GREMLIN Database
Q97YI0 - L-carnitine dehydratase, putative (CaiB)
UniProt: Q97YI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (346)
Sequences: 10438 (6933)
Seq/√Len: 372.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_S100_V3.6451.00
26_E57_R3.5401.00
277_M281_E3.1841.00
17_G83_I3.1511.00
111_C163_I3.0821.00
111_C159_C2.9641.00
65_K68_G2.8551.00
77_R104_T2.8091.00
73_L104_T2.7631.00
92_D97_S2.6401.00
219_S279_L2.6191.00
101_I108_L2.5661.00
277_M282_I2.5391.00
69_K73_L2.5041.00
98_D102_F2.4881.00
169_M174_H2.4721.00
61_V72_F2.4691.00
3_R26_E2.4681.00
220_S278_K2.3951.00
278_K281_E2.3691.00
277_M285_I2.3361.00
336_G339_T2.2641.00
218_K275_S2.2291.00
74_R77_R2.2091.00
70_E74_R2.1721.00
273_K276_S2.1691.00
81_V163_I2.1211.00
71_V348_Y2.0921.00
7_L72_F2.0911.00
262_N265_I1.9521.00
268_E272_Q1.9441.00
339_T343_L1.9401.00
338_D341_Y1.9401.00
57_R341_Y1.9141.00
3_R78_N1.8981.00
100_V103_S1.8851.00
118_K176_R1.8721.00
151_T183_N1.8711.00
5_I76_V1.8511.00
269_K272_Q1.8331.00
169_M172_P1.8311.00
23_L165_W1.8131.00
244_L273_K1.8071.00
161_I164_L1.7911.00
169_M327_L1.7881.00
124_L287_R1.7701.00
298_N301_D1.7601.00
62_D65_K1.7591.00
215_E267_H1.7471.00
91_M96_L1.7431.00
121_Y124_L1.7361.00
21_R55_G1.7041.00
252_R265_I1.7021.00
82_L108_L1.6981.00
121_Y305_N1.6891.00
76_V101_I1.6851.00
5_I79_S1.6791.00
334_N337_E1.6731.00
244_L247_L1.6731.00
2_Y167_L1.6541.00
57_R345_E1.6481.00
6_E17_G1.6461.00
98_D110_Y1.6391.00
280_E284_N1.6381.00
181_Q310_W1.6171.00
133_A226_Y1.6111.00
61_V68_G1.5861.00
240_K245_E1.5471.00
241_A285_I1.5311.00
66_E69_K1.5281.00
255_T258_D1.5251.00
273_K282_I1.5231.00
22_H54_R1.5141.00
284_N288_Y1.5091.00
76_V105_N1.5071.00
135_S183_N1.5031.00
279_L301_D1.4971.00
270_L274_F1.4941.00
180_I308_V1.4901.00
244_L269_K1.4701.00
240_K248_L1.4691.00
304_S309_E1.4381.00
142_G203_A1.4351.00
219_S225_F1.4321.00
109_V170_K1.4291.00
331_H337_E1.4201.00
340_L344_K1.4121.00
59_I342_I1.4071.00
154_N186_W1.4071.00
218_K271_Q1.4031.00
258_D261_R1.3961.00
61_V71_V1.3941.00
107_S170_K1.3931.00
59_I339_T1.3891.00
74_R348_Y1.3841.00
84_E112_S1.3811.00
281_E285_I1.3691.00
174_H326_S1.3571.00
333_P338_D1.3551.00
265_I268_E1.3531.00
247_L269_K1.3501.00
217_F267_H1.3411.00
279_L295_K1.3291.00
254_K258_D1.3271.00
75_L346_L1.3201.00
218_K224_E1.3201.00
236_T249_A1.3171.00
238_L242_L1.3151.00
121_Y134_E1.3041.00
73_L100_V1.3031.00
113_I159_C1.3001.00
162_T323_L1.2931.00
4_V81_V1.2931.00
300_K304_S1.2841.00
274_F282_I1.2821.00
237_K240_K1.2751.00
174_H328_N1.2751.00
73_L96_L1.2721.00
236_T240_K1.2561.00
164_L168_L1.2471.00
242_L273_K1.2461.00
241_A289_N1.2341.00
90_V93_R1.2341.00
235_F239_C1.2331.00
232_N236_T1.2221.00
33_L60_S1.2211.00
128_G132_E1.2001.00
7_L82_L1.1991.00
178_S181_Q1.1961.00
67_K70_E1.1941.00
218_K274_F1.1931.00
168_L171_K1.1901.00
184_T308_V1.1831.00
233_E237_K1.1671.00
158_Y185_V1.1621.00
55_G330_Q1.1461.00
120_K307_L1.1411.00
225_F282_I1.1361.00
283_M293_V1.1321.00
91_M110_Y1.1281.00
63_L94_L1.1181.00
281_E284_N1.1161.00
229_V238_L1.1131.00
80_H170_K1.1131.00
200_L300_K1.1041.00
60_S339_T1.1041.00
162_T175_Y1.1011.00
71_V346_L1.1011.00
16_A160_V1.1001.00
132_E151_T1.0921.00
126_A131_I1.0911.00
2_Y168_L1.0901.00
297_N305_N1.0871.00
76_V104_T1.0841.00
64_R94_L1.0821.00
126_A179_I1.0781.00
167_L170_K1.0681.00
36_D39_R1.0651.00
184_T302_L1.0621.00
134_E305_N1.0581.00
222_E279_L1.0491.00
225_F274_F1.0391.00
116_Y134_E1.0391.00
283_M295_K1.0291.00
19_I161_I1.0271.00
200_L298_N1.0251.00
252_R262_N1.0241.00
58_S333_P1.0181.00
214_Y228_A1.0181.00
280_E283_M1.0141.00
5_I72_F1.0111.00
330_Q338_D1.0091.00
101_I110_Y1.0091.00
272_Q276_S1.0071.00
238_L270_L1.0001.00
265_I269_K0.9971.00
174_H327_L0.9941.00
3_R28_I0.9921.00
71_V74_R0.9891.00
84_E91_M0.9851.00
16_A159_C0.9821.00
187_L299_L0.9791.00
218_K222_E0.9721.00
285_I288_Y0.9711.00
73_L77_R0.9701.00
286_L293_V0.9611.00
72_F96_L0.9601.00
7_L91_M0.9601.00
8_G13_A0.9581.00
3_R79_S0.9501.00
31_E39_R0.9481.00
77_R105_N0.9481.00
18_E22_H0.9471.00
240_K289_N0.9461.00
166_A174_H0.9421.00
81_V109_V0.9421.00
280_E295_K0.9361.00
169_M328_N0.9311.00
207_E263_R0.9301.00
18_E54_R0.9291.00
172_P327_L0.9281.00
69_K96_L0.9231.00
66_E70_E0.9211.00
160_V164_L0.9201.00
235_F259_R0.9161.00
297_N301_D0.9131.00
284_N287_R0.9061.00
82_L101_I0.9031.00
253_F265_I0.9011.00
129_T228_A0.8971.00
318_V334_N0.8971.00
86_L90_V0.8911.00
161_I168_L0.8901.00
21_R27_V0.8901.00
68_G71_V0.8901.00
237_K241_A0.8891.00
158_Y182_A0.8881.00
253_F262_N0.8881.00
53_N56_K0.8871.00
236_T248_L0.8851.00
285_I289_N0.8821.00
45_V318_V0.8811.00
72_F76_V0.8791.00
114_K117_P0.8781.00
271_Q275_S0.8761.00
81_V167_L0.8741.00
279_L283_M0.8731.00
70_E73_L0.8721.00
10_V127_F0.8721.00
256_N260_V0.8711.00
341_Y345_E0.8681.00
71_V343_L0.8671.00
30_I72_F0.8661.00
12_S113_I0.8651.00
30_I59_I0.8641.00
271_Q274_F0.8621.00
82_L91_M0.8551.00
225_F283_M0.8541.00
20_L163_I0.8511.00
194_Y300_K0.8511.00
26_E341_Y0.8501.00
181_Q312_T0.8441.00
216_L226_Y0.8441.00
115_G126_A0.8441.00
225_F279_L0.8411.00
28_I342_I0.8391.00
226_Y294_G0.8391.00
269_K273_K0.8381.00
3_R57_R0.8361.00
129_T226_Y0.8351.00
15_F19_I0.8351.00
307_L310_W0.8341.00
133_A294_G0.8331.00
72_F82_L0.8331.00
92_D99_D0.8321.00
134_E297_N0.8301.00
49_F53_N0.8281.00
97_S110_Y0.8241.00
73_L105_N0.8221.00
194_Y200_L0.8211.00
68_G343_L0.8201.00
220_S281_E0.8171.00
23_L161_I0.8161.00
8_G17_G0.8131.00
78_N345_E0.8111.00
82_L110_Y0.8091.00
144_A224_E0.8031.00
107_S172_P0.7981.00
326_S329_S0.7971.00
73_L76_V0.7951.00
60_S335_V0.7941.00
251_E254_K0.7921.00
92_D112_S0.7901.00
131_I151_T0.7891.00
69_K95_G0.7891.00
278_K282_I0.7881.00
242_L270_L0.7881.00
139_D298_N0.7831.00
283_M287_R0.7831.00
100_V104_T0.7811.00
243_G285_I0.7791.00
119_G307_L0.7791.00
111_C175_Y0.7741.00
220_S276_S0.7741.00
59_I71_V0.7731.00
99_D102_F0.7721.00
71_V347_G0.7711.00
333_P337_E0.7701.00
68_G348_Y0.7701.00
109_V166_A0.7681.00
90_V94_L0.7671.00
314_R320_K0.7661.00
5_I82_L0.7651.00
133_A138_M0.7651.00
35_G39_R0.7641.00
26_E345_E0.7611.00
225_F293_V0.7601.00
87_S90_V0.7591.00
237_K289_N0.7571.00
143_K215_E0.7551.00
30_I61_V0.7531.00
69_K94_L0.7501.00
216_L296_L0.7491.00
161_I165_W0.7471.00
320_K324_P0.7471.00
59_I343_L0.7451.00
98_D108_L0.7451.00
312_T324_P0.7431.00
58_S336_G0.7421.00
308_V312_T0.7411.00
253_F269_K0.7401.00
84_E118_K0.7401.00
305_N308_V0.7391.00
287_R293_V0.7391.00
35_G335_V0.7381.00
308_V313_F0.7341.00
191_L195_Q0.7341.00
268_E271_Q0.7321.00
184_T312_T0.7291.00
157_T161_I0.7281.00
267_H271_Q0.7261.00
191_L303_I0.7241.00
29_K36_D0.7221.00
140_A187_L0.7201.00
16_A83_I0.7151.00
11_I52_N0.7151.00
76_V96_L0.7141.00
89_H92_D0.7121.00
74_R78_N0.7121.00
176_R310_W0.7090.99
23_L325_G0.7050.99
130_I294_G0.7020.99
68_G72_F0.6970.99
151_T155_A0.6970.99
311_D324_P0.6960.99
212_A260_V0.6960.99
295_K301_D0.6960.99
89_H123_N0.6950.99
28_I79_S0.6940.99
22_H55_G0.6920.99
215_E271_Q0.6910.99
104_T107_S0.6900.99
121_Y307_L0.6900.99
155_A182_A0.6890.99
14_P152_D0.6880.99
6_E13_A0.6870.99
134_E295_K0.6870.99
212_A267_H0.6870.99
272_Q275_S0.6860.99
70_E104_T0.6860.99
264_K268_E0.6830.99
276_S282_I0.6790.99
87_S125_P0.6790.99
5_I78_N0.6780.99
117_P176_R0.6770.99
303_I313_F0.6760.99
154_N157_T0.6740.99
234_K292_P0.6710.99
109_V168_L0.6700.99
266_L270_L0.6690.99
50_V332_V0.6680.99
155_A179_I0.6680.99
19_I160_V0.6660.99
194_Y198_G0.6660.99
231_D234_K0.6650.99
98_D112_S0.6650.99
227_L274_F0.6650.99
207_E267_H0.6640.99
105_N108_L0.6630.99
237_K290_D0.6630.99
60_S336_G0.6630.99
61_V343_L0.6620.99
141_N147_P0.6590.99
78_N346_L0.6580.99
177_V182_A0.6570.99
84_E89_H0.6560.99
114_K176_R0.6540.99
6_E9_H0.6530.99
50_V318_V0.6520.99
15_F153_M0.6490.99
140_A299_L0.6470.99
134_E294_G0.6470.99
253_F266_L0.6460.99
68_G347_G0.6440.99
239_C245_E0.6430.99
174_H325_G0.6420.99
9_H37_P0.6410.99
15_F185_V0.6400.99
137_I187_L0.6400.99
74_R346_L0.6380.99
20_L160_V0.6360.99
125_P290_D0.6360.99
154_N182_A0.6350.99
99_D103_S0.6350.99
5_I75_L0.6310.99
57_R330_Q0.6280.99
257_A261_R0.6270.99
227_L293_V0.6260.99
180_I307_L0.6250.99
137_I146_L0.6230.99
129_T214_Y0.6230.99
127_F292_P0.6230.99
260_V263_R0.6220.99
166_A175_Y0.6220.99
63_L72_F0.6200.99
45_V50_V0.6180.99
219_S282_I0.6170.99
11_I149_S0.6150.99
127_F231_D0.6140.99
156_S160_V0.6110.99
137_I183_N0.6080.98
159_C177_V0.6070.98
207_E215_E0.6070.98
311_D314_R0.6050.98
256_N259_R0.6030.98
17_G56_K0.6030.98
330_Q341_Y0.6020.98
2_Y170_K0.6000.98
227_L238_L0.6000.98
302_L308_V0.5980.98
92_D100_V0.5970.98
81_V170_K0.5960.98
58_S337_E0.5950.98
58_S335_V0.5950.98
221_E279_L0.5950.98
225_F286_L0.5940.98
159_C163_I0.5930.98
12_S155_A0.5920.98
160_V165_W0.5910.98
219_S222_E0.5840.98
250_D253_F0.5830.98
221_E278_K0.5820.98
39_R49_F0.5810.98
88_P114_K0.5780.98
219_S274_F0.5770.98
28_I78_N0.5770.98
10_V37_P0.5750.98
84_E110_Y0.5750.98
73_L95_G0.5740.98
325_G328_N0.5730.98
252_R269_K0.5730.98
15_F156_S0.5700.98
113_I155_A0.5700.98
221_E280_E0.5700.98
123_N287_R0.5680.98
13_A83_I0.5680.98
76_V82_L0.5670.98
153_M188_G0.5660.98
112_S118_K0.5650.98
246_D269_K0.5650.98
43_V47_S0.5650.98
325_G329_S0.5620.97
89_H97_S0.5610.97
232_N259_R0.5600.97
52_N153_M0.5600.97
31_E35_G0.5590.97
258_D262_N0.5590.97
220_S275_S0.5590.97
193_A210_F0.5590.97
341_Y344_K0.5570.97
102_F110_Y0.5550.97
7_L63_L0.5550.97
58_S338_D0.5540.97
127_F130_I0.5530.97
104_T108_L0.5520.97
92_D118_K0.5520.97
135_S180_I0.5510.97
16_A156_S0.5500.97
319_P334_N0.5480.97
151_T179_I0.5470.97
17_G27_V0.5470.97
60_S71_V0.5450.97
76_V79_S0.5450.97
141_N145_R0.5420.97
89_H93_R0.5420.97
306_E309_E0.5420.97
343_L346_L0.5410.97
29_K35_G0.5410.97
57_R338_D0.5390.97
45_V334_N0.5380.97
6_E56_K0.5380.97
270_L273_K0.5370.97
241_A288_Y0.5370.97
330_Q337_E0.5360.97
245_E248_L0.5310.96
238_L286_L0.5310.96
342_I345_E0.5300.96
342_I346_L0.5280.96
165_W325_G0.5270.96
165_W168_L0.5260.96
242_L245_E0.5260.96
241_A291_I0.5240.96
87_S290_D0.5220.96
155_A177_V0.5190.96
319_P337_E0.5150.96
175_Y325_G0.5150.96
31_E58_S0.5140.96
73_L91_M0.5140.96
282_I285_I0.5140.96
138_M216_L0.5140.96
81_V164_L0.5140.96
34_L40_K0.5130.96
131_I179_I0.5120.96
130_I292_P0.5120.96
28_I75_L0.5120.96
146_L150_I0.5120.96
97_S103_S0.5110.96
212_A263_R0.5100.96
339_T344_K0.5090.95
3_R346_L0.5090.95
13_A113_I0.5050.95
153_M186_W0.5050.95
65_K69_K0.5050.95
98_D174_H0.5030.95
234_K237_K0.5030.95
2_Y164_L0.5020.95
259_R262_N0.5000.95
88_P118_K0.5000.95
102_F107_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q7eA 2 0.9699 100 0.092 Contact Map
2vjqA 2 0.9863 100 0.096 Contact Map
3ubmA 2 0.9918 100 0.1 Contact Map
1xk7A 2 0.9863 100 0.113 Contact Map
4ed9A 2 0.9454 100 0.128 Contact Map
4hl6A 2 0.9481 100 0.141 Contact Map
2yimA 2 0.8989 100 0.191 Contact Map
2g04A 2 0.8907 100 0.221 Contact Map
1vl6A 4 0.5219 93.9 0.947 Contact Map
2a9fA 2 0.5328 85.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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