GREMLIN Database
Q97YG5 - Dolichyl-phosphate mannose synthase related protein
UniProt: Q97YG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (191)
Sequences: 46667 (38611)
Seq/√Len: 2793.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_R175_V3.2591.00
34_E105_A3.1871.00
35_E63_N2.8421.00
26_S97_F2.5091.00
58_F77_I2.4151.00
191_N195_A2.3901.00
31_A64_T2.3591.00
90_R94_E2.2921.00
65_P69_K2.1691.00
116_K208_I2.1011.00
122_A204_K2.0501.00
28_I91_G2.0311.00
53_E74_K1.9951.00
57_V91_G1.9691.00
63_N66_E1.9661.00
24_M98_Q1.9461.00
39_G43_E1.9401.00
88_L104_D1.9331.00
29_I54_V1.8941.00
173_K201_Y1.8571.00
26_S53_E1.8491.00
39_G71_F1.8471.00
40_K108_P1.8361.00
84_K88_L1.7771.00
65_P77_I1.7741.00
78_S90_R1.7721.00
76_I94_E1.7721.00
82_L86_M1.7441.00
35_E67_V1.7391.00
39_G67_V1.7211.00
117_I168_L1.7051.00
65_P75_L1.7011.00
99_R168_L1.6971.00
101_L168_L1.6791.00
25_I118_L1.6741.00
113_E117_I1.6741.00
109_I113_E1.6621.00
56_V68_V1.6351.00
123_D170_N1.6291.00
43_E71_F1.6021.00
24_M51_N1.5891.00
29_I41_T1.5741.00
32_F81_R1.5601.00
74_K94_E1.5111.00
31_A56_V1.4871.00
39_G70_K1.4681.00
69_K77_I1.4491.00
33_N61_H1.4371.00
53_E97_F1.4311.00
90_R93_T1.4271.00
88_L102_L1.4131.00
76_I90_R1.4081.00
85_G188_F1.3991.00
31_A34_E1.3991.00
49_L118_L1.3931.00
112_E116_K1.3811.00
101_L114_L1.3731.00
43_E47_S1.3671.00
93_T179_D1.3381.00
92_I174_V1.3361.00
110_T211_I1.3321.00
103_L109_I1.3301.00
59_D81_R1.3001.00
101_L113_E1.2971.00
34_E37_R1.2851.00
116_K119_S1.2821.00
176_S199_R1.2781.00
176_S201_Y1.2751.00
115_N119_S1.2741.00
26_S95_S1.2651.00
172_E176_S1.2541.00
68_V75_L1.2531.00
123_D201_Y1.2441.00
79_K82_L1.2391.00
100_V171_R1.2381.00
67_V71_F1.2181.00
31_A105_A1.2141.00
58_F78_S1.2131.00
25_I114_L1.1921.00
42_L71_F1.1881.00
67_V70_K1.1811.00
24_M97_F1.1741.00
49_L52_A1.1561.00
167_K193_I1.1461.00
173_K196_F1.1401.00
58_F65_P1.1311.00
181_L184_N1.1271.00
40_K213_D1.1261.00
26_S55_V1.1251.00
117_I127_P1.1141.00
95_S171_R1.1121.00
79_K90_R1.1061.00
98_Q170_N1.1031.00
92_I102_L1.0931.00
84_K188_F1.0861.00
86_M182_I1.0831.00
172_E175_V1.0741.00
63_N67_V1.0611.00
42_L54_V1.0591.00
124_L203_I1.0561.00
57_V87_A1.0531.00
53_E96_N1.0441.00
170_N173_K1.0401.00
46_S72_P1.0241.00
25_I168_L1.0231.00
44_K109_I1.0211.00
124_L196_F0.9961.00
66_E69_K0.9871.00
92_I100_V0.9791.00
30_P87_A0.9751.00
84_K164_A0.9731.00
78_S82_L0.9611.00
41_T103_L0.9581.00
86_M90_R0.9561.00
78_S87_A0.9511.00
54_V73_V0.9461.00
66_E70_K0.9351.00
101_L109_I0.9341.00
74_K96_N0.9291.00
181_L191_N0.9271.00
84_K104_D0.9221.00
47_S111_E0.9201.00
93_T180_E0.9201.00
45_I54_V0.9161.00
24_M96_N0.9141.00
88_L188_F0.9041.00
116_K206_V0.9031.00
42_L56_V0.9031.00
43_E46_S0.9031.00
45_I103_L0.9001.00
128_R205_E0.8971.00
59_D87_A0.8931.00
112_E115_N0.8901.00
129_R165_G0.8831.00
174_V192_L0.8791.00
27_V45_I0.8791.00
46_S71_F0.8751.00
65_P78_S0.8381.00
123_D202_K0.8381.00
79_K86_M0.8281.00
44_K108_P0.8251.00
130_K209_N0.8231.00
113_E127_P0.8181.00
178_L181_L0.8071.00
27_V101_L0.7941.00
121_D202_K0.7851.00
59_D82_L0.7841.00
130_K211_I0.7831.00
40_K43_E0.7801.00
110_T113_E0.7781.00
99_R118_L0.7761.00
117_I125_V0.7611.00
42_L46_S0.7541.00
57_V90_R0.7501.00
31_A38_I0.7481.00
89_K93_T0.7471.00
46_S73_V0.7461.00
31_A68_V0.7391.00
52_A114_L0.7381.00
118_L168_L0.7361.00
30_P105_A0.7331.00
52_A72_P0.7321.00
85_G89_K0.7261.00
75_L78_S0.7251.00
177_V199_R0.7251.00
92_I95_S0.7241.00
196_F201_Y0.7201.00
164_A167_K0.7161.00
99_R170_N0.7151.00
59_D83_G0.7141.00
108_P211_I0.7111.00
134_M137_K0.7081.00
23_K98_Q0.7071.00
55_V94_E0.7071.00
82_L87_A0.7051.00
128_R207_E0.7051.00
113_E166_V0.7001.00
30_P88_L0.6991.00
38_I67_V0.6971.00
44_K112_E0.6961.00
69_K78_S0.6921.00
33_N58_F0.6891.00
61_H64_T0.6861.00
137_K140_F0.6851.00
87_A104_D0.6851.00
95_S100_V0.6831.00
35_E39_G0.6831.00
38_I105_A0.6821.00
177_V196_F0.6811.00
147_V151_I0.6801.00
113_E116_K0.6801.00
41_T44_K0.6791.00
60_G81_R0.6781.00
110_T130_K0.6741.00
84_K87_A0.6741.00
210_Y213_D0.6721.00
27_V114_L0.6671.00
55_V91_G0.6631.00
128_R131_I0.6621.00
48_T115_N0.6611.00
122_A126_I0.6561.00
69_K75_L0.6521.00
98_Q172_E0.6501.00
45_I109_I0.6481.00
32_F59_D0.6471.00
145_F149_T0.6451.00
25_I101_L0.6441.00
38_I68_V0.6411.00
65_P68_V0.6401.00
138_R141_L0.6381.00
169_V174_V0.6351.00
55_V74_K0.6341.00
29_I105_A0.6301.00
58_F61_H0.6301.00
32_F60_G0.6291.00
136_L140_F0.6281.00
173_K176_S0.6251.00
87_A90_R0.6251.00
123_D173_K0.6221.00
117_I166_V0.6191.00
187_L190_V0.6171.00
35_E66_E0.6121.00
41_T45_I0.6091.00
173_K177_V0.6071.00
132_I136_L0.6071.00
137_K141_L0.6021.00
26_S96_N0.6011.00
192_L196_F0.6011.00
206_V209_N0.5981.00
169_V193_I0.5971.00
78_S81_R0.5921.00
100_V174_V0.5881.00
144_A147_V0.5871.00
56_V73_V0.5861.00
169_V192_L0.5851.00
148_L151_I0.5831.00
122_A125_V0.5821.00
120_T204_K0.5801.00
104_D188_F0.5791.00
30_P59_D0.5761.00
84_K189_D0.5751.00
102_L169_V0.5751.00
29_I45_I0.5721.00
40_K44_K0.5701.00
51_N72_P0.5701.00
190_V194_Y0.5701.00
24_M118_L0.5671.00
120_T123_D0.5661.00
44_K211_I0.5661.00
49_L115_N0.5661.00
151_I154_P0.5661.00
169_V196_F0.5651.00
50_P115_N0.5641.00
101_L166_V0.5621.00
89_K180_E0.5611.00
33_N64_T0.5601.00
139_R143_K0.5601.00
123_D172_E0.5591.00
108_P213_D0.5561.00
109_I114_L0.5491.00
37_R40_K0.5451.00
29_I56_V0.5421.00
55_V95_S0.5411.00
149_T153_F0.5371.00
28_I57_V0.5371.00
24_M49_L0.5361.00
102_L180_E0.5361.00
37_R41_T0.5331.00
179_D192_L0.5331.00
136_L139_R0.5311.00
82_L90_R0.5311.00
123_D127_P0.5301.00
84_K102_L0.5291.00
126_I205_E0.5251.00
24_M52_A0.5231.00
24_M53_E0.5211.00
23_K49_L0.5171.00
86_M183_I0.5141.00
27_V52_A0.5121.00
126_I129_R0.5121.00
174_V179_D0.5051.00
48_T112_E0.5031.00
173_K200_H0.5031.00
122_A202_K0.5021.00
35_E38_I0.5001.00
41_T107_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0 100 0.343 Contact Map
3bcvA 2 0.7412 100 0.349 Contact Map
1qg8A 1 0.8202 100 0.353 Contact Map
2z86A 2 0.9649 100 0.356 Contact Map
1xhbA 1 0.9561 100 0.361 Contact Map
2d7iA 1 1 100 0.368 Contact Map
5ajoA 1 1 100 0.378 Contact Map
4fixA 3 0.9956 100 0.393 Contact Map
3ckjA 2 0.9518 100 0.394 Contact Map
2bo4A 4 0.864 100 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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