GREMLIN Database
Q97YF5 - Pyruvate dehydrogenase, beta subunit (Lipoamide). (PdhB-1)
UniProt: Q97YF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (300)
Sequences: 13993 (8150)
Seq/√Len: 470.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_E328_K4.5581.00
19_E47_K3.6731.00
230_M324_Y3.2841.00
319_N322_T2.9021.00
212_L327_A2.7991.00
67_S79_V2.7801.00
203_A253_T2.7661.00
225_L240_V2.4131.00
207_K228_A2.4031.00
15_R47_K2.3231.00
207_K229_E2.2361.00
15_R48_F2.2111.00
230_M320_V2.1801.00
228_A240_V2.1671.00
210_T237_S2.1361.00
146_I157_L2.1271.00
226_K320_V2.1171.00
297_S329_K2.0871.00
320_V324_Y2.0761.00
251_E283_R2.0291.00
213_T261_T1.9911.00
212_L238_A1.9761.00
314_N319_N1.9461.00
255_I283_R1.9161.00
70_A75_L1.9011.00
76_H110_P1.8811.00
223_R320_V1.8371.00
230_M233_K1.8221.00
297_S326_E1.7881.00
211_D237_S1.7691.00
224_S267_V1.7621.00
239_E260_K1.7341.00
19_E48_F1.7331.00
232_Q237_S1.7321.00
64_M98_M1.7141.00
239_E257_S1.7011.00
135_S270_D1.7001.00
68_V98_M1.6851.00
207_K232_Q1.6731.00
286_S298_R1.6691.00
255_I287_K1.6631.00
278_G282_F1.6601.00
214_I224_S1.6451.00
108_Q142_G1.6371.00
216_S224_S1.6251.00
230_M321_N1.6231.00
324_Y328_K1.6221.00
211_D262_G1.6181.00
239_E261_T1.6181.00
272_M300_A1.6071.00
138_A279_E1.5921.00
144_K164_D1.5901.00
251_E287_K1.5821.00
205_I239_E1.5771.00
143_F169_I1.5671.00
311_P314_N1.5561.00
226_K229_E1.5531.00
16_Q155_K1.5491.00
78_V162_L1.5411.00
325_S329_K1.5351.00
144_K166_N1.5341.00
281_A296_I1.5281.00
256_K261_T1.5231.00
25_V70_A1.5191.00
112_P161_A1.5111.00
17_E159_I1.5001.00
208_E239_E1.4971.00
223_R226_K1.4791.00
138_A282_F1.4671.00
161_A168_V1.4511.00
64_M113_I1.4451.00
8_Q36_A1.4291.00
216_S221_V1.4231.00
215_I243_V1.4141.00
229_E233_K1.4141.00
222_H226_K1.4091.00
326_E329_K1.4071.00
265_L330_L1.4051.00
223_R323_I1.3761.00
64_M79_V1.3761.00
13_G155_K1.3621.00
314_N321_N1.3551.00
322_T326_E1.3481.00
241_I253_T1.3471.00
137_F169_I1.3441.00
227_A324_Y1.3411.00
214_I327_A1.3391.00
21_N76_H1.3311.00
230_M234_E1.3301.00
203_A243_V1.3181.00
13_G159_I1.3101.00
17_E163_R1.3001.00
18_M44_L1.2911.00
159_I163_R1.2891.00
250_D283_R1.2881.00
204_A242_D1.2861.00
110_P166_N1.2731.00
98_M113_I1.2711.00
144_K245_T1.2641.00
273_S303_D1.2571.00
83_F86_F1.2571.00
205_I208_E1.2541.00
14_I78_V1.2541.00
243_V276_V1.2491.00
17_E24_I1.2461.00
153_D242_D1.2411.00
76_H112_P1.2391.00
64_M90_G1.2321.00
8_Q12_E1.2301.00
241_I257_S1.2291.00
229_E232_Q1.2281.00
160_K200_F1.2271.00
94_M143_F1.2241.00
27_L67_S1.2181.00
149_S221_V1.2171.00
146_I245_T1.2141.00
249_L254_I1.2061.00
265_L327_A1.2061.00
94_M115_V1.2041.00
199_E202_K1.2031.00
281_A285_Q1.2001.00
17_E162_L1.1791.00
213_T257_S1.1741.00
27_L56_T1.1671.00
153_D244_R1.1661.00
23_R75_L1.1641.00
256_K260_K1.1551.00
215_I264_V1.1541.00
268_D277_T1.1521.00
43_G46_D1.1461.00
110_P165_N1.1371.00
252_E256_K1.1301.00
25_V75_L1.1231.00
26_V41_T1.1191.00
255_I288_A1.1161.00
149_S242_D1.1111.00
12_E155_K1.1061.00
214_I238_A1.0971.00
238_A327_A1.0951.00
255_I259_R1.0941.00
297_S330_L1.0921.00
206_R221_V1.0871.00
146_I168_V1.0831.00
264_V284_I1.0791.00
115_V169_I1.0671.00
16_Q159_I1.0571.00
322_T325_S1.0561.00
9_A151_P1.0551.00
202_K252_E1.0541.00
17_E20_R1.0541.00
12_E16_Q1.0531.00
71_A77_P1.0511.00
13_G16_Q1.0491.00
203_A241_I1.0481.00
12_E43_G1.0471.00
135_S139_H1.0441.00
85_D133_L1.0411.00
21_N24_I1.0411.00
267_V323_I1.0371.00
283_R287_K1.0361.00
220_M223_R1.0331.00
258_A284_I1.0321.00
285_Q296_I1.0301.00
91_F136_L1.0301.00
247_V303_D1.0221.00
251_E255_I1.0181.00
209_G237_S1.0161.00
207_K237_S1.0151.00
134_Y217_A1.0141.00
281_A298_R1.0131.00
20_R159_I1.0091.00
205_I241_I0.9991.00
18_M24_I0.9981.00
205_I253_T0.9961.00
265_L268_D0.9941.00
307_P315_A0.9931.00
144_K168_V0.9931.00
282_F298_R0.9901.00
234_E324_Y0.9791.00
16_Q20_R0.9781.00
67_S111_M0.9771.00
84_V171_F0.9671.00
61_Q93_Q0.9621.00
15_R19_E0.9571.00
257_S260_K0.9461.00
135_S274_Y0.9451.00
263_R330_L0.9431.00
213_T239_E0.9421.00
217_A246_F0.9421.00
43_G47_K0.9381.00
227_A323_I0.9301.00
265_L299_L0.9281.00
321_N325_S0.9271.00
21_N162_L0.9261.00
76_H165_N0.9221.00
26_V31_V0.9201.00
8_Q11_A0.9171.00
266_I277_T0.9161.00
149_S204_A0.9121.00
16_Q19_E0.9001.00
317_I322_T0.8951.00
311_P315_A0.8941.00
108_Q166_N0.8911.00
56_T66_I0.8861.00
213_T241_I0.8831.00
32_T53_V0.8821.00
63_F79_V0.8801.00
134_Y171_F0.8761.00
266_I269_E0.8751.00
98_M111_M0.8731.00
131_Q301_V0.8711.00
304_V315_A0.8681.00
231_L327_A0.8641.00
8_Q176_L0.8571.00
158_T170_I0.8531.00
305_P308_F0.8511.00
144_K248_P0.8501.00
42_M46_D0.8481.00
146_I200_F0.8471.00
263_R295_P0.8431.00
327_A330_L0.8431.00
23_R76_H0.8421.00
243_V246_F0.8421.00
256_K259_R0.8411.00
87_L137_F0.8411.00
35_G80_S0.8381.00
120_G313_E0.8341.00
198_I201_G0.8271.00
236_I328_K0.8261.00
224_S240_V0.8261.00
84_V137_F0.8251.00
299_L326_E0.8231.00
154_A172_G0.8221.00
160_K199_E0.8181.00
62_T66_I0.8121.00
173_H177_T0.8111.00
254_I283_R0.8091.00
25_V54_I0.8061.00
232_Q238_A0.8031.00
190_E193_E0.8021.00
212_L265_L0.8021.00
134_Y270_D0.8011.00
66_I70_A0.7991.00
27_L54_I0.7971.00
143_F167_P0.7961.00
94_M137_F0.7951.00
48_F52_R0.7931.00
253_T257_S0.7931.00
215_I241_I0.7921.00
64_M115_V0.7911.00
211_D236_I0.7891.00
249_L283_R0.7861.00
267_V299_L0.7841.00
228_A232_Q0.7781.00
123_Y310_E0.7771.00
160_K163_R0.7761.00
88_G91_F0.7751.00
45_F48_F0.7751.00
26_V78_V0.7741.00
147_V217_A0.7731.00
29_E35_G0.7731.00
14_I41_T0.7711.00
223_R313_E0.7671.00
284_I296_I0.7641.00
223_R319_N0.7631.00
312_L316_V0.7621.00
231_L324_Y0.7611.00
13_G17_E0.7591.00
138_A246_F0.7581.00
13_G158_T0.7571.00
144_K200_F0.7571.00
159_I195_P0.7541.00
314_N322_T0.7501.00
99_A305_P0.7481.00
226_K230_M0.7481.00
216_S220_M0.7471.00
97_H113_I0.7391.00
264_V268_D0.7371.00
112_P168_V0.7361.00
246_F250_D0.7291.00
208_E260_K0.7281.00
116_I172_G0.7271.00
301_V316_V0.7261.00
11_A15_R0.7261.00
10_I80_S0.7261.00
65_G93_Q0.7241.00
191_V194_E0.7231.00
99_A140_L0.7191.00
87_L117_T0.7181.00
29_E63_F0.7181.00
304_V316_V0.7171.00
133_L171_F0.7171.00
71_A111_M0.7171.00
45_F53_V0.7161.00
44_L53_V0.7141.00
156_G159_I0.7141.00
144_K247_V0.7141.00
189_E192_P0.7111.00
227_A267_V0.7091.00
298_R326_E0.7091.00
136_L140_L0.7071.00
100_K126_S0.7051.00
265_L297_S0.7021.00
325_S328_K0.7021.00
254_I284_I0.6971.00
207_K225_L0.6971.00
27_L66_I0.6971.00
152_Y192_P0.6921.00
150_T206_R0.6921.00
250_D278_G0.6851.00
285_Q288_A0.6831.00
201_G204_A0.6791.00
27_L63_F0.6761.00
94_M113_I0.6761.00
213_T260_K0.6721.00
257_S261_T0.6721.00
98_M167_P0.6701.00
276_V280_I0.6701.00
326_E330_L0.6691.00
178_G222_H0.6691.00
160_K197_E0.6671.00
126_S129_H0.6671.00
138_A274_Y0.6661.00
79_V113_I0.6651.00
268_D275_G0.6641.00
157_L244_R0.6641.00
206_R225_L0.6581.00
134_Y145_V0.6561.00
87_L115_V0.6561.00
146_I160_K0.6551.00
9_A13_G0.6541.00
227_A327_A0.6511.00
217_A243_V0.6501.00
150_T189_E0.6461.00
43_G55_D0.6421.00
22_D52_R0.6421.00
272_M286_S0.6401.00
262_G265_L0.6401.00
302_P316_V0.6391.00
72_S109_Y0.6381.00
304_V307_P0.6381.00
205_I256_K0.6371.00
309_S312_L0.6341.00
279_E282_F0.6321.00
71_A109_Y0.6321.00
258_A264_V0.6321.00
145_V169_I0.6321.00
208_E256_K0.6301.00
266_I296_I0.6290.99
163_R195_P0.6260.99
44_L48_F0.6230.99
156_G160_K0.6210.99
146_I161_A0.6200.99
67_S80_S0.6190.99
120_G312_L0.6190.99
264_V267_V0.6180.99
274_Y278_G0.6170.99
140_L143_F0.6140.99
251_E286_S0.6120.99
277_T300_A0.6100.99
32_T45_F0.6070.99
78_V158_T0.6060.99
24_I162_L0.6050.99
108_Q165_N0.6040.99
152_Y156_G0.6040.99
84_V133_L0.6030.99
92_D96_N0.5990.99
54_I66_I0.5990.99
24_I78_V0.5960.99
318_P322_T0.5950.99
211_D238_A0.5920.99
10_I158_T0.5900.99
95_F140_L0.5890.99
202_K250_D0.5880.99
265_L269_E0.5810.99
11_A36_A0.5800.99
266_I280_I0.5800.99
138_A276_V0.5780.99
88_G133_L0.5770.99
263_R266_I0.5770.99
302_P305_P0.5760.99
138_A145_V0.5750.99
272_M298_R0.5730.99
151_P189_E0.5730.99
262_G293_K0.5730.99
305_P309_S0.5720.99
161_A170_I0.5720.99
268_D271_Y0.5700.99
286_S297_S0.5700.99
144_K201_G0.5700.99
227_A320_V0.5680.99
90_G94_M0.5680.99
299_L318_P0.5680.99
33_Y55_D0.5680.99
201_G245_T0.5670.99
91_F139_H0.5670.99
208_E237_S0.5660.99
15_R53_V0.5650.99
266_I298_R0.5640.99
147_V218_G0.5620.99
205_I257_S0.5580.99
265_L326_E0.5580.99
220_M267_V0.5550.99
264_V296_I0.5540.99
59_T62_T0.5540.99
313_E318_P0.5540.99
64_M81_L0.5510.99
302_P322_T0.5500.99
70_A77_P0.5490.99
221_V240_V0.5480.99
216_S243_V0.5470.99
173_H219_L0.5450.99
42_M48_F0.5450.99
156_G195_P0.5450.99
277_T298_R0.5440.99
231_L238_A0.5430.99
213_T263_R0.5410.98
99_A143_F0.5400.98
155_K159_I0.5360.98
164_D168_V0.5360.98
278_G298_R0.5350.98
156_G197_E0.5330.98
149_S153_D0.5320.98
131_Q271_Y0.5320.98
135_S271_Y0.5300.98
76_H162_L0.5290.98
224_S268_D0.5280.98
245_T248_P0.5260.98
159_I197_E0.5260.98
112_P158_T0.5250.98
93_Q97_H0.5250.98
279_E298_R0.5240.98
88_G136_L0.5240.98
5_G8_Q0.5220.98
192_P196_Y0.5220.98
246_F276_V0.5210.98
112_P170_I0.5210.98
231_L236_I0.5190.98
228_A238_A0.5190.98
203_A250_D0.5190.98
18_M53_V0.5180.98
306_I316_V0.5180.98
211_D263_R0.5130.98
219_L223_R0.5060.98
164_D200_F0.5060.98
213_T264_V0.5060.98
288_A293_K0.5050.98
214_I267_V0.5030.98
18_M48_F0.5000.97
15_R18_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w85B 2 0.9669 100 0.211 Contact Map
1umdB 2 0.9639 100 0.222 Contact Map
1ik6A 3 0.8373 100 0.225 Contact Map
2ozlB 2 0.9789 100 0.234 Contact Map
1qs0B 2 0.9849 100 0.239 Contact Map
2o1xA 2 0.9127 100 0.252 Contact Map
2bfdB 2 0.9669 100 0.258 Contact Map
4kxvA 2 0.9127 100 0.264 Contact Map
2o1sA 2 0.9036 100 0.264 Contact Map
1gpuA 2 0.8886 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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