GREMLIN Database
Q97YH1 - Uncharacterized protein
UniProt: Q97YH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (210)
Sequences: 693 (493)
Seq/√Len: 34.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K201_E4.1881.00
33_L167_V3.9961.00
193_S199_D3.9711.00
87_D91_N3.4471.00
94_A106_H3.4421.00
58_L85_I3.3211.00
112_F129_A3.2951.00
34_K59_E3.1981.00
5_I18_G3.1651.00
27_G163_A3.1491.00
54_G71_L2.8721.00
34_K56_S2.8431.00
116_G119_L2.8081.00
65_S69_R2.6181.00
199_D202_R2.5971.00
132_A138_I2.5391.00
39_A86_V2.3530.99
68_I72_T2.2870.99
17_V31_P2.1820.99
84_G115_Q2.0910.99
16_G142_I2.0680.98
84_G113_T2.0650.98
96_T104_A2.0270.98
195_D198_R2.0250.98
47_N75_D1.9490.98
29_F46_A1.8700.97
165_I187_D1.8210.96
193_S202_R1.7710.96
79_E98_R1.7690.96
92_A108_V1.7570.96
126_E130_K1.7360.95
31_P163_A1.7260.95
7_I138_I1.7220.95
27_G31_P1.7110.95
14_A139_Y1.6980.95
107_I125_L1.6740.94
107_I126_E1.6490.94
114_V129_A1.6260.93
57_L71_L1.6200.93
14_A168_R1.5720.92
109_G112_F1.5080.90
72_T83_I1.5060.90
120_A124_V1.5050.90
68_I85_I1.4990.90
109_G133_E1.4880.90
105_G125_L1.4850.90
64_A91_N1.4500.89
33_L165_I1.4450.88
63_S66_D1.4000.87
96_T100_C1.3860.86
140_E208_V1.3720.86
54_G67_S1.3580.85
32_W51_G1.3540.85
18_G142_I1.3260.84
53_N74_S1.3230.84
40_I54_G1.3160.83
128_M131_E1.3120.83
140_E147_K1.3060.83
136_G144_R1.3060.83
20_A150_E1.3030.83
94_A108_V1.2980.82
64_A87_D1.2940.82
42_T52_I1.2750.81
40_I83_I1.2750.81
139_Y186_V1.2590.80
7_I132_A1.2530.80
70_I73_E1.2490.80
150_E159_K1.2430.80
129_A133_E1.2410.79
112_F133_E1.2400.79
23_F46_A1.2230.78
62_Y70_I1.2150.78
103_Y121_G1.1920.77
68_I83_I1.1810.76
50_Y72_T1.1720.75
66_D69_R1.1620.75
204_L208_V1.1530.74
160_Q192_D1.1430.73
130_K133_E1.1420.73
19_V30_V1.1400.73
94_A113_T1.1340.73
17_V41_A1.1300.73
53_N56_S1.1130.71
8_Y111_N1.1040.71
5_I128_M1.1020.71
84_G94_A1.0980.70
127_A130_K1.0980.70
54_G85_I1.0790.69
140_E201_E1.0720.69
54_G57_L1.0680.68
8_Y15_W1.0440.66
21_S183_G1.0400.66
34_K37_V1.0400.66
87_D92_A1.0350.66
70_I74_S1.0340.66
67_S71_L1.0300.65
44_A100_C1.0170.64
22_K160_Q1.0120.64
57_L62_Y1.0050.63
128_M149_G1.0030.63
146_L166_V0.9980.63
58_L67_S0.9930.62
101_Y118_I0.9810.62
159_K195_D0.9610.60
10_P111_N0.9570.60
166_V190_V0.9540.59
29_F48_L0.9530.59
56_S60_K0.9450.59
109_G190_V0.9380.58
11_D136_G0.9310.57
47_N54_G0.9270.57
62_Y66_D0.9220.57
33_L41_A0.9140.56
33_L39_A0.9060.55
15_W39_A0.9040.55
24_L32_W0.9010.55
9_D184_K0.8980.55
24_L206_L0.8940.54
202_R206_L0.8850.54
7_I122_E0.8800.53
66_D70_I0.8790.53
139_Y164_I0.8790.53
184_K204_L0.8790.53
20_A149_G0.8760.53
3_F128_M0.8750.53
6_V86_V0.8750.53
24_L203_L0.8670.52
192_D202_R0.8660.52
57_L60_K0.8650.52
47_N71_L0.8620.52
7_I42_T0.8610.52
23_F192_D0.8490.51
130_K134_G0.8440.50
122_E126_E0.8440.50
24_L188_L0.8360.49
185_Y211_F0.8360.49
8_Y12_E0.8350.49
106_H149_G0.8290.49
20_A159_K0.8210.48
32_W42_T0.8160.48
10_P110_N0.8120.47
107_I129_A0.8090.47
8_Y64_A0.8070.47
5_I114_V0.8050.47
17_V39_A0.8040.47
57_L70_I0.8020.47
116_G125_L0.7980.46
100_C149_G0.7950.46
28_A48_L0.7940.46
44_A101_Y0.7930.46
72_T78_R0.7920.46
72_T75_D0.7870.45
18_G145_A0.7860.45
44_A80_K0.7860.45
26_V163_A0.7830.45
14_A138_I0.7800.45
143_L164_I0.7750.44
3_F150_E0.7740.44
9_D218_N0.7720.44
100_C104_A0.7700.44
37_V55_L0.7670.44
131_E148_A0.7630.43
58_L78_R0.7600.43
15_W167_V0.7530.43
114_V128_M0.7490.42
121_G151_S0.7490.42
168_R185_Y0.7450.42
166_V200_L0.7430.42
6_V39_A0.7400.41
147_K195_D0.7390.41
37_V59_E0.7270.40
162_A200_L0.7210.40
45_L100_C0.7170.40
26_V161_S0.7140.39
190_V203_L0.7130.39
44_A155_D0.7120.39
63_S91_N0.7110.39
44_A157_R0.7100.39
5_I138_I0.7060.39
147_K198_R0.7020.38
12_E140_E0.7010.38
9_D132_A0.6990.38
22_K155_D0.6970.38
5_I145_A0.6950.38
84_G104_A0.6930.38
110_N133_E0.6910.37
190_V199_D0.6910.37
56_S137_K0.6900.37
59_E122_E0.6870.37
9_D138_I0.6860.37
6_V84_G0.6810.37
214_E218_N0.6800.37
3_F197_L0.6800.37
79_E99_E0.6800.37
23_F209_A0.6750.36
150_E197_L0.6720.36
16_G136_G0.6700.36
147_K197_L0.6670.36
30_V41_A0.6660.36
132_A136_G0.6610.35
114_V132_A0.6560.35
214_E217_V0.6540.35
171_E184_K0.6520.34
64_A67_S0.6480.34
155_D158_G0.6480.34
9_D204_L0.6470.34
3_F125_L0.6460.34
44_A160_Q0.6450.34
213_E217_V0.6440.34
67_S85_I0.6410.34
49_T52_I0.6410.34
121_G124_V0.6390.33
3_F116_G0.6350.33
66_D110_N0.6300.33
75_D199_D0.6290.33
45_L76_P0.6270.33
12_E15_W0.6230.32
22_K46_A0.6220.32
15_W64_A0.6220.32
100_C106_H0.6220.32
60_K195_D0.6190.32
186_V207_W0.6170.32
28_A196_P0.6170.32
216_M219_V0.6150.32
38_G55_L0.6140.32
6_V41_A0.6140.32
22_K29_F0.6090.31
54_G58_L0.6080.31
108_V195_D0.6070.31
40_I67_S0.6050.31
49_T78_R0.6050.31
89_K111_N0.6030.31
143_L204_L0.6020.31
155_D159_K0.6020.31
21_S210_T0.6020.31
103_Y156_R0.6010.31
107_I114_V0.6010.31
201_E205_D0.5990.31
60_K198_R0.5960.30
190_V200_L0.5920.30
96_T103_Y0.5890.30
121_G126_E0.5880.30
71_L78_R0.5870.30
67_S72_T0.5860.30
21_S192_D0.5850.30
47_N193_S0.5810.29
127_A198_R0.5810.29
9_D211_F0.5810.29
21_S163_A0.5800.29
22_K209_A0.5780.29
24_L207_W0.5740.29
136_G171_E0.5710.29
157_R160_Q0.5680.28
91_N151_S0.5680.28
46_A50_Y0.5670.28
192_D199_D0.5660.28
108_V146_L0.5660.28
40_I51_G0.5660.28
17_V32_W0.5650.28
144_R147_K0.5610.28
30_V128_M0.5590.28
46_A183_G0.5580.28
17_V28_A0.5580.28
187_D190_V0.5570.28
17_V86_V0.5500.27
209_A214_E0.5490.27
212_V215_E0.5480.27
127_A131_E0.5470.27
56_S98_R0.5470.27
20_A30_V0.5450.27
206_L210_T0.5420.27
49_T53_N0.5410.27
5_I89_K0.5410.27
100_C155_D0.5400.26
41_A115_Q0.5400.26
54_G68_I0.5390.26
86_V132_A0.5390.26
140_E166_V0.5390.26
106_H113_T0.5330.26
40_I98_R0.5330.26
3_F95_F0.5310.26
188_L203_L0.5300.26
130_K194_P0.5300.26
44_A192_D0.5280.26
69_R73_E0.5280.26
71_L75_D0.5260.26
155_D209_A0.5260.26
217_V221_D0.5250.25
143_L147_K0.5250.25
21_S168_R0.5250.25
9_D186_V0.5230.25
7_I128_M0.5230.25
135_K198_R0.5220.25
64_A93_S0.5210.25
105_G122_E0.5200.25
92_A140_E0.5180.25
29_F155_D0.5160.25
120_A150_E0.5160.25
25_A191_D0.5160.25
45_L101_Y0.5150.25
74_S78_R0.5120.25
197_L201_E0.5100.25
3_F115_Q0.5080.24
59_E195_D0.5080.24
113_T133_E0.5070.24
19_V160_Q0.5070.24
3_F20_A0.5060.24
89_K130_K0.5060.24
15_W24_L0.5050.24
15_W88_S0.5040.24
11_D59_E0.5030.24
80_K101_Y0.5030.24
123_E127_A0.5030.24
213_E216_M0.5030.24
78_R95_F0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2imhA 2 0.8209 100 0.223 Contact Map
2gezB 2 0.4179 76 0.954 Contact Map
4pv2B 2 0.4179 71.7 0.955 Contact Map
1p4kA 2 0.4403 63.4 0.958 Contact Map
1k2xB 2 0.4291 49.4 0.961 Contact Map
1apyB 2 0.4552 39.1 0.963 Contact Map
3c17A 2 0.4366 38.5 0.964 Contact Map
4o0cA 2 0.459 29.2 0.966 Contact Map
2jugA 2 0.1828 9.2 0.973 Contact Map
4xx6A 2 0.2687 9.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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