GREMLIN Database
Q97YH0 - Permease, multidrug efflux
UniProt: Q97YH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 559 (430)
Sequences: 19022 (14543)
Seq/√Len: 701.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_P105_E5.2201.00
86_T178_G5.1851.00
84_I116_G4.2111.00
93_F172_L3.9491.00
208_T256_I3.3471.00
91_L109_F3.2261.00
402_V410_A3.1421.00
212_G250_I3.1401.00
53_G111_I2.9741.00
363_L379_I2.8811.00
216_I246_G2.7901.00
97_N105_E2.7691.00
311_S318_W2.7341.00
99_G108_L2.5761.00
74_R130_D2.5691.00
211_L249_L2.5651.00
268_E406_Y2.5521.00
333_M385_L2.4871.00
92_L109_F2.4611.00
219_A243_M2.4551.00
329_G381_F2.4481.00
204_A256_I2.4471.00
165_I169_Y2.4361.00
61_L115_I2.4061.00
79_N182_T2.3871.00
88_G116_G2.2391.00
162_L169_Y2.2351.00
38_I98_T2.2331.00
185_S189_L2.1991.00
79_N186_Y2.1931.00
223_G234_W2.0871.00
240_I244_V2.0621.00
251_G255_Y2.0541.00
57_V111_I2.0351.00
166_D169_Y2.0201.00
266_R406_Y2.0061.00
439_S443_T1.9961.00
438_A442_P1.9641.00
360_G383_M1.9191.00
88_G112_I1.9141.00
14_G78_Y1.9081.00
183_I187_T1.9061.00
136_E139_K1.8981.00
283_F421_G1.8921.00
287_I425_S1.8891.00
403_P406_Y1.8701.00
65_F119_F1.8581.00
132_F140_A1.8191.00
202_D205_G1.8011.00
138_G342_D1.7941.00
301_Q319_A1.7931.00
79_N185_S1.7841.00
98_T107_I1.7651.00
440_T444_A1.7511.00
12_T147_A1.7271.00
81_G119_F1.7181.00
372_N375_E1.6971.00
75_V79_N1.6861.00
16_L151_G1.6811.00
212_G246_G1.6521.00
215_L242_S1.6271.00
299_F308_H1.6261.00
46_Y98_T1.6221.00
38_I46_Y1.6161.00
89_S174_S1.6101.00
163_S317_F1.6041.00
88_G109_F1.6021.00
270_F276_T1.6021.00
254_I258_N1.5971.00
105_E109_F1.5921.00
338_G342_D1.5831.00
291_G429_F1.5761.00
258_N268_E1.5741.00
67_R71_I1.5721.00
440_T443_T1.5701.00
68_L77_L1.5621.00
95_T105_E1.5611.00
12_T143_I1.5601.00
360_G379_I1.5591.00
7_A131_A1.5521.00
290_G422_Q1.5501.00
203_W207_T1.5461.00
260_V263_P1.5411.00
70_D408_G1.5361.00
246_G250_I1.5331.00
169_Y176_P1.5151.00
360_G386_G1.5091.00
92_L106_L1.5041.00
356_I386_G1.5041.00
311_S316_P1.4961.00
28_S170_I1.4921.00
31_A34_R1.4901.00
276_T280_L1.4721.00
76_R191_E1.4721.00
69_S123_N1.4711.00
374_P378_L1.4631.00
339_W343_R1.4571.00
61_L118_A1.4541.00
253_F257_E1.4521.00
69_S74_R1.4481.00
90_I94_L1.4471.00
439_S442_P1.4381.00
129_T137_R1.4341.00
441_L444_A1.4341.00
53_G107_I1.4331.00
83_L182_T1.4321.00
90_I175_V1.4291.00
43_S46_Y1.4271.00
437_L441_L1.4241.00
256_I260_V1.4181.00
215_L249_L1.4011.00
33_F47_L1.3961.00
66_G70_D1.3931.00
222_Y232_L1.3801.00
60_T210_G1.3771.00
318_W321_I1.3731.00
95_T109_F1.3641.00
348_L351_T1.3621.00
134_F137_R1.3551.00
358_G362_L1.3551.00
329_G333_M1.3461.00
219_A246_G1.3431.00
333_M388_G1.3431.00
133_P136_E1.3291.00
91_L105_E1.3281.00
326_L384_G1.3281.00
212_G249_L1.3241.00
437_L443_T1.3181.00
437_L442_P1.3181.00
345_G348_L1.3141.00
57_V114_G1.2971.00
245_A249_L1.2941.00
278_G398_I1.2931.00
441_L445_L1.2881.00
21_N24_I1.2871.00
21_N174_S1.2871.00
184_W188_K1.2851.00
64_S206_N1.2841.00
8_L132_F1.2801.00
254_I267_L1.2771.00
86_T182_T1.2731.00
360_G382_I1.2631.00
74_R191_E1.2571.00
255_Y258_N1.2561.00
255_Y259_K1.2551.00
442_P446_A1.2491.00
10_N181_G1.2371.00
19_S148_A1.2281.00
353_G390_F1.2271.00
24_I170_I1.2211.00
82_F181_G1.2181.00
310_Y322_Y1.2141.00
241_G245_A1.2081.00
160_G316_P1.2071.00
87_I91_L1.1961.00
50_I106_L1.1951.00
218_I222_Y1.1941.00
13_I181_G1.1901.00
443_T446_A1.1871.00
10_N188_K1.1851.00
373_Y377_A1.1741.00
86_T90_I1.1741.00
300_L322_Y1.1731.00
22_G55_N1.1661.00
374_P377_A1.1661.00
80_L84_I1.1651.00
237_P241_G1.1571.00
353_G389_M1.1561.00
355_V359_I1.1541.00
300_L376_F1.1481.00
53_G57_V1.1411.00
68_L72_F1.1391.00
252_A255_Y1.1381.00
362_L366_L1.1281.00
339_W342_D1.1221.00
75_V191_E1.1201.00
179_I183_I1.1161.00
444_A448_A1.1131.00
347_R351_T1.1101.00
54_Y117_G1.1011.00
445_L448_A1.1001.00
442_P445_L1.0921.00
443_T447_N1.0911.00
310_Y318_W1.0901.00
279_N417_I1.0851.00
70_D74_R1.0841.00
368_P371_F1.0821.00
161_I164_V1.0781.00
362_L365_T1.0761.00
86_T175_V1.0761.00
75_V186_Y1.0751.00
438_A443_T1.0721.00
273_R277_A1.0691.00
163_S311_S1.0681.00
17_M178_G1.0661.00
322_Y373_Y1.0611.00
219_A239_V1.0591.00
79_N83_L1.0551.00
215_L245_A1.0541.00
444_A447_N1.0521.00
437_L440_T1.0511.00
92_L171_F1.0491.00
205_G256_I1.0491.00
182_T186_Y1.0491.00
208_T249_L1.0431.00
158_L161_I1.0431.00
357_V386_G1.0391.00
378_L381_F1.0371.00
250_I254_I1.0351.00
449_V453_G1.0341.00
285_R390_F1.0241.00
78_Y185_S1.0161.00
52_M221_T1.0141.00
273_R276_T1.0121.00
353_G386_G1.0081.00
10_N184_W1.0031.00
128_I144_N1.0021.00
378_L382_I1.0011.00
135_N139_K0.9961.00
243_M247_I0.9861.00
94_L172_L0.9861.00
184_W187_T0.9851.00
77_L119_F0.9841.00
219_A242_S0.9821.00
348_L352_L0.9821.00
6_V188_K0.9811.00
162_L173_V0.9801.00
363_L366_L0.9791.00
275_F279_N0.9781.00
275_F410_A0.9771.00
31_A35_G0.9751.00
421_G425_S0.9741.00
217_L423_T0.9701.00
230_S233_G0.9691.00
200_G262_Y0.9661.00
232_L236_N0.9651.00
73_G76_R0.9631.00
208_T252_A0.9611.00
77_L80_L0.9601.00
232_L238_F0.9591.00
91_L94_L0.9581.00
129_T407_R0.9561.00
232_L239_V0.9561.00
91_L112_I0.9541.00
86_T179_I0.9441.00
72_F77_L0.9441.00
375_E378_L0.9441.00
38_I47_L0.9421.00
63_V209_F0.9391.00
211_L215_L0.9381.00
176_P179_I0.9371.00
283_F417_I0.9361.00
272_I403_P0.9361.00
265_F413_M0.9311.00
108_L111_I0.9301.00
187_T190_K0.9301.00
25_T50_I0.9301.00
367_L371_F0.9261.00
220_I223_G0.9241.00
328_I332_T0.9241.00
81_G116_G0.9201.00
200_G261_K0.9191.00
105_E108_L0.9181.00
238_F242_S0.9181.00
99_G105_E0.9121.00
438_A441_L0.9091.00
335_P339_W0.9091.00
175_V179_I0.9081.00
445_L449_V0.9071.00
191_E194_V0.9061.00
361_F383_M0.9061.00
49_W53_G0.9031.00
84_I88_G0.9021.00
336_I339_W0.8991.00
442_P448_A0.8961.00
138_G338_G0.8951.00
377_A381_F0.8951.00
11_T124_S0.8941.00
272_I406_Y0.8941.00
272_I276_T0.8931.00
96_P99_G0.8881.00
207_T211_L0.8861.00
237_P240_I0.8861.00
5_W9_S0.8831.00
235_G240_I0.8831.00
295_M430_F0.8821.00
326_L383_M0.8821.00
361_F365_T0.8801.00
76_R80_L0.8791.00
352_L356_I0.8791.00
367_L379_I0.8781.00
279_N413_M0.8771.00
351_T358_G0.8771.00
236_N239_V0.8751.00
24_I159_G0.8721.00
108_L112_I0.8691.00
18_A120_L0.8691.00
266_R409_V0.8691.00
258_N267_L0.8671.00
149_L330_F0.8661.00
70_D409_V0.8661.00
398_I414_R0.8601.00
432_I436_S0.8571.00
57_V61_L0.8571.00
74_R126_A0.8561.00
318_W322_Y0.8561.00
127_I131_A0.8521.00
447_N451_Q0.8491.00
442_P453_G0.8471.00
96_P168_R0.8461.00
256_I259_K0.8461.00
196_S199_E0.8451.00
142_G146_I0.8451.00
340_L344_Y0.8441.00
201_I206_N0.8421.00
222_Y231_Q0.8411.00
333_M336_I0.8371.00
234_W239_V0.8361.00
340_L349_L0.8351.00
437_L444_A0.8311.00
395_T414_R0.8311.00
301_Q316_P0.8311.00
126_A408_G0.8311.00
24_I173_V0.8251.00
239_V242_S0.8211.00
32_I106_L0.8201.00
431_T435_I0.8201.00
88_G91_L0.8201.00
138_G142_G0.8171.00
440_T447_N0.8171.00
247_I250_I0.8161.00
14_G120_L0.8111.00
211_L245_A0.8061.00
78_Y127_I0.8031.00
389_M393_P0.8031.00
298_I302_G0.8011.00
10_N185_S0.8001.00
446_A449_V0.7981.00
252_A256_I0.7981.00
281_A394_N0.7951.00
60_T214_I0.7941.00
51_L294_I0.7921.00
247_I251_G0.7881.00
428_L431_T0.7881.00
251_G254_I0.7871.00
352_L389_M0.7861.00
235_G238_F0.7841.00
354_M390_F0.7831.00
369_Y372_N0.7831.00
50_I98_T0.7821.00
297_I319_A0.7791.00
333_M389_M0.7781.00
329_G385_L0.7731.00
59_A423_T0.7721.00
300_L308_H0.7711.00
130_D407_R0.7711.00
303_I308_H0.7701.00
351_T355_V0.7661.00
36_I98_T0.7661.00
161_I317_F0.7631.00
176_P180_L0.7621.00
69_S126_A0.7601.00
333_M337_S0.7601.00
125_A144_N0.7601.00
442_P449_V0.7601.00
230_S234_W0.7571.00
345_G349_L0.7571.00
164_V317_F0.7531.00
371_F375_E0.7531.00
146_I150_A0.7521.00
210_G214_I0.7521.00
244_V248_G0.7491.00
66_G412_G0.7491.00
236_N240_I0.7431.00
85_F116_G0.7411.00
337_S389_M0.7391.00
205_G260_V0.7391.00
29_L47_L0.7381.00
35_G167_W0.7381.00
349_L352_L0.7371.00
241_G244_V0.7361.00
344_Y349_L0.7341.00
213_L420_T0.7331.00
274_M401_S0.7301.00
172_L176_P0.7301.00
80_L83_L0.7301.00
366_L379_I0.7291.00
249_L252_A0.7281.00
35_G168_R0.7271.00
268_E271_K0.7261.00
321_I325_P0.7251.00
139_K339_W0.7251.00
16_L147_A0.7221.00
248_G252_A0.7181.00
375_E379_I0.7181.00
344_Y348_L0.7181.00
58_T419_N0.7171.00
364_L367_L0.7171.00
74_R192_I0.7141.00
243_M246_G0.7141.00
19_S151_G0.7131.00
141_L145_Q0.7101.00
28_S32_I0.7101.00
443_T448_A0.7091.00
436_S440_T0.7091.00
162_L165_I0.7081.00
83_L87_I0.7081.00
443_T451_Q0.7061.00
356_I382_I0.7051.00
160_G320_G0.7051.00
17_M174_S0.7021.00
292_L383_M0.7021.00
15_V148_A0.7021.00
26_L51_L0.7021.00
92_L95_T0.6971.00
282_S414_R0.6971.00
438_A445_L0.6951.00
47_L298_I0.6951.00
148_A152_S0.6921.00
211_L214_I0.6921.00
341_S396_A0.6911.00
75_V190_K0.6911.00
238_F241_G0.6891.00
58_T117_G0.6871.00
153_L327_M0.6861.00
350_A397_S0.6841.00
443_T449_V0.6841.00
33_F38_I0.6841.00
32_I35_G0.6831.00
57_V115_I0.6831.00
5_W139_K0.6821.00
359_I363_L0.6821.00
199_E262_Y0.6821.00
399_M411_S0.6811.00
209_F264_M0.6791.00
128_I140_A0.6771.00
439_S444_A0.6761.00
396_A400_N0.6741.00
94_L109_F0.6731.00
448_A452_A0.6731.00
446_A450_T0.6721.00
90_I172_L0.6711.00
8_L140_A0.6641.00
337_S388_G0.6631.00
271_K276_T0.6591.00
131_A190_K0.6591.00
65_F122_A0.6571.00
14_G82_F0.6541.00
415_A418_Q0.6541.00
275_F398_I0.6541.00
245_A252_A0.6541.00
272_I401_S0.6501.00
145_Q149_L0.6491.00
454_A458_A0.6491.00
341_S393_P0.6481.00
21_N85_F0.6471.00
212_G254_I0.6471.00
257_E260_V0.6461.00
130_D192_I0.6451.00
430_F434_I0.6451.00
147_A151_G0.6451.00
89_S113_Q0.6431.00
169_Y172_L0.6421.00
354_M358_G0.6421.00
294_I426_M0.6421.00
7_A10_N0.6401.00
54_Y85_F0.6391.00
163_S166_D0.6381.00
60_T206_N0.6361.00
335_P338_G0.6361.00
151_G156_L0.6331.00
5_W132_F0.6321.00
356_I385_L0.6291.00
279_N414_R0.6271.00
442_P447_N0.6261.00
444_A450_T0.6261.00
439_S452_A0.6251.00
163_S316_P0.6251.00
321_I324_I0.6241.00
59_A420_T0.6241.00
57_V116_G0.6211.00
55_N422_Q0.6171.00
157_I324_I0.6171.00
66_G408_G0.6171.00
440_T446_A0.6161.00
132_F136_E0.6141.00
443_T450_T0.6131.00
151_G155_G0.6121.00
289_Y387_N0.6121.00
55_N423_T0.6111.00
168_R172_L0.6101.00
126_A411_S0.6081.00
186_Y190_K0.6051.00
453_G457_L0.6051.00
319_A323_T0.6041.00
88_G113_Q0.6031.00
17_M82_F0.6021.00
282_S394_N0.6021.00
311_S317_F0.6001.00
208_T253_F0.6001.00
204_A207_T0.6001.00
6_V9_S0.5991.00
204_A208_T0.5981.00
141_L396_A0.5981.00
124_S144_N0.5971.00
218_I242_S0.5961.00
129_T141_L0.5961.00
93_F168_R0.5951.00
82_F182_T0.5941.00
69_S408_G0.5921.00
443_T453_G0.5911.00
205_G257_E0.5911.00
109_F112_I0.5891.00
25_T171_F0.5891.00
223_G239_V0.5891.00
204_A260_V0.5881.00
21_N89_S0.5871.00
392_S395_T0.5861.00
137_R400_N0.5831.00
139_K143_I0.5821.00
442_P451_Q0.5801.00
438_A452_A0.5791.00
206_N210_G0.5791.00
32_I47_L0.5781.00
296_L380_I0.5781.00
223_G232_L0.5771.00
222_Y239_V0.5771.00
311_S319_A0.5771.00
442_P450_T0.5771.00
70_D73_G0.5761.00
423_T427_A0.5761.00
326_L380_I0.5751.00
439_S445_L0.5751.00
325_P329_G0.5751.00
325_P377_A0.5741.00
300_L310_Y0.5741.00
377_A380_I0.5741.00
236_N241_G0.5731.00
364_L380_I0.5721.00
450_T454_A0.5721.00
438_A444_A0.5721.00
355_V358_G0.5711.00
54_Y110_R0.5701.00
149_L334_G0.5691.00
442_P452_A0.5691.00
446_A452_A0.5671.00
20_I24_I0.5671.00
16_L154_V0.5671.00
193_S196_S0.5671.00
72_F76_R0.5661.00
66_G123_N0.5651.00
29_L51_L0.5651.00
283_F424_L0.5651.00
72_F201_I0.5631.00
183_I186_Y0.5621.00
52_M430_F0.5621.00
282_S286_S0.5621.00
399_M407_R0.5611.00
23_T155_G0.5591.00
201_I205_G0.5591.00
50_I53_G0.5581.00
322_Y377_A0.5561.00
274_M277_A0.5561.00
111_I115_I0.5551.00
206_N264_M0.5551.00
49_W56_V0.5541.00
22_G418_Q0.5541.00
258_N261_K0.5531.00
281_A354_M0.5511.00
137_R418_Q0.5511.00
215_L246_G0.5491.00
21_N54_Y0.5481.00
352_L355_V0.5481.00
172_L175_V0.5471.00
446_A453_G0.5461.00
19_S152_S0.5461.00
96_P109_F0.5461.00
26_L294_I0.5451.00
222_Y238_F0.5451.00
92_L113_Q0.5431.00
353_G360_G0.5431.00
190_K193_S0.5421.00
407_R411_S0.5411.00
152_S327_M0.5411.00
17_M21_N0.5401.00
453_G458_A0.5401.00
288_A361_F0.5391.00
357_V360_G0.5391.00
65_F118_A0.5371.00
128_I131_A0.5371.00
353_G393_P0.5351.00
125_A411_S0.5341.00
110_R113_Q0.5341.00
31_A301_Q0.5341.00
142_G145_Q0.5341.00
15_V124_S0.5331.00
308_H371_F0.5321.00
21_N110_R0.5321.00
359_I362_L0.5311.00
7_A127_I0.5301.00
322_Y325_P0.5301.00
310_Y373_Y0.5291.00
23_T152_S0.5291.00
275_F402_V0.5281.00
332_T335_P0.5271.00
218_I238_F0.5271.00
390_F393_P0.5271.00
154_V158_L0.5271.00
71_I198_S0.5261.00
427_A431_T0.5251.00
234_W240_I0.5251.00
84_I112_I0.5241.00
329_G332_T0.5231.00
174_S178_G0.5221.00
32_I36_I0.5221.00
370_N373_Y0.5221.00
74_R127_I0.5201.00
191_E195_P0.5181.00
253_F265_F0.5171.00
270_F413_M0.5151.00
233_G236_N0.5151.00
76_R79_N0.5140.99
297_I323_T0.5140.99
47_L98_T0.5130.99
286_S418_Q0.5130.99
385_L389_M0.5130.99
290_G418_Q0.5110.99
274_M278_G0.5100.99
275_F413_M0.5090.99
395_T399_M0.5080.99
80_L119_F0.5070.99
157_I321_I0.5070.99
341_S345_G0.5070.99
93_F169_Y0.5070.99
78_Y82_F0.5060.99
154_V157_I0.5060.99
46_Y99_G0.5060.99
442_P456_Q0.5050.99
384_G388_G0.5040.99
276_T279_N0.5040.99
437_L445_L0.5030.99
381_F385_L0.5020.99
433_V436_S0.5010.99
119_F123_N0.5010.99
308_H311_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.7406 100 0.508 Contact Map
1pw4A 1 0.7245 100 0.512 Contact Map
4j05A 3 0.6816 100 0.519 Contact Map
3wdoA 1 0.7979 100 0.524 Contact Map
4zw9A 1 0.7764 100 0.529 Contact Map
4gc0A 1 0.771 100 0.537 Contact Map
2gfpA 2 0.6691 100 0.541 Contact Map
4ldsA 2 0.7317 100 0.543 Contact Map
4tphA 2 0.7406 100 0.552 Contact Map
3o7qA 1 0.6852 100 0.561 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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