GREMLIN Database
Q97YE4 - Transposase ISC1217
UniProt: Q97YE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (296)
Sequences: 1048 (802)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_V155_E6.6231.00
189_F205_G3.6311.00
129_I179_L3.5381.00
152_V158_R3.4651.00
214_V219_S3.2181.00
155_E158_R3.1071.00
145_I178_S3.0961.00
36_L303_F2.9171.00
89_I172_L2.8831.00
166_K174_E2.8681.00
154_E157_K2.7891.00
287_L307_K2.7271.00
222_V228_G2.6921.00
87_L179_L2.5761.00
91_D192_W2.4351.00
90_D274_R2.3361.00
89_I187_K2.3081.00
224_E228_G2.2701.00
152_V157_K2.2061.00
90_D278_E2.1841.00
143_H178_S2.1441.00
223_G228_G2.1291.00
222_V226_P2.1231.00
221_P227_Q2.1121.00
142_I182_L2.0951.00
204_M271_W2.0681.00
128_V281_I2.0280.99
127_L193_Y2.0150.99
228_G232_V2.0120.99
274_R278_E2.0080.99
26_T30_K1.9630.99
88_I132_K1.9510.99
221_P226_P1.9410.99
153_E157_K1.9300.99
154_E158_R1.8780.99
32_V59_T1.8670.99
222_V229_E1.8520.99
143_H175_F1.8350.99
240_K244_I1.8220.99
278_E285_K1.8080.99
130_G139_I1.7900.99
153_E158_R1.7810.99
91_D168_K1.7290.98
85_V131_V1.7240.98
153_E156_L1.7230.98
221_P228_G1.7030.98
220_V223_G1.6970.98
91_D193_Y1.6740.98
293_S299_R1.6720.98
294_F299_R1.6370.97
145_I174_E1.6340.97
222_V227_Q1.6070.97
62_N65_D1.6060.97
90_D285_K1.5790.97
275_W278_E1.5610.97
63_N292_G1.5550.97
152_V156_L1.5520.97
22_I25_M1.5420.96
240_K243_V1.4680.95
145_I301_S1.4660.95
95_H117_H1.4510.95
296_T307_K1.4510.95
64_L306_L1.4470.95
193_Y274_R1.4420.95
220_V229_E1.4160.94
22_I30_K1.4080.94
86_L270_T1.4000.94
193_Y285_K1.3730.93
221_P224_E1.3710.93
194_V205_G1.3660.93
220_V226_P1.3620.93
202_N258_T1.3480.93
274_R285_K1.3450.92
130_G281_I1.3430.92
226_P229_E1.3400.92
93_H121_E1.3280.92
170_D173_L1.3260.92
93_H114_C1.3240.92
70_A74_E1.3190.92
91_D275_W1.3070.91
224_E230_Y1.2990.91
224_E227_Q1.2870.91
220_V228_G1.2860.91
223_G230_Y1.2790.90
71_K76_V1.2750.90
211_A256_F1.2750.90
220_V232_V1.2730.90
89_I129_I1.2680.90
199_L205_G1.2650.90
279_V283_E1.2590.90
167_T170_D1.2540.90
103_P300_N1.2480.89
147_Y165_F1.2440.89
190_D278_E1.2250.88
168_K193_Y1.2230.88
295_L303_F1.2080.88
92_T278_E1.2070.88
129_I175_F1.2060.88
90_D275_W1.1970.87
203_T258_T1.1920.87
223_G227_Q1.1920.87
275_W285_K1.1900.87
109_A122_S1.1890.87
240_K257_S1.1810.86
33_A37_L1.1720.86
156_L159_R1.1690.86
43_G142_I1.1690.86
223_G232_V1.1670.86
220_V227_Q1.1670.86
303_F310_S1.1660.86
224_E229_E1.1640.86
72_L75_I1.1600.85
114_C121_E1.1590.85
94_D102_M1.1560.85
292_G300_N1.1510.85
263_T266_D1.1510.85
243_V246_D1.1340.84
194_V200_Q1.1210.83
86_L188_V1.1160.83
160_G163_V1.1160.83
46_A293_S1.1140.83
24_S71_K1.1130.83
130_G280_L1.1120.83
115_R192_W1.1050.83
186_S270_T1.1040.82
102_M124_I1.0960.82
249_G257_S1.0950.82
93_H112_F1.0950.82
63_N67_A1.0920.82
304_V307_K1.0900.82
36_L40_A1.0830.81
306_L310_S1.0810.81
225_F228_G1.0670.80
88_I188_V1.0660.80
73_I77_K1.0410.79
87_L184_V1.0390.78
195_N210_S1.0390.78
231_L234_Y1.0370.78
145_I171_A1.0350.78
96_K109_A1.0240.77
69_Q302_G1.0200.77
19_N23_L1.0150.77
221_P233_E1.0140.77
206_E253_R1.0130.77
222_V232_V1.0120.77
230_Y233_E0.9900.75
90_D277_I0.9880.75
29_R67_A0.9790.74
189_F194_V0.9770.74
276_D311_L0.9740.74
297_W301_S0.9730.74
204_M257_S0.9700.73
240_K245_D0.9690.73
139_I276_D0.9680.73
188_V270_T0.9640.73
20_E25_M0.9620.73
108_G288_G0.9570.72
141_V311_L0.9560.72
227_Q232_V0.9540.72
28_T33_A0.9530.72
274_R281_I0.9500.72
227_Q231_L0.9480.72
150_R154_E0.9430.71
71_K75_I0.9430.71
37_L309_L0.9400.71
171_A175_F0.9390.71
27_G31_D0.9390.71
103_P297_W0.9380.71
159_R163_V0.9330.71
277_I285_K0.9320.70
94_D126_L0.9300.70
275_W314_V0.9280.70
128_V141_V0.9280.70
108_G148_I0.9250.70
21_V27_G0.9230.70
225_F232_V0.9190.69
48_E51_Q0.9170.69
114_C117_H0.9090.69
112_F115_R0.9080.68
139_I280_L0.9080.68
21_V24_S0.9080.68
299_R303_F0.9010.68
221_P225_F0.9000.68
22_I29_R0.8950.67
92_T275_W0.8940.67
220_V224_E0.8900.67
159_R162_E0.8890.67
241_L254_Y0.8880.67
18_V34_K0.8870.67
37_L71_K0.8850.66
114_C125_Q0.8830.66
103_P124_I0.8810.66
124_I300_N0.8790.66
141_V312_L0.8780.66
117_H121_E0.8770.66
125_Q149_P0.8710.65
150_R187_K0.8690.65
90_D168_K0.8660.65
211_A254_Y0.8660.65
285_K314_V0.8640.65
242_L267_I0.8590.64
129_I176_L0.8590.64
28_T31_D0.8520.63
127_L172_L0.8510.63
126_L304_V0.8490.63
207_L256_F0.8450.63
125_Q168_K0.8430.63
141_V280_L0.8410.62
25_M29_R0.8410.62
39_G49_I0.8380.62
57_Y61_L0.8350.62
124_I148_I0.8350.62
29_R296_T0.8320.62
111_I122_S0.8300.61
263_T269_T0.8290.61
34_K38_L0.8280.61
225_F231_L0.8240.61
126_L300_N0.8230.61
112_F124_I0.8210.61
129_I187_K0.8200.60
281_I285_K0.8170.60
94_D304_V0.8170.60
58_E62_N0.8110.60
208_K212_R0.8100.60
221_P229_E0.8090.59
122_S149_P0.8020.59
127_L145_I0.8010.59
112_F121_E0.7970.58
38_L41_V0.7890.58
102_M146_A0.7860.57
102_M292_G0.7860.57
157_K162_E0.7830.57
102_M126_L0.7830.57
189_F208_K0.7830.57
191_S208_K0.7830.57
222_V233_E0.7820.57
92_T285_K0.7810.57
255_F271_W0.7810.57
115_R121_E0.7800.57
33_A36_L0.7790.57
94_D128_V0.7790.57
26_T32_V0.7770.56
17_A20_E0.7760.56
82_D136_N0.7710.56
205_G256_F0.7680.55
92_T274_R0.7680.55
244_I247_Y0.7670.55
110_Q151_K0.7650.55
184_V282_R0.7630.55
21_V25_M0.7620.55
222_V230_Y0.7610.55
223_G226_P0.7600.55
319_Y322_G0.7540.54
207_L278_E0.7520.54
281_I284_L0.7500.54
127_L171_A0.7500.54
114_C275_W0.7490.54
221_P231_L0.7470.53
18_V33_A0.7450.53
74_E265_E0.7400.53
190_D274_R0.7360.52
90_D193_Y0.7290.52
127_L168_K0.7280.52
26_T29_R0.7270.51
48_E293_S0.7230.51
93_H120_F0.7190.51
91_D277_I0.7180.51
191_S207_L0.7170.50
277_I287_L0.7130.50
17_A21_V0.7120.50
257_S293_S0.7110.50
91_D281_I0.7110.50
58_E72_L0.7110.50
21_V213_V0.7070.49
193_Y275_W0.7060.49
192_W275_W0.7050.49
278_E281_I0.7040.49
16_K19_N0.7000.49
83_H156_L0.6990.49
93_H125_Q0.6980.49
48_E283_E0.6980.49
36_L293_S0.6920.48
32_V63_N0.6920.48
23_L30_K0.6880.48
271_W274_R0.6880.48
92_T304_V0.6880.48
246_D249_G0.6870.47
62_N67_A0.6850.47
18_V37_L0.6800.47
69_Q98_Y0.6790.47
101_A129_I0.6790.47
111_I120_F0.6770.46
63_N69_Q0.6750.46
220_V234_Y0.6720.46
239_I243_V0.6710.46
60_V72_L0.6690.46
40_A45_N0.6670.45
68_A302_G0.6670.45
77_K182_L0.6650.45
288_G291_G0.6620.45
181_G185_K0.6610.45
33_A300_N0.6590.45
127_L147_Y0.6580.45
207_L211_A0.6580.45
111_I121_E0.6580.45
89_I175_F0.6540.44
98_Y295_L0.6540.44
16_K20_E0.6520.44
98_Y109_A0.6510.44
316_Y322_G0.6500.44
279_V282_R0.6460.43
229_E233_E0.6450.43
224_E231_L0.6440.43
275_W281_I0.6430.43
39_G60_V0.6400.43
89_I229_E0.6390.43
111_I118_K0.6380.43
94_D303_F0.6360.42
69_Q306_L0.6360.42
41_V267_I0.6360.42
21_V34_K0.6350.42
75_I316_Y0.6340.42
18_V21_V0.6340.42
147_Y168_K0.6310.42
228_G231_L0.6310.42
289_L304_V0.6310.42
231_L240_K0.6290.42
32_V35_R0.6280.42
112_F149_P0.6280.42
257_S267_I0.6270.42
233_E237_T0.6250.41
40_A306_L0.6240.41
25_M30_K0.6220.41
45_N305_A0.6210.41
92_T289_L0.6210.41
284_L289_L0.6180.41
20_E24_S0.6170.41
69_Q305_A0.6160.41
115_R120_F0.6150.40
120_F308_A0.6110.40
17_A313_V0.6110.40
223_G231_L0.6080.40
127_L289_L0.6080.40
90_D190_D0.6060.40
189_F192_W0.6050.40
196_S290_E0.6040.39
58_E292_G0.6030.39
27_G74_E0.6030.39
102_M300_N0.6020.39
172_L194_V0.5990.39
193_Y278_E0.5980.39
95_H114_C0.5980.39
296_T308_A0.5970.39
114_C120_F0.5960.39
57_Y275_W0.5960.39
239_I242_L0.5940.38
207_L241_L0.5930.38
132_K273_N0.5930.38
166_K177_S0.5900.38
36_L39_G0.5890.38
102_M122_S0.5890.38
179_L182_L0.5860.38
95_H121_E0.5850.38
223_G229_E0.5850.38
302_G305_A0.5840.38
47_T299_R0.5820.37
45_N50_A0.5820.37
210_S250_Y0.5810.37
170_D196_S0.5800.37
102_M118_K0.5790.37
102_M293_S0.5780.37
103_P301_S0.5770.37
127_L274_R0.5760.37
214_V265_E0.5760.37
44_R98_Y0.5750.37
282_R285_K0.5730.37
241_L251_G0.5710.36
97_L121_E0.5710.36
39_G108_G0.5700.36
300_N304_V0.5680.36
73_I76_V0.5660.36
98_Y283_E0.5650.36
245_D251_G0.5630.36
40_A284_L0.5630.36
149_P187_K0.5610.35
124_I303_F0.5610.35
45_N311_L0.5610.35
45_N118_K0.5600.35
45_N288_G0.5590.35
32_V62_N0.5590.35
318_K322_G0.5590.35
44_R50_A0.5580.35
123_A271_W0.5580.35
101_A246_D0.5580.35
39_G45_N0.5570.35
31_D150_R0.5570.35
168_K171_A0.5530.35
16_K23_L0.5530.35
64_L302_G0.5520.35
227_Q233_E0.5510.35
295_L310_S0.5510.35
116_A290_E0.5480.34
200_Q205_G0.5470.34
67_A302_G0.5460.34
300_N307_K0.5450.34
112_F125_Q0.5430.34
168_K278_E0.5350.33
60_V142_I0.5340.33
29_R33_A0.5330.33
287_L305_A0.5320.33
67_A131_V0.5310.33
203_T268_I0.5310.33
179_L188_V0.5310.33
278_E314_V0.5300.33
292_G299_R0.5290.33
60_V63_N0.5280.32
48_E257_S0.5250.32
131_V189_F0.5250.32
144_I311_L0.5220.32
148_I152_V0.5210.32
86_L272_E0.5210.32
83_H183_N0.5210.32
91_D191_S0.5210.32
301_S306_L0.5200.32
135_V138_Q0.5190.32
46_A195_N0.5170.32
29_R32_V0.5160.31
156_L162_E0.5150.31
54_E67_A0.5150.31
31_D68_A0.5150.31
282_R293_S0.5130.31
44_R291_G0.5130.31
142_I179_L0.5120.31
51_Q142_I0.5110.31
283_E286_A0.5100.31
192_W208_K0.5090.31
28_T36_L0.5080.31
168_K194_V0.5060.31
296_T311_L0.5040.30
228_G233_E0.5020.30
38_L46_A0.5010.30
78_K221_P0.5010.30
22_I27_G0.5000.30
294_F310_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9266 99.9 0.715 Contact Map
2kkoA 2 0.3023 15.3 0.966 Contact Map
3hdeA 2 0.2825 13.2 0.967 Contact Map
3hdfA 1 0.2797 11.2 0.968 Contact Map
3qfiA 1 0.2571 7.6 0.97 Contact Map
2j49A 1 0.2288 7.6 0.97 Contact Map
2zkzA 2 0.2514 6.8 0.971 Contact Map
1xjuA 2 0.2994 6.1 0.972 Contact Map
1qgpA 1 0.2034 5.9 0.972 Contact Map
1xjtA 1 0.2994 5.6 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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