GREMLIN Database
Q97YH3 - Second ORF in transposon ISC1904
UniProt: Q97YH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (214)
Sequences: 147 (70)
Seq/√Len: 4.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Y72_L2.8370.64
78_D115_K2.6220.57
75_H118_L2.5350.55
229_K236_E2.3440.49
229_K235_E2.3250.48
225_S234_D2.3000.47
131_R134_E2.2810.47
63_R196_E2.2520.46
81_I115_K2.2340.45
153_E229_K2.1400.42
134_E152_L2.1360.42
73_A129_T2.0680.40
15_S126_V1.9520.37
234_D237_V1.9360.36
75_H115_K1.8830.35
97_K176_T1.8760.34
73_A187_L1.8700.34
22_Y26_L1.7950.32
78_D81_I1.7360.30
76_Y118_L1.7060.30
133_H232_R1.6960.29
30_I183_I1.6720.29
139_S157_P1.6580.28
163_K189_T1.6490.28
91_W203_L1.6460.28
30_I92_R1.6430.28
90_S123_G1.6190.27
147_R160_K1.6190.27
136_I164_V1.6030.27
147_R153_E1.5890.27
220_V234_D1.5860.27
76_Y82_N1.5840.27
59_Y73_A1.5810.26
36_L183_I1.5780.26
55_K81_I1.5520.26
89_K170_Y1.5510.26
17_E147_R1.5340.25
37_T153_E1.5260.25
27_Q30_I1.5220.25
75_H81_I1.5200.25
73_A134_E1.5160.25
98_G126_V1.4850.24
229_K234_D1.4670.24
217_R220_V1.4650.24
96_I222_S1.4620.24
13_E97_K1.4600.24
125_S232_R1.4480.23
87_I156_E1.4430.23
59_Y74_S1.4420.23
109_K222_S1.4380.23
166_L201_I1.4310.23
79_K116_T1.4170.23
104_K126_V1.4000.22
219_K229_K1.3950.22
132_P155_G1.3840.22
132_P167_P1.3830.22
63_R219_K1.3620.21
20_K24_T1.3550.21
131_R152_L1.3500.21
215_V219_K1.3480.21
89_K190_L1.3390.21
33_L115_K1.3360.21
76_Y80_A1.3270.21
223_F231_E1.3240.21
127_R173_P1.3220.21
99_R185_S1.3120.20
76_Y79_K1.3060.20
166_L226_K1.3050.20
146_S182_A1.3040.20
89_K163_K1.2980.20
128_I138_F1.2960.20
73_A131_R1.2930.20
82_N116_T1.2890.20
75_H78_D1.2880.20
29_A54_K1.2760.20
14_K94_R1.2690.20
92_R166_L1.2580.19
138_F141_S1.2520.19
91_W119_R1.2430.19
221_Q234_D1.2410.19
87_I92_R1.2380.19
86_S127_R1.2360.19
91_W216_K1.2320.19
120_K137_T1.2300.19
129_T187_L1.2100.18
98_G177_P1.2080.18
166_L222_S1.2000.18
13_E199_V1.1810.18
30_I180_F1.1800.18
140_W173_P1.1790.18
94_R156_E1.1700.18
172_L190_L1.1680.18
138_F192_A1.1580.17
190_L220_V1.1550.17
197_K209_L1.1540.17
10_S133_H1.1520.17
30_I87_I1.1490.17
7_I169_R1.1470.17
99_R236_E1.1390.17
53_P229_K1.1300.17
92_R183_I1.1260.17
106_R128_I1.1190.17
91_W95_A1.1180.17
54_K59_Y1.1010.16
63_R172_L1.0920.16
55_K76_Y1.0880.16
123_G166_L1.0870.16
34_W181_L1.0870.16
136_I233_V1.0860.16
93_K154_L1.0830.16
127_R176_T1.0790.16
189_T213_M1.0750.16
78_D116_T1.0700.16
27_Q222_S1.0620.16
13_E31_D1.0580.16
107_V215_V1.0530.16
118_L221_Q1.0480.15
195_G214_E1.0420.15
78_D117_T1.0420.15
11_E14_K1.0370.15
35_N57_E1.0200.15
188_Y191_D1.0180.15
63_R164_V1.0170.15
192_A201_I1.0110.15
94_R126_V1.0050.15
159_I233_V1.0020.15
40_Q89_K0.9940.15
8_K11_E0.9930.15
8_K14_K0.9930.15
25_L36_L0.9910.15
63_R229_K0.9840.14
7_I11_E0.9770.14
58_V82_N0.9710.14
55_K74_S0.9690.14
97_K159_I0.9640.14
7_I10_S0.9580.14
150_K181_L0.9520.14
34_W85_F0.9520.14
55_K75_H0.9500.14
227_H230_R0.9500.14
35_N125_S0.9490.14
79_K210_K0.9300.14
109_K196_E0.9250.14
78_D118_L0.9250.14
81_I114_I0.9240.14
29_A33_L0.9240.14
29_A183_I0.9220.14
99_R162_E0.9200.13
219_K222_S0.9110.13
180_F185_S0.9100.13
7_I162_E0.8990.13
30_I94_R0.8960.13
63_R222_S0.8960.13
163_K232_R0.8910.13
153_E178_V0.8900.13
109_K221_Q0.8870.13
182_A195_G0.8840.13
15_S111_Y0.8820.13
139_S145_F0.8800.13
41_V117_T0.8770.13
64_E167_P0.8750.13
140_W157_P0.8680.13
168_F206_L0.8660.13
78_D135_Y0.8580.13
79_K115_K0.8570.13
75_H80_A0.8520.13
39_I96_I0.8520.13
120_K164_V0.8500.12
27_Q94_R0.8460.12
92_R154_L0.8450.12
119_R210_K0.8450.12
18_L120_K0.8410.12
66_L72_L0.8410.12
99_R144_W0.8350.12
138_F190_L0.8350.12
147_R225_S0.8330.12
97_K104_K0.8310.12
151_E222_S0.8300.12
90_S162_E0.8250.12
151_E165_Y0.8170.12
154_L199_V0.8170.12
228_T231_E0.8160.12
145_F223_F0.8100.12
11_E139_S0.8090.12
101_S112_V0.8060.12
59_Y83_D0.8050.12
73_A152_L0.8050.12
31_D34_W0.8030.12
31_D97_K0.7990.12
65_E233_V0.7910.12
99_R135_Y0.7910.12
79_K82_N0.7890.12
79_K117_T0.7880.12
181_L227_H0.7860.12
138_F194_D0.7840.12
126_V192_A0.7820.12
153_E171_K0.7770.12
63_R149_V0.7750.11
113_R155_G0.7710.11
132_P144_W0.7710.11
30_I89_K0.7580.11
76_Y81_I0.7570.11
30_I216_K0.7560.11
119_R216_K0.7560.11
155_G214_E0.7550.11
22_Y107_V0.7540.11
113_R156_E0.7520.11
16_K20_K0.7500.11
23_R232_R0.7480.11
59_Y152_L0.7430.11
109_K214_E0.7420.11
86_S99_R0.7410.11
58_V117_T0.7410.11
87_I94_R0.7370.11
16_K112_V0.7370.11
173_P189_T0.7370.11
39_I129_T0.7360.11
20_K34_W0.7340.11
66_L210_K0.7250.11
160_K209_L0.7240.11
106_R162_E0.7220.11
73_A79_K0.7210.11
153_E190_L0.7180.11
35_N65_E0.7150.11
93_K124_E0.7080.11
138_F201_I0.7080.11
105_P186_N0.7010.11
105_P184_D0.7010.11
17_E151_E0.7000.11
128_I169_R0.6980.11
214_E220_V0.6950.11
83_D87_I0.6930.10
128_I159_I0.6930.10
138_F169_R0.6850.10
157_P173_P0.6750.10
75_H79_K0.6720.10
127_R145_F0.6710.10
119_R148_R0.6650.10
56_K175_V0.6640.10
75_H127_R0.6640.10
80_A237_V0.6630.10
55_K59_Y0.6620.10
191_D201_I0.6620.10
173_P225_S0.6620.10
108_K191_D0.6580.10
109_K174_W0.6520.10
170_Y213_M0.6460.10
54_K115_K0.6450.10
55_K79_K0.6440.10
42_R175_V0.6410.10
84_A100_A0.6380.10
73_A203_L0.6370.10
80_A209_L0.6350.10
88_L113_R0.6340.10
17_E90_S0.6240.10
207_Y214_E0.6210.10
62_L216_K0.6200.10
100_A177_P0.6200.10
80_A129_T0.6190.10
178_V181_L0.6180.10
89_K189_T0.6170.10
7_I164_V0.6160.10
128_I182_A0.6150.10
60_K129_T0.6140.10
71_H220_V0.6130.10
93_K236_E0.6130.10
118_L127_R0.6120.10
55_K212_S0.6110.10
98_G170_Y0.6110.10
160_K172_L0.6100.10
41_V55_K0.6090.10
191_D210_K0.6090.10
63_R235_E0.6090.10
26_L107_V0.6070.09
190_L217_R0.6050.09
88_L149_V0.6030.09
118_L129_T0.6030.09
133_H233_V0.6020.09
41_V116_T0.6000.09
160_K166_L0.6000.09
147_R220_V0.5940.09
7_I26_L0.5940.09
182_A215_V0.5920.09
124_E166_L0.5910.09
59_Y96_I0.5890.09
67_E189_T0.5880.09
17_E154_L0.5840.09
53_P113_R0.5810.09
120_K155_G0.5780.09
54_K112_V0.5760.09
82_N111_Y0.5740.09
84_A92_R0.5730.09
134_E170_Y0.5680.09
63_R216_K0.5640.09
157_P161_E0.5640.09
75_H116_T0.5620.09
20_K88_L0.5600.09
123_G181_L0.5540.09
190_L237_V0.5480.09
182_A201_I0.5450.09
79_K114_I0.5430.09
103_E162_E0.5400.09
30_I42_R0.5400.09
63_R74_S0.5370.09
11_E140_W0.5370.09
147_R234_D0.5330.09
53_P191_D0.5290.09
125_S154_L0.5260.09
63_R212_S0.5240.09
136_I160_K0.5230.09
123_G154_L0.5220.09
88_L159_I0.5210.09
129_T135_Y0.5190.09
32_Y79_K0.5170.09
168_F190_L0.5160.09
120_K193_Y0.5140.09
110_A151_E0.5100.08
76_Y213_M0.5080.08
94_R119_R0.5050.08
161_E233_V0.5020.08
83_D107_V0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bw2A 1 0.523 22.6 0.962 Contact Map
3e9vA 1 0.431 7.7 0.969 Contact Map
4oh8B 1 0.1757 7.2 0.969 Contact Map
2e5yA 2 0.5146 7.1 0.969 Contact Map
3fxdA 1 0.205 6.6 0.97 Contact Map
4fkeA 1 0.2343 5.5 0.971 Contact Map
2qe7H 1 0.5146 5.5 0.971 Contact Map
4lvqA 1 0.2176 4.4 0.972 Contact Map
4i2oA 2 0.251 4.3 0.972 Contact Map
2rq6A 1 0.5105 4.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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