GREMLIN Database
Q97YI1 - Acetyl-CoA synthetase (Acetate-CoA ligase) amino-end. (AcsA-2)
UniProt: Q97YI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (239)
Sequences: 70303 (53985)
Seq/√Len: 3492.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_P207_L3.7151.00
72_D108_R3.2111.00
90_G134_A2.9581.00
51_Y259_P2.8931.00
68_K108_R2.8661.00
131_Q195_Y2.7231.00
87_D135_K2.6541.00
83_V111_A2.6161.00
233_V259_P2.5591.00
37_D68_K2.5421.00
48_I61_V2.4551.00
77_I81_I2.4071.00
127_Y202_A2.3991.00
70_L101_I2.3911.00
44_V47_N2.3791.00
39_K44_V2.3241.00
68_K72_D2.2981.00
51_Y61_V2.1661.00
106_L111_A2.0991.00
227_A231_E2.0671.00
88_V114_L2.0421.00
52_Y97_V1.9981.00
102_S138_I1.9981.00
186_K189_D1.9051.00
84_K87_D1.8711.00
51_Y281_C1.8601.00
126_E130_R1.8511.00
63_T66_Q1.8241.00
276_A280_K1.7711.00
65_A69_S1.7681.00
46_D65_A1.7641.00
85_R189_D1.7621.00
79_R109_L1.7601.00
86_G189_D1.7321.00
88_V112_I1.7301.00
74_L101_I1.7201.00
37_D108_R1.7181.00
221_Q256_F1.7051.00
81_I155_K1.7041.00
232_D284_P1.6381.00
30_N38_R1.6301.00
38_R43_G1.6221.00
135_K154_T1.6181.00
45_G65_A1.6091.00
40_V68_K1.5991.00
209_A212_F1.5911.00
71_S108_R1.5901.00
90_G116_I1.5801.00
195_Y205_G1.5661.00
107_Y191_A1.5541.00
261_V283_L1.5431.00
94_Q140_E1.5201.00
62_Y101_I1.5071.00
52_Y55_E1.4921.00
89_V106_L1.4851.00
270_S273_D1.4731.00
233_V261_V1.4461.00
273_D276_A1.4331.00
187_S211_R1.4321.00
48_I259_P1.4321.00
48_I51_Y1.4301.00
127_Y131_Q1.4221.00
39_K43_G1.4161.00
77_I173_V1.4141.00
47_N231_E1.4081.00
188_D211_R1.4041.00
253_S258_K1.4001.00
62_Y97_V1.3921.00
88_V193_L1.3811.00
227_A232_D1.3801.00
114_L132_S1.3791.00
238_A244_G1.3791.00
117_S241_G1.3751.00
228_P231_E1.3651.00
49_A64_F1.3571.00
277_I281_C1.3501.00
263_Y277_I1.3481.00
72_D76_T1.3401.00
129_I134_A1.3231.00
104_L254_L1.3031.00
136_A155_K1.2991.00
132_S195_Y1.2941.00
235_Y283_L1.2841.00
208_H212_F1.2821.00
232_D285_P1.2561.00
49_A67_L1.2541.00
53_E264_R1.2531.00
31_I34_S1.2411.00
122_V126_E1.2371.00
90_G129_I1.2341.00
196_T206_V1.2101.00
188_D209_A1.2081.00
70_L73_S1.2031.00
185_T189_D1.1981.00
80_E176_T1.1981.00
131_Q202_A1.1971.00
193_L205_G1.1911.00
89_V111_A1.1721.00
233_V283_L1.1701.00
92_Y125_V1.1681.00
74_L105_S1.1661.00
51_Y261_V1.1611.00
83_V87_D1.1511.00
75_I108_R1.1451.00
112_I190_P1.1421.00
30_N34_S1.1361.00
126_E149_K1.1311.00
77_I80_E1.1201.00
37_D72_D1.1081.00
235_Y263_Y1.0991.00
141_G160_D1.0851.00
83_V136_A1.0851.00
62_Y70_L1.0651.00
88_V133_D1.0621.00
99_T240_W1.0501.00
216_H247_G1.0431.00
69_S73_S1.0301.00
103_I113_S1.0301.00
67_L101_I1.0261.00
83_V89_V1.0251.00
261_V281_C1.0251.00
130_R202_A1.0161.00
91_I102_S1.0141.00
232_D258_K1.0111.00
234_F253_S1.0011.00
68_K180_H0.9981.00
103_I246_I0.9961.00
120_M128_R0.9851.00
67_L104_L0.9831.00
261_V277_I0.9811.00
127_Y130_R0.9711.00
123_E127_Y0.9671.00
93_L159_A0.9641.00
66_Q69_S0.9611.00
75_I109_L0.9611.00
74_L138_I0.9321.00
122_V149_K0.9291.00
90_G137_I0.9231.00
50_I100_V0.9201.00
87_D111_A0.9191.00
55_E97_V0.9161.00
70_L98_E0.9141.00
169_N172_E0.9021.00
98_E101_I0.9021.00
90_G114_L0.8991.00
61_V281_C0.8981.00
140_E143_R0.8951.00
48_I63_T0.8901.00
116_I125_V0.8871.00
94_Q142_S0.8861.00
62_Y67_L0.8811.00
100_V262_A0.8791.00
79_R84_K0.8751.00
123_E126_E0.8661.00
121_G124_A0.8631.00
217_I255_Y0.8591.00
93_L96_R0.8541.00
103_I107_Y0.8531.00
253_S260_I0.8471.00
81_I136_A0.8431.00
36_L40_V0.8421.00
139_I156_I0.8371.00
91_I113_S0.8361.00
216_H220_Y0.8351.00
139_I158_V0.8351.00
73_S178_G0.8311.00
97_V101_I0.8291.00
96_R140_E0.8241.00
51_Y233_V0.8231.00
141_G158_V0.8201.00
147_R150_L0.8151.00
190_P209_A0.8141.00
50_I97_V0.8131.00
47_N259_P0.8131.00
71_S105_S0.8111.00
78_L138_I0.8091.00
235_Y277_I0.8081.00
76_T79_R0.8041.00
74_L102_S0.8041.00
61_V259_P0.7981.00
79_R181_Y0.7881.00
70_L97_V0.7881.00
221_Q252_P0.7831.00
67_L71_S0.7831.00
113_S246_I0.7831.00
78_L106_L0.7751.00
105_S109_L0.7741.00
38_R41_K0.7731.00
93_L99_T0.7721.00
145_E148_E0.7721.00
198_G204_K0.7711.00
208_H243_I0.7701.00
244_G247_G0.7651.00
192_Q208_H0.7611.00
66_Q70_L0.7581.00
147_R151_R0.7571.00
35_I39_K0.7541.00
35_I218_P0.7521.00
77_I177_S0.7491.00
80_E177_S0.7481.00
37_D41_K0.7471.00
269_F274_T0.7431.00
33_E185_T0.7381.00
106_L113_S0.7381.00
200_T204_K0.7381.00
157_I161_E0.7371.00
239_D242_W0.7361.00
44_V257_G0.7301.00
79_R180_H0.7281.00
192_Q246_I0.7271.00
36_L68_K0.7241.00
235_Y278_M0.7231.00
114_L134_A0.7211.00
34_S38_R0.7191.00
220_Y247_G0.7181.00
122_V145_E0.7141.00
191_A210_H0.7111.00
48_I52_Y0.7091.00
92_Y143_R0.7071.00
127_Y195_Y0.7051.00
219_A223_Y0.7031.00
276_A279_Q0.7021.00
103_I251_L0.6991.00
47_N228_P0.6931.00
100_V249_V0.6931.00
101_I105_S0.6891.00
277_I280_K0.6891.00
85_R185_T0.6891.00
33_E37_D0.6881.00
33_E107_Y0.6881.00
104_L251_L0.6871.00
272_K276_A0.6871.00
73_S77_I0.6851.00
174_K177_S0.6831.00
236_T245_A0.6821.00
233_V284_P0.6761.00
278_M283_L0.6751.00
92_Y137_I0.6721.00
46_D63_T0.6711.00
123_E202_A0.6691.00
76_T177_S0.6671.00
263_Y274_T0.6641.00
233_V282_E0.6591.00
89_V136_A0.6581.00
231_E284_P0.6541.00
74_L77_I0.6541.00
74_L78_L0.6541.00
180_H183_V0.6531.00
122_V146_V0.6521.00
199_S204_K0.6511.00
39_K257_G0.6491.00
36_L104_L0.6491.00
84_K111_A0.6481.00
90_G132_S0.6481.00
136_A157_I0.6471.00
197_S204_K0.6471.00
218_P222_L0.6461.00
128_R205_G0.6461.00
76_T178_G0.6441.00
67_L100_V0.6411.00
218_P255_Y0.6401.00
212_F215_G0.6391.00
50_I260_I0.6311.00
273_D277_I0.6291.00
31_I210_H0.6271.00
141_G161_E0.6251.00
144_K147_R0.6251.00
76_T179_V0.6241.00
44_V228_P0.6241.00
139_I143_R0.6231.00
69_S178_G0.6201.00
40_V45_G0.6181.00
34_S37_D0.6171.00
70_L174_K0.6131.00
185_T210_H0.6101.00
52_Y264_R0.6091.00
41_K68_K0.6071.00
82_G111_A0.6051.00
76_T181_Y0.6041.00
131_Q205_G0.6001.00
236_T260_I0.5981.00
33_E108_R0.5961.00
226_M285_P0.5961.00
112_I193_L0.5961.00
191_A213_L0.5961.00
35_I214_L0.5951.00
79_R183_V0.5901.00
245_A249_V0.5891.00
194_F243_I0.5891.00
201_G204_K0.5891.00
192_Q213_L0.5861.00
145_E149_K0.5861.00
144_K148_E0.5851.00
68_K71_S0.5851.00
274_T278_M0.5831.00
107_Y113_S0.5831.00
35_I255_Y0.5811.00
220_Y252_P0.5791.00
226_M232_D0.5791.00
101_I170_F0.5781.00
77_I176_T0.5771.00
275_L279_Q0.5751.00
236_T262_A0.5751.00
106_L109_L0.5741.00
264_R273_D0.5731.00
172_E175_K0.5711.00
259_P281_C0.5711.00
236_T249_V0.5711.00
75_I105_S0.5711.00
216_H248_D0.5701.00
193_L207_L0.5671.00
83_V109_L0.5671.00
114_L128_R0.5651.00
102_S106_L0.5591.00
94_Q143_R0.5581.00
33_E210_H0.5581.00
120_M125_V0.5581.00
116_I129_I0.5571.00
98_E140_E0.5561.00
76_T180_H0.5541.00
216_H219_A0.5531.00
62_Y66_Q0.5531.00
114_L195_Y0.5461.00
84_K135_K0.5451.00
91_I99_T0.5441.00
236_T248_D0.5431.00
217_I252_P0.5431.00
155_K158_V0.5411.00
217_I251_L0.5411.00
85_R183_V0.5401.00
71_S74_L0.5361.00
130_R152_N0.5341.00
93_L140_E0.5331.00
69_S179_V0.5311.00
263_Y273_D0.5311.00
115_S194_F0.5301.00
107_Y210_H0.5251.00
196_T204_K0.5241.00
40_V43_G0.5201.00
48_I233_V0.5191.00
93_L102_S0.5181.00
99_T103_I0.5181.00
71_S75_I0.5181.00
29_F211_R0.5161.00
44_V65_A0.5131.00
235_Y274_T0.5121.00
244_G248_D0.5121.00
247_G252_P0.5081.00
76_T80_E0.5071.00
249_V253_S0.5061.00
158_V161_E0.5061.00
246_I251_L0.5051.00
189_D210_H0.5031.00
137_I156_I0.5011.00
103_I192_Q0.5011.00
79_R182_A0.5011.00
100_V254_L0.5001.00
72_D180_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ry2A 1 0.9895 100 0.244 Contact Map
2vsqA 1 0.9338 100 0.244 Contact Map
1pg4A 1 0.9895 100 0.245 Contact Map
4wd1A 1 0.9791 100 0.25 Contact Map
3etcA 2 0.9861 100 0.25 Contact Map
1amuA 1 0.8815 100 0.257 Contact Map
3tsyA 2 0.9059 100 0.261 Contact Map
1mdbA 1 0.9303 100 0.266 Contact Map
1v25A 2 0.9024 100 0.268 Contact Map
1t5hX 2 0.8362 100 0.269 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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