Q97YI1 - SULSO - GREMLIN Contacts

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Q97YI1 - Acetyl-CoA synthetase (Acetate-CoA ligase) amino-end. (AcsA-2)

UniProt:	Q97YI1	Sequences: MLEVDLREIRFHNYDELVRTFKWNIPSRFNIGESILDRKVKEGVGDNIAIYYEDEEGDHFVYTFAQLKSLSDSLITILREIGVKRGDVVGIYLQPRVETVISILSLYRLGAISLSISPLMGVEAVEYRIRQSDAKAIIIEGSRKEVREKLRNVTKIIVADEARDESEINFDEVKKTSGVHYAVDTKSDDPAQLFYTSGSTGAPKGVLHAHRFLLGHIPAYQLYFEMAPREEDVFYTPADWGWIGAIGDVILPSLYFGKPIVAYRRLGKFSPKDTLAIMQKCELPPHK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (239)
Sequences:	70303 (53985)
Seq/√Len:	3492.0

ECOLI - ENTF ACSA AAS PRPE CAIC FADK LCFA ENTE MENE
BACSU - SRFAC PPSE PPSB PPSC ACSA YNGI YDAB LCFB YTCI DHBE LCFA MENE YHFT DLTA DHBF PPSD PKSN SRFAB
HALSA - Q9HRY8 Q9HNK0 Q9HQU8 Q9HSM3 Q9HQ43 Q9HQN8 Q9HRY4
SULSO - Q97YI1 Q97UX8 Q97U22 Q97WQ9 Q97WU4 Q97WQ0 Q97VT6 Q97UW7 Q97YK9 Q97XW4 Q97WK0 Q97VU7 Q97UF6 Q97V27 Q97X52 Q97WS5 Q980E4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_P	207_L	3.715	1.00
72_D	108_R	3.211	1.00
90_G	134_A	2.958	1.00
51_Y	259_P	2.893	1.00
68_K	108_R	2.866	1.00
131_Q	195_Y	2.723	1.00
87_D	135_K	2.654	1.00
83_V	111_A	2.616	1.00
233_V	259_P	2.559	1.00
37_D	68_K	2.542	1.00
48_I	61_V	2.455	1.00
77_I	81_I	2.407	1.00
127_Y	202_A	2.399	1.00
70_L	101_I	2.391	1.00
44_V	47_N	2.379	1.00
39_K	44_V	2.324	1.00
68_K	72_D	2.298	1.00
51_Y	61_V	2.166	1.00
106_L	111_A	2.099	1.00
227_A	231_E	2.067	1.00
88_V	114_L	2.042	1.00
52_Y	97_V	1.998	1.00
102_S	138_I	1.998	1.00
186_K	189_D	1.905	1.00
84_K	87_D	1.871	1.00
51_Y	281_C	1.860	1.00
126_E	130_R	1.851	1.00
63_T	66_Q	1.824	1.00
276_A	280_K	1.771	1.00
65_A	69_S	1.768	1.00
46_D	65_A	1.764	1.00
85_R	189_D	1.762	1.00
79_R	109_L	1.760	1.00
86_G	189_D	1.732	1.00
88_V	112_I	1.730	1.00
74_L	101_I	1.720	1.00
37_D	108_R	1.718	1.00
221_Q	256_F	1.705	1.00
81_I	155_K	1.704	1.00
232_D	284_P	1.638	1.00
30_N	38_R	1.630	1.00
38_R	43_G	1.622	1.00
135_K	154_T	1.618	1.00
45_G	65_A	1.609	1.00
40_V	68_K	1.599	1.00
209_A	212_F	1.591	1.00
71_S	108_R	1.590	1.00
90_G	116_I	1.580	1.00
195_Y	205_G	1.566	1.00
107_Y	191_A	1.554	1.00
261_V	283_L	1.543	1.00
94_Q	140_E	1.520	1.00
62_Y	101_I	1.507	1.00
52_Y	55_E	1.492	1.00
89_V	106_L	1.485	1.00
270_S	273_D	1.473	1.00
233_V	261_V	1.446	1.00
273_D	276_A	1.433	1.00
187_S	211_R	1.432	1.00
48_I	259_P	1.432	1.00
48_I	51_Y	1.430	1.00
127_Y	131_Q	1.422	1.00
39_K	43_G	1.416	1.00
77_I	173_V	1.414	1.00
47_N	231_E	1.408	1.00
188_D	211_R	1.404	1.00
253_S	258_K	1.400	1.00
62_Y	97_V	1.392	1.00
88_V	193_L	1.381	1.00
227_A	232_D	1.380	1.00
114_L	132_S	1.379	1.00
238_A	244_G	1.379	1.00
117_S	241_G	1.375	1.00
228_P	231_E	1.365	1.00
49_A	64_F	1.357	1.00
277_I	281_C	1.350	1.00
263_Y	277_I	1.348	1.00
72_D	76_T	1.340	1.00
129_I	134_A	1.323	1.00
104_L	254_L	1.303	1.00
136_A	155_K	1.299	1.00
132_S	195_Y	1.294	1.00
235_Y	283_L	1.284	1.00
208_H	212_F	1.282	1.00
232_D	285_P	1.256	1.00
49_A	67_L	1.254	1.00
53_E	264_R	1.253	1.00
31_I	34_S	1.241	1.00
122_V	126_E	1.237	1.00
90_G	129_I	1.234	1.00
196_T	206_V	1.210	1.00
188_D	209_A	1.208	1.00
70_L	73_S	1.203	1.00
185_T	189_D	1.198	1.00
80_E	176_T	1.198	1.00
131_Q	202_A	1.197	1.00
193_L	205_G	1.191	1.00
89_V	111_A	1.172	1.00
233_V	283_L	1.170	1.00
92_Y	125_V	1.168	1.00
74_L	105_S	1.166	1.00
51_Y	261_V	1.161	1.00
83_V	87_D	1.151	1.00
75_I	108_R	1.145	1.00
112_I	190_P	1.142	1.00
30_N	34_S	1.136	1.00
126_E	149_K	1.131	1.00
77_I	80_E	1.120	1.00
37_D	72_D	1.108	1.00
235_Y	263_Y	1.099	1.00
141_G	160_D	1.085	1.00
83_V	136_A	1.085	1.00
62_Y	70_L	1.065	1.00
88_V	133_D	1.062	1.00
99_T	240_W	1.050	1.00
216_H	247_G	1.043	1.00
69_S	73_S	1.030	1.00
103_I	113_S	1.030	1.00
67_L	101_I	1.026	1.00
83_V	89_V	1.025	1.00
261_V	281_C	1.025	1.00
130_R	202_A	1.016	1.00
91_I	102_S	1.014	1.00
232_D	258_K	1.011	1.00
234_F	253_S	1.001	1.00
68_K	180_H	0.998	1.00
103_I	246_I	0.996	1.00
120_M	128_R	0.985	1.00
67_L	104_L	0.983	1.00
261_V	277_I	0.981	1.00
127_Y	130_R	0.971	1.00
123_E	127_Y	0.967	1.00
93_L	159_A	0.964	1.00
66_Q	69_S	0.961	1.00
75_I	109_L	0.961	1.00
74_L	138_I	0.932	1.00
122_V	149_K	0.929	1.00
90_G	137_I	0.923	1.00
50_I	100_V	0.920	1.00
87_D	111_A	0.919	1.00
55_E	97_V	0.916	1.00
70_L	98_E	0.914	1.00
169_N	172_E	0.902	1.00
98_E	101_I	0.902	1.00
90_G	114_L	0.899	1.00
61_V	281_C	0.898	1.00
140_E	143_R	0.895	1.00
48_I	63_T	0.890	1.00
116_I	125_V	0.887	1.00
94_Q	142_S	0.886	1.00
62_Y	67_L	0.881	1.00
100_V	262_A	0.879	1.00
79_R	84_K	0.875	1.00
123_E	126_E	0.866	1.00
121_G	124_A	0.863	1.00
217_I	255_Y	0.859	1.00
93_L	96_R	0.854	1.00
103_I	107_Y	0.853	1.00
253_S	260_I	0.847	1.00
81_I	136_A	0.843	1.00
36_L	40_V	0.842	1.00
139_I	156_I	0.837	1.00
91_I	113_S	0.836	1.00
216_H	220_Y	0.835	1.00
139_I	158_V	0.835	1.00
73_S	178_G	0.831	1.00
97_V	101_I	0.829	1.00
96_R	140_E	0.824	1.00
51_Y	233_V	0.823	1.00
141_G	158_V	0.820	1.00
147_R	150_L	0.815	1.00
190_P	209_A	0.814	1.00
50_I	97_V	0.813	1.00
47_N	259_P	0.813	1.00
71_S	105_S	0.811	1.00
78_L	138_I	0.809	1.00
235_Y	277_I	0.808	1.00
76_T	79_R	0.804	1.00
74_L	102_S	0.804	1.00
61_V	259_P	0.798	1.00
79_R	181_Y	0.788	1.00
70_L	97_V	0.788	1.00
221_Q	252_P	0.783	1.00
67_L	71_S	0.783	1.00
113_S	246_I	0.783	1.00
78_L	106_L	0.775	1.00
105_S	109_L	0.774	1.00
38_R	41_K	0.773	1.00
93_L	99_T	0.772	1.00
145_E	148_E	0.772	1.00
198_G	204_K	0.771	1.00
208_H	243_I	0.770	1.00
244_G	247_G	0.765	1.00
192_Q	208_H	0.761	1.00
66_Q	70_L	0.758	1.00
147_R	151_R	0.757	1.00
35_I	39_K	0.754	1.00
35_I	218_P	0.752	1.00
77_I	177_S	0.749	1.00
80_E	177_S	0.748	1.00
37_D	41_K	0.747	1.00
269_F	274_T	0.743	1.00
33_E	185_T	0.738	1.00
106_L	113_S	0.738	1.00
200_T	204_K	0.738	1.00
157_I	161_E	0.737	1.00
239_D	242_W	0.736	1.00
44_V	257_G	0.730	1.00
79_R	180_H	0.728	1.00
192_Q	246_I	0.727	1.00
36_L	68_K	0.724	1.00
235_Y	278_M	0.723	1.00
114_L	134_A	0.721	1.00
34_S	38_R	0.719	1.00
220_Y	247_G	0.718	1.00
122_V	145_E	0.714	1.00
191_A	210_H	0.711	1.00
48_I	52_Y	0.709	1.00
92_Y	143_R	0.707	1.00
127_Y	195_Y	0.705	1.00
219_A	223_Y	0.703	1.00
276_A	279_Q	0.702	1.00
103_I	251_L	0.699	1.00
47_N	228_P	0.693	1.00
100_V	249_V	0.693	1.00
101_I	105_S	0.689	1.00
277_I	280_K	0.689	1.00
85_R	185_T	0.689	1.00
33_E	37_D	0.688	1.00
33_E	107_Y	0.688	1.00
104_L	251_L	0.687	1.00
272_K	276_A	0.687	1.00
73_S	77_I	0.685	1.00
174_K	177_S	0.683	1.00
236_T	245_A	0.682	1.00
233_V	284_P	0.676	1.00
278_M	283_L	0.675	1.00
92_Y	137_I	0.672	1.00
46_D	63_T	0.671	1.00
123_E	202_A	0.669	1.00
76_T	177_S	0.667	1.00
263_Y	274_T	0.664	1.00
233_V	282_E	0.659	1.00
89_V	136_A	0.658	1.00
231_E	284_P	0.654	1.00
74_L	77_I	0.654	1.00
74_L	78_L	0.654	1.00
180_H	183_V	0.653	1.00
122_V	146_V	0.652	1.00
199_S	204_K	0.651	1.00
39_K	257_G	0.649	1.00
36_L	104_L	0.649	1.00
84_K	111_A	0.648	1.00
90_G	132_S	0.648	1.00
136_A	157_I	0.647	1.00
197_S	204_K	0.647	1.00
218_P	222_L	0.646	1.00
128_R	205_G	0.646	1.00
76_T	178_G	0.644	1.00
67_L	100_V	0.641	1.00
218_P	255_Y	0.640	1.00
212_F	215_G	0.639	1.00
50_I	260_I	0.631	1.00
273_D	277_I	0.629	1.00
31_I	210_H	0.627	1.00
141_G	161_E	0.625	1.00
144_K	147_R	0.625	1.00
76_T	179_V	0.624	1.00
44_V	228_P	0.624	1.00
139_I	143_R	0.623	1.00
69_S	178_G	0.620	1.00
40_V	45_G	0.618	1.00
34_S	37_D	0.617	1.00
70_L	174_K	0.613	1.00
185_T	210_H	0.610	1.00
52_Y	264_R	0.609	1.00
41_K	68_K	0.607	1.00
82_G	111_A	0.605	1.00
76_T	181_Y	0.604	1.00
131_Q	205_G	0.600	1.00
236_T	260_I	0.598	1.00
33_E	108_R	0.596	1.00
226_M	285_P	0.596	1.00
112_I	193_L	0.596	1.00
191_A	213_L	0.596	1.00
35_I	214_L	0.595	1.00
79_R	183_V	0.590	1.00
245_A	249_V	0.589	1.00
194_F	243_I	0.589	1.00
201_G	204_K	0.589	1.00
192_Q	213_L	0.586	1.00
145_E	149_K	0.586	1.00
144_K	148_E	0.585	1.00
68_K	71_S	0.585	1.00
274_T	278_M	0.583	1.00
107_Y	113_S	0.583	1.00
35_I	255_Y	0.581	1.00
220_Y	252_P	0.579	1.00
226_M	232_D	0.579	1.00
101_I	170_F	0.578	1.00
77_I	176_T	0.577	1.00
275_L	279_Q	0.575	1.00
236_T	262_A	0.575	1.00
106_L	109_L	0.574	1.00
264_R	273_D	0.573	1.00
172_E	175_K	0.571	1.00
259_P	281_C	0.571	1.00
236_T	249_V	0.571	1.00
75_I	105_S	0.571	1.00
216_H	248_D	0.570	1.00
193_L	207_L	0.567	1.00
83_V	109_L	0.567	1.00
114_L	128_R	0.565	1.00
102_S	106_L	0.559	1.00
94_Q	143_R	0.558	1.00
33_E	210_H	0.558	1.00
120_M	125_V	0.558	1.00
116_I	129_I	0.557	1.00
98_E	140_E	0.556	1.00
76_T	180_H	0.554	1.00
216_H	219_A	0.553	1.00
62_Y	66_Q	0.553	1.00
114_L	195_Y	0.546	1.00
84_K	135_K	0.545	1.00
91_I	99_T	0.544	1.00
236_T	248_D	0.543	1.00
217_I	252_P	0.543	1.00
155_K	158_V	0.541	1.00
217_I	251_L	0.541	1.00
85_R	183_V	0.540	1.00
71_S	74_L	0.536	1.00
130_R	152_N	0.534	1.00
93_L	140_E	0.533	1.00
69_S	179_V	0.531	1.00
263_Y	273_D	0.531	1.00
115_S	194_F	0.530	1.00
107_Y	210_H	0.525	1.00
196_T	204_K	0.524	1.00
40_V	43_G	0.520	1.00
48_I	233_V	0.519	1.00
93_L	102_S	0.518	1.00
99_T	103_I	0.518	1.00
71_S	75_I	0.518	1.00
29_F	211_R	0.516	1.00
44_V	65_A	0.513	1.00
235_Y	274_T	0.512	1.00
244_G	248_D	0.512	1.00
247_G	252_P	0.508	1.00
76_T	80_E	0.507	1.00
249_V	253_S	0.506	1.00
158_V	161_E	0.506	1.00
246_I	251_L	0.505	1.00
189_D	210_H	0.503	1.00
137_I	156_I	0.501	1.00
103_I	192_Q	0.501	1.00
79_R	182_A	0.501	1.00
100_V	254_L	0.500	1.00
72_D	180_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ry2A	1	0.9895	100	0.244	Contact Map
2vsqA	1	0.9338	100	0.244	Contact Map
1pg4A	1	0.9895	100	0.245	Contact Map
4wd1A	1	0.9791	100	0.25	Contact Map
3etcA	2	0.9861	100	0.25	Contact Map
1amuA	1	0.8815	100	0.257	Contact Map
3tsyA	2	0.9059	100	0.261	Contact Map
1mdbA	1	0.9303	100	0.266	Contact Map
1v25A	2	0.9024	100	0.268	Contact Map
1t5hX	2	0.8362	100	0.269	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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