GREMLIN Database
Q97YH9 - Uncharacterized protein
UniProt: Q97YH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (189)
Sequences: 127 (120)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_K167_D3.8000.97
75_K78_A3.3550.94
71_N74_T3.2270.93
179_E185_K3.1920.92
37_K41_W2.5490.80
50_D54_H2.3740.75
145_Y156_M2.3720.75
55_T58_I2.3200.73
97_L194_P2.2720.72
64_E67_E2.1900.69
69_L72_F2.1550.67
74_T78_A2.1360.67
68_S73_V2.1260.66
184_V187_S2.0900.65
175_K189_V2.0660.64
69_L73_V2.0600.64
186_I189_V1.8990.57
89_R179_E1.8920.57
44_I48_I1.8760.56
98_G101_W1.8240.54
206_A209_K1.8140.54
172_R176_E1.8080.53
42_Q46_R1.8030.53
51_L55_T1.7520.51
113_V116_I1.7360.50
64_E68_S1.7320.50
50_D53_N1.7180.50
57_K60_K1.6970.49
80_N84_K1.6400.46
130_Y210_D1.6150.45
36_V39_M1.6150.45
61_E66_K1.6050.45
43_V48_I1.5990.44
82_A85_D1.5980.44
35_L38_L1.5890.44
111_Q114_Y1.5750.43
68_S72_F1.5350.42
168_L191_V1.5230.41
115_E216_I1.5060.41
37_K40_P1.4750.39
97_L196_L1.4720.39
58_I62_L1.4620.39
130_Y156_M1.4390.38
65_V69_L1.4050.36
67_E70_K1.3920.36
175_K186_I1.3780.35
68_S71_N1.3750.35
83_T87_I1.3710.35
108_A196_L1.3470.34
149_I157_I1.3450.34
61_E67_E1.3450.34
68_S74_T1.3230.33
46_R49_D1.3220.33
72_F76_E1.3130.33
60_K63_G1.3080.33
30_I40_P1.3020.32
139_E180_R1.2980.32
109_F178_Y1.2960.32
160_T164_K1.2910.32
118_K214_E1.2910.32
26_Q40_P1.2840.32
27_R40_P1.2760.31
27_R30_I1.2700.31
155_V190_I1.2610.31
107_D165_R1.2590.31
73_V76_E1.2550.31
175_K184_V1.2520.31
30_I39_M1.2420.30
26_Q30_I1.2360.30
26_Q38_L1.2340.30
76_E83_T1.2300.30
112_G215_I1.2260.30
44_I51_L1.1820.28
101_W161_S1.1750.28
71_N75_K1.1680.28
70_K77_D1.1640.27
32_Y36_V1.1570.27
61_E70_K1.1520.27
175_K187_S1.1510.27
104_L114_Y1.1390.27
42_Q53_N1.1320.26
51_L58_I1.1200.26
80_N85_D1.1160.26
110_R173_K1.1090.26
110_R178_Y1.1000.25
60_K64_E1.0970.25
168_L207_M1.0870.25
65_V68_S1.0800.25
129_V154_L1.0770.25
80_N83_T1.0760.25
126_K157_I1.0520.24
119_S143_V1.0480.24
117_M174_K1.0450.24
81_F85_D1.0390.23
27_R31_L1.0340.23
153_N187_S1.0340.23
62_L65_V1.0280.23
154_L186_I1.0280.23
76_E79_K1.0280.23
57_K188_K1.0250.23
111_Q177_F1.0220.23
30_I37_K1.0210.23
50_D64_E1.0050.22
140_P178_Y0.9990.22
38_L41_W0.9880.22
28_P32_Y0.9860.22
82_A87_I0.9850.22
189_V206_A0.9810.22
129_V181_N0.9760.22
109_F173_K0.9700.21
56_Q60_K0.9690.21
62_L67_E0.9570.21
28_P40_P0.9520.21
46_R60_K0.9520.21
27_R37_K0.9520.21
136_V178_Y0.9490.21
110_R140_P0.9480.21
130_Y140_P0.9440.21
76_E80_N0.9380.20
187_S215_I0.9350.20
78_A189_V0.9280.20
109_F194_P0.9180.20
65_V73_V0.9150.20
114_Y152_G0.9100.20
113_V137_Y0.9040.20
114_Y187_S0.8970.19
63_G67_E0.8940.19
35_L40_P0.8920.19
84_K87_I0.8910.19
73_V78_A0.8870.19
35_L42_Q0.8870.19
105_S173_K0.8750.19
126_K144_E0.8690.19
68_S75_K0.8610.18
128_L145_Y0.8610.18
42_Q56_Q0.8580.18
29_E180_R0.8560.18
45_I48_I0.8510.18
168_L197_H0.8500.18
171_I189_V0.8500.18
163_I191_V0.8460.18
31_L43_V0.8370.18
54_H59_E0.8350.18
25_A30_I0.8310.18
193_T196_L0.8290.18
133_T180_R0.8200.17
114_Y177_F0.8190.17
32_Y45_I0.8160.17
31_L40_P0.8150.17
96_G105_S0.8000.17
82_A86_D0.7990.17
47_D52_K0.7980.17
136_V173_K0.7920.17
54_H61_E0.7870.17
163_I207_M0.7860.17
120_E157_I0.7860.17
156_M186_I0.7860.17
187_S196_L0.7820.16
196_L204_L0.7790.16
92_T99_A0.7790.16
45_I59_E0.7770.16
105_S184_V0.7740.16
108_A114_Y0.7700.16
36_V45_I0.7620.16
103_L180_R0.7600.16
145_Y184_V0.7550.16
80_N87_I0.7540.16
74_T77_D0.7450.16
155_V175_K0.7420.16
111_Q159_I0.7380.15
90_L183_N0.7340.15
32_Y37_K0.7320.15
52_K59_E0.7300.15
133_T187_S0.7210.15
53_N123_V0.7190.15
46_R67_E0.7180.15
107_D206_A0.7160.15
61_E64_E0.7150.15
37_K42_Q0.7130.15
136_V140_P0.7130.15
32_Y35_L0.7100.15
161_S214_E0.7060.15
45_I121_G0.6980.15
58_I65_V0.6970.15
188_K214_E0.6950.14
28_P33_D0.6930.14
93_I159_I0.6910.14
145_Y189_V0.6900.14
98_G194_P0.6900.14
124_A173_K0.6880.14
66_K69_L0.6880.14
108_A125_K0.6870.14
109_F155_V0.6870.14
29_E85_D0.6840.14
27_R39_M0.6830.14
61_E68_S0.6810.14
34_V45_I0.6780.14
148_M157_I0.6750.14
106_E131_D0.6720.14
124_A188_K0.6710.14
92_T118_K0.6710.14
107_D157_I0.6670.14
86_D91_E0.6660.14
105_S110_R0.6640.14
28_P31_L0.6640.14
76_E84_K0.6630.14
65_V72_F0.6570.14
156_M172_R0.6560.14
112_G178_Y0.6540.14
107_D111_Q0.6530.14
169_P207_M0.6500.14
29_E41_W0.6490.14
103_L116_I0.6480.14
97_L193_T0.6460.13
97_L108_A0.6450.13
57_K61_E0.6440.13
129_V132_K0.6370.13
33_D66_K0.6320.13
103_L183_N0.6320.13
70_K73_V0.6290.13
129_V182_K0.6280.13
90_L111_Q0.6250.13
28_P34_V0.6170.13
41_W44_I0.6150.13
136_V177_F0.6140.13
34_V40_P0.6090.13
169_P184_V0.6080.13
110_R136_V0.6040.13
122_I129_V0.6040.13
163_I167_D0.6010.13
67_E71_N0.6010.13
197_H203_R0.6000.13
103_L140_P0.5960.13
38_L63_G0.5930.12
113_V171_I0.5900.12
63_G66_K0.5890.12
144_E174_K0.5880.12
68_S76_E0.5820.12
46_R53_N0.5820.12
66_K70_K0.5820.12
123_V137_Y0.5800.12
35_L45_I0.5780.12
57_K62_L0.5730.12
145_Y210_D0.5700.12
71_N78_A0.5690.12
196_L217_N0.5680.12
30_I41_W0.5650.12
48_I51_L0.5650.12
113_V129_V0.5640.12
194_P216_I0.5630.12
57_K160_T0.5630.12
97_L147_L0.5610.12
177_F183_N0.5580.12
196_L215_I0.5540.12
41_W45_I0.5520.12
90_L181_N0.5510.12
173_K178_Y0.5480.12
156_M185_K0.5470.12
180_R203_R0.5470.12
92_T217_N0.5460.12
43_V47_D0.5450.12
168_L206_A0.5440.12
48_I53_N0.5390.11
59_E63_G0.5370.11
183_N205_K0.5360.11
139_E217_N0.5350.11
76_E143_V0.5320.11
33_D37_K0.5320.11
71_N77_D0.5240.11
63_G128_L0.5240.11
102_G131_D0.5240.11
102_G106_E0.5240.11
69_L74_T0.5220.11
32_Y40_P0.5170.11
96_G140_P0.5150.11
38_L45_I0.5150.11
68_S114_Y0.5140.11
104_L108_A0.5080.11
43_V46_R0.5080.11
114_Y118_K0.5070.11
26_Q31_L0.5060.11
186_I206_A0.5020.11
155_V194_P0.5000.11
117_M186_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y88A 5 0.4725 95.2 0.917 Contact Map
1xmxA 2 0.9312 95 0.917 Contact Map
2inbA 2 0.4404 83.1 0.937 Contact Map
2wcwA 2 0.4266 79.3 0.939 Contact Map
2dfsA 2 0.5413 67 0.945 Contact Map
2vldA 2 0.6514 64.9 0.946 Contact Map
2bnxA 2 0.2294 55.8 0.949 Contact Map
1m0dA 2 0.4541 52.2 0.95 Contact Map
2eo0A 2 0.3945 50.1 0.95 Contact Map
1ob8A 1 0.3945 49.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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