GREMLIN Database
Q97YF7 - Second ORF in transposon ISC1316
UniProt: Q97YF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (213)
Sequences: 4758 (2898)
Seq/√Len: 198.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_D110_K4.7231.00
180_A210_N3.8031.00
128_H131_Q3.3921.00
160_L167_L3.1911.00
153_R169_L2.7771.00
123_V219_S2.6571.00
151_E155_V2.6121.00
113_K117_E2.5921.00
124_M156_L2.4621.00
47_L152_L2.4451.00
133_V145_S2.3831.00
8_V20_I2.3651.00
190_S193_D2.2051.00
157_K169_L2.1891.00
218_G221_S2.1651.00
178_T185_V2.0821.00
174_Y177_K2.0821.00
66_L142_R2.0811.00
116_A160_L2.0101.00
175_T215_I1.9621.00
65_A103_L1.9541.00
197_V204_I1.9241.00
109_M155_V1.9241.00
138_R141_R1.9121.00
151_E154_D1.8851.00
109_M158_Y1.8831.00
170_V215_I1.8611.00
177_K189_L1.8061.00
105_T151_E1.7831.00
72_L89_A1.7661.00
122_V160_L1.7541.00
6_W25_D1.7421.00
181_R203_W1.7241.00
40_I48_L1.7011.00
152_L156_L1.6891.00
109_M159_Q1.6841.00
112_G155_V1.6801.00
108_Y155_V1.6701.00
182_C201_C1.6641.00
47_L107_L1.6521.00
109_M112_G1.6421.00
124_M167_L1.6211.00
120_D165_K1.6141.00
108_Y151_E1.5661.00
194_R207_R1.5561.00
198_C201_C1.4901.00
89_A93_L1.4811.00
182_C198_C1.4751.00
84_H87_F1.4611.00
157_K161_E1.4591.00
76_L90_K1.4481.00
124_M169_L1.4351.00
179_C182_C1.4181.00
124_M153_R1.4161.00
196_F205_A1.3701.00
38_V119_Y1.3691.00
50_T54_E1.3461.00
49_V209_Y1.3411.00
196_F203_W1.3401.00
125_E172_P1.3341.00
179_C198_C1.3341.00
179_C201_C1.3331.00
98_E102_N1.3261.00
126_D169_L1.3191.00
79_K89_A1.3141.00
17_R98_E1.3131.00
37_V216_L1.3101.00
186_K189_L1.3091.00
75_E79_K1.2821.00
87_F90_K1.2761.00
112_G158_Y1.2521.00
213_L217_R1.2521.00
186_K196_F1.2501.00
46_K49_V1.2501.00
82_L86_W1.2391.00
37_V121_V1.2331.00
13_T16_E1.2291.00
180_A213_L1.2251.00
68_K72_L1.2211.00
72_L75_E1.2211.00
114_W118_H1.1941.00
11_K21_T1.1911.00
184_Y199_P1.1851.00
15_S98_E1.1821.00
39_A216_L1.1781.00
144_L149_F1.1611.00
40_I50_T1.1541.00
112_G159_Q1.1531.00
128_H172_P1.1531.00
112_G152_L1.1471.00
195_V204_I1.1391.00
116_A163_Y1.1221.00
186_K199_P1.1111.00
38_V50_T1.1041.00
42_V153_R1.0831.00
155_V158_Y1.0691.00
42_V149_F1.0601.00
186_K190_S1.0571.00
117_E163_Y1.0471.00
69_V97_Y1.0461.00
180_A205_A1.0431.00
189_L193_D1.0371.00
105_T155_V1.0271.00
76_L89_A1.0261.00
72_L96_A1.0241.00
13_T17_R1.0191.00
184_Y200_N1.0171.00
73_H77_S1.0131.00
37_V220_G1.0081.00
116_A165_K1.0081.00
157_K167_L1.0061.00
108_Y152_L1.0051.00
65_A100_L1.0041.00
191_L194_R0.9981.00
159_Q162_K0.9931.00
51_S212_S0.9921.00
44_V147_V0.9901.00
178_T218_G0.9811.00
113_K163_Y0.9780.99
209_Y213_L0.9740.99
170_V218_G0.9730.99
34_T120_D0.9520.99
49_V55_Y0.9500.99
205_A213_L0.9490.99
170_V219_S0.9480.99
175_T218_G0.9450.99
108_Y112_G0.9410.99
76_L93_L0.9360.99
160_L165_K0.9290.99
177_K187_N0.9260.99
205_A209_Y0.9150.99
154_D157_K0.9100.99
69_V93_L0.9040.99
7_R23_V0.9030.99
36_K120_D0.9020.99
138_R145_S0.8650.99
191_L207_R0.8540.99
17_R102_N0.8520.99
79_K85_N0.8510.99
172_P175_T0.8470.99
150_G154_D0.8450.99
9_V21_T0.8440.99
177_K185_V0.8430.99
133_V141_R0.8410.98
61_P103_L0.8390.98
37_V123_V0.8380.98
108_Y148_G0.8360.98
86_W90_K0.8290.98
210_N214_N0.8290.98
69_V77_S0.8240.98
99_H103_L0.8190.98
189_L196_F0.8180.98
121_V168_I0.8160.98
123_V215_I0.8160.98
73_H93_L0.8080.98
126_D172_P0.8070.98
174_Y218_G0.8000.98
55_Y206_D0.7960.98
92_K95_R0.7960.98
121_V166_K0.7950.98
101_K105_T0.7940.98
44_V143_R0.7920.98
180_A211_A0.7900.98
13_T98_E0.7830.98
190_S194_R0.7820.98
90_K94_A0.7790.98
112_G156_L0.7790.98
69_V100_L0.7760.97
123_V168_I0.7760.97
72_L92_K0.7740.97
10_V20_I0.7590.97
61_P65_A0.7570.97
194_R206_D0.7560.97
209_Y212_S0.7550.97
126_D153_R0.7520.97
71_H75_E0.7490.97
116_A122_V0.7470.97
51_S55_Y0.7450.97
33_N36_K0.7420.97
107_L111_L0.7410.97
58_N147_V0.7410.97
62_Y66_L0.7370.97
76_L86_W0.7360.96
70_K74_R0.7360.96
46_K55_Y0.7300.96
31_L165_K0.7280.96
115_F122_V0.7250.96
73_H97_Y0.7250.96
180_A203_W0.7250.96
190_S207_R0.7130.96
102_N106_D0.7090.96
46_K57_P0.7080.96
177_K188_D0.7070.96
85_N88_K0.7040.95
58_N61_P0.7020.95
111_L114_W0.7010.95
48_L111_L0.7000.95
158_Y162_K0.7000.95
96_A100_L0.6990.95
44_V133_V0.6990.95
129_A150_G0.6990.95
129_A149_F0.6900.95
193_D196_F0.6900.95
168_I219_S0.6890.95
178_T214_N0.6880.95
193_D207_R0.6790.95
65_A69_V0.6780.94
113_K159_Q0.6760.94
123_V216_L0.6740.94
43_G49_V0.6740.94
180_A217_R0.6710.94
75_E78_R0.6680.94
72_L93_L0.6680.94
140_L144_L0.6670.94
11_K14_R0.6660.94
28_F162_K0.6660.94
55_Y209_Y0.6650.94
82_L87_F0.6640.94
195_V205_A0.6630.94
31_L34_T0.6590.94
49_V56_F0.6510.93
174_Y185_V0.6480.93
177_K186_K0.6470.93
69_V73_H0.6460.93
211_A214_N0.6410.93
54_E114_W0.6400.93
133_V138_R0.6390.93
62_Y65_A0.6350.92
117_E121_V0.6340.92
70_K73_H0.6280.92
105_T109_M0.6270.92
83_S86_W0.6260.92
74_R77_S0.6240.92
28_F161_E0.6210.91
50_T115_F0.6190.91
127_I172_P0.6160.91
155_V159_Q0.6130.91
42_V48_L0.6120.91
5_H8_V0.6110.91
56_F111_L0.6110.91
51_S209_Y0.6080.91
110_K113_K0.6070.91
100_L146_D0.6040.90
133_V139_S0.6030.90
74_R78_R0.6020.90
68_K96_A0.6020.90
35_G120_D0.6010.90
178_T187_N0.6010.90
38_V122_V0.6010.90
52_D119_Y0.5990.90
104_R146_D0.5990.90
213_L216_L0.5970.90
70_K77_S0.5960.90
39_A123_V0.5950.90
63_E66_L0.5910.89
181_R213_L0.5900.89
153_R157_K0.5900.89
65_A96_A0.5890.89
87_F91_V0.5830.89
97_Y104_R0.5810.89
181_R205_A0.5800.88
8_V22_F0.5800.88
11_K23_V0.5800.88
47_L112_G0.5770.88
188_D193_D0.5770.88
64_K67_W0.5750.88
47_L108_Y0.5730.88
38_V51_S0.5720.88
132_L144_L0.5720.88
131_Q172_P0.5690.88
111_L152_L0.5680.87
77_S93_L0.5670.87
205_A210_N0.5640.87
150_G153_R0.5640.87
191_L206_D0.5640.87
47_L147_V0.5630.87
215_I218_G0.5620.87
45_E49_V0.5620.87
46_K206_D0.5610.87
140_L143_R0.5610.87
71_H74_R0.5570.86
173_A177_K0.5550.86
76_L79_K0.5520.86
189_L207_R0.5510.86
119_Y122_V0.5490.86
102_N105_T0.5470.85
48_L152_L0.5460.85
174_Y178_T0.5460.85
56_F59_L0.5420.85
93_L97_Y0.5420.85
13_T18_I0.5410.85
75_E92_K0.5400.85
153_R167_L0.5360.84
86_W89_A0.5360.84
109_M113_K0.5360.84
100_L104_R0.5300.84
16_E98_E0.5280.83
196_F207_R0.5270.83
178_T183_G0.5260.83
197_V203_W0.5230.83
11_K18_I0.5220.83
65_A99_H0.5200.82
39_A51_S0.5200.82
176_S189_L0.5180.82
141_R145_S0.5180.82
63_E143_R0.5170.82
187_N190_S0.5160.82
122_V156_L0.5160.82
113_K155_V0.5150.82
123_V218_G0.5140.82
112_G115_F0.5140.82
48_L124_M0.5120.81
142_R146_D0.5070.81
189_L194_R0.5060.81
131_Q140_L0.5050.81
187_N196_F0.5050.81
178_T196_F0.5050.81
217_R220_G0.5040.80
75_E89_A0.5020.80
68_K71_H0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.5792 93.1 0.906 Contact Map
1nu0A 1 0.5417 92.5 0.908 Contact Map
1iv0A 1 0.4042 88.5 0.916 Contact Map
4aybP 1 0.1792 88.2 0.916 Contact Map
1vq8Z 1 0.275 86.3 0.919 Contact Map
3j20Y 1 0.2083 85.6 0.92 Contact Map
1ffkW 1 0.2625 84.1 0.921 Contact Map
1qypA 1 0.1917 83 0.922 Contact Map
2k4xA 1 0.2292 82.2 0.923 Contact Map
1vd4A 1 0.2333 81.4 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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