GREMLIN Database
Q97YF6 - Pyruvate dehydrogenase, alpha subunit (Lipoamide). (PdhA-1)
UniProt: Q97YF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (316)
Sequences: 5188 (2872)
Seq/√Len: 161.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_K316_E4.2171.00
180_A224_Y3.5941.00
306_D309_I3.5571.00
194_I250_A3.0921.00
247_I251_R2.9891.00
248_E252_K2.7741.00
169_A197_I2.7631.00
229_Y245_K2.7411.00
307_S311_A2.7151.00
106_K327_F2.6211.00
78_T168_F2.6011.00
60_R329_I2.5291.00
164_V247_I2.4961.00
190_E213_S2.4701.00
230_L262_L2.4551.00
36_I96_H2.3921.00
300_L307_S2.3891.00
89_V152_A2.3271.00
35_I320_Q2.3211.00
150_A182_T2.2901.00
296_E300_L2.2471.00
249_R254_F2.2381.00
249_R257_T2.2291.00
156_F165_A2.2151.00
338_D341_G2.1991.00
22_K25_D2.1661.00
305_A310_L2.1381.00
106_K323_E2.1331.00
326_D330_N2.0811.00
296_E314_R2.0531.00
285_F288_S2.0161.00
78_T243_S1.9931.00
156_F161_K1.9871.00
146_F179_F1.9691.00
83_R162_D1.9621.00
297_N301_R1.9521.00
179_F183_L1.9381.00
312_R316_E1.8791.00
221_G228_S1.8791.00
319_K323_E1.8741.00
235_D238_D1.8451.00
296_E310_L1.8311.00
250_A257_T1.8141.00
85_E163_N1.7751.00
197_I217_H1.7691.00
150_A195_I1.7331.00
28_N32_R1.7311.00
196_V261_A1.7301.00
234_M266_Y1.7131.00
156_F163_N1.7061.00
78_T166_I1.6961.00
117_T331_S1.6941.00
172_G203_A1.6751.00
231_V242_T1.6581.00
300_L310_L1.6131.00
23_A309_I1.6101.00
227_P249_R1.6051.00
227_P255_G1.5641.00
153_A193_L1.5591.00
229_Y242_T1.5571.00
78_T196_V1.5541.00
26_L299_L1.5361.00
123_K342_G1.5161.00
309_I312_R1.5071.00
29_M236_V1.4911.00
146_F182_T1.4711.00
219_Q222_L1.4701.00
199_D260_E1.4671.00
246_A257_T1.4651.00
29_M80_Y1.4601.00
327_F331_S1.4521.00
323_E327_F1.4501.00
298_R302_L1.4371.00
154_F158_Y1.4321.00
169_A173_A1.4291.00
244_K248_E1.4041.00
27_L309_I1.3891.00
121_K342_G1.3831.00
104_D107_G1.3711.00
34_L317_A1.3691.00
234_M263_T1.3651.00
183_L226_V1.3581.00
315_E319_K1.3481.00
23_A304_Y1.3421.00
25_D28_N1.3391.00
242_T259_I1.3241.00
197_I258_L1.3211.00
316_E320_Q1.3191.00
243_S259_I1.3161.00
293_R297_N1.3011.00
218_Y230_L1.2981.00
74_V261_A1.2971.00
41_E69_I1.2961.00
23_A27_L1.2861.00
281_E284_E1.2821.00
166_I194_I1.2771.00
286_W289_L1.2701.00
98_A136_F1.2701.00
87_V156_F1.2611.00
280_K284_E1.2571.00
216_F219_Q1.2571.00
324_A328_A1.2521.00
190_E255_G1.2491.00
131_D134_K1.2471.00
231_V238_D1.2391.00
201_K262_L1.2381.00
77_G239_V1.2381.00
27_L305_A1.2301.00
38_Y318_R1.2221.00
196_V243_S1.2171.00
164_V250_A1.2151.00
30_Y34_L1.2031.00
110_A117_T1.1911.00
34_L314_R1.1901.00
84_D134_K1.1821.00
284_E287_S1.1761.00
308_D311_A1.1731.00
308_D312_R1.1581.00
177_G181_E1.1581.00
311_A315_E1.1491.00
240_Y244_K1.1371.00
32_R80_Y1.1351.00
326_D329_I1.1331.00
74_V196_V1.1251.00
284_E288_S1.1161.00
322_Q326_D1.1111.00
335_E338_D1.1091.00
42_S322_Q1.1071.00
187_S226_V1.1071.00
77_G236_V1.1061.00
166_I243_S1.1051.00
81_D240_Y1.1021.00
35_I105_L1.0981.00
81_D244_K1.0901.00
175_N220_R1.0860.99
152_A165_A1.0840.99
139_S144_A1.0810.99
82_I247_I1.0720.99
141_I144_A1.0680.99
82_I166_I1.0670.99
294_R298_R1.0660.99
81_D247_I1.0640.99
150_A193_L1.0630.99
85_E101_K1.0610.99
310_L314_R1.0610.99
116_A332_K1.0560.99
23_A302_L1.0540.99
175_N211_V1.0510.99
164_V194_I1.0510.99
105_L320_Q1.0500.99
320_Q324_A1.0500.99
38_Y321_V1.0470.99
232_D238_D1.0430.99
212_M217_H1.0430.99
185_I189_W1.0420.99
26_L295_L1.0350.99
123_K338_D1.0330.99
38_Y314_R1.0330.99
166_I196_V1.0330.99
43_I112_I1.0320.99
245_K248_E1.0270.99
229_Y257_T1.0270.99
34_L292_I1.0250.99
237_I295_L1.0230.99
228_S258_L1.0210.99
115_K333_Y1.0200.99
266_Y287_S1.0120.99
190_E254_F1.0070.99
164_V251_R1.0070.99
46_I325_I1.0060.99
80_Y240_Y1.0000.99
34_L38_Y0.9900.99
28_N80_Y0.9900.99
31_K35_I0.9830.99
221_G226_V0.9820.99
26_L237_I0.9810.99
264_Y286_W0.9770.99
295_L299_L0.9730.99
317_A321_V0.9710.99
146_F169_A0.9710.99
29_M240_Y0.9680.99
30_Y313_L0.9640.99
21_L25_D0.9640.99
305_A309_I0.9580.99
194_I247_I0.9560.99
42_S45_K0.9530.99
33_M292_I0.9520.99
149_A193_L0.9520.99
32_R76_V0.9500.99
229_Y259_I0.9390.99
42_S325_I0.9370.99
82_I88_V0.9350.98
296_E307_S0.9320.98
169_A174_A0.9220.98
246_A250_A0.9220.98
241_S245_K0.9200.98
33_M73_A0.9180.98
157_K190_E0.9170.98
30_Y296_E0.9150.98
235_D294_R0.9150.98
38_Y41_E0.9100.98
143_G179_F0.9080.98
107_G133_S0.9060.98
202_Y282_E0.9030.98
162_D252_K0.9030.98
150_A191_L0.8970.98
214_T219_Q0.8960.98
187_S225_N0.8930.98
278_R282_E0.8910.98
35_I317_A0.8900.98
319_K322_Q0.8890.98
264_Y282_E0.8880.98
238_D241_S0.8860.98
281_E285_F0.8840.98
174_A179_F0.8810.98
116_A121_K0.8800.98
143_G173_A0.8790.98
85_E162_D0.8790.98
25_D240_Y0.8760.98
149_A167_S0.8740.98
268_G274_G0.8740.98
47_Y271_E0.8700.98
183_L258_L0.8660.98
187_S213_S0.8650.97
323_E326_D0.8630.97
280_K283_V0.8540.97
320_Q323_E0.8540.97
174_A217_H0.8520.97
232_D294_R0.8500.97
187_S190_E0.8470.97
106_K324_A0.8440.97
317_A320_Q0.8440.97
297_N300_L0.8430.97
216_F230_L0.8420.97
49_E60_R0.8400.97
46_I113_L0.8380.97
182_T195_I0.8370.97
239_V261_A0.8280.97
194_I243_S0.8220.97
106_K331_S0.8180.96
68_S96_H0.8170.96
153_A192_P0.8160.96
299_L304_Y0.8140.96
76_V236_V0.8130.96
149_A165_A0.8120.96
295_L298_R0.8040.96
305_A313_L0.8000.96
73_A77_G0.7970.96
88_V97_H0.7950.96
98_A103_V0.7950.96
64_E270_F0.7930.96
246_A249_R0.7920.96
216_F262_L0.7900.96
39_F109_A0.7840.96
27_L31_K0.7750.95
30_Y314_R0.7710.95
110_A331_S0.7710.95
267_V271_E0.7690.95
249_R255_G0.7640.95
246_A259_I0.7640.95
44_R48_H0.7640.95
242_T246_A0.7640.95
64_E271_E0.7610.95
231_V259_I0.7610.95
74_V263_T0.7560.95
28_N31_K0.7550.95
194_I257_T0.7520.94
318_R322_Q0.7520.94
311_A314_R0.7510.94
254_F257_T0.7500.94
25_D244_K0.7490.94
26_L304_Y0.7470.94
31_K313_L0.7460.94
77_G81_D0.7460.94
97_H168_F0.7440.94
243_S247_I0.7440.94
32_R100_A0.7430.94
234_M294_R0.7430.94
237_I298_R0.7390.94
83_R247_I0.7380.94
83_R163_N0.7360.94
285_F289_L0.7350.94
203_A211_V0.7310.94
312_R315_E0.7300.93
283_V287_S0.7280.93
109_A325_I0.7280.93
99_I108_L0.7270.93
21_L240_Y0.7250.93
99_I105_L0.7190.93
249_R253_G0.7160.93
188_A211_V0.7130.93
27_L299_L0.7120.93
179_F258_L0.7110.93
238_D242_T0.7100.93
266_Y290_D0.7100.93
44_R271_E0.7090.92
314_R318_R0.7080.92
143_G146_F0.7030.92
110_A115_K0.7000.92
69_I267_V0.6990.92
201_K209_S0.6980.92
119_L129_L0.6980.92
68_S75_A0.6980.92
135_N163_N0.6950.92
71_Q198_E0.6950.92
275_E283_V0.6930.92
24_S28_N0.6920.92
289_L294_R0.6890.91
147_P178_T0.6880.91
38_Y317_A0.6850.91
175_N212_M0.6850.91
235_D298_R0.6840.91
264_Y283_V0.6820.91
107_G119_L0.6800.91
79_L168_F0.6770.91
204_D270_F0.6760.91
300_L305_A0.6760.91
169_A195_I0.6720.90
168_F196_V0.6700.90
142_V176_H0.6690.90
39_F108_L0.6670.90
153_A191_L0.6660.90
105_L321_V0.6640.90
103_V134_K0.6630.90
89_V148_Q0.6620.90
103_V119_L0.6610.90
300_L306_D0.6600.90
221_G258_L0.6580.89
316_E319_K0.6550.89
227_P257_T0.6540.89
207_P210_F0.6540.89
106_K110_A0.6530.89
77_G243_S0.6510.89
143_G176_H0.6480.89
144_A148_Q0.6460.89
110_A327_F0.6460.89
296_E305_A0.6440.88
310_L313_L0.6440.88
121_K338_D0.6440.88
142_V173_A0.6430.88
68_S95_H0.6420.88
241_S244_K0.6410.88
31_K320_Q0.6410.88
278_R283_V0.6380.88
232_D289_L0.6380.88
67_L267_V0.6370.88
30_Y310_L0.6330.88
313_L317_A0.6290.87
34_L313_L0.6270.87
25_D80_Y0.6260.87
234_M264_Y0.6260.87
29_M237_I0.6240.87
126_H137_A0.6220.87
162_D247_I0.6220.87
218_Y228_S0.6200.86
298_R304_Y0.6190.86
79_L101_K0.6180.86
123_K341_G0.6180.86
111_E118_G0.6180.86
217_H258_L0.6170.86
42_S46_I0.6160.86
89_V145_S0.6130.86
204_D272_G0.6130.86
153_A165_A0.6130.86
171_E217_H0.6120.86
186_A195_I0.6120.86
220_R223_A0.6100.86
40_E47_Y0.6090.85
327_F330_N0.6090.85
332_K335_E0.6090.85
293_R296_E0.6070.85
205_S271_E0.6040.85
124_G127_M0.6040.85
43_I109_A0.6020.85
117_T332_K0.6010.85
89_V149_A0.6010.85
92_H145_S0.5990.85
35_I99_I0.5980.84
196_V239_V0.5940.84
116_A338_D0.5930.84
226_V258_L0.5930.84
242_T245_K0.5910.84
21_L26_L0.5910.84
101_K134_K0.5860.83
44_R69_I0.5860.83
30_Y292_I0.5840.83
31_K317_A0.5840.83
294_R297_N0.5810.83
226_V256_P0.5810.83
231_V261_A0.5800.83
32_R35_I0.5790.82
85_E161_K0.5760.82
337_T341_G0.5750.82
152_A155_A0.5740.82
90_S136_F0.5730.82
44_R267_V0.5720.82
113_L329_I0.5710.82
194_I259_I0.5710.82
30_Y305_A0.5690.81
322_Q325_I0.5680.81
29_M76_V0.5670.81
328_A331_S0.5670.81
27_L304_Y0.5670.81
212_M220_R0.5660.81
69_I266_Y0.5660.81
146_F183_L0.5640.81
180_A223_A0.5640.81
87_V135_N0.5640.81
324_A327_F0.5630.81
153_A156_F0.5630.81
33_M295_L0.5630.81
165_A193_L0.5630.81
90_S94_P0.5620.81
208_K212_M0.5600.80
204_D271_E0.5580.80
231_V239_V0.5550.80
78_T97_H0.5550.80
132_K135_N0.5530.80
88_V101_K0.5530.80
124_G137_A0.5530.80
202_Y266_Y0.5480.79
227_P245_K0.5480.79
97_H166_I0.5480.79
214_T217_H0.5450.79
21_L241_S0.5430.78
230_L260_E0.5430.78
319_K326_D0.5420.78
166_I247_I0.5410.78
36_I76_V0.5410.78
173_A197_I0.5390.78
19_A241_S0.5390.78
92_H270_F0.5380.78
92_H204_D0.5360.77
201_K208_K0.5360.77
88_V168_F0.5360.77
59_G62_R0.5360.77
29_M77_G0.5340.77
44_R67_L0.5320.77
299_L305_A0.5320.77
209_S215_T0.5320.77
199_D208_K0.5310.77
111_E140_G0.5300.77
127_M142_V0.5300.77
39_F95_H0.5290.77
229_Y246_A0.5260.76
187_S224_Y0.5250.76
268_G275_E0.5240.76
67_L268_G0.5200.75
237_I241_S0.5190.75
88_V136_F0.5190.75
39_F43_I0.5190.75
263_T286_W0.5180.75
71_Q91_T0.5180.75
35_I324_A0.5170.75
63_G270_F0.5170.75
87_V163_N0.5150.75
113_L328_A0.5140.74
47_Y64_E0.5140.74
215_T219_Q0.5120.74
83_R251_R0.5100.74
311_A319_K0.5100.74
46_I49_E0.5090.74
78_T194_I0.5080.74
182_T193_L0.5070.73
214_T225_N0.5060.73
89_V167_S0.5040.73
94_P198_E0.5040.73
109_A328_A0.5040.73
125_G128_H0.5040.73
91_T145_S0.5030.73
35_I321_V0.5030.73
194_I246_A0.5020.73
306_D312_R0.5000.72
87_V165_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qs0A 2 0.9681 100 0.275 Contact Map
1umdA 2 0.9681 100 0.278 Contact Map
2bfdA 2 0.9072 100 0.281 Contact Map
2ozlA 2 0.9652 100 0.319 Contact Map
1w85A 2 0.9449 100 0.323 Contact Map
2xt6A 2 0.887 100 0.421 Contact Map
2yicA 2 0.8957 100 0.422 Contact Map
2jgdA 2 0.8696 100 0.444 Contact Map
5c4iC 2 0.7275 100 0.658 Contact Map
1itzA 2 0.8609 100 0.677 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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