GREMLIN Database
Q97YH8 - Uncharacterized protein
UniProt: Q97YH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (206)
Sequences: 4976 (3752)
Seq/√Len: 261.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_T188_L5.5471.00
41_K47_Y4.3401.00
98_H121_Y3.5251.00
124_K128_Y3.4091.00
50_I102_T3.1451.00
124_K166_E3.0551.00
46_Q97_S2.8601.00
119_K163_V2.8381.00
46_Q98_H2.7061.00
92_T95_D2.7021.00
100_I189_V2.5531.00
221_D224_E2.5411.00
123_S187_M2.4731.00
47_Y91_I2.3941.00
179_T186_S2.3171.00
186_S201_S2.2301.00
47_Y96_I2.2201.00
175_E192_N2.1741.00
43_E46_Q2.0971.00
176_V189_V1.9591.00
101_I112_I1.9521.00
41_K91_I1.9321.00
87_A92_T1.9091.00
48_V98_H1.8821.00
224_E227_N1.8731.00
50_I189_V1.8651.00
174_I191_F1.8131.00
190_K197_R1.8081.00
177_K190_K1.8001.00
47_Y97_S1.7921.00
98_H119_K1.7561.00
180_G228_A1.7441.00
94_D116_R1.6561.00
169_E172_K1.6521.00
126_G183_H1.6511.00
42_T45_D1.6211.00
192_N197_R1.6161.00
102_T189_V1.6101.00
83_E93_T1.6061.00
190_K199_C1.5841.00
175_E190_K1.5021.00
176_V187_M1.4621.00
91_I95_D1.4581.00
39_L96_I1.4451.00
50_I200_I1.4201.00
203_S232_M1.4161.00
99_I120_L1.4131.00
49_L96_I1.4111.00
84_N87_A1.4071.00
112_I120_L1.4061.00
145_Y149_L1.4051.00
94_D117_K1.3891.00
127_W131_V1.3861.00
147_P151_R1.3521.00
193_F196_K1.3161.00
188_L199_C1.3121.00
190_K235_E1.3121.00
227_N231_Y1.3061.00
47_Y95_D1.3061.00
102_T201_S1.2701.00
48_V174_I1.2581.00
230_D234_R1.2511.00
236_C239_V1.2241.00
227_N230_D1.2111.00
86_L91_I1.2021.00
148_R151_R1.2001.00
40_I50_I1.1981.00
38_F240_I1.1881.00
39_L91_I1.1861.00
83_E114_M1.1841.00
150_T153_Y1.1781.00
42_T46_Q1.1671.00
127_W164_L1.1631.00
165_V187_M1.1631.00
177_K188_L1.1631.00
129_E184_R1.1471.00
104_V122_F1.1471.00
199_C237_D1.1321.00
135_S138_P1.1151.00
39_L49_L1.1141.00
38_F200_I1.1051.00
188_L203_S1.1041.00
152_E155_F1.0801.00
146_L149_L1.0771.00
196_K238_V1.0741.00
96_I115_F1.0701.00
99_I112_I1.0531.00
169_E173_G1.0511.00
229_Y233_R1.0511.00
42_T48_V1.0471.00
147_P150_T1.0471.00
104_V109_I1.0451.00
153_Y156_D1.0391.00
85_A88_K1.0361.00
20_E23_W1.0311.00
219_A222_I1.0311.00
96_I118_A1.0261.00
126_G185_S1.0261.00
80_E88_K1.0251.00
123_S167_N1.0231.00
121_Y165_V1.0211.00
179_T228_A1.0131.00
50_I100_I1.0101.00
123_S178_W1.0041.00
42_T172_K1.0031.00
159_W162_I0.9761.00
200_I240_I0.9711.00
197_R237_D0.9681.00
87_A93_T0.9651.00
52_T112_I0.9551.00
83_E87_A0.9531.00
177_K235_E0.9451.00
40_I174_I0.9441.00
164_L167_N0.9311.00
168_Q178_W0.9221.00
145_Y148_R0.9181.00
121_Y163_V0.9171.00
133_T136_P0.9111.00
113_H116_R0.9101.00
55_P111_R0.9101.00
226_L230_D0.9091.00
204_A241_P0.9081.00
141_N144_I0.8911.00
206_V209_N0.8871.00
81_K84_N0.8861.00
144_I147_P0.8781.00
49_L52_T0.8721.00
111_R114_M0.8701.00
203_S228_A0.8571.00
126_G130_D0.8551.00
141_N145_Y0.8521.00
143_D146_L0.8490.99
219_A229_Y0.8470.99
104_V130_D0.8460.99
213_N230_D0.8460.99
125_K128_Y0.8450.99
78_H84_N0.8330.99
151_R155_F0.8320.99
47_Y86_L0.8300.99
49_L86_L0.8300.99
225_C229_Y0.8270.99
168_Q175_E0.8220.99
38_F198_W0.8210.99
142_R146_L0.8200.99
142_R145_Y0.8200.99
100_I187_M0.8160.99
26_D29_K0.8140.99
177_K199_C0.8120.99
167_N187_M0.8080.99
124_K164_L0.8070.99
169_E175_E0.8040.99
191_F196_K0.7990.99
205_F210_F0.7980.99
141_N147_P0.7930.99
231_Y235_E0.7910.99
215_P226_L0.7870.99
40_I48_V0.7810.99
223_Y226_L0.7800.99
198_W240_I0.7790.99
145_Y151_R0.7750.99
149_L153_Y0.7670.99
39_L47_Y0.7660.99
128_Y131_V0.7640.99
99_I115_F0.7610.99
208_N212_Q0.7550.99
144_I149_L0.7520.99
180_G224_E0.7480.99
93_T114_M0.7470.99
145_Y150_T0.7470.99
188_L232_M0.7450.99
52_T111_R0.7440.99
167_N178_W0.7430.99
192_N195_K0.7420.99
149_L152_E0.7420.99
149_L154_L0.7420.99
39_L85_A0.7410.99
128_Y133_T0.7340.99
145_Y153_Y0.7330.99
142_R149_L0.7330.99
222_I226_L0.7310.98
198_W238_V0.7290.98
105_Q108_T0.7290.98
188_L228_A0.7280.98
199_C232_M0.7210.98
158_A164_L0.7130.98
80_E84_N0.7100.98
37_S82_I0.7090.98
152_E156_D0.7080.98
172_K192_N0.7080.98
200_I242_S0.7070.98
213_N233_R0.7070.98
38_F241_P0.7060.98
84_N88_K0.7050.98
164_L168_Q0.7020.98
122_F127_W0.7020.98
48_V100_I0.6970.98
219_A225_C0.6910.98
146_L150_T0.6910.98
133_T137_S0.6870.98
141_N146_L0.6850.98
231_Y234_R0.6850.98
147_P152_E0.6770.98
226_L229_Y0.6770.98
150_T154_L0.6760.97
143_D149_L0.6730.97
168_Q231_Y0.6730.97
160_N165_V0.6710.97
162_I165_V0.6710.97
230_D233_R0.6710.97
100_I174_I0.6690.97
160_N164_L0.6690.97
50_I201_S0.6620.97
90_N95_D0.6610.97
209_N225_C0.6580.97
142_R147_P0.6580.97
86_L89_L0.6540.97
52_T99_I0.6540.97
165_V168_Q0.6510.97
126_G129_E0.6480.97
134_P137_S0.6410.97
20_E24_M0.6370.96
101_I120_L0.6370.96
125_K167_N0.6350.96
105_Q241_P0.6300.96
23_W26_D0.6190.96
104_V126_G0.6190.96
101_I109_I0.6150.96
38_F242_S0.6140.96
48_V171_I0.6140.96
154_L157_E0.6120.96
153_Y157_E0.6110.95
144_I148_R0.6100.95
214_I218_I0.6060.95
144_I150_T0.5960.95
148_R152_E0.5940.95
109_I112_I0.5940.95
143_D150_T0.5890.95
53_G101_I0.5870.94
175_E178_W0.5860.94
103_P107_Y0.5850.94
56_D84_N0.5850.94
145_Y155_F0.5850.94
103_P108_T0.5840.94
59_S77_Q0.5820.94
223_Y227_N0.5820.94
113_H161_R0.5810.94
221_D227_N0.5790.94
152_E157_E0.5780.94
86_L95_D0.5780.94
126_G186_S0.5770.94
49_L99_I0.5740.94
161_R164_L0.5740.94
22_F26_D0.5730.94
57_D110_G0.5730.94
51_N243_Y0.5730.94
177_K231_Y0.5730.94
55_P219_A0.5720.94
170_V176_V0.5720.94
165_V176_V0.5720.94
101_I104_V0.5720.94
123_S126_G0.5700.93
34_S205_F0.5690.93
52_T101_I0.5690.93
151_R156_D0.5650.93
194_D197_R0.5620.93
108_T243_Y0.5580.93
79_V84_N0.5570.93
54_L58_L0.5550.93
119_K161_R0.5530.92
143_D147_P0.5520.92
174_I189_V0.5520.92
35_F54_L0.5500.92
241_P244_D0.5500.92
125_K166_E0.5480.92
204_A232_M0.5470.92
107_Y243_Y0.5440.92
162_I168_Q0.5440.92
41_K95_D0.5360.91
51_N107_Y0.5350.91
232_M236_C0.5350.91
39_L89_L0.5320.91
161_R165_V0.5280.91
224_E228_A0.5280.91
148_R153_Y0.5260.90
106_D110_G0.5240.90
151_R154_L0.5230.90
83_E198_W0.5200.90
43_E47_Y0.5200.90
190_K237_D0.5190.90
21_V24_M0.5160.90
46_Q171_I0.5150.90
51_N108_T0.5150.90
205_F217_G0.5130.89
204_A209_N0.5130.89
123_S127_W0.5120.89
207_M244_D0.5120.89
99_I118_A0.5110.89
163_V166_E0.5100.89
121_Y176_V0.5100.89
181_C186_S0.5100.89
216_I219_A0.5090.89
37_S242_S0.5090.89
199_C236_C0.5060.89
146_L153_Y0.5050.89
237_D241_P0.5040.89
200_I241_P0.5040.89
158_A161_R0.5030.88
122_F164_L0.5010.88
122_F162_I0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aj3A 2 0.9533 100 0.382 Contact Map
2r2dA 5 0.9767 100 0.385 Contact Map
3dhaA 1 0.93 100 0.417 Contact Map
4zo2A 2 0.9183 100 0.43 Contact Map
4le6A 4 0.7626 100 0.433 Contact Map
1p9eA 3 0.9183 100 0.449 Contact Map
3eshA 5 0.93 100 0.457 Contact Map
2zo4A 1 0.8288 100 0.523 Contact Map
3iogA 1 0.8171 99.9 0.538 Contact Map
2vw8A 2 0.8638 99.9 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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