GREMLIN Database
Q97YE3 - Uncharacterized protein
UniProt: Q97YE3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (149)
Sequences: 162 (128)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_F142_S4.9961.00
54_L93_L4.3780.99
50_W112_T3.9260.99
88_A96_I3.7380.98
47_F90_T3.5830.98
126_L139_A3.4570.97
32_E36_E3.2850.96
121_Y139_A3.1690.95
85_G93_L2.5520.86
120_R132_P2.5240.86
121_Y126_L2.5080.85
113_T117_G2.3190.80
121_Y136_R2.2060.77
11_E14_K2.1940.76
62_F82_M2.1930.76
50_W139_A2.1550.75
58_V88_A2.0670.72
58_V96_I2.0550.71
31_I151_V2.0310.70
112_T146_L1.9000.65
19_R43_A1.8970.65
136_R139_A1.8720.64
55_S88_A1.8500.63
118_I142_S1.7030.56
44_S122_A1.6960.56
50_W146_L1.6670.54
94_I142_S1.5990.51
24_L154_V1.5580.49
95_G135_S1.5380.48
20_L144_K1.4780.46
139_A146_L1.4710.45
53_L108_L1.4260.43
4_Q128_E1.3360.39
39_S121_Y1.3230.38
65_I81_Y1.3200.38
151_V154_V1.3180.38
14_K17_R1.3180.38
26_E34_L1.3160.38
60_T81_Y1.3120.38
94_I133_F1.2910.37
55_S96_I1.2850.37
147_I154_V1.2840.37
82_M147_I1.2800.37
126_L136_R1.2550.35
27_L143_I1.2420.35
112_T139_A1.2410.35
42_S48_L1.2160.34
30_S127_D1.1610.32
54_L90_T1.1570.31
90_T93_L1.1540.31
101_E106_K1.1520.31
40_R131_S1.1160.30
84_I137_S1.1150.30
31_I77_E1.1080.29
50_W126_L1.1000.29
126_L140_I1.0800.28
64_K67_E1.0800.28
61_N64_K1.0580.28
103_L150_E1.0470.27
40_R43_A1.0290.26
49_S137_S1.0250.26
46_L97_A1.0200.26
140_I144_K1.0050.26
94_I117_G1.0040.26
30_S42_S0.9980.25
150_E153_I0.9680.24
76_D130_I0.9660.24
16_S60_T0.9650.24
15_Y56_S0.9530.24
71_K105_F0.9520.24
100_L146_L0.9480.24
33_M86_Y0.9440.23
12_P59_V0.9440.23
39_S136_R0.9420.23
107_G153_I0.9340.23
33_M83_R0.9290.23
8_F55_S0.9240.23
51_K137_S0.9200.23
5_L121_Y0.9200.23
26_E48_L0.9090.22
44_S65_I0.9060.22
52_A118_I0.9010.22
105_F146_L0.8940.22
117_G132_P0.8880.22
134_H152_E0.8640.21
53_L98_R0.8620.21
85_G103_L0.8500.20
51_K71_K0.8390.20
115_M137_S0.8390.20
21_L70_K0.8360.20
5_L8_F0.8290.20
83_R120_R0.8260.20
41_N51_K0.8220.20
86_Y105_F0.8190.20
94_I98_R0.8140.19
28_Y38_Y0.8090.19
70_K93_L0.8010.19
33_M38_Y0.8010.19
19_R65_I0.7990.19
126_L134_H0.7930.19
50_W121_Y0.7900.19
69_K86_Y0.7850.19
63_G108_L0.7840.19
16_S29_L0.7820.18
80_W138_E0.7760.18
34_L52_A0.7740.18
92_G117_G0.7720.18
16_S78_I0.7690.18
41_N142_S0.7650.18
92_G134_H0.7620.18
102_N113_T0.7550.18
28_Y83_R0.7540.18
70_K154_V0.7510.18
13_E93_L0.7490.18
66_M82_M0.7430.17
31_I147_I0.7430.17
108_L151_V0.7330.17
25_Q128_E0.7280.17
102_N141_I0.7260.17
78_I138_E0.7250.17
45_K157_M0.7210.17
18_L128_E0.7160.17
91_T147_I0.7140.17
48_L58_V0.7060.16
29_L132_P0.6940.16
17_R105_F0.6900.16
25_Q28_Y0.6900.16
81_Y120_R0.6870.16
49_S122_A0.6840.16
62_F81_Y0.6800.16
19_R22_E0.6790.16
70_K148_K0.6750.16
30_S150_E0.6750.16
120_R144_K0.6710.16
54_L100_L0.6660.15
58_V104_G0.6650.15
80_W104_G0.6630.15
6_P104_G0.6610.15
41_N45_K0.6610.15
5_L104_G0.6550.15
149_A152_E0.6550.15
12_P47_F0.6530.15
24_L147_I0.6510.15
95_G107_G0.6500.15
103_L157_M0.6440.15
75_E151_V0.6440.15
11_E17_R0.6370.15
149_A153_I0.6370.15
27_L38_Y0.6370.15
31_I144_K0.6360.15
118_I132_P0.6310.15
40_R44_S0.6270.14
54_L57_I0.6210.14
18_L126_L0.6210.14
31_I47_F0.6190.14
92_G146_L0.6190.14
40_R48_L0.6170.14
66_M135_S0.6150.14
32_E46_L0.6100.14
11_E86_Y0.6070.14
112_T145_G0.6060.14
51_K101_E0.6050.14
107_G114_A0.6030.14
28_Y77_E0.6030.14
48_L131_S0.6000.14
62_F85_G0.6000.14
7_K49_S0.5990.14
18_L84_I0.5980.14
79_K83_R0.5970.14
6_P50_W0.5960.14
59_V62_F0.5950.14
44_S48_L0.5930.14
48_L122_A0.5930.14
69_K95_G0.5930.14
101_E109_V0.5930.14
34_L91_T0.5920.14
129_D134_H0.5910.14
28_Y96_I0.5880.14
52_A63_G0.5830.13
77_E143_I0.5830.13
8_F122_A0.5820.13
118_I143_I0.5810.13
53_L142_S0.5780.13
90_T128_E0.5760.13
17_R84_I0.5750.13
78_I83_R0.5750.13
64_K104_G0.5730.13
13_E20_L0.5700.13
110_N113_T0.5680.13
47_F93_L0.5680.13
111_L138_E0.5670.13
94_I104_G0.5670.13
94_I114_A0.5660.13
51_K120_R0.5660.13
11_E69_K0.5640.13
56_S90_T0.5610.13
150_E157_M0.5550.13
33_M54_L0.5520.13
51_K107_G0.5520.13
23_A30_S0.5500.13
143_I154_V0.5480.13
14_K21_L0.5470.13
96_I154_V0.5470.13
94_I113_T0.5460.13
80_W129_D0.5430.13
137_S144_K0.5420.13
41_N49_S0.5380.13
71_K133_F0.5370.13
4_Q78_I0.5330.12
96_I132_P0.5290.12
22_E40_R0.5280.12
67_E124_N0.5280.12
63_G79_K0.5280.12
14_K108_L0.5280.12
26_E42_S0.5270.12
110_N114_A0.5250.12
145_G156_S0.5220.12
26_E139_A0.5160.12
71_K83_R0.5140.12
70_K103_L0.5100.12
23_A55_S0.5060.12
17_R97_A0.5030.12
30_S155_G0.5020.12
44_S131_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j4wA 3 0.435 78.4 0.937 Contact Map
2hsbA 2 0.6836 78.2 0.938 Contact Map
3o10A 2 0.7345 78 0.938 Contact Map
4j4rA 3 0.4576 69 0.942 Contact Map
2jpuA 1 0.7232 68.6 0.942 Contact Map
1wolA 1 0.6554 61.5 0.945 Contact Map
4j4yA 4 0.4407 57.8 0.946 Contact Map
3ov9A 3 0.4407 49 0.949 Contact Map
4nqfA 2 0.7458 45.3 0.95 Contact Map
1ufbA 3 0.6836 39.3 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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