
8_F171_I0.8780.98
90_F98_P0.8780.98
36_W100_E0.8780.98
188_V274_V0.8750.97
110_V160_V0.8750.97
226_E229_R0.8730.97
274_V366_I0.8690.97
272_V317_K0.8690.97
331_A354_W0.8680.97
280_A301_G0.8670.97
362_A365_N0.8660.97
347_F358_R0.8650.97
247_A251_L0.8630.97
369_G373_E0.8630.97
59_L62_R0.8610.97
202_S363_S0.8600.97
250_Y254_L0.8600.97
68_Y76_V0.8580.97
33_T37_A0.8560.97
74_Q114_Y0.8560.97
227_L237_W0.8550.97
115_G138_S0.8520.97
26_L67_E0.8510.97
160_V172_T0.8500.97
78_Q110_V0.8500.97
259_Y299_G0.8470.97
195_V284_V0.8450.97
58_A77_Q0.8440.97
134_T142_T0.8420.97
41_F45_D0.8340.97
197_K206_Y0.8260.96
360_Y363_S0.8230.96
331_A368_R0.8210.96
34_L54_L0.8200.96
203_D270_Y0.8190.96
264_K310_Q0.8170.96
209_N212_P0.8150.96
41_F49_L0.8110.96
291_L295_L0.8110.96
195_V294_R0.8090.96
110_V158_R0.8060.96
17_L169_I0.8060.96
272_V319_I0.8020.96
328_K337_K0.8000.96
220_V251_L0.7990.96
340_L358_R0.7990.96
212_P254_L0.7940.96
186_G271_D0.7920.95
60_D64_Q0.7880.95
200_V206_Y0.7880.95
319_I370_S0.7860.95
222_H226_E0.7850.95
262_L265_W0.7850.95
189_V202_S0.7840.95
325_Y369_G0.7840.95
23_Q27_A0.7830.95
119_L136_K0.7820.95
278_I323_P0.7820.95
187_K271_D0.7810.95
71_L74_Q0.7800.95
332_R364_L0.7770.95
364_L367_L0.7760.95
361_N365_N0.7760.95
51_Q54_L0.7740.95
223_L243_K0.7700.95
93_G96_R0.7700.95
213_Y217_L0.7690.95
111_Y137_L0.7680.95
220_V224_H0.7670.95
196_E200_V0.7660.95
258_L262_L0.7660.95
158_R174_V0.7650.95
205_E265_W0.7640.95
193_V199_L0.7610.94
134_T137_L0.7590.94
74_Q77_Q0.7590.94
39_I87_R0.7580.94
228_S244_L0.7560.94
301_G305_G0.7540.94
132_L137_L0.7530.94
34_L58_A0.7520.94
53_E56_Q0.7480.94
209_N298_V0.7470.94
12_T143_F0.7460.94
42_Y87_R0.7440.94
335_Y347_F0.7430.94
78_Q82_R0.7410.94
277_G304_R0.7390.93
163_L169_I0.7350.93
329_T365_N0.7350.93
241_K245_A0.7350.93
38_D84_Y0.7340.93
199_L262_L0.7320.93
161_V171_I0.7290.93
189_V273_V0.7280.93
10_A171_I0.7260.93
120_H133_I0.7260.93
25_K29_K0.7250.93
221_K225_R0.7240.93
26_L71_L0.7220.93
55_R59_L0.7200.93
109_L113_Q0.7190.93
325_Y329_T0.7180.92
184_N187_K0.7180.92
83_Y87_R0.7170.92
213_Y216_A0.7150.92
30_I79_I0.7130.92
59_L63_K0.7120.92
87_R91_F0.7100.92
19_A23_Q0.7090.92
243_K246_R0.7090.92
212_P216_A0.7080.92
26_L29_K0.7050.92
37_A61_L0.7040.92
80_A84_Y0.7020.92
22_A26_L0.7000.92
37_A54_L0.6990.91
274_V367_L0.6960.91
141_G144_K0.6960.91
87_R90_F0.6950.91
137_L143_F0.6940.91
274_V319_I0.6900.91
207_F210_L0.6880.91
73_S115_G0.6880.91
227_L230_K0.6870.91
225_R228_S0.6870.91
216_A247_A0.6850.91
325_Y336_V0.6850.91
234_S237_W0.6850.91
200_V207_F0.6830.90
14_E18_R0.6830.90
236_N239_K0.6800.90
145_V148_H0.6780.90
282_Q323_P0.6780.90
221_K228_S0.6720.90
135_L159_V0.6710.90
15_Q18_R0.6700.90
104_H107_Y0.6700.90
216_A250_Y0.6690.90
74_Q115_G0.6680.90
38_D87_R0.6680.90
149_R152_P0.6640.89
289_R296_S0.6630.89
59_L73_S0.6610.89
42_Y46_G0.6610.89
206_Y360_Y0.6580.89
255_R297_D0.6580.89
136_K140_L0.6570.89
179_F312_E0.6570.89
340_L345_R0.6550.89
8_F149_R0.6530.88
37_A41_F0.6530.88
268_E272_V0.6530.88
366_I369_G0.6530.88
192_D359_D0.6530.88
5_G174_V0.6510.88
214_E293_R0.6480.88
251_L297_D0.6470.88
7_R162_K0.6400.87
339_D344_D0.6400.87
9_R170_Y0.6390.87
155_K176_D0.6380.87
356_A361_N0.6380.87
233_L238_F0.6380.87
19_A22_A0.6370.87
75_V109_L0.6360.87
309_Y313_K0.6350.87
43_Q46_G0.6350.87
202_S360_Y0.6340.87
225_R229_R0.6340.87
37_A40_Y0.6340.87
307_L318_L0.6340.87
207_F262_L0.6330.87
273_V307_L0.6320.87
335_Y338_N0.6310.87
36_W39_I0.6300.87
280_A300_F0.6280.86
306_V310_Q0.6260.86
230_K234_S0.6210.86
26_L68_Y0.6190.86
266_F270_Y0.6170.85
342_L357_D0.6160.85
33_T61_L0.6120.85
199_L207_F0.6120.85
199_L303_L0.6100.85
332_R356_A0.6100.85
59_L80_A0.6090.85
41_F47_K0.6090.85
198_L298_V0.6060.84
79_I83_Y0.6060.84
81_D112_P0.6050.84
284_V289_R0.6050.84
182_L185_T0.6040.84
214_E217_L0.6010.84
111_Y115_G0.5960.83
20_L24_L0.5950.83
168_R253_N0.5950.83
132_L136_K0.5930.83
226_E243_K0.5920.83
368_R373_E0.5920.83
270_Y273_V0.5910.83
337_K344_D0.5910.83
38_D48_G0.5890.83
280_A283_L0.5880.83
196_E345_R0.5880.83
48_G54_L0.5870.83
248_Y255_R0.5860.82
107_Y163_L0.5830.82
111_Y116_W0.5820.82
187_K270_Y0.5800.82
221_K289_R0.5790.82
207_F258_L0.5790.82
11_Y146_I0.5780.82
238_F242_V0.5770.81
304_R308_K0.5770.81
198_L263_G0.5770.81
337_K358_R0.5730.81
259_Y262_L0.5720.81
264_K267_A0.5710.81
54_L57_L0.5700.81
12_T17_L0.5690.81
194_G197_K0.5680.80
283_L295_L0.5680.80
71_L76_V0.5680.80
23_Q111_Y0.5670.80
23_Q71_L0.5670.80
226_E240_A0.5650.80
327_S340_L0.5650.80
311_L314_Y0.5650.80
198_L259_Y0.5640.80
112_P116_W0.5630.80
92_E95_A0.5620.80
134_T144_K0.5620.80
192_D327_S0.5620.80
282_Q286_K0.5610.80
190_A363_S0.5610.80
86_A98_P0.5610.80
329_T334_G0.5610.80
115_G118_I0.5590.79
22_A71_L0.5590.79
194_G200_V0.5580.79
274_V369_G0.5570.79
49_L54_L0.5560.79
299_G302_E0.5510.78
38_D41_F0.5500.78
190_A202_S0.5500.78
22_A25_K0.5500.78
222_H225_R0.5490.78
187_K203_D0.5480.78
38_D42_Y0.5470.78
72_Y113_Q0.5470.78
256_T260_M0.5470.78
348_V354_W0.5470.78
145_V150_D0.5460.78
135_L138_S0.5450.78
329_T347_F0.5450.78
329_T338_N0.5440.78
7_R256_T0.5420.77
327_S341_S0.5420.77
134_T138_S0.5410.77
214_E218_W0.5390.77
73_S112_P0.5370.77
137_L159_V0.5370.77
182_L316_K0.5370.77
333_C337_K0.5360.77
48_G84_Y0.5350.76
162_K165_R0.5350.76
262_L303_L0.5350.76
15_Q19_A0.5340.76
282_Q295_L0.5330.76
75_V111_Y0.5310.76
137_L140_L0.5300.76
274_V371_G0.5300.76
72_Y111_Y0.5290.76
291_L294_R0.5270.75
23_Q72_Y0.5260.75
248_Y252_K0.5260.75
335_Y339_D0.5240.75
215_K218_W0.5230.75
47_K53_E0.5220.75
33_T67_E0.5190.74
210_L258_L0.5190.74
114_Y117_K0.5190.74
76_V79_I0.5180.74
354_W364_L0.5180.74
253_N257_D0.5180.74
23_Q109_L0.5150.74
324_A328_K0.5150.74
7_R172_T0.5150.74
190_A274_V0.5150.74
31_Y35_R0.5120.73
10_A143_F0.5120.73
108_S160_V0.5110.73
368_R371_G0.5090.73
251_L255_R0.5090.73
214_E294_R0.5080.73
111_Y118_I0.5070.73
6_F149_R0.5050.72
322_N325_Y0.5040.72
7_R170_Y0.5020.72
329_T335_Y0.5020.72
261_K264_K0.5010.72
208_P211_R0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.34 92.3 0.937 Contact Map
1nu0A 1 0.3226 91.5 0.938 Contact Map
4aybP 1 0.1067 88.2 0.942 Contact Map
2aklA 1 0.1861 87.2 0.943 Contact Map
1qypA 1 0.1141 85.1 0.945 Contact Map
1ffkW 1 0.1787 84.6 0.945 Contact Map
3j20Y 1 0.1241 84.4 0.945 Contact Map
1iv0A 1 0.2407 84 0.946 Contact Map
2k4xA 1 0.1365 83.7 0.946 Contact Map
1vq8Z 1 0.1638 82.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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